News Article | December 9, 2016
With an upcoming publication in the Worldwide Leaders in Healthcare, Pamela Lynn Genkinger, RN, BSN, joins the prestigious ranks of the International Nurses Association. Pamela is a Registered Nurse with 14 years of experience in her field and an extensive expertise in all facets of nursing, especially teaching in a clinical setting, psycho motor skills, and evaluation. Pamela is currently serving as Clinical Coordinator in the Associate Degree Nursing Program at Niagara County Community College in Sanborn, New York Pamela graduated with her Associate of Science Degree from Niagara County Community College, before completing her Bachelor of Science Degree in Nursing in 2002 from Niagara University. An advocate for continuing education, Pamela is currently pursuing her Master of Science Degree at Daemen College, with a projected graduation date in 2017. Pamela is certified in Basic Life Support, has served in the Army Reserves as 2nd Lieutenant, and has received multiple recognitions, including a Certificate of Appreciation – Operation Nuevos Horizons, El Salvador, a Certificate of Training – Duty Appointed Retention NCO, an Army Achievement Medal, and a Certificate of Appreciation – JTF San Marcos New Horizons, Guatemala. Pamela keeps up to date with the latest advances and developments in her field through her professional memberships with the Niagara Society of Professional Nurses, the National League of Nurses, and the National Youth Sports Coaches Association. For her excellence, she was voted Outstanding Adjunct Faculty Member in 2015, and is an active volunteer for school events for her children, such as Pendleton Athletic Boosters Association – Assistant Cheerleading Coach. Pamela attributes her success to her great role models. When she is not working, Pamela dedicates her free time to being with her family, as well as scrapbooking. Learn more about Pamela here: http://inanurse.org/network/index.php?do=/4134032/info/ and read her upcoming publication in the Worldwide Leaders in Healthcare.
News Article | December 15, 2016
New York, NY, December 15, 2016 --( “We are excited about adding this young industry leader to head our crucial AV managed services group,” said Berry. “As a global company, we need to continue to grow and satisfy our clients’ needs. Michael gives us that opportunity through his hands-on-approach to problem resolution and just getting the job done.” Shinn joins Verrex with over 12 years of experience in the audio visual industry focused on operational and service excellence. Career highlights include Vice President of Customer Relations, promoted from Director of Operations, at IMS Technology Services; Adjunct Faculty/Professor of Computer Science at La Salle University; Service Manager at IMS Audio Visual; and Coordinator of Multimedia Services at La Salle. He holds a Bachelor of Arts in Communications from La Salle University and has completed numerous AV industry training and certification courses. He was named to Commercial Integrator Magazine’s “Top 40 Influencers Under 40” list in 2014 and has contributed expertise to a number of AV industry publications and organizations, including InfoComm International, NSCA (National Systems Contractor Association), and AVNation. “I am thrilled to be joining Verrex in this role to lead the GMS team,” said Shinn. “The continuing trend in the industry is a focus on Managed Services and Verrex is offering me the opportunity to grow their business on a global scale, hone their GMS process, and expand the efficiency of the department. I’m extremely excited to be joining this team at such a strong uptick in the managed services trend.” Shinn is based out of Verrex & Global headquarters in Mountainside, New Jersey. He can be reached at firstname.lastname@example.org. New York, NY, December 15, 2016 --( PR.com )-- Verrex, an APEx-certified global provider of superior AV technology solutions and experiences announced that Michael Shinn has joined the AV systems integrator as Director of Global Managed Services. This key hire comes at an opportune time as growth of AV managed services continues to align with corporate clients’ ever-evolving technology usage. Shinn will be responsible for service operations and solutions creating additional value for global clients in the company’s highly successful managed service portfolio. He will focus on accelerating Verrex’s innovation in AV-as-a-Service including cloud-conferencing and remote monitoring, as well as expanding the integrator’s break/fix, global service desk, maintenance, and onsite support. Shinn reports directly to Verrex CEO, Thomas Berry, CTS.“We are excited about adding this young industry leader to head our crucial AV managed services group,” said Berry. “As a global company, we need to continue to grow and satisfy our clients’ needs. Michael gives us that opportunity through his hands-on-approach to problem resolution and just getting the job done.”Shinn joins Verrex with over 12 years of experience in the audio visual industry focused on operational and service excellence. Career highlights include Vice President of Customer Relations, promoted from Director of Operations, at IMS Technology Services; Adjunct Faculty/Professor of Computer Science at La Salle University; Service Manager at IMS Audio Visual; and Coordinator of Multimedia Services at La Salle. He holds a Bachelor of Arts in Communications from La Salle University and has completed numerous AV industry training and certification courses. He was named to Commercial Integrator Magazine’s “Top 40 Influencers Under 40” list in 2014 and has contributed expertise to a number of AV industry publications and organizations, including InfoComm International, NSCA (National Systems Contractor Association), and AVNation.