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Thamizhselvi R.K.,Advinus Therapeutics Pvt. Ltd.
Indian Journal of Animal Sciences | Year: 2010

A study of 49 contract broiler farmers under 4 leading integrators in and around Puducherry revealed that the contract is one sided favouring the integrator as the contract stipulates standards for the outputs from the farmer but it does not specify any standards for the inputs the integrator supplies such as weight of the day-old chick, quality standards for feed and medicines. The findings also indicated that the weight of the day-old chicks supplied was less than the standard weight of 40 g, an important cause for low body weight gain as well as high mortality. Although the integrators are bearing the risk of production and marketing, the contract broiler farming is exploitative as the integrators are paying on an average 4.61/bird, mostly on the basis of production cost. The integrators may do well by bearing the cost of the miscellaneous inputs being provided by the farmers and by taking feed conversion ratio as the basis for payment rather than production cost on which the farmer has very little control. Source

Singh U.P.,Indian Institute of Science | Singh U.P.,Advinus Therapeutics Pvt. Ltd.
Journal of Molecular Structure | Year: 2010

Structure of a cyclic water tetramer in channels (pores) formed by self-assembly of N6-methyl-5′-AMP·Na2 molecules is described and a hypothetical model is proposed for growth of water clusters. © 2010 Elsevier B.V. All rights reserved. Source

Anitha A.,Sahyadri Science College | Venugopala K.R.,Sahyadri Science College | Vittala K.S.,Sahyadri Science College | Fasiulla A.,Manipal University India | And 3 more authors.
Der Pharma Chemica | Year: 2011

In the present study, bisazo dye 2, 21 [benzene-1, 3-diyl di(E) diazene 2,1-diyl] bis (4-nitroaniline) has been synthesized by the diazotization and coupling of Meta phenylene diamine with 4-nitroaniline. Further azo metal (II) complexes of Co, Cu, Mn, Ni and Zn have been synthesized. The ligand and all the metal complexes were characterized by various physicochemical techniques like elemental analysis, electronic, Infrared, Proton NMR and TGA. The metal chelates have metal to ligand ratio of 1:1. All the synthesized compounds were screened for antimicrobial activity. Source

Tiwari A.,Advinus Therapeutics Pvt. Ltd.
Drugs of the Future | Year: 2012

Luseogliflozin (TS-071), developed by Taisho Pharmaceutical, is a novel, potent sodium/glucose cotransporter 2 (SGLT2) inhibitor for the potential treatment of type 2 diabetes (T2D) and type 1 diabetes (T1D). Luseogliflozin exhibits high selectivity for SGLT2 over SGLT1 and the glucose transporters GLUT2 and GLUT4, with favorable pharmacokinetic and pharmacodynamic properties. Luseogliflozin exhibited increased urinary glucose excretion, with improved glucose tolerance and a significant reduction in fasting plasma glucose and postprandial plasma glucose, with body weight loss after chronic treatment in different animal models of diabetes and without an increase in plasma insulin. Clinical data in Japanese patients demonstrated that luseogliflozin was orally bioavailable, with a prolonged half-life, suitability for once-daily dosing and effective in significantly reducing glycated hemoglobin and fasting plasma glucose, with body weight loss. Luseogliflozin was well tolerated, without the risk of hypoglycemia and clinically meaningful changes in urinary volume, electrolyte excretion and renal function. The results from phase III clinical trials in T2D and T1D patients will be pivotal; however, the available data suggest that luseogliflozin has potential for success in this niche market segment. Copyright © 2012 Prous Science, S.A.U. or its licensors. All rights reserved. Source

Basavaiah K.,University of Mysore | Tharpa K.,University of Mysore | Vinay K.B.,Advinus Therapeutics Pvt. Ltd.
Ecletica Quimica | Year: 2010

Four simple titrimetric procedures are described for the determination of lisinopril (LNP) in bulk and in pharmaceuticals based on the neutralization of basic-amino and acidic carboxylic acid groups present in LNP. Method A is based on the neutralization of basic amino groups using perchloric acid as titrant in anhydrous acetic acid medium. Method B, method C and method D are based on neutralization of carboxylic acid group using NaOH, sodium methoxide and methanolic KOH, as titrants, respectively. Method A is applicable over 2.0-20.0 mg range and the calculations are based in the molar ratio of 1:2 (LNP:HClO4). Method B, method C and method D are applicable over 2.0-20.0 mg, 1.0-10.0 mg and 5.0-15.0 mg range, respectively, and their respective molar ratios are 1:1 (LNP:NaOH), 1:2 (LNP:CH3ONa) and 1:1 (LNP:KOH). Intraday and inter day accuracy and precision of the methods were evaluated and the results showed intra- and inter-day precision less than 2.7% (RSD), and accuracy of < 2.5 % (RE). The developed methods were applied to determine LNP in tablets and the results were validated statistically by comparing the results with those of the reference method by applying the Student's t-test and F-test. The accuracy was further ascertained by recovery studies via standard addition technique. No interferences from common tablet exipients was observed. Source

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