Miyawaki A.,Advanced Research Corp. |
Nature Reviews Molecular Cell Biology | Year: 2011
Proteins are always on the move, and this may occur through diffusion or active transport. The realization that the regulation of signal transduction is highly dynamic in space and time has stimulated intense interest in the movement of proteins. Over the past decade, numerous new technologies using fluorescent proteins have been developed, allowing us to observe the spatiotemporal dynamics of proteins in living cells. These technologies have greatly advanced our understanding of protein dynamics, including protein movement and protein interactions. © 2011 Macmillan Publishers Limited. All rights reserved.
Fukutake N.,Advanced Research Corp.
Journal of the Optical Society of America B: Optical Physics | Year: 2013
We report a theoretical study on the optical resolution of coherent nonlinear microscopy by means of double-sided Feynman diagrams. Through the use of the diagrams, we offer a simple techniqueto calculate the coherent transfer function (CTF), which is employed as the indicator of the optical resolution. In particular, we deal with the CTFs of coherent anti-Stokes Raman scattering (CARS) microscopy and stimulated Raman scattering (SRS) microscopy. Our results show that CARS and SRS microscopy possess nearly identical optical resolutions if a molecularvibrational frequency of interest is assumed to be negligible compared with excitation photon energy. The peculiar image-formation properties of third-harmonic generation (THG) microscopy also can be explained by our technique. © 2013 Optical Society of America.
Agency: Department of Energy | Branch: | Program: STTR | Phase: Phase I | Award Amount: 150.00K | Year: 2015
As magnetically confined plasmas progress towards ignition and very long pulse experiments, the physics of the pedestal and divertor regions has become increasingly important. There is a critical need for comprehensive measurements in boundary layer plasmas and the importance of such measurements to the improvement of predictive numerical simulations. The focus of this proposal is the direct, spatially resolved, measurement of the energy spectra of ions in the edge of a plasma using in-situ probes that are easily replaced and require minimal resources. This will be accomplished by the development of a Micro Scale Ion Spectrometer. In the Phase I research, a proof of concept device will be fabricated and tested. This device will be constructed of sensing elements of the same size as a fully functional device and hence provide a very high degree of confidence in the applicability of this instrument. The benefits of a successful completion of Phase I and Phase II are significant in that the resulting sensor and instrument of a new Micro Ion Spectrometer which will exhibit extremely small size and low power consumption and which can be positioned and manipulated easily inside sealed chambers such as plasma and related vacuum process chambers. The MIS sensor has the potential to play a useful role in fundamental physic plasma research such as in fusion plasma devices and in the broader community of plasma physics and chemistry research at national research laboratories, private industry, and universities. The extended commercial applications include the gamut of plasma processes as used in semiconductor manufacturing technologies. It is thought that all plasma processing equipment are a potential site for on-board OEM packages of the MIS that could fulfill the need for real time in-situ plasma sensing. Future developments of the sensor will be that of a Micro Mass Spectrometer. The extension to semiconductor device processing will help create semiconductor structures that will lead to new and novel devices. In space based applications, such as being a part of the instrumentation package for CubeSats and other micro-satellites, the new device can be used to yield new information about energetic charged particles ion the heliosphere and magnetosphere and thereby support the expanding field of space weather research. Early warnings of space weather events are critically needed for space-based communications infrastructure and ground-based electrical distribution networks.
Agency: Department of Defense | Branch: Navy | Program: SBIR | Phase: Phase I | Award Amount: 79.91K | Year: 2015
An innovative system called In-Water Container Lifting System (IWCLS) is proposed for lifting ISO shipping containers floating in the open ocean to the decks of Advanced Force Sea-Basings and other vessels of opportunity. It fills a gap in enabling technology for lift-on/lift-off heavy container transfer in high sea conditions up to sea state 4. The IWCLS is essentially a telescopic ramp based container launching and recovery system. The system is very compact and can be fit into an ISO twenty-foot equivalent (TEU) container. It meets all the US heavy-lift aircraft transport and airdrop parameters. The system is highly automated and can self-erect with support from a very minimal number of personnel and two small crafts. It carries its own power source that it can self-erect and then lift at least four containers. The telescopic ramp can accommodate vessels with different freeboard up to at least 10 meter.
West Virginia University and Advanced Research Corp. | Date: 2015-04-21
Various examples are provided for collimator assemblies and/or energy analyzer arrays of plasma spectrometers. In one example, among others, an ultra-compact plasma spectrometer includes a collimator assembly; an energy analyzer array that receives charged particles from the collimator; and a detector plate that detects charged particles exiting the energy analyzer array. The energy analyzer array can include a plurality of analyzer plates having distinct energy channels. In another example, a method includes bonding a stack of analyzer plates to form an energy analyzer array, affixing a collimator assembly to the entrance surface of the energy analyzer array, and affixing an array of detectors to the exit surface of the energy analyzer array. The analyzer plates include energy analyzer bands extending from the entrance surface to the exit surface. The aperture arrays and the detectors can align with the energy analyzer bands.