Advance Institute of Biotech and Paramedical science

Kānpur, India

Advance Institute of Biotech and Paramedical science

Kānpur, India
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Thakur M.,Charité - Medical University of Berlin | Thakur M.,Advance Institute of Biotech and Paramedical science | Thakur M.,Dr Hari Singh Gour University | Weng A.,Charité - Medical University of Berlin | And 6 more authors.
Carbohydrate Polymers | Year: 2012

Rasayana constitutes a very important class of Ayurvedic herbs, which acts as rejuvenators and tonic. Despite intensive research on evaluating the medicinal basis for the purported medical benefits of Rasayana herbs, still a specific chemical guiding principle for the characterization of these herbs in one single category is unclear. Here we explore the possibility that polysaccharides play a key role in Rasayana properties exhibited by medicinal plants. Further on this could be a possible field for exploration for a common factor present in some of the Ayurvedic herbs. The present review covers a literature spanning from 1956 to 2011. Some translations of traditional Ayurvedic texts dating back to the first century AD have been referred to as well. In our assessment of the present literature and studies carried out it is presupposed that the presence of benevolent plant polysaccharides must be one of the important features symbolizing a common effectiveness in most of the Ayurvedic Rasayana herbs. Of the many plant metabolites polysaccharides have not so far been considered and studied effectively compared to other secondary metabolites like saponins, alkaloids, etc. Although all the results reported until now suggest a major contribution of polysaccharide towards the maintenance of physiological homeostasis, which is the guiding principle of Rasayana therapy. The present review is an attempt to find a connective link between the concept of Rasayana and well-being; and the role of plant polysaccharides. Lack of clinical information on number of polysaccharides showing promise is a limiting factor for a complete understanding. It is also important to carry out a molecular interaction study to understand the behavior of polysaccharides discussed in the present review. © 2011 Elsevier Ltd. All Rights Reserved.


Yadav R.,University of Medical science | Srivastava D.K.,University of Medical science | Yadav S.,Government Medical College JamnagarGujarat | Kumar S.,University of Medical science | And 2 more authors.
Indian Journal of Community Health | Year: 2017

Backgroung: Job satisfaction defined as the end state of feeling, the feeling that is experienced after a task is accomplished. Job stress can be defined as the harmful physical and emotional responses that occur when the requirements of the job do not match the capabilities, resources, or need of the worker. Objectives: To study the relationship between job satisfaction and job stress among various employees of tertiary care level hospital and to find the co-relates of job stress and job satisfaction. Materials & Methods: A cross sectional study carried out for a period of 2 month among various employees working in Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, a tertiary care level hospital. A total 225 Participants 75 from each medical, paramedical and office staff were selected by purposive sampling technique. The study was conducted using pretested structured questionnaire regarding socio-demographic profile, job satisfaction and job stress. Data was analyzed using chi square test. Result: A total of 225 participants,75 from each medical, paramedical and office staff were interviewed. On doing analysis of questionnaire regarding job satisfaction and job stress it was found that majority believe that their job was well recognized and working in a good institute and were not satisfied with the management and salary and were coping well with their job stress and were having average level of satisfaction. Conclusion: The present study conclude that majority of the participants felt they are well recognized with their job, working in a good institute but not satisfied with the management and salary. © 2017, Indian Association of Preventive and Social Medicine. All rights reserved.


Lamba H.S.,KC Institute of Pharmaceutical science | Lamba H.S.,Advance Institute of Biotech and Paramedical science | Bhargava C.S.,Advance Institute of Biotech and Paramedical science | Thakur M.,Advance Institute of Biotech and Paramedical science | Bhargava S.,Advance Institute of Biotech and Paramedical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2011

Background: Inhibition of α-glucosidase and aldose reductase inhibitors plays a major role in hyperglycemia induced vascular damage. It has also been implicated as a major process affecting the glucose uptake mechanism. Objective: Reported study was done for a comparative evaluation of α-glucosidase and aldose reductase inhibitory activity of Tribulus terrestris and Curculigo orchioides which are well-known Ayurvedic Rasayana herbs. Design: A total of 48 Wistar strain rats were rendered hyperglycemic by treating them with streptozotocin (75 mg/Kg body weight). Diabetic rats were treated for 30 days with 100 mg/kg body weight of ethanolic extract of T. terrestris (TT100) and C. orchioides (CO100) once daily. Settings: Enzymatic and other parameters viz. blood glucose level, glycated hemoglobin, insulin, liver glycogen and urinary albumin levels were measured using an auto analyzer. Body weight of the rats was also recorded past treatment for 30 days. In vitro α-glucosidase inhibition was determined using acarbose and epicatechin as controls. Main outcome measures: Both TT and CO were effective in inhibiting α-glucosidase and aldose reductase. There was a reduction in fasting blood glucose level observed as well. Treatment with extracts could also ameliorate the loss of body weight as observed in case of hyperglycemic control group animals. ResultS and conclusion: A significant (p < 0.05) decrease in fasting blood glucose level was observed in case of TT100 treated group similar to the one treated with gibencalmide. A 59.6 ± 2.1% inhibition of α- glucosidase and 98.6% ± 1.1% inhibition of aldose reductase was observed at a dose of 30 μg in case of TT100. For CO100 the decrease in fasting blood glucose level was also significant (p < 0.05). A 60.4 ± 1.2% inhibition was observed in case of α- glucosidase and 99.2 ± 1.4%, inhibition was observed in case of aldose reductase activity. Elevation in glycated hemoglobin and liver glycogen levels were also observed in case of diabetic rats, and were similar to untreated control group animals in case of WG100 treated group. Similar to acarbose a significantly higher α-glucosidase inhibitory action was observed with WG. The low albumin excretion rate correlated well with the protective effects of the extracts. The study provides molecular interventions for the utilization of C. orchioides and T. terrestris in Ayurvedic system of medicine.


Rajput R.,Advance Institute of Biotech and Paramedical science | Mishra A.P.,Advance Institute of Biotech and Paramedical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Quinazolinones is considered as an important chemical synthesis of various physiological significance and pharmacological utility. Quinazolinones are a large class of active chemical compounds exhibiting a broad spectrum of biological activities in animals as well as in humans. Literature studies on quinazolinones have shown that these derivatives possess a wide variety of biological activities such as anti HIV, anticancer, antifungal, antibacterial, antimutagenic, anticoccidial, anticonvulsant, anti-inflammatory, CNS depressant, antimalarial, antioxidant, antileukemic activity, antileishmanial activity. This review focused on the various biological activities of quinazolinones.


Mishra V.,Advance Institute of Biotech and Paramedical science | Kaur R.,Advance Institute of Biotech and Paramedical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

The study was proposed to assess the variation in quality specifications between the standard formulation of the Punarnavadi guggulu made according to the Ayurvedic pharmacopoeia and market variants of Punarnavadi Guggulu so that industry and regulatory agencies can be made aware about the defects if any, and recommendations may be proposed about the quality and consistency status of the products available in the market. Different physico - chemical parameters such as diameter, thickness, weight variation, ash values, extractive values of sample in water and alcohol, Thin Layer Chromatography, HPTLC, heavy metals and aflalatoxins presence were done to ascertain the quality of this drug.


Mishra V.,Advance Institute of Biotech and Paramedical science | Kaur R.,Advance Institute of Biotech and Paramedical science
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Floating microballoons of famotidine were prepared by the Solvent diffusion and Evaporation method, using acrylic polymers dissolved in the mixture of Dichloromethane, Ethanol and Isopropyl alcohol. The effect of the various formulation parameters on the morphology, drug Incorporation efficiency, In-vitro floating behavior, particle size distribution, along with In-vivo bioavailability of Famotidine were studied. The prepared Microballoons were spherical in shape with porous smooth surface, the Microballoons showed the good in vitro floating behavior. The release rate of the drug was significantly affected by the type of combination and amount of the polymer used. It was observed that the size of Microballoons was strongly depend on the amount of polymer and the solvent system. The In-vitro study suggested that the Microballoons could float for a longer period of time and the in-vivo study supported the in vitro floating characteristics of hollow Microballoons. In-vivo bioavailability studies performed on rabbits and Cmax, tmax and AUC were calculated and confirmed significant improvement in bioavailability of Famotidine. The result of the present study indicate that the floating Microballoons can be successfully designed to give the controlled drug delivery and improved the oral bioavailability of Famotidine.


Prajapati N.,Advance Institute of Biotech and Paramedical science | Srivastava P.,Advance Institute of Biotech and Paramedical science | Bhargava S.,Advance Institute of Biotech and Paramedical science
Current Drug Therapy | Year: 2012

With the present scenario of development of newer drug delivery systems, correspondingly various routes are also being explored for systemic or local drug delivery to the patients. In the same context, nasal drug delivery is serving as a very effective route for the delivery of therapeutically active compounds. In such drug delivery system, drugs having lower absorption rate can be administered with the use of absorption enhancers through thin nasal mucosal layer. Similarly, drug residence time in the nasal cavity can also be increased by using various synthetic and natural polymers. Some mucoadhesive polymers have been reported to serve both of the above functions. The present review deals in depth with, nasal physiology and factors affecting drugs permeability which special reference to biological and pharmaceutical considerations. Structural features and various nasal delivery systems have also been discussed. Furthermore, applications of various natural polymers for the delivery of small organic molecules, antibiotics, proteins, vaccines and DNA through the nasal route have been extensively reviewed. © 2012 Bentham Science Publishers.


Sharma P.,Advance Institute of Biotech and Paramedical science | Kapoor A.,Advance Institute of Biotech and Paramedical science | Bhargava S.,Advance Institute of Biotech and Paramedical science
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Solid dispersions have been known to be one amongst the recent means of improving the dissolution rate by enhancement of solubility, and hence the bioavailability of poorly water soluble drugs. According, to - Chiou and Riegelman Solid dispersions are "The dispersion of one or more active ingredients in an inert carrier or matrix, where the active ingredients could exist in finely crystalline, solubilized or amorphous state."This review is the brief compilation of the solid dispersion as a technique of solubility enhancement in the current consensus. It deals with the mechanism of solubility enhancement, various techniques of solubility enhancement and the methods of formulation of solid dispersion. The implications of a deeper understanding of the dissolution mechanisms have been discussed, with particular emphasis on optimization of manufacturing methods along with type of polymer used. With the recent development in the screening of potential therapeutic agents, the number of poorly water soluble drugs have risen sharply and gained large interest due to the challenges in the oral solubility of the drug which leads to the major cause for which the techniques are meant to be implemented. One amongst such techniques is the formulation of solid dispersion for the solubility enhancement.


Jaiswal S.,Advance Institute of Biotech and Paramedical science | Mishra A.P.,Advance Institute of Biotech and Paramedical science | Srivastava A.,Pranveer Singh Institute of Technology
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Benzoheterocycles such as benzothiazoles can serve as unique and versatile scaffolds for experimental drug design. Among the all benzohaterocycles, benzothiazole has considerable place in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. The small and simple benzothiazole nucleus possesses numerous pharmacological activities like- antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. Since, a wide range of different reactions are available for synthesizing 2-substituted benzothiazole nucleus and its derivatives by using different type of catalysts but a real need exists for new procedures that support many kinds of structural diversity and various substitution. The present review focuses on the different kind of reactions involved in synthesis as well as cyclisation of benzothiazole nucleus and its derivatives.


Srivastava P.,Advance Institute of Biotech and Paramedical science | Malviya R.,Crossing tech
Indian Journal of Natural Products and Resources | Year: 2011

Plant and their products have always been a source of various drugs and excipients used in pharmaceutical formulations. Pectin, a naturally occurring polysaccharide, has in recent years gained increased importance. The benefits of natural pectin are also appreciated by scientists and consumer due to its biodegradability. Pectin is the methylated ester of polygalacturonic acid and it is commercially extracted from citrus peels and apple pomace under mildly acidic conditions. Pectin is divided into two major groups on the basis of their degree of esterification. The association of pectin chains leads to the formation of the three dimensional networks giving gel formation. Since ages pectin is being used in the formulation of various dosage forms wherein it acts as a promising natural polymer for drug delivery. Pectin possesses several requisite characteristics to be used as polymer in drug development and release kinetics. In the present review we have compiled the major sources, extraction process and properties of pectin. The major fields and areas of its applications as a promising polymer have also been discussed. The pectin, by itself or by its gelling properties, is employed in pharmaceutical industry as a carrier for drug delivery to the gastrointestinal tract, such as matrix tablets, gel beads, film-coated dosage form. This review has also discussed the important chemistry and general properties of pectin, and its gel formation mechanism and properties.

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