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Patent
Advion Inc. | Date: 2016-10-19

Systems and methods for ionization of a sample and mass separation of the ions by a mass spectrometer are disclosed herein.


Eikel D.,Advion Inc.
Rapid communications in mass spectrometry : RCM | Year: 2011

An automated surface-sampling technique called liquid extraction surface analysis (LESA), coupled with infusion nano-electrospray high-resolution mass spectrometry and tandem mass spectrometry (MS/MS), is described and applied to the qualitative determination of surface chemical residues resulting from the artificial spraying of selected fresh fruits and vegetables with representative pesticides. Each of the targeted pesticides was readily detected with both high-resolution and full-scan collision-induced dissociation (CID) mass spectra. In the case of simazine and sevin, a mass resolution of 100,000 was insufficient to distinguish the isobaric protonated molecules for these compounds. When the surface of a spinach leaf was analyzed by LESA, trace levels of diazinon were readily detected on the spinach purchased directly from a supermarket before they were sprayed with the five-pesticide mixture. A 30 s rinse under hot running tap water appeared to quantitatively remove all remaining residues of this pesticide. Diazinon was readily detected by LESA analysis on the skin of the artificially sprayed spinach. Finally, incurred pyrimethanil at a level of 169 ppb in a batch slurry of homogenized apples was analyzed by LESA and this pesticide was readily detected by both high-resolution mass spectrometry and full-scan CID mass spectrometry, thus showing that pesticides may also be detected in whole fruit homogenized samples. This report shows that representative pesticides on fruit and vegetable surfaces present at levels 20-fold below generally allowed EPA tolerance levels are readily detected and confirmed by the title technologies making LESA-MS as interesting screening method for food safety purposes. Copyright © 2011 John Wiley & Sons, Ltd.


Patent
Advion Inc. | Date: 2016-01-12

Surface extraction interface systems can include a seal assembly with a cavity assembly, an actuator, and a force gauge. Methods of preparing a sample for analysis can include: receiving data identifying characteristics of a surface supporting the sample; determining a pressure to be applied by a seal assembly against the surface; pressing a cavity assembly against the surface facing the open side of the cavity until the pressure is achieved; and extracting a sample from the surface by flowing a stream of extraction solvent through the sealed extraction cavity.


Patent
Advion Inc. | Date: 2011-05-04

A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.


Patent
Advion Inc. | Date: 2012-07-30

A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.


Patent
Advion Inc. | Date: 2011-08-18

Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.


Patent
Advion Inc. | Date: 2012-03-15

Systems and methods for purification of radiotracers and non-radioactive materials produced by both microfluidic, conventional, semi-automated and manual synthesis systems are described herein.


Patent
Advion Inc. | Date: 2010-12-03

Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.


An electrospray device comprises a capillary tube (52) having a passage for conducting fluids through the capillary tube and connecting an entrance orifice and an exit orifice (56). First and the second electrodes are positioned to define an electric field surrounding the exit orifice (56). The first electrode (70) circumscribes the capillary tube proximate the exit orifice, and the second electrode imparts a second potential to the fluid. A mass spectrometry device may be provided to receive fluid droplets/sprays of fluid (60,62) from the exit orifice (56).


Patent
Scientific Analysis Instruments Ltd. and Advion Inc. | Date: 2012-08-01

Methods and systems for mass spectrometry and more particularly to an interface providing charged particles to a mass spectrometer are described herein.

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