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Sui Z.,Aesthetic and Plastic Surgery Center | Gu T.,Aesthetic and Plastic Surgery Center | Liu B.,Jilin University | Peng S.,Aesthetic and Plastic Surgery Center | And 4 more authors.
Carbohydrate Polymers | Year: 2011

A polysaccharide was isolated from the Herba Cistanches. This polysaccharides contained glucose, galactose, rhamnose, arabinose and fructose. The native polysaccharide could be fractionated by size exclusion chromatography into one major fraction. The apparent average molecular weight of the purified polysaccharide was estimated to be approximately 385 kDa by size-exclusion HPLC. Furthermore, this polysaccharides still exhibited strong antioxidant activities in aged rats' skin. Namely, Herba Cistanches polysaccharides inhibited the oxidative modification of lipids, thus protecting cells from injury by the oxidized molecules in aged rats' skin. The present results were in accordance with previous studies on the mode of the protective effect of the plant extract which showed positively that the protection may possibly be attributed to the combination of more than one biological activities and that the use of antioxidants might be an useful approach in the treatment of some skin aging diseases. © 2011 Elsevier Ltd. All rights reserved.


Sui Z.,Aesthetic and Plastic Surgery Center | Yang R.,Aesthetic and Plastic Surgery Center | Liu B.,Jilin University | Gu T.,Aesthetic and Plastic Surgery Center | And 3 more authors.
International Journal of Biological Macromolecules | Year: 2010

Agaricus blazei polysaccharides were analyzed by GC-MS. Results indicated that the polysaccharides contained glucose (93.87%), mannose (3.54%), and arabinose (2.25%). The compositional analysis was completed by the methylation data. These data indicated that Agaricus blazei polysaccharides are glucans. Compared to model rats, rats fed with Agaricus blazei polysaccharides showed a decrease of ratio of IL-1β/β-actin and IL-1β level in skin of burn wound. Recovery rate of wound skin increased with increasing dose of polysaccharides. The results indicated that Agaricus blazei polysaccharides could be useful in promote burn wound healing. © 2010 Elsevier B.V.


Sui Z.,Aesthetic and Plastic Surgery Center | Li L.,Aesthetic and Plastic Surgery Center | Liu B.,Jilin University | Gu T.,Aesthetic and Plastic Surgery Center | And 4 more authors.
Carbohydrate Polymers | Year: 2013

Optimization of Radix Rehmanniae polysaccharides (RRPs) was done using response surface methodology (RSM). Optimum extraction conditions for maximizing the determination of Radix Rehmanniae polysaccharides were: extraction temperature 100 °C, extraction time 2 h and ratio of liquid to solid 6. The model had a satisfactory coefficient of R2 (=0.9815) and was verified experimentally. The results suggested that the conditions were mild and useful for extraction yield of Radix Rehmanniae polysaccharides. Pharmacological experiment showed that Radix Rehmanniae polysaccharides could enhance serum interleukin-2 (IL-2), interleukin-4 (IL-4) and interleukin-10 (IL-10) levels, skin glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities, and decrease skin malondialdehyde (MDA) level in ultraviolet B (UVB) ray treated mice, this study suggests that Radix Rehmanniae polysaccharides extract may prove to be a useful therapeutic option in the reversal of skin diseases. © 2012 Elsevier Ltd. All rights reserved.

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