“I am thrilled to be joining Verrex in this role to lead the GMS team,” said Shinn. “The continuing trend in the industry is a focus on Managed Services and Verrex is offering me the opportunity to grow their business on a global scale, hone their GMS process, and expand the efficiency of the department. I’m extremely excited to be joining this team at such a strong uptick in the managed services trend.”Shinn is based out of Verrex & Global headquarters in Mountainside, New Jersey. He can be reached at email@example.com. Click here to view the list of recent Press Releases from Verrex
News Article | October 31, 2016
NEW YORK CITY (October 31, 2016)--The Brain & Behavior Research Foundation honored nine scientists with its 2016 Outstanding Achievement Prizes for their work in schizophrenia, mood disorders, child and adolescent psychiatry, and cognitive neuroscience. The award presentation took place on Friday, October 28th at the Foundation's 29th Annual National Awards Dinner, celebrating the transformative power of neuroscience and psychiatric research to improve the lives of people with mental illness, which affects one in five people. According to Foundation President and CEO Jeffrey Borenstein, M.D., the Outstanding Achievement Prizes, which cover five categories, are among the most prestigious awards in the field of psychiatric research. The recipients were selected by the Foundation's Scientific Council, comprised of 173 leading experts across disciplines in brain and behavior research, including two Nobel laureates; the current director of the National Institute of Mental Health and four former directors; four recipients of the National Medal of Science; 13 members of the National Academy of Sciences; 26 chairs of psychiatry and neuroscience departments at leading medical institutions; and 55 members of the National Academy of Medicine. "These scientists have dedicated their lives to understanding complex psychiatric conditions in order to help millions of affected people and their families," said Dr. Borenstein. "We are proud to honor them and highlight the inspiring work of these outstanding scientists, teachers and mentors." The 2016 Outstanding Achievement Prizewinners are as follows: The Lieber Prize was established in 1987 by the late Constance E. Lieber, Foundation President Emerita, and her husband, Stephen A. Lieber, Chair of the Foundation's Board of Directors. Michael F. Green, Ph.D., Professor, Semel Institute for Neuroscience and Human Behavior at UCLA; Director VA Research Enhancement Award Program (REAP) on Enhancing Community Integration for Homeless Veterans; and Director Treatment Unit, VA VISN 22 Mental Illness Research, Education and Clinical Center (MIRECC) Dr. Green's clinical research laboratory explores the relationship between cognitive and social cognitive impairments in schizophrenia and activities of daily living. His team also explores the neural mechanisms of cognitive and social cognitive dysfunction in schizophrenia and bipolar disorder. Dr. Green is a leading researcher in the evaluation of social cognitive retraining and novel pharmacological interventions to improve cognitive impairments. His laboratory also studies the determinants of community integration for homeless veterans, many of whom have psychotic disorders. His identification of the importance of cognition in schizophrenia launched the national Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) effort, and stimulated novel and innovative treatments for cognitive dysfunction. Stephen R. Marder, M.D., Daniel X. Freedman Professor of Psychiatry, Vice Chair for Education in Psychiatry and Director, Section on Psychosis, Semel Institute for Neuroscience and Human Behavior at UCLA; Director VA Desert Pacific MIRECC; NARSAD Distinguished Investigator 2011. During his career, Dr. Marder has focused on pharmacological and non-pharmacological approaches to improving the outcomes of serious mental illnesses, particularly schizophrenia. His clinical intervention research began with studies that evaluated strategies for reducing adverse side effects of antipsychotic medications, and studies that evaluated the interactions of psychosocial interventions and pharmacological approaches to improving the outcome of serious mental illnesses. Together with Dr. Green, his fellow Lieber Prize recipient, he led the NIMH-MATRICS initiative, which addressed key issues in the development of medications for improving cognition in schizophrenia. Established in 2005, the prize was renamed in 2016 in honor of Board Members Milton and Tamar Maltz. The Maltz Prize is awarded to an investigator who has undertaken innovative and promising research in schizophrenia. Winners