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Adrian, MI, United States

Adrian College is a private, co-educational liberal arts college conferring Bachelor's degrees in 40 academic majors and programs. The college is located in the city of Adrian, Michigan, a drive of approximately 45 minutes northwest of Toledo, Ohio, or 45 minutes southwest of Ann Arbor or 90 minutes southwest of Detroit. The 100 acre campus contains newly constructed facilities along with historic buildings. The collegefeatures a variety of athletic programs as well as a theatre department. Adrian College is affiliated with the United Methodist Church and is accredited by the North Central Association of Colleges and Schools in the United States. The fall 2010 enrollment was 1,654 students. The student center is Caine. Wikipedia.

Eutarsopolipus americanus sp. nov. (Acari: Podapolipidae), subelytral, haemolymph-feeding parasite of Chlaenius praesinus Dejean 1826 (Coleoptera: Carabidae), is described from Oceana County, Michigan and Adair and St. Louis Counties, Missouri. Relationships with 17 previously described species in the myzus group of Eutarsopolipus are discussed. Species in the myzus group parasitize beetle species of the genera Chlaenius, Poecilus, Scarites and Diplocheila. Eutarsopolipus americanus is the first species in the Western Hemisphere in the myzus group with adult females with stylets exceeding 80 micrometers. © 2013 Systematic & Applied Acarology Society.

Schantz M.M.,U.S. National Institute of Standards and Technology | McGaw E.,U.S. National Institute of Standards and Technology | McGaw E.,Adrian College | Wise S.A.,U.S. National Institute of Standards and Technology
Analytical Chemistry | Year: 2012

Four particulate matter Standard Reference Materials (SRMs) available from the National Institute of Standards and Technology (NIST) were used to evaluate the effect of solvent, number of static cycles and static times, pressure, and temperature when using pressurized liquid extraction (PLE) for the extraction of polycyclic aromatic hydrocarbons (PAHs) and nitrated-PAHs. The four materials used in the study were SRM 1648a Urban Particulate Matter, SRM 1649b Urban Dust, SRM 1650b Diesel Particulate Matter, and SRM 2975 Diesel Particulate Matter (Industrial Forklift). The results from the study indicate that the choice of solvent, dichloromethane compared to toluene and toluene/methanol mixtures, had little effect on the extraction efficiency. With three to five extraction cycles, increasing the extraction time for each cycle from 5 to 30 min had no significant effect on the extraction efficiency. The differences in extraction efficiency were not significant (with over 95% of the differences being <10%) when the pressure was increased from 13.8 to 20.7 MPa. The largest increase in extraction efficiency occurred for selected PAHs when the temperature of extraction was increased from 100 to 200 °C. At 200 °C naphthalene, biphenyl, fluorene, dibenzothiophene, and anthracene show substantially higher mass fractions (>30%) than when extracted at 100 °C in all the SRMs studied. For SRM 2975, large increases (>100%) are also observed for some other PAHs including benz[a]anthracene, benzo[k]fluoranthene, benzo[e]pyrene, benzo[a]pyrene, benzo[ghi]perylene, and benzo[b]chrysene when extracted at the higher temperatures; however, similar trends were not observed for the other diesel particulate sample, SRM 1650b. The results are discussed in relation to the use of the SRMs for evaluating analytical methods. © This article not subject to U.S. Copyright. Published 2012 by the American Chemical Society.

Davidsen J.M.,Johns Hopkins University | Bartley D.M.,Johns Hopkins University | Bartley D.M.,Adrian College | Townsend C.A.,Johns Hopkins University
Journal of the American Chemical Society | Year: 2013

Nocardicin A is a monocyclic β-lactam isolated from the actinomycete Nocardia uniformis that shows moderate antibiotic activity against a broad spectrum of Gram-negative bacteria. The monobactams are of renewed interest due to emerging Gram-negative strains resistant to clinically available penicillins and cephalosporins. Like isopenicillin N, nocardicin A has a tripeptide core of non-ribosomal origin. Paradoxically, the nocardicin A gene cluster encodes two non-ribosomal peptide synthetases (NRPSs), NocA and NocB, predicted to encode five modules pointing to a pentapeptide precursor in nocardicin A biosynthesis, unless module skipping or other nonlinear reactions are occurring. Previous radiochemical incorporation experiments and bioinformatic analyses predict the incorporation of p-hydroxy-l-phenylglycine (l-pHPG) into positions 1, 3, and 5 and l-serine into position 4. No prediction could be made for position 2. Multidomain constructs of each module were heterologous expressed in Escherichia coli for determination of the adenylation domain (A-domain) substrate specificity using the ATP/PPi exchange assay. Three of the five A-domains, from modules 1, 2, and 4, required the addition of stoichiometric amounts of MbtH family protein NocI to detect exchange activity. On the basis of these analyses, the predicted product of the NocA and NocB NRPSs is l-pHPG-l-Arg-d-pHPG-l-Ser- l-pHPG, a pentapeptide. Despite being flanked by non-proteinogenic amino acids, proteolysis of this pentapeptide by trypsin yields two fragments from cleavage at the C terminus of the l-Arg residue. Thus, a proteolytic step is likely involved in the biosynthesis of nocardicin A, a rare but precedented editing event in the formation of non-ribosomal natural products that is supported by the identification of trypsin-encoding genes in N. uniformis. © 2013 American Chemical Society.

Kurosa K.,Nishi Ikebukuro 5 21 15 | Husband R.W.,Adrian College
Systematic and Applied Acarology | Year: 2013

Simalurapolipus hiraii n. gen., n. sp. (Acari: Podapolipidae) collected in Shizuoka Prefecture, Japan is described from Simalura coerulea (Lewis) (Coleoptera: Tenebrionidae) and compared with Tenebrapolipus ceropriae Kurosa and Husband, 2001 from Ceropria induta (Wiedemann, 1819) and T. imasakai Kurosa and Husband, 2001 from Ceropria laticollis Fairmaire,1903 collected in Japan. The unusual occurence of many larval females of the species on the host body surface is reported. © 2013 Systematic & Applied Acarology Society.

Husband R.W.,Adrian College | Kurosa K.,Nishi Ikebukuro 5 21 15
Systematic and Applied Acarology | Year: 2013

Eutarsopolipus asiaticus sp. nov. (Acari: Podapolipidae), subelytral parasite of Chlaenius costiger Chaudoir (Coleoptera: Carabidae), is described from Japan. Relationships with 18 previously described species in the myzus group of Eutarsopolipus are discussed and keys are provided to species in the myzus group. This is the first record of Eutarsopolipus in the myzus group in Japan and represents a subgroup of species in the myzus group with cheliceral stylets 90 micrometers or longer. © 2013 Systematic & Applied Acarology Society.

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