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Maple Grove, MN, United States

Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 224.57K | Year: 2015

DESCRIPTION provided by applicant The goal of this project is to develop a portable low cost tool to aid in the diagnosis intervention and improvement of outcomes for neonates born with neurologic complications The project will develop instrumentation technology to enable early detection of neurologic brain injury and seizure activity for newborns delivered in care facilities that lack a full suite of neurological diagnostic tools In neonates with birth asphyxia seizures are very common and most frequently subclinical Many studies have observed that even experienced clinicians have difficulty correctly identifying seizures in this population Subsequently clinical paroxysms that do not truly represent seizure are frequently over treated and subclinical seizures including status epilepticus go unrecognized and untreated As such the use of continuous video electroencephalograph EEG monitoring is the gold standard for recognizing and treating seizures in this population It is also very helpful at identifying which children have sustained brain injury including hypoxia This resource intense modality has become the standard of care at many tertiary medical centers but unfortunately remains unavailable to many clinicians at smaller birth facilities Quantitative EEG including the use of amplitude integrated EEG aEEG has gained widespread use at most neonatal ICUs and represents a more user friendly bedside tool for identifying brain injury and seizures The goal of the phase I project is to specify design prototype and evaluate a low cost telemedicine enabled aEEG monitor that is portable and supports widespread use in smaller facilities A prototype instrument will be specified designed built and evaluated The follow on phase II program will conduct a large human trial PUBLIC HEALTH RELEVANCE The project will develop technology to aid in the diagnosis intervention and improvement of outcomes for neonates born with neurologic complications


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 719.96K | Year: 2016

DESCRIPTION provided by applicant We propose to develop and evaluate the utility of a thermal imaging system as an input modality to a retinal prosthetic Retinal prostheses restore partial vision to people blinded by outer retinal degenerative diseases such as Retinitis Pigmentosa RP or Macular Degeneration The Argus II retinal prosthesis system is intended to provide electrical stimulation of the retina to elicit visual perception in blind individuals with severe to profound retinitis pigmentosa The implanted epiretinal array provides a grid of electrodes Electrical pulses at these sites stimulate the retinaandapos s remaining cells and result in te perception of patterns of light in the brain Ordinary light and color information is difficult for wearers to effectively process in many important tasks with the limited perceived spatial resolution Current compensation techniques in reduced resolution systems apply enhancement magnification and panning of visible light imagery and these techniques have utility to retinal implants However other information sources such as thermal imaging more naturally align to the limited resolution of retinal arrays and improve the utility of the system i important tasks such as people finding and mobility The proposed project seeks to provide thermal imagery as an input modality to retinal implants Following successful development of a prototype thermal imaging system and promising results during tests in Argus II retinal prosthesis wearers in phase I we are now proposing the development and validation of an integrated visible and thermal imaging system under phase II A fully integrated prototype system will be developed that includes visible and thermal cameras and associated digital signal processing software to provide user controllable combined thermal visible imagery options to prosthesis wearers This new system will be evaluated in a substantial trial PUBLIC HEALTH RELEVANCE The proposed project relates to the utilization of thermal imaging as an input modality to a retinal prosthetic Retinal prostheses aim to help people who have lost their vision due to degenerative eye conditions such as retinitis pigmentosa or macular degeneration to perceive shapes and movement to become more mobile or to perform other day to day activities


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 223.78K | Year: 2015

DESCRIPTION provided by applicant Heat illness during practice or competition is a leading cause of death and disability among U S high school athletes In approximately million boys and million girls participated in high school sports There are various types of exertional heat illness EHI including heat cramps heat syncope heat exhaustion and exertional heat stroke EHS that are sources of concern for both athletes and medical staff Guidelines for the prevention and management of heat illness support a wide range of prevention strategies Unfortunately development of more aggressive prevention campaigns is hampered by a lack of basic descriptive data on EHI incidence and circumstances These epidemiologic data can assist public health professionals in the development and distribution of EHI interventions Proposed is a system that monitors athlete temperature and collects epidemiological data The system provides team and individualized risk based on many factors including environmental conditions acclimation history biometrics real time activity intensity and real time temperature PUBLIC HEALTH RELEVANCE Exertional heat illness affects approximately high school athletes each year and results in many deaths that are preventable Exertional heat illness can be prevented with proper education and tools for coaches and athletic trainers including athlete monitoring Known factors in exertional heat illness including environment biometrics acclimation real time temperature and real time activity levels can be used to determine athletes at risk


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase I | Award Amount: 224.99K | Year: 2015

DESCRIPTION provided by applicant The goal of this project is to develop a unique and engaging educational game that promotes behavioral modification regarding energy balance related behaviors EBRB The game targets high school aged students attending Alternative Learning AL programs through the platform of a serious game While serious games promoting positive behaviors regarding general nutrition have been developed and successfully implemented for younger students no examples have been found specifically targeting older teens in AL settings Few if any evidence based strategies or curricula exist to address EBRB for this population Because EBRB established in adolescence have a likelihood of continuing into adulthood and impacting weight and health adolescence provides an important window during which to positively address and modify these kinds of behaviors The unique formative youth voice approach to development of this game increases the likelihood of game play that makes learning highly engaging and relevant to the context social environmental cultural in which the participants live play learn and work Further participation in and incentives for the development and piloting of this game provides AL youth with an important leadership opportunity which may spark interest in careers related to research serious gaming or health promotion Finally this game has great potential for use by and integration with Supplemental Nutrition Assistance Program Education SNAP Ed programming in AL settings through which multilevel approaches system environmental policy can be implemented to support and reinforce positive behavioral goals During adolescence a high quality diet ensuring adequate intake of energy and nutrients is critical to optimize physical growth and development and prevent diet related chronic diseases that manifest in adulthood including heart disease cancer and osteoporosis Lifestyle changes and the drive for greater autonomy in food choice during adolescence can negatively impact eating behaviors and patterns High school students attending an AL programs are more likely to engage in poor eating and sedentary living practices than students attending a regular high school PUBLIC HEALTH RELEVANCE During adolescence a high quality diet ensuring adequate intake of energy and nutrients is critical to optimize physical growth and development and prevent diet related chronic diseases that manifest in adulthood including heart disease cancer and osteoporosis Lifestyle changes and the drive for greater autonomy in food choice during adolescence can negatively impact eating behaviors and patterns Since poor food choices in adolescence tend to continue into adulthood adolescence is an important time to intervene to promote healthy habits


Grant
Agency: Department of Health and Human Services | Branch: National Institutes of Health | Program: SBIR | Phase: Phase II | Award Amount: 672.63K | Year: 2016

DESCRIPTION provided by applicant This project will develop a state of the art technology platform to support psychosocial interventions for persons with Alzheimerandapos s disease AD and other dementia PWD and their family members and friends FMs A tool will be developed that automatically solicits media allows communicating with caregivers and checks the quality of media feeding into the SimpleC Companion a behavior management technology for persons with Alzheimerandapos s disease and other dementia The main goals are to improve therapy personalization make it scalable thereby positively affecting the effectiveness of the SimpleC care intervention The number of people with dementia is large and growing Approximately million people in the U S and million worldwide have dementia These estimates are expected to nearly triple by Currently there is no cure and the cost to families the health care system and society is large Not only is dementia the sole top U S disease that cannot be prevented cured or slowed but it is also one of the costliest chronic diseases estimated national cost is $ billion half of which is carried by Medicare and expected to rise to $ trillion by if nothing changes In addition there are few tools to meet the needs of this population The general approach is medication which is costly and sedates people with dementia rather than engaging them Psychosocial interventions such as those offered by SimpleC are alternatives to pharmacology to address dementia related symptoms while improving both quality of care and quality of life Personalization is one key ingredient to the success of the interventions While SimpleCandapos s highly personalized interventions human customer service and advanced wireless computing network enable the creation and delivery of meaningful care interventions on a large cost effective scale these interventions still require significant manpower to gather personalized therapeutic content which is usually non digital e g Polaroid pictures reel to reel audio and video tape from caregivers and family members who are likely very busy stressed and may live far away The first goal of the proposed project mitigates this barrier by reducing manpower requirements providing guidance to caregivers and enabling even wider spread deployment Furthermore this project will both increase and sustain care recipientsandapos engagement which is crucial to psychosocial interventions The second goal addresses communication needs between care giving parties The proposed project addresses the challenge of offering a channel to communicate that is respectful of busy schedules and high workloads of all involved The project will assess technology acceptance and barriers in the field In phase I AME demonstrated feasibility of a caregiver tool that supports the collection of media required for psychosocial interventions and facilitates communication between staff caregivers and family members friends of older adults with dementia In phase II AME will partner with SimpleC to expand and integrate this functionality into their technology platform and products as well as conduct an in market test of the entire platform Testing will occur in the long term care facility high staff and high resident turnover and home market where the majority of persons with dementia PWD live PUBLIC HEALTH RELEVANCE Alzheimerandapos s Disease and related dementias is one of the costliest chronic diseases and they cannot be prevented cured or slowed SimpleC has developed a wireless media based behavior management technology that delivers psychosocial care interventions to improve the quality of life of persons with Alzheimerandapos s disease and related dementias PWD To better support caregivers AME is partnering with SimpleC to increase care interventionsandapos scalability to a large number of geographical diverse users while sustaining PWD engagement Additional support includes a new means for care giving parties to communicate

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