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Los Angeles, CA, United States

Shahzad K.,East Carolina University | Fatima A.,Advanced Heart Failure Program | Cadeiras M.,Advanced Heart Failure Program | Wisniewski N.,Advanced Heart Failure Program | And 4 more authors.
Current Genomics | Year: 2012

In the post-genome era, high throughput gene expression profiling has been successfully used to develop genomic biomarker panels (GBP) that can be integrated into clinical decision making. The development of GBPs in the context of personalized medicine is a scientifically challenging and resource-intense process. It needs to be accomplished in a systematic phased approach to address biological variation related to a clinical phenotype (e.g. disease etiology, gender, etc.) and minimize technical variation (noise). Here we present the methodological aspects of GBP development based on the experience of the Cardiac Allograft Rejection Gene Expression Observation (CARGO) study, a study that lead to the development of a molecular classifier for rejection screening in heart transplant patients. © 2012 Bentham Science Publishers. Source

Shrestha P.L.,Advanced Heart Failure Program | Shrestha P.A.,Advanced Heart Failure Program | Vivo R.P.,Advanced Heart Failure Program
Current Opinion in Cardiology | Year: 2016

Purpose of review: Hypertension affects an enormous number of people and uncommonly presents in isolation. This review aims to summarize contemporary data that is relevant to the epidemiology of specific comorbidities occurring frequently in individuals with hypertension. Recent findings: Hypertension is invariably diagnosed along with multiple comorbidities, particularly diabetes mellitus, obesity, chronic kidney disease, coronary artery disease, and heart failure. Evidence pertinent to prevalence, incidence, and temporal trends is reported, with an emphasis on differences according to age, gender, and race/ethnicity. Summary: The clustering of these conditions requires a thorough - and often multidisciplinary - approach in the evaluation and management of individuals with hypertension. Populations with higher risk include the elderly, women, and racial/ethnic groups. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Source

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