ADVANCE Medical

Palo Alto, CA, United States

ADVANCE Medical

Palo Alto, CA, United States

An advance health care directive, also known as living will, personal directive, advance directive, or advance decision, is a legal document in which a person specifies what actions should be taken for their health if they are no longer able to make decisions for themselves because of illness or incapacity. In the U.S. it has a legal status in itself, whereas in some countries it is legally persuasive without being a legal document.A living will is one form of advance directive, leaving instructions for treatment. Another form is a specific type of power of attorney or health care proxy, in which the person authorizes someone to make decisions on their behalf when they are incapacitated. People are often encouraged to complete both documents to provide comprehensive guidance regarding their care. An example of combination documents includes the Five Wishes in the United States. The term living will is also the commonly recognised vernacular in many countries, especially the U.K. Wikipedia.

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Patent
ADVANCE Medical | Date: 2014-11-10

A method treating a root canal in a tooth by introducing into the pulp chamber of a tooth and pulsing a laser light into the fluid reservoir so as to disintegrate pulp within the root canal without generation of any significant heat in said liquid fluid so as to avoid elevating the temperature of any of the dentin, tooth, or other adjacent tissue more than about 5 C.


Greer J.A.,Harvard University | Jackson V.A.,Harvard University | Meier D.E.,ADVANCE Medical | Temel J.S.,Harvard University
CA Cancer Journal for Clinicians | Year: 2013

Answer questions and earn CME/CNE Scientific advances in novel cancer therapeutics have led to remarkable changes in oncology practice and longer lives for patients diagnosed with incurable malignancies. However, the myriad options for treatment have established a culture of cancer care that has not been matched with a similar availability of efficacious supportive care interventions aimed at relieving debilitating symptoms due to progressive disease and treatment side effects. Accumulating data show that the introduction of palliative care services at the time of diagnosis of advanced cancer leads to meaningful improvement in the experiences of patients and family caregivers by emphasizing symptom management, quality of life, and treatment planning. In this review article, the rationale and evidence base for this model of early palliative care services integrated into standard oncology care are presented. In addition, the implications and limitations of the existing data to 1) elucidate the mechanisms by which early palliative care benefits patients and families; 2) guide the dissemination and application of this model in outpatient settings; and 3) inform health care policy regarding the delivery of high-quality, cost-effective, and comprehensive cancer care are discussed. Copyright © 2013 American Cancer Society, Inc.


Park J.-H.,ADVANCE Medical | Yamaguchi Y.,ADVANCE Medical | Inouye M.,ADVANCE Medical
Applied and Environmental Microbiology | Year: 2012

The genomes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) consist of single-stranded RNA encoding polyproteins, which are processed to individual functional proteins by virus-encoded specific proteases. These proteases have been used as targets for drug development. Here, instead of targeting these proteases to inhibit viral infection, we utilized the protease activity to activate a toxic protein to prevent viral infection. We engineered the MazE-MazF antitoxin-toxin system of Escherichia coli to fuse a C-terminal 41-residue fragment of antitoxin MazE to the N-terminal end of toxin MazF with a linker having a specific protease cleavage site for either HIV PR (HIV-1 protease), NS3 protease (HCV protease), or factor Xa. These fusion proteins formed a stable dimer (instead of the MazF2-MazE2-MazF2 heterohexamer in nature) to inactivate the ACA (sequence)-specific mRNA interferase activity of MazF. When the fusion proteins were incubated with the corresponding proteases, the MazE fragment was cleaved from the fusion proteins, releasing active MazF, which then acted as an ACA-specific mRNA interferase cleaving single-stranded MS2 phage RNA. The intramolecular regulation of MazF toxicity by proteases as demonstrated may provide a novel approach for preventive and therapeutic treatments of infection by HIV-1, HCV, and other single-stranded RNA viruses. © 2012, American Society for Microbiology.


Kalb T.H.,ADVANCE Medical
Critical Care Clinics | Year: 2015

This article explores the hypothesis that a telemedicine intensive care unit (Tele-ICU) platform is uniquely suited to facilitate quality performance improvement (PI). This article addresses some substantial hurdles to overcome that may limit the effectiveness of a Tele-ICU platform to achieve PI objectives. Lastly, this article describes the author's experience with a PI project to improve ventilator management conducted via a Tele-ICU hub interacting with 11 geographically dispersed ICUs. Using this example to illustrate the concepts, the author hopes to shed some light on the successes and lessons learned so as to generate best-practice guidelines for Tele-ICU-directed PI initiatives. © 2015 Elsevier Inc.