are selected by the Lieber Prize recipient(s) of the same year. William P. Horan, Ph.D., Research Psychologist, Department of Psychiatry and Biobehavioral Sciences University of California, Los Angles; Clinical Research Psychologist, Veterans Administration Greater Los Angeles; Faculty VA VISN 22 MIRECC; NARSAD Young Investigator 2008 and 2004 Dr. Horan conducts translational research to identify factors that contribute to difficulties in community integration among people with schizophrenia and other forms of psychosis, and has been a leader in the development of innovative treatments that may help patients improve the quality of their lives. More recently, he has begun applying this translational research approach to investigations of bipolar disorder and homelessness. In addition, he has focused on the development and validation of the Social Cognitive Skills Training Program for people with psychosis. The goal of this research is to develop new treatments that enable people with psychosis to live independently, pursue personally meaningful vocational and educational goals, and develop more satisfying social networks in the community. His work has led to a deeper understanding of the impairments in motivation and social behaviors that affect the lives of many people with schizophrenia, previously viewed by most clinicians as untreatable, and led to a new sense of optimism that these problems can be addressed in the clinic. Amanda McCleery, Ph.D., Assistant Research Psychologist, Semel Institute for Neuroscience and Human Behavior at UCLA, VA Greater Los Angeles Healthcare System VISN 22 MIRECC; NARSAD Young Investigator 2015 Dr. McCleery's research focuses on cognitive predictors of functional outcome in schizophrenia and related conditions. Her recent work uses EEG techniques in conjunction with performance-based measures to better understand the nature of the relationships between early-stage information processing, higher-order cognition, and community functioning across phases of illness in schizophrenia. Her work is also informed by developmental psychopathology in order to gain a nuanced understanding of the trajectory of cognition over the course of illness to identify potential critical periods and targets for intervention, as well as possible mechanisms of change. Established in 1993 the prize was re-named in 2012 to honor a Foundation supporter, the late Oliver D. Colvin, Jr., who bequeathed the largest single contribution in the Foundation's history. Francis J. McMahon, M.D., Senior Investigator and Chief Human Genetics Branch National Institute of Mental Health Intramural Research Program; NARSAD Independent Investigator 2006 and 1998, and Young Investigator 1994 Dr. McMahon's research is aimed at discovering and characterizing genes involved in mood and anxiety disorders in order to develop better methods of diagnosis and treatment. For more than a decade, his work has focused on pharmacogenomics, including genetic studies of antidepressant outcome, lithium response, and treatment-resistant depression. Still in its early stages, pharmacogenomics underlies the increasing interest in personalized and precision medicine, promising to reduce trial and error in the selection of the most effective treatments, while minimizing adverse events. Thomas G. Schulze, M.D., Professor and Director Institute of Psychiatric Phenomics and Genomics (IPPG) Medical Center of the University of Munich; Adjunct Faculty, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University; Associate Investigator Human Genetics Branch, National Institute of Mental Health Intramural Program; NARSAD Young Investigator 2007 and 2002 Dr. Schulze's research focuses on genotype-phenotype relationships in psychiatric disorders. He coordinates a German-wide center grant on longitudinal psychosis research and spearheads an international study on the genetic basis of response to lithium treatment in bipolar disorder, comprising several research groups from Europe, the Americas, Africa, Asia, and Australia. In addition, he and his team have embarked on population-based genetic studies in Ethiopia, focusing on the interplay of khat abuse (a plant that is used as a drug), trauma, and psychosis. Within the framework of a German government-funded, multi-site network, he is entrusted with the job of setting up a national federated biobanking and phenotyping platform. Pamela Sklar, M.D., Ph.D., Founding Chief, Division of Psychiatric Genomics, Vice-Chair, Department of Genetics and Genomic Sciences, Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Icahn School of Medicine Mount Sinai; Foundation Scientific Council Member, NARSAD Independent Investigator 2006, and Young Investigator 1998 and 1995 Dr. Sklar's pioneering work in the genetic basis of bipolar disorder has led to a new understanding of the condition and potential treatments. In addition to her breakthrough discovery that schizophrenia is caused by genetic risk factors that overlap with bipolar disorder, Dr. Sklar's lab identified the first replicated genetic finding in bipolar disorder, identified two novel deletions strongly associated with schizophrenia, and identified the complex polygenic molecular nature of schizophrenia and bipolar