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Yamada A.,Advanced ICT Research Institute Biophysics
Journal of the National Institute of Information and Communications Technology | Year: 2013

Our skeletal muscles consume much energy when a high tension is maintained for a long time. In contrast, bivalve adductor muscles can maintain high passive tension with little energy expenditure. It has been clarified that its mechanism is based on the molecular interactions of contractile protein molecules in the muscle cells. Source


Kojima H.,Advanced ICT Research Institute Biophysics
Journal of the National Institute of Information and Communications Technology | Year: 2013

To achieve natural communications, we need adequate reproduction of the senses brought by molecules such as olfaction in addition to visual and acoustic senses. One reasonable way to achieve this issue would be constructing sensing system by using biomolecules and cells as they are, or by extracting their mechanisms. Here, we introduce the research activity of Bio ICT Laboratory concerning the reconstitution of sensor system consisting biomolecules, cells and their mechanisms. Source


Kojima H.,Advanced ICT Research Institute Biophysics
Journal of the National Institute of Information and Communications Technology | Year: 2013

To understand the mechanism of cellular and bio-molecular functions, it is crucial to develop the method for characterizing their dynamics and structures by observing and manipulating them directly in the physiological conditions. Here, we introduce the principles, system configurations, and applications of the microscopy at single molecule level, the laser trap nanometry, and the reconstitution technique of bio-molecular functions mainly from the technical point of view. Source


Tanaka H.,Advanced ICT Research Institute Biophysics
Journal of the National Institute of Information and Communications Technology | Year: 2013

Here, we show a simple model of a kind of nano machine as an example. We design a simple model for a machine which works in the presence of thermal noise, and mathematically calculate physical motion (time evolution) of the modeled machine. As a calculation result, we show we can design the model, which works by rectifying thermal noise and autonomously regulates the motion (direction switching, velocity control) according to environment. Understanding and trying to apply such processing algorithms for stochastic functioning would give us useful suggestions to design autonomously regulating and functioning machines under various (unknown) circumstances. Source


Furuta K.,Advanced ICT Research Institute Biophysics
Journal of the National Institute of Information and Communications Technology | Year: 2013

Bio-molecular machines are nanoscale molecular complexes that perform important biological functions in ensemble, despite their seemingly unrelated behavior in the cell. Understanding how individual machines cooperate productively has become increasingly important for understanding mechanisms that enable the macroscopic functions. In this paper, I briefly review the recent advances in experimental techniques for studying these biomolecular interactions. Source

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