News Article | November 15, 2016
Bio Simulation Technology Market is estimated at $1.01 billion in 2015 and is projected to reach $2.99 billion by 2022 growing at a CAGR of 16.6% from 2015 to 2022. Reduction in the cost of drug discovery and development and risk of failure of drug molecule are some of the factors driving the market growth. Furthermore, R&D investments in biotechnology and pharmaceutical industries, growth in the biologics and biosimilars markets, increased use of personalized medicines, technological advancements and periodic product upgradation are the key factors vitalizing the market growth. However, lack of standardization, high R&D costs associated with development of biosimulation software and lack of skilled professionals are some of the major restraints hampering the market growth. Industrial bioprocessing, nutraceuticals, agri-food production and biosimulation in the defense will provide opportunities for market growth over the forecast period. Pharmaceutical and biotechnology companies segment is valued to account largest share across the global market. North America is anticipated to command the largest share and Europe is expected to register the highest growth due to increasing government funding and the large number of pharmaceuticals and biotechnology companies in this region. Some of the key players in this market include Certara USA Inc., Simulation Plus Inc., Dassault Systèmes SA, Schrödinger Inc., Advanced Chemistry Development Inc., Chemical Computing Group Inc., Entelos Holding Corporation, Genedata Ag, Physiomics PLC, Rhenovia Pharma Ltd., Insilico biosciences, Archimedes, Insilico biotechnology, Accelrys, LeadScope and Compugen. Application Covered: • Application In Drug Development o Clinical Trials o Preclinical Testing • In Patient Validation • Application In Drug Discovery o Target Validation o Target Identification o Lead Identification/Discovery o Lead Optimization Product Covered: • Software o Toxicity Prediction Software o Molecular Modeling and Simulation Software o Trial Design Software o PK/PD Modeling and Simulation Software o Pbpk Modeling and Simulation Software o Other Software • Services o External/Contract Services o In-House Services Regions Covered: • North America o US o Canada o Mexico • Europe o Germany o France o Italy o UK o Spain o Rest of Europe • Asia Pacific o Japan o China o India o Australia o New Zealand o Rest of Asia Pacific • Rest of the World o Middle East o Brazil o Argentina o South Africa o Egypt What our report offers: - Market share assessments for the regional and country level segments - Market share analysis of the top industry players - Strategic recommendations for the new entrants - Market forecasts for a minimum of 7 years of all the mentioned segments, sub segments and the regional markets - Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations) - Strategic recommendations in key business segments based on the market estimations - Competitive landscaping mapping the key common trends - Company profiling with detailed strategies, financials, and recent developments - Supply chain trends mapping the latest technological advancements About Us Wise Guy Reports is part of the Wise Guy Consultants Pvt. Ltd. and offers premium progressive statistical surveying, market research reports, analysis & forecast data for industries and governments around the globe. Wise Guy Reports understand how essential statistical surveying information is for your organization or association. Therefore, we have associated with the top publishers and research firms all specialized in specific domains, ensuring you will receive the most reliable and up to date research data available.
Golotvin S.S.,Advanced Chemistry Development Ltd |
Pol R.,Advanced Chemistry Development Ltd |
Sasaki R.R.,Advanced Chemistry Development Inc. |
Nikitina A.,Advanced Chemistry Development Inc. |
Keyes P.,Lexicon Pharmaceuticals Inc.
Magnetic Resonance in Chemistry | Year: 2012
Automated structure verification using 1H NMR data or a combination of 1H and heteronuclear single-quantum correlation (HSQC) data is gaining more interest as a routine application for qualitative evaluation of large compound libraries produced by synthetic chemistry. The goal of this automated software method is to identify a manageable subset of compounds and data that require human review. In practice, the automated method will flag structure and data combinations that exhibit some inconsistency (i.e. strange chemical shifts, conflicts in multiplicity, or overestimated and underestimated integration values) and validate those that appear consistent. One drawback of this approach is that no automated system can guarantee that all passing structures are indeed correct structures. The major reason for this is that approaches using only 1H or even 1H and HSQC spectra often do not provide sufficient information to properly distinguish between similar structures. Therefore, current implementations of automated structure verification systems allow, in principle, false positive results. Presented in this work is a method that greatly reduces the probability of an automated validation system passing incorrect structures (i.e. false positives). This novel method was applied to automatically validate 127 non-proprietary compounds from several commercial sources. Presented also is the impact of this approach on false positive and false negative results. Copyright © 2012 John Wiley & Sons, Ltd.
Williams A.J.,Royal Society of Chemistry |
Yerin A.,Advanced Chemistry Development Inc.
Wiley Interdisciplinary Reviews: Computational Molecular Science | Year: 2013
The availability of systematic chemical names allows for the simple textual exchange of chemical structure information encoded into a name. The exchange of molecular structures in graphical format, molecular connection tables, or text strings encoding the molecule (e.g., SMILES and InChIs) is well established in cheminformatics and a plethora of chemical structure drawing tools exist to facilitate this exchange. However, even with well-established systematic naming rules, software tools to allow for the generation of chemical names from structural inputs, and the reversal of these systematic names back to the original chemical structure, have only been available for a short time relative to the rules themselves. Although early tools were lacking in both capability and quality, they have matured over the years to provide excellent tools for chemists. Here, we review the capabilities of existing systematic naming software algorithms and tools and review some of the challenges, limitations, and future challenges for development. © 2012 John Wiley & Sons, Ltd.
Evans R.,University of Manchester |
Deng Z.,University of Manchester |
Rogerson A.K.,University of Manchester |
McLachlan A.S.,Advanced Chemistry Development Inc. |
And 4 more authors.
Angewandte Chemie - International Edition | Year: 2013
Appealingly simple: A new method is described that allows the diffusion coefficient of a small molecule to be estimated given only the molecular weight and the viscosity of the solvent used. This method makes possible the quantitative interpretation of the diffusion domain of diffusion-ordered NMR spectra (see picture). © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Cheatham S.F.,DuPont Company |
Kline M.,DuPont Company |
Sasaki R.R.,Advanced Chemistry Development Inc. |
Blinov K.A.,Advanced Chemistry Development |
And 2 more authors.
Magnetic Resonance in Chemistry | Year: 2010
The availability of cryogenically cooled probes permits routine acquisition of data from low sensitivity pulse sequences such as inadequate and 1,1-adequate. We demonstrate that the use of cryo-probe generated 1,1-adequate data in conjunction with HMBC dramatically improves computer-assisted structure elucidation (CASE) both in terms of speed and accuracy of structure generation. In this study data were obtained on two dissimilar natural products and subjected to CASE analysis with and without the incorporation of two-bond specific data. Dramatic improvements in both structure calculation times and structure candidates were observed by the inclusion of the two-bond specific data. Copyright © 2010 John Wiley & Sons, Ltd.
PubMed | Advanced Chemistry Development Inc., Ohio State University and Nature's Sunshine Products
Type: Journal Article | Journal: Organic letters | Year: 2015
Melanodiol 4-O-protocatechuate (1) and melanodiol (2) represent novel flavonoid derivatives isolated from a botanical dietary supplement ingredient, dried black chokeberry (Aronia melanocarpa) fruit juice. These noncrystalline compounds possess an unprecedented fused pentacyclic core with two contiguous hemiketals. Due to having significant hydrogen deficiency indices, their structures were determined using computer-assisted structure elucidation software. The in vitro hydroxyl radical-scavenging and quinone reductase-inducing activity of each compound are reported, and a plausible biogenetic scheme is proposed.
Sasaki R.R.,Advanced Chemistry Development Inc.
Chimica Oggi/Chemistry Today | Year: 2014
The rapid identification, elucidation, and characterization of impurities is an intense and comprehensive undertaking. Presented is a perspective on a new laboratory informatics approach to improve productivity in this environment. Impurity Resolution Management (IRM) is a specific application of Unified Laboratory Intelligence (ULI) to identify and characterize impurities for control, resolution, and reporting during the development and acceptance of a new drug substance.
Advanced Chemistry Development Inc. | Date: 2016-11-07
Computer software for mass spectrometry analysis, chemical chromatography, spectroscopy, chemical searching and naming, chemical property prediction, spectral prediction, molecular modeling, structure drawing and database management, for use in chemistry, biochemistry, pharmacology and structure/sequence handling and data management. Providing computer software in downloadable format on the global computer network and facilitating the downloading of computer software, namely, application service provider; Software as a service (SAAS) provider in the field of providing mass spectrometry analysis, chemical chromatography, spectroscopy, chemical searching and naming, chemical property prediction, spectral prediction, molecular modeling, structure drawing and database management, for use in chemistry, biochemistry, pharmacology and chemical/biological structure handling and data management.
Advanced Chemistry Development Inc. | Date: 2011-11-01
Computer software for analytical chemistry, chemical data and knowledge handling, workflow management, chromatography, spectroscopy, chemical and spectral searching, chemical property prediction, spectral prediction, molecular modeling, structure drawing, knowledge and database management, for use in chemistry, biochemistry, pharmaceutical chemistry and related industries.
Advanced Chemistry Development Inc. | Date: 2012-09-18
Computer software for analytical chemistry, chemical data and knowledge handling, workflow management, chromatography, spectroscopy, chemical and spectral searching, chemical property prediction, toxicity prediction, spectral prediction, molecular modeling, structure drawing and knowledge and database management, for use in chemistry, biochemistry, pharmaceutical chemistry, and related industries.