disorder. Dr. Sklar is developing programs in genetics and translational research in the areas of next-generation sequencing, stem cell biology, proof-of-concept drug trials, and large-scale sample collections. Her team, comprised of experts in statistical genetics, stem cell biology, neurocognition, and imaging, is pioneering ways to translate genetic insights into the clinical practice of psychiatry. The Ruane Prize was initiated in 2000 by philanthropists Joy and William Ruane, and recognizes significant advances in research toward the understanding and treatment of early-onset brain and behavior disorders. John L.R. Rubenstein, M.D., Ph.D., Nina Ireland Distinguished Professor in Child Psychiatry, University of California at San Francisco; Foundation Scientific Council Member, NARSAD Distinguished Investigator 1997, and Young Investigator 1992 and 1990 Dr. Rubenstein's genetic analyses of frontal lobe development led to identification of genes that are associated with Autism Spectrum Disorders. He has made major contributions to understanding fundamental mechanisms of forebrain development, including studies on forebrain organization, patterning centers, transcription factors that control regional specification of brain and craniofacial subdivisions, the linking of regional and cell type specification in the telencephalon, the demonstration that cortical inhibitory neurons are generated in the basal ganglia and tangentially migrate to the cortex, and the postnatal differentiation of cortical inhibitory neurons. His studies have implications on mechanisms underlying several developmental disorders, such as autism and epilepsy. The Goldman-Rakic Prize was created by Constance and Stephen Lieber in memory of Dr. Patricia Goldman-Rakic, a neuroscientist renowned for discoveries about the brain's frontal lobe, who died in an automobile accident in 2003. Building on Pat Goldman-Rakic's groundbreaking studies, Dr. Miller's work in primates has broken new ground in the understanding of cognition. Using innovative experimental and theoretical approaches to study the neural basis of high-level cognitive functions, his laboratory has provided insights into how categories, concepts, and rules are learned, how attention is focused, and how the brain coordinates thought and action. The laboratory has innovated techniques for studying the activity of many neurons in multiple brain areas simultaneously, providing insight into how different brain structures interact and collaborate. This work has established a foundation upon which to construct more detailed, mechanistic accounts of how executive control is implemented in the brain and its dysfunction in diseases such as autism, schizophrenia and attention deficit disorder, and has led to new approaches relevant to severe mental illnesses in children and adults. The Brain & Behavior Research Foundation is committed to alleviating the suffering of mental illness by awarding grants that will lead to advances and breakthroughs in scientific research. The Foundation funds the most innovative ideas in neuroscience and psychiatry to better understand the causes and develop new ways to treat brain and behavior disorders. These disorders include depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, anxiety, borderline personality disorder, obsessive-compulsive disorder, and post-traumatic stress disorder. Since 1987, the Foundation has awarded more than $360 million to fund more than 5,000 grants to more than 4,000 leading scientists around the world. This has led to over $3.5 billion in additional funding for these scientists. The Foundation is also dedicated to educating the public about mental health and the importance of research, including the impact that new discoveries have on improving the lives of those with mental illness, which will ultimately enable people to live full, happy and productive lives. For more information, visit http://www. .
Garg S.,BITS |
Ramprasaath R.S.,BITS |
Kapur S.,BITS |
Rao K.M.M.,Adjunct Faculty
2014 IEEE International Conference on Image Processing, ICIP 2014 | Year: 2014
Recent times have seen a wide ranging and large scale use of paper as a potential material in sensors for determining the concentration of an analyte upon appropriate end-point development. Today's clinical, food and environmental sectors require low-cost practical analytical devices which are portable and offer on-site real time detection. We present a novel technique for estimating any analyte's concentration using a mobile app that analyses the image of the paper subsequent to a chromogenic assay. Making use of snakuscules for capturing the region of interest in the image, followed by basic strategies for removing illumination artifacts using the Von-Kries Coefficient Law, we correlated the luminosity of the colour developed on the paper strip against the analyte's concentration. We evaluate our algorithm by determining the glucose concentration levels in blood using commercially available glucometer strips using image processing and comparing them with actual glucose levels as estimated by auto analyzers. The results obtained correlated well with the conventional assay and were almost indistinguishable from the actual values. © 2014 IEEE.
News Article | February 22, 2017
WASHINGTON--(BUSINESS WIRE)--Cohen Milstein Sellers & Toll PLLC, a leading national plaintiffs’ law firm, has announced that partners Betsy A. Miller and Victoria S. Nugent will lead the firm’s Public Client Practice Group. The group represents state attorneys general, municipalities, and other government entities in affirmative, civil law enforcement investigations and litigation. Areas of focus include protecting state and local governments – and the consumers, patients, and government treasuries within those states and municipalities – from false claims for public funds and unfair and deceptive trade practices. Miller joined the firm in 2009 as a founding member of the Public Client Practice. Nugent joined the firm in 2000 and has worked with the Public Client Practice since 2011. During their tenures at Cohen Milstein, Miller and Nugent have directed major cases in the areas of mortgage fraud, financial fraud, health-care fraud, and deceptive advertising across a variety of industries. Most recently, Miller served as counsel for the co-lead state in last month’s $864 million settlement achieved by 22-states and the U.S. Department of Justice with Moody’s, one of the nation’s largest credit rating agencies. Together with the $1.375 billion-dollar settlement with Standard & Poor’s, in which Miller also represented a co-lead state in 2015, these cases produced key industry reforms that guarantee greater transparency for consumers and divested the credit rating agencies of more than $2.2 billion for their conduct contributing to the national housing crisis and Great Recession. Nugent is currently representing multiple states that are investigating and litigating against some of the nation’s largest for-profit nursing home chains, in cases alleging that these companies promised, but failed to provide, basic care to their elderly residents. “Cohen Milstein’s Public Client Practice is nationally recognized as a top choice for government clients seeking to supplement their firepower against deceptive conduct at the state and local level,” said Betsy A. Miller, Co-Chair of the Public Client Practice Group at Cohen Milstein Sellers & Toll. “Now more than ever, states and municipalities will play an important role in this effort. The Public Client Practice provides smart, sophisticated legal counsel for our government clients – whether in the form of hard-fought litigation or settlement outcomes that reform industry practices and policies in a way only achievable through voluntary resolution with the defendant. Public-sector lawyers do the hard work every day, and it is an honor to be in a position where we can support them with assistance from our talented team at Cohen Milstein. State and local governments hire us to help level the playing field against powerful corporations with vast litigation and lobbying budgets.” “Whether it is standing up to investment banks, nursing homes, pharmaceutical companies, or other actors in the marketplace, we work with our clients to attain meaningful results in the toughest of cases,” said Victoria S. Nugent, Co-Chair of the Public Client Practice Group at Cohen Milstein Sellers & Toll. “States and municipalities investigate the lion’s share of bad conduct without assistance from outside counsel, but there are occasions when they need more resources than their limited budgets can provide. Our Public Client Practice provides support to government clients in this narrow area. It is a privilege to be enlisted by them to take on these crucial cases.” “Betsy Miller and Victoria Nugent are highly respected and thoughtful leaders who have dedicated their careers to taking on important challenges and to delivering impressive results. They are driven by a commitment to look at each case as an opportunity to improve the lives of vulnerable consumers through results that can deliver immediate and long-lasting impact,” said Joe Sellers, Chair of the Executive Committee at Cohen Milstein. “We are thrilled to have them co-chair our Public Client Practice.” An accomplished litigator and negotiator, Miller has been recognized by the National Law Journal as one of Washington, D.C.’s “Rising Stars.” Prior to joining Cohen Milstein, she served as Chief of Staff and Senior Counsel in the Office of the Attorney General for the District of Columbia, where she managed high-profile legal issues and policy initiatives. Prior to that, she served as Counsel on the U.S. Senate Committee on the Judiciary, where she worked for former Chairman, Patrick J. Leahy (D-VT). She also spent eight years as a litigator at Jones Day and Crowell & Moring, where she represented some of the nation’s largest companies and individuals in matters including First Amendment litigation, complex commercial disputes, collective bargaining negotiations and arbitration, employment class actions and internal corporate audits. Since 2001, she has served on the Adjunct Faculty at Georgetown University Law Center, where she teaches seminars on negotiation and mediation. Miller graduated magna cum laude from Dartmouth College and earned her law degree from Harvard Law School, where she was awarded post-graduate fellowships for her commitment to government service and public interest work. Before joining the Public Client Practice, Nugent spent 11 years in Cohen Milstein’s Consumer Protection Practice, where she focused on telecommunications and investment services, interest sales practices, and product safety litigation. Upon joining the firm’s Public Client Practice Group in 2011, Nugent represented the state of Nevada in efforts to hold investment banks, lenders, and loan servicers accountable for the mortgage crisis that rocked the state. Those efforts yielded substantial payments to the state, mortgage modifications and other equitable relief valued at more than $1 billion. Prior to joining Cohen Milstein, Nugent worked for seven years at Public Citizen, the national, non-profit consumer advocacy organization founded by Ralph Nader; there, she worked on legislative and organizing campaigns addressing issues that ranged from auto safety to international trade agreements. Immediately following law school, Nugent was awarded a fellowship from the National Association for Public Interest Law to develop and prosecute impact litigation in the areas of mandatory arbitration and consumer credit at Public Justice. She has served on the D.C. Bar Committee on the Rules of Professional Conduct since 2012. She is a graduate of Wesleyan University and earned her law degree from Georgetown University. Founded in 1969, Cohen Milstein Sellers & Toll PLLC is recognized as one of the premier law firms in the country handling major, complex plaintiff-side litigation. With more than 90 attorneys, Cohen Milstein has offices in Washington, D.C., Chicago, Ill., Denver, Colo., New York, N.Y., Palm Beach Gardens, Fla., Philadelphia, Pa., and Raleigh, N.C. For additional information, visit www.cohenmilstein.com or call 202.408.4600.
News Article | November 11, 2016
Adolfson & Peterson Construction (AP) recently joined with Front Range Community College (FRCC), OZ Architecture and FRCC students and staff to celebrate the grand opening of the LEED Silver Certified Mount Antero building, the main Welcome Center for the FRCC Larimer Campus in Fort Collins, Colorado. Along with 37,000-sf additions at the north and south wings of the existing building, AP also remodeled the center of the building and added a two-story atrium by opening up the roof. The Mount Antero building houses Human Resources, Administration, College Leadership, Financial Aid, Office of the Registrar, Admission & Outreach, College Now, Advising, Career & Counseling, Student Success Center, Campus Security, Adjunct Faculty Touchdown Area, Online Learning, Learning Opportunity Center and the Cashier’s Office. The enhancement to this campus symbolizes the growth of the college and the redevelopment of the campus, while responding to the needs of the students and improving their success. Construction on these facilities were made on an active, occupied campus. Mount Antero was the fourth phase of a $28 million campus-wide construction and renovation project of adding classrooms, expanding student-oriented space, supporting the instructional needs of faculty and students and providing additional parking. AP has completed all four phases of this ongoing project and has touched multiple buildings including: Mount Antero, Blanca Peak, Maroon Peak, Little Bear Peak, Red Cloud Peak and the Southwest Parking Lot. Adolfson & Peterson Construction (AP) is a U.S.-based, privately held builder that is consistently ranked among the top 50 construction managers and general contractors in the nation. Headquartered in Minneapolis, Minnesota, the company delivers innovative and collaborative building solutions for clients across the country from its regional offices in Charlotte, Dallas, Denver, Minneapolis and Phoenix. Founded in 1946, AP serves clients in the education, healthcare, commercial, municipal, multifamily, hospitality and senior living market sectors. For more information, visit http://www.a-p.com or follow us on Facebook, LinkedIn and Twitter.
PubMed | Resident, Adjunct Faculty, Professor, Assistant Professor and Assistant Director and University of Rochester
Type: Journal Article | Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons | Year: 2016
The objective of this study was to investigate the analgesic effect of a collagen conduit (Neuragen, Integra LifeSciences Corp, Plainsboro, NJ) using duloxetine (Cymbalta, Lilly, Indianapolis, IN) with or without pregabalin (Lyrica, Pfizer, NY) on pain induced by partial sciatic nerve transection in a rat model.Adult male Sprague-Dawley rats were divided into 5 groups (n= 10 per group): group 1, nerve damage with no treatment; group 2, nerve damage treated with the application of a collagen conduit and saline; group 3, nerve damage treated with the application of a collagen conduit and duloxetine; group 4, nerve damage treated with the application of a collagen conduit and pregabalin; and group 5, nerve damage treated with the application of a collagen conduit and pregabalin plus duloxetine. Pain levels were evaluated by responses to mechanical and thermal stimuli at baseline before and 3 and 7days after surgery. Interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF) levels were evaluated in blood, sciatic nerve, and dorsal root ganglion samples collected 7 days after surgery.The group treated with the collagen conduit and pregabalin exhibited markedly less pain 7 days postoperatively in response to mechanical and thermal stimuli compared with the other groups. IL-10 levels were considerably increased in the group treated with pregabalin. The groups treated with a collagen conduit and duloxetine and a combination of pregabalin and duloxetine also exhibited markedly less pain in response to mechanical and thermal stimuli 7 days after surgery compared with the group that had only nerve injury. The decrease in pain using duloxetine was not as robust but was associated with a decrease of TNF-. The combination of pregabalin and duloxetine resulted in a substantial decrease in IL-6.Using a collagen conduit and duloxetine, pregabalin, and their combination helped alleviate neuropathic pain. The mechanism of action might be associated, at least in part, to cytokines.
Collins R.L.,Adjunct Faculty
Process Safety Progress | Year: 2011
In this article, the author will summarize and review Heinrich's work originally published in 1931. The author will then supplement that original work with accident data collected and compiled by the United States Bureau of Labor Statistics over a recent 17-year period. This additional data will then be used to expand the top layer of Heinrich's Triangle to include accidents resulting in OSHA recordable cases, lost workday cases, and fatalities. The result will be an updated version of Heinrich's Triangle consisting of five levels instead of the original three. These will start at the top with accidents resulting in fatalities and work down through lost workday cases, OSHA recordable incidents and first-aid cases to accidents with no injuries. Analysis of this additional data will lead to some interesting and significant conclusions about the validity of the underlying data. © 2010 American Institute of Chemical Engineers.
Varilla V.,Center on Aging |
Schneiderman H.,Yale University |
Schneiderman H.,St Francis Hospital And Medical Center |
Aprn S.K.,Adjunct Faculty |
Aprn S.K.,St Francis Hospital And Medical Center
Connecticut Medicine | Year: 2015
A 62-year-old woman with advanced cancer was admitted to the hospital experiencing inadequate pain control. Underdosing of opiates resulted from the persistent and inappropriate labeling of her behavior as drug-seeking, and the medical staff expressed discomfort about the administration of high doses of opiates. Palliative care personnel achieved better symptom control by the use of more confident and more liberal opiate dosing. The patient's quality of life improved immensely without adverse effects. We investigated reasons that account for the widespread practice of opiate underdosing. These include biases such as opiophobia - often unspoken and sometimes unrecognized. We share these insights to enhance the practice of others.
Collins R.L.,Adjunct Faculty
Process Safety Progress | Year: 2010
As businesses in the "Goods Producing" sector moved their operations outside of the United States over the last several decades, relatively higher accident rates went with them. The net result has been a trend towards business types, mostly in the "Service Providing" sector, which have historically lower accident rates. In this article, the author will show that a significant portion of the reductions in fatal occupational accidents over the 16-year span from 1992 to 2008 in the United States were the result of business trends away from the "Goods Producing" sector towards the "Service Providing" sector. This is not to say that improvements in accident prevention policies and procedures were not a major contributor to reductions in fatal occupational accidents as well. Instead, these policy and program improvements were augmented by the changing distribution of business types in the United States. The net result was a reduction in overall fatal occupational accident rates of~ 435% with ~ 23% of this reduction resulting from the changing distribution of business types in the United States. With the limited analysis demonstrated in this article, it is not possible to infer this same effect for other spans of time. It seems likely, however, that any span of years that sees a decrease in the percentage of hours worked in "Goods Producing" sector with a corresponding increase in the percentage of hours worked in "Service Providing" sector would have a decrease in total fatal accidents attributable only to the changing distribution of business types in the United States. © 2010 American Institute of Chemical Engineers.