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Tholkappiyan B.,Vinayaka Missions University | Charles Martin A.,Vinayaka Missions University | Rawoof Khan G.,Aditya Bangalore Institute for Pharmacy Education and Research | Narayanan N.,Vinayaka Missions University | And 2 more authors.
International Journal of Pharma and Bio Sciences | Year: 2011

Cosmetic products are formulated for application on the body for the purpose of cleansing, beautifying, or altering appearance and enhancing the beauty. The ozone layