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Gotthelf S.J.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis
Revista de la Federacion Argentina de Cardiologia | Year: 2014

Introduction: The TG / HDL index has been described as a predictor of cardiometabolic risk closely related to insulin resistance and an atherogenic lipid profile. Objective: To assess the prevalence of TG / HDL index among adolescent students of the Province of Salta and its relationship to family,nutritional and biochemical factors. Material and Methods: Cross-sectional study. Population:659 adolescents between 16 and 20 years old, attending the last grade of public and private high schools of Salta, Cafayate and Joaquín González (2008-09). Variables: high TG/HDL ≥3. MS IDF criteria: ≥80cm waist circumference women, men ≥90 cm, TG ≥ 150 mg / dl, HDL ≤50mg/dl women, men ≤40mg/dL, systolic / diastolic blood pressure ≥130/85 mmHg, fasting glucose ≥100mg/dl. LDL and cholesterol. BMI z score (WHO). Sociodemographic: sex, residence, family income. Parental history of obesity, hypertension, diabetes, hypercholesterolemia, and cardiovascular disease. Statistical analysis: Chi square, Fisher (proportions). Kolgomorov (normality), Mann- Whitney U, Kruskal Wallis (median). Logistic regression (SPSS17) p<0.05. Results: The prevalence of high TG/HDL was 11.8%, 8.6% in women and 16.4% in men (p = 0.003), 9.6% at the Capital city and 15% in the rest of the province (p = 0.04) and 9.6% in normally nourished and 22.2% in overweight / obese individuals (p = 0.000). Median BG and CHOL were significantly higher in those with high TG/HDL.The OR for high TG/HDL was associated with male sex (OR 2.40 CI:1.05 -5.46), overweight / obesity (OR 3.05 CI: 1.56 -5.97), to beingfrom the rest of the province (OR 3.53 CI:1.62-7.66) and parental history of hypertension (OR 2.22 CI:1.14-4.39) and diabetes (OR 2.40 CI;0.99-5.80). Conclusions: The TG/HDL index is easy to apply and could be useful for measuring the metabolic risk associated with obesity in adolescents.

Gotthelf S.J.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis | da Fonseca M.J.M.,Escuela Nacional de Salud Publica
Revista de la Federacion Argentina de Cardiologia | Year: 2012

Introduction: The prevalence of hypertension in children is 1-3% in childhood and reaches 10% in adolescence. Body weight has a direct relationship with blood pressure, and its association with high blood pressure has been documented in different age groups. Objective: To evaluate the association between hypertension and anthropometric variables in adolescents from public and private schools in the city of Salta. Material and Methods: A cross sectional study. School adolescents, 16 to 20 years, evaluated in 2009. Variables: Blood Pressure, Body Mass Index (BMI), waist circumference (WC) and WC / Height Ratio. Education: Public / private. Statistical analysis: Student test, Chi square, Fischer, Logistic regression. SPSS 15 Program. Results: The final sample was composed of 395 students from 5 public schools and 3 private. Logistic regression models adjusted for sex and school type showed that the probability of hypertension was 7.85 in adolescents with overweight / obesity in relation to normal nutrition status and 4.43 and 6.06 times in the WC and WC / Height Ratio increased. Also there was a higher probability of hypertension in men (OR between 4 and 5). Conclusions: It confirms the presence of a current health problem in adolescents: Hypertension, closely related to weight gain. The three indicators of obesity analyzed showed significant association with the presence of the disease.

In 2007 a new definition of Metabolic Syndrome (MS) for children and adolescents, arises from the IDF (International Diabetes Federation), giving to the obesity abdominal region, a prevalent role associated with increased risk of cardiovascular disease and type 2 diabetes. To estimate the prevalence of MS using IDF criteria among adolescent students in the province of Salta (2008-2009). Methodology: Cross-sectional study. Population: 659 adolescents between 16 and 20 years old, attending the last grade of public and private high schools of Salta (Capital), Cafayate and JV.Gonzalez. Variables: MS: WC ≥80 cm women, men ≥90 cm, TG ≥150 mg / dl, HDL: women ≤50 mg/dl, men ≤40 mg/dl; systolic / diastolic ≥130/85 mmHg, fasting glucose ≥100mg/dl. BMI z score (WHO). Sociodemographic: sex, residence, school, family income. Statistical analysis: Chi square, Fisher (proportions). Kolgomorov (normal), Mann-Whitney U, Kruskal Wallis (median). Logistic regression (SPSS 17) p <0.05. Results: The overall prevalence of MS was 4.1%, 3.1% in women and 5.5% in men; 3.4% and 5.1% in the Capital and the rest of the province; 0.4% in normally nourished, 13.2% overweight and 50% obese individuals. Median TG, glucose and systolic /diastolic were significantly higher in men, the rest of the province and obese, the WC was higher in the Capital, in men and obese individuals. The multivariate regression analysis was associated with overweight/obesity increased odds of MS (0R 77.46) adjusted by sex, residence and family income. Conclusions: There is a MS prevalence similar to that reported in other studies with variable features into its components by sex, residence and nutritional status.

Santini M.S.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis | Gould I.T.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis | Acosta M.M.,Instituto Nacional Of Medicina Tropical Inmet | Berrozpe P.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis | And 6 more authors.
Revista do Instituto de Medicina Tropical de Sao Paulo | Year: 2013

The first Argentinian autochthonous human case of visceral leishmaniasis (VL) was confirmed in Posadas (Misiones) in 2006. Since then, the disease has increased its incidence and geographical distribution. In the 2006-2012 period, 107 human cases were detected (11 deaths). The presence of Lutzomyia longipalpis was detected in peridomiciles in Puerto Iguazú urban area in 2010; some of these findings were associated with households where cases of canine VL had already been reported. The objective of this study was to ascertain the abundance and spatial distribution of Lu. longipalpis in Puerto Iguazú City, on the Argentina-Brazil-Paraguay border. Lu. longipalpis proved to be exclusively urban and was found in 31% of the households sampled (n = 53), 67% of which belonged to areas of low abundance, 20% to areas of moderate abundance and 13% to areas of high abundance. Nyssomyia whitmani was the only species found both in urban and peri-urban environments, and Migonemyia migonei was registered only on the outskirts of the city. Due to the fact that Puerto Iguazú is considered to be at moderate risk at the moment, it is necessary to intensify human and canine case controls, as well as take integrated prevention and control measures regarding the environment, vectors and reservoirs on the Argentina-Brazil-Paraguay border area.

Taboas M.,Administracion Nacional Of Laboratorios E Institutos Of Salud Anlis | Taboas M.,CONICET | Gomez Acuna L.,University of Buenos Aires | Scaia M.F.,University of Buenos Aires | And 7 more authors.
PLoS ONE | Year: 2014

Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most frequent inborn error of metabolism and accounts for 90-95% of CAH cases. In the present work, we analyzed the functional consequence of four novel previously reported point CYP21A2 mutations -p.R132C, p.R149C, p.M283V, p.E431K- found in Argentinean 21-hydroxylase deficient patients. In addition, we report an acceptor splice site novel point mutation, c.652-2A>G, found in a classical patient in compound heterozygosity with the rare p.R483Q mutation. We performed bioinformatic and functional assays to evaluate the biological implication of the novel mutation. Our analyses revealed that the residual enzymatic activity of the isolated mutants coding for CYP21A2 aminoacidic substitutions was reduced to a lesser than 50% of the wild type with both progesterone and 17-OH progesterone as substrates. Accordingly, all the variants would predict mild non-classical alleles. In one non-classical patient, the p.E431K mutation was found in cis with the p.D322G one. The highest decrease in enzyme activity was obtained when both mutations were assayed in the same construction, with a residual activity most likely related to the simple virilizing form of the disease. For the c.652-2A>G mutation, bioinformatic tools predicted the putative use of two different cryptic splicing sites. Nevertheless, functional analyses revealed the use of only one cryptic splice acceptor site located within exon 6, leading to the appearance of an mRNA with a 16 nt deletion. A severe allele is strongly suggested due to the presence of a premature stop codon in the protein only 12 nt downstream. © 2014 Taboas et al.

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