Trademark
ADVANCE Medical | Date: 2016-04-05

Cosmetic products, including but not limited to cream, lotion, gel cream, shampoo, soaps, detergent, exfoliator, astringent, depilatory cream, product for cleaning and general treatment of skin, products for acne treatment, dermatological product, sanitary preparations for different medical areas directly or indirectly linked to general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery. Dermatologic products, medicines, pharmaceutical, medical and veterinary; products and systems for in vitro diagnostic use, intended for clinical or industrial applications, diagnostic solutions, such as reagents for autoimmunity and allergy biochemistry calibrators and controls, electrophoresis, hematology, immunology by elisa, hemostasis, latex, fast testing, turbidimetry, blood typology, urinalysis, immunology, proteins, hormones, markers, mycology, gastric panel, parasitology, retroviruses, Toxins, products for qualitative and quantitative detection of infectious agents to virology, bacteriology and coagulation factors; washing solutions for equipment; enzymes, vitamins; immunofluorescence; immunology by chemiluminescence method, culture media, supplements and microbiology devices; microbiological dyes, cytological, hematopathological; products for histocompatibility; products for flow cytometry; products for immunohistochemistry; bottles or materials for collection, storage or transportation of biological samples; complement fixation, western blot and other family categories. Medical devices and equipment for use in medicine, such as: appliances and equipment for the reduction of localized fat; reduction in underarm sweat; instruments; software (including laboratory management and diagnostic centers); automated diagnostic systems; plate washer, plates reader, plates incubator, ELISA methodology automated equipment, automated analyzers for methodology HALF magnetized (immunoassay magnetic microparticles); automated equipment for immunofluorescence tests and chemiluminescence; biochemistry analyzer; hematology analyzer; coagulometric analyzer, chromogenic and immunological testing; gas analyzer, electrolytes, glucose, lactate and co-oximetry; analyzer ACT (Activated Clotting Tempode); equipment and devices for electrophoresis by agarose gel method; equipment for electrophoresis methodology by capillarity; equipment for electrophoresis methodology by capillarity; apparatus for reduction of localized fat (LASER lipolysis, liposuction technology and criolipolysis); apparatus for reducing sweat in the armpits; LASER devices, light and other sources of radiation and emission of energy, such as microwaves, ultrasound and radiofrequency, for medical areas, but not limited to, treatment of acne, scars, stretch marks, hair removal, removal of pigments (natural and artificial), skin tightening, collagen stimulation and skin rejuvenation in general, as well as discrete vascular lesions, superficial in the face or lower limbs through (cryo)sclerotherapy, LASER and associated technologies; varicose veins; LASERs, fittings, systems and technologies for treatment of soft tissue, with or without contact, during surgical procedures, including those using endoscopes, catheters or introducers; LASERS, accessories, systems and technologies for the incision, excision, vaporization, ablation, hemostasis or coagulation of soft tissue procedures linked directly or indirectly to the general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery; equipment and surgical instruments, medical, dental and veterinary, members; orthopedic articles such as prostheses, orthotics for orthopedics and other specialties); suture materials, disposable products; equipment (with or without LASER technology) for applications in ophthalmology, vascular surgery, urology; systems, records and tapes to research isolated immunospecific; products for blood banks, such as blood bags, homogenizing, transfusion equipment, sealing devices and scientific research instruments for laboratories; molecular biology; supplies for hospitals and laboratories; Supplies (plastics, glassware etc.) and surgical instruments; video equipment for surgery; corator/colorator automated blades. Trade, import, export and distribution of medical apparatus and equipment for use in medicine, such as: appliances and equipment for the reduction of localized fat; reduction in underarm sweat; instruments; ; Automated Diagnostic Systems; plate washer, plates reader, plates Incubator, ELISA methodology automated equipment, automated analyzers for methodology HALF magnetized (immunoassay magnetic microparticles); automated equipment for immunofluorescence tests, and chemiluminescence, reconditioning parts, parts and equipment, biochemistry analyzer; hematology analyzer; analyzer coagulometric, chromogenic and immunological testing; gas analyzer, electrolytes, glucose, lactate and co-oximetry; analyzer ACT (Activated Clotting Tempode); equipment for electrophoresis by agarose gel method; equipment for electrophoresis methodology by capillarity; Equipment for electrophoresis methodology by capillarity; apparatus for reduction of localized fat (LASER lipolysis, liposuction technology and criolipolysis); apparatus for reducing sweat in the armpits; LASER devices, light and other sources of radiation and emission of energy, such as microwaves, ultrasound and radiofrequency, for medical areas, but not limited to, treatment of acne, scars, stretch marks, hair removal, removal of pigments ( natural and artificial), skin tightening, collagen stimulation and skin rejuvenation in general, as well as discrete vascular lesions, superficial in the face or lower limbs through (cryo)sclerotherapy, LASER and associated technologies; varicose veins; LASERs, fittings, systems and technologies for treatment of soft tissue, with or without contact, during surgical procedures, including those using endoscopes, catheters or introducers; LASERs, accessories, systems and technologies for the incision, excision, vaporization, ablation, hemostasis or coagulation of soft tissue procedures linked directly or indirectly to the general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery. Activity directly or indirectly related to logistics, packaging, storage, distribution and dispatch of products for in vitro diagnostics, pharmaceuticals, disposable, sterile equipment and devices for use in diagnostics, aesthetic (including parts and components), use of health materials. Production and project development, equipment research and equipment for medical purposes; technical assistance in medical devices and equipment, and laboratory research; Automated Diagnostic Systems; reconditioning parts and equipment, engineering services and scientific undertake of evaluations, research and reports in scientific and technological fields (including technical advice); scientific research and related services for medical purposes; scientific and technological services and research and design relating thereto; industrial analysis and research services. Medical and aesthetic clinics and offices, laboratory tests and diagnostics products and systems for in vitro diagnostic use intended for clinical or industrial applications, diagnostic solutions.


Trademark
ADVANCE Medical | Date: 2016-04-05

Cosmetic products, including but not limited to cream, lotion, gel cream, shampoo, soaps, detergent, exfoliator, astringent, depilatory cream, product for cleaning and general treatment of skin, products for acne treatment, dermatological product, sanitary preparations for different medical areas directly or indirectly linked to general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery. Dermatologic products, medicines, pharmaceutical, medical and veterinary; products and systems for in vitro diagnostic use, intended for clinical or industrial applications, diagnostic solutions, such as reagents for autoimmunity and allergy biochemistry calibrators and controls, electrophoresis, hematology, immunology by elisa, hemostasis, latex, fast testing, turbidimetry, blood typology, urinalysis, immunology, proteins, hormones, markers, mycology, gastric panel, parasitology, retroviruses, Toxins, products for qualitative and quantitative detection of infectious agents to virology, bacteriology and coagulation factors; washing solutions for equipment; enzymes, vitamins; immunofluorescence; immunology by chemiluminescence method, culture media, supplements and microbiology devices; microbiological dyes, cytological, hematopathological; products for histocompatibility; products for flow cytometry; products for immunohistochemistry; bottles or materials for collection, storage or transportation of biological samples; complement fixation, western blot and other family categories. Medical devices and equipment for use in medicine, such as: appliances and equipment for the reduction of localized fat; reduction in underarm sweat; instruments; software (including laboratory management and diagnostic centers); automated diagnostic systems; plate washer, plates reader, plates incubator, ELISA methodology automated equipment, automated analyzers for methodology HALF magnetized (immunoassay magnetic microparticles); automated equipment for immunofluorescence tests and chemiluminescence; biochemistry analyzer; hematology analyzer; coagulometric analyzer, chromogenic and immunological testing; gas analyzer, electrolytes, glucose, lactate and co-oximetry; analyzer ACT (Activated Clotting Tempode); equipment and devices for electrophoresis by agarose gel method; equipment for electrophoresis methodology by capillarity; equipment for electrophoresis methodology by capillarity; apparatus for reduction of localized fat (LASER lipolysis, liposuction technology and criolipolysis); apparatus for reducing sweat in the armpits; LASER devices, light and other sources of radiation and emission of energy, such as microwaves, ultrasound and radiofrequency, for medical areas, but not limited to, treatment of acne, scars, stretch marks, hair removal, removal of pigments (natural and artificial), skin tightening, collagen stimulation and skin rejuvenation in general, as well as discrete vascular lesions, superficial in the face or lower limbs through (cryo)sclerotherapy, LASER and associated technologies; varicose veins; LASERs, fittings, systems and technologies for treatment of soft tissue, with or without contact, during surgical procedures, including those using endoscopes, catheters or introducers; LASERS, accessories, systems and technologies for the incision, excision, vaporization, ablation, hemostasis or coagulation of soft tissue procedures linked directly or indirectly to the general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery; equipment and surgical instruments, medical, dental and veterinary, members; orthopedic articles such as prostheses, orthotics for orthopedics and other specialties); suture materials, disposable products; equipment (with or without LASER technology) for applications in ophthalmology, vascular surgery, urology; systems, records and tapes to research isolated immunospecific; products for blood banks, such as blood bags, homogenizing, transfusion equipment, sealing devices and scientific research instruments for laboratories; molecular biology; supplies for hospitals and laboratories; Supplies (plastics, glassware etc.) and surgical instruments; video equipment for surgery; corator/colorator automated blades. Trade, import, export and distribution of medical apparatus and equipment for use in medicine, such as: appliances and equipment for the reduction of localized fat; reduction in underarm sweat; instruments; ; Automated Diagnostic Systems; plate washer, plates reader, plates Incubator, ELISA methodology automated equipment, automated analyzers for methodology HALF magnetized (immunoassay magnetic microparticles); automated equipment for immunofluorescence tests, and chemiluminescence, reconditioning parts, parts and equipment, biochemistry analyzer; hematology analyzer; analyzer coagulometric, chromogenic and immunological testing; gas analyzer, electrolytes, glucose, lactate and co-oximetry; analyzer ACT (Activated Clotting Tempode); equipment for electrophoresis by agarose gel method; equipment for electrophoresis methodology by capillarity; Equipment for electrophoresis methodology by capillarity; apparatus for reduction of localized fat (LASER lipolysis, liposuction technology and criolipolysis); apparatus for reducing sweat in the armpits; LASER devices, light and other sources of radiation and emission of energy, such as microwaves, ultrasound and radiofrequency, for medical areas, but not limited to, treatment of acne, scars, stretch marks, hair removal, removal of pigments ( natural and artificial), skin tightening, collagen stimulation and skin rejuvenation in general, as well as discrete vascular lesions, superficial in the face or lower limbs through (cryo)sclerotherapy, LASER and associated technologies; varicose veins; LASERs, fittings, systems and technologies for treatment of soft tissue, with or without contact, during surgical procedures, including those using endoscopes, catheters or introducers; LASERs, accessories, systems and technologies for the incision, excision, vaporization, ablation, hemostasis or coagulation of soft tissue procedures linked directly or indirectly to the general surgery, urology, gynecology, otolaryngology, dermatology, ophthalmology, plastic surgery and vascular surgery. Activity directly or indirectly related to logistics, packaging, storage, distribution and dispatch of products for in vitro diagnostics, pharmaceuticals, disposable, sterile equipment and devices for use in diagnostics, aesthetic (including parts and components), use of health materials. Production and project development, equipment research and equipment for medical purposes; technical assistance in medical devices and equipment, and laboratory research; Automated Diagnostic Systems; reconditioning parts and equipment, engineering services and scientific undertake of evaluations, research and reports in scientific and technological fields (including technical advice); scientific research and related services for medical purposes; scientific and technological services and research and design relating thereto; industrial analysis and research services. Medical and aesthetic clinics and offices, laboratory tests and diagnostics products and systems for in vitro diagnostic use intended for clinical or industrial applications, diagnostic solutions.


Patent
ADVANCE Medical | Date: 2010-09-03

Methods and apparatuses for treating a root canal in a tooth or hard and/or soft tissue within a tooth and surrounding tissues by pulsing a laser light into a reservoir, preferably after introducing liquid fluid into the reservoir, so as to disintegrate, separate, or otherwise neutralize pulp, plaque, calculus, and/or bacteria within and adjacent the fluid reservoir without elevating the temperature of any of the dentin, tooth, bones, gums, other soft tissues, other hard tissues, and any other adjacent tissue more than about 5 C.


peHUB ADVANCE Medical said Wednesday that it has closed $20 million in financing. New investors Aberdare Ventures and Arboretum Ventures participated in the round as did existing investors Venrock and Jose Bonchristiano. Also, the company has inked an agreement to acquire Brazil-based Imunotech Sistemas Diagnosticos, a distributor of laboratory and medical equipment. No financial terms were disclosed for this transaction. With facilities in Brazil and Mexico, ADVANCE Medical is a distributor of medical devices, diagnostics and laboratory equipment. ADVANCE Medical, a medical device, equipment and diagnostics distribution company backed by leading United States and Latin American investors, whose mission is to become the commercial partner-of-choice for innovative global medical technology companies looking to commercialize their products into leading physician clinics, hospitals and laboratories in Latin America, announced today it has raised US$20 million in an equity financing from new investors Aberdare Ventures and Arboretum Ventures, as well as existing investors including Venrock and Jose Bonchristiano. ADVANCE Medical also announced it has reached a definitive agreement to acquire all of the outstanding shares of Imunotech Sistemas Diagnosticos, a privately-held company in Brazil with a greater than 25-year track record in distribution of medical and laboratory equipment and reagents. The acquisition solidifies the combined entity’s Latin American distribution leadership and deepens ADVANCE Medical’s commercial footprint inside leading physician clinics, hospitals and laboratories. The Company also announced the addition of Hector Sobrino, MD, as General Manager for Mexico Operations. Dr. Sobrino was previously at Sanofi where he spent seven years in commercial roles in Mexico as well as in other countries in Latin America. In his two most recent roles at Sanofi, Dr. Sobrino was Specialty Therapies, Innovation and Market Access Director for all of Latin America and prior to that was Deputy General Manager for Aventis Mexico. Prior to Sanofi, he spent a combined 10 years in a variety of commercial roles at Pfizer, Johnson & Johnson and WorldCare Clinical. ADVANCE Medical also announced the addition of Claudia Goulart, former CEO of General Electric Healthcare (GE Healthcare) for Latin America, to the board of directors of ADVANCE Medical. Ms. Goulart led GE Healthcare’s activities in Latin America from 2003 to 2011. Prior to GE Healthcare, she held senior leadership roles in a number of private-equity backed companies and is presently on the board of directors of several healthcare companies. “We are very fortunate to have top US venture investors lead our Series B round and to combine with Imunotech, a company and team with a long and distinguished commercial track record. Our expanded team, and combined resources and capabilities, greatly enhance our ability to become the Latin American commercial partner-of-choice for innovative companies globally,” stated Fred Aslan, M.D., founder and Chief Executive Officer of ADVANCE Medical. “I am also pleased to welcome Hector Sobrino and Claudia Goulart to our team. Both Claudia’s and Hector’s commercial experience and track record with medical devices, equipment, and specialty products in Latin America are tremendous assets for ADVANCE.” “We are pleased to have joined forces with ADVANCE Medical,” stated Franz Sigfried Hoyler, founder, former President, and now Executive Advisor of Imunotech Sistemas Diagnosticos. “We believe this combination offers the best of both worlds to our suppliers and customers: Imunotech can maintain its focused commercial operation while leveraging the resources of ADVANCE Medical to enhance our team’s effectiveness. This was the logical next step for Imunotech as our team strives to help build one of the strongest distribution companies in Latin America.” About ADVANCE Medical ADVANCE Medical is a medical device, diagnostics and laboratory equipment distribution company with operations in Brazil and Mexico. Backed by leading United States and Latin American investors, the Company’s mission is to become the partner-of-choice for innovative global medical technology companies looking to commercialize their products in Latin America. The Company specializes in commercializing products that require a more sophisticated sales and marketing approach, offering a complete set of commercial, distribution and financing services to target leading physician clinics, hospitals and laboratories. ADVANCE Medical employs experienced executives with a strong track record of launching and commercializing products in Latin America. Brazil and Mexico have respectively the seventh and thirteenth largest nominal GDP (Gross Domestic Product) in the world with a combined population of over 300 million people. Latin America healthcare product imports have been growing at double digit rates, offering attractive markets for companies with innovative products and services.


News Article | September 4, 2013
Site: www.massdevice.com

Advance Medical had a big week, raising $20 million through a new equity financing round, nabbing all the assets of rival Brazilian distributor Imunotech Sistemas and adding a pair of medtech veterans to its team. The company, a medical device and diagnostics distribution firm, raised its latest funding from new investors Aberdare Ventures and Arboretum Ventures, as well as existing investors, including Venrock and Jose Bonchristiano, according to a company statement. Advance, which has headquarters in California, Brazil and Mexico, also signed a definitive agreement to acquire privately help Brazilian firm Imunotech Sistemas Diagnosticos, which has been dealing medical devices and laboratory equipment in the country for more than 25 years. The terms of the deal were not disclosed, but Advance said the merger "solidifies the combined entity’s Latin American distribution leadership and deepens ADVANCE Medical’s commercial footprint inside leading physician clinics, hospitals and laboratories." Topping off a busy week, Advance added a pair of new members to its management team, poaching them from Sanofi (NYSE:SNY) and GE Healthcare (NYSE:GE). The company’s board of directors welcomed former GE Healthcare Latin America CEO Claudia Goulart, who led GE’s Latin America presence for about 8 years and who is presently on the board of "several healthcare companies," according to a company statement. Advance also welcomed new Mexico operations general manager Dr. Hector Sobrino, who managed Mexican and other international commercial operations at Sanofi for 7 years. "We are very fortunate to have top US venture investors lead our Series B round and to combine with Imunotech, a company and team with a long and distinguished commercial track record," Advance founder and CEO Dr. Fred Aslan said in prepared remarks. "Our expanded team, and combined resources and capabilities, greatly enhance our ability to become the Latin American commercial partner-of-choice for innovative companies globally."

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