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Ding Y.,Deakin University | Li Y.,RMIT University | Lin J.,Advanced Material Research and Development Center | Wen C.,RMIT University
Journal of Materials Chemistry B | Year: 2015

The successful applications of magnesium (Mg) alloys as biodegradable orthopedic implants are mainly restricted due to their rapid degradation rate in the physiological environment, leading to a loss of mechanical integrity. This study systematically investigated the degradation behaviors of novel Mg-Zr-Sr alloys using electrochemical techniques, hydrogen evolution, and weight loss in simulated body fluid (SBF). The microstructure and degradation behaviors of the alloys were characterized using optical microscopy, XRD, SEM, and EDX. The results indicate that Zr and Sr concentrations in Mg alloys strongly affected the degradation rate of the alloys in SBF. A high concentration of 5 wt% Zr led to acceleration of anodic dissolution, which significantly decreased the biocorrosion resistance of the alloys and their biocompatibility. A high volume fraction of Mg17Sr2 phases due to the addition of excessive Sr (over 5 wt%) resulted in enhanced galvanic effects between the Mg matrix and Mg17Sr2 phases, which reduced the biocorrosion resistance. The average Sr release rate is approximately 0.15 mg L-1 day-1, which is much lower than the body burden and proves its good biocompatibility. A new biocorrosion model has been established to illustrate the degradation of alloys and the formation of degradation products on the surface of the alloys. It can be concluded that the optimal concentration of Zr and Sr is less than 2 wt% for as-cast Mg-Zr-Sr alloys used as biodegradable orthopedic implants. © The Royal Society of Chemistry.2015.

Ozan S.,Swinburne University of Technology | Ozan S.,Ege University | Lin J.,Advanced Material Research and Development Center | Lin J.,Jilin University | And 4 more authors.
Acta Biomaterialia | Year: 2015

A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28Nb-35.4Zr and Ti-24.8Nb-40.7Zr (wt.% hereafter) were fabricated using the cold-crucible levitation technique, and the effects of alloying element content on their microstructures, mechanical properties (tensile strength, yield strength, compressive yield strength, Young's modulus, elastic energy, toughness, and micro-hardness), and cytocompatibilities were investigated and compared. Microstructural examinations revealed that the TNZ alloys consisted of β phase. The alloy samples displayed excellent ductility with no cracking, or fracturing during compression tests. Their tensile strength, Young's modulus, elongation at rupture, and elastic admissible strain were measured in the ranges of 704-839 MPa, 62-65 GPa, 9.9-14.8% and 1.08-1.31%, respectively. The tensile strength, Young's modulus and elongation at rupture of the Ti-34Nb-25Zr alloy were measured as 839 ± 31.8 MPa, 62 ± 3.6 GPa, and 14.8 ± 1.6%, respectively; this alloy exhibited the elastic admissible strain of approximately 1.31%. Cytocompatibility tests indicated that the cell viability ratios (CVR) of the alloys are greater than those of the control group; thus the TNZ alloys possess excellent cytocompatibility. © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

Mushahary D.,Deakin University | Wen C.,Swinburne University of Technology | Kumar J.M.,CSIR - Central Electrochemical Research Institute | Lin J.,Advanced Material Research and Development Center | And 4 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2014

Biodegradable magnesium-zirconia-calcium (Mg-Zr-Ca) alloy implants were coated with Collagen type-I (Coll-I) and assessed for their rate and efficacy of bone mineralization and implant stabilization. The phases, microstructure and mechanical properties of these alloys were analyzed using X-ray diffraction (XRD), optical microscopy and compression test, respectively, and the corrosion behavior was established by their hydrogen production rate in simulated body fluid (SBF). Coll-I extracted from rat tail, and characterized using fourier transform infrared (FT-IR) spectroscopy, was used for dip-coating the Mg-based alloys. The coated alloys were implanted into the femur bones of male New Zealand white rabbits. In vivo bone formation around the implants was quantified by measuring the bone mineral content/density (BMC/BMD) using dual-energy X-ray absorptiometry (DXA). Osseointegration of the implant and new bone mineralization was visualized by histological and immunohistochemical analysis. Upon surface coating with Coll-I, these alloys demonstrated high surface energy showing enhanced performance as an implant material that is suitable for rapid and efficient new bone tissue induction with optimal mineral content and cellular properties. The results demonstrate that Coll-I coated Mg-Zr-Ca alloys have a tendency to form superior trabecular bone structure with better osteoinduction around the implants and higher implant secondary stabilization, through the phenomenon of contact osteogenesis, compared to the control and uncoated ones in shorter periods of implantation. Hence, Coll-I surface coating of Mg-Zr-Ca alloys is a promising method for expediting new bone formation in vivo and enhancing osseointegration in load bearing implant applications. © 2014 Elsevier B.V.

Liu Y.T.,Advanced Material Research and Development Center | Lin J.X.,Advanced Material Research and Development Center | Wu X.P.,Advanced Material Research and Development Center | Niu L.Y.,Advanced Material Research and Development Center | Li G.Y.,Jilin University
Advanced Materials Research | Year: 2013

The effect of Al-10Sr master alloy modifier with different content on the microstructure and properties of as-cast Al-12.6Si-0.35 Mg alloy was investigated. The results show that, eutectic silicon varies from original needle and flake to fibrous shape; The shape, size, and quantity of α -Al all changed; When Sr content is 0.023%, the modification effect is most ideal, α -Al shows the highest quantity and smallest size. Meanwhile, the tensile strength and elongation of the alloy reach to the optimum values of 248.2 MPa and 7.2% respectively. These two values are 1.34 and 2.77 times higher than the 185 MPa and 2.6% before modification respectively. © (2013) Trans Tech Publications, Switzerland.

Liu Y.T.,Advanced Material Research and Development Center | Tong X.,Advanced Material Research and Development Center | Lin J.X.,Advanced Material Research and Development Center | Niu L.Y.,Advanced Material Research and Development Center | Li G.Y.,Jilin University
Advanced Materials Research | Year: 2014

In this study, Mg2Si in in-situ Mg2Si/Al composites were subjected to modification treatment using rare earth element Holmium(Ho). The phase composition and microstructure before and after modification of Mg2Si were also analyzed using X-ray diffraction (XRD) and optical microscope (OM); in addition, its mechanical properties were detected as well. The results showed that moderate addition of rare earth element Ho in in-situ Mg2Si/Al composites presents good modification effects on Mg2Si, the morphology of primary Mg2Si was changed from cross shape before modification to dispersed irregular mass; optimal modification effect was obtained when 0.4% rare earth element Ho was added. Under this condition, the average size of primary Mg2Si was decreased from 74 μm before modification to 16 μm; its mechanical properties were promoted significantly; and its tensile strength increased from 134 MPa before modification to 174.6 MPa, its brinell hardness elevated from 76 HB to 90 HB. © (2014) Trans Tech Publications, Switzerland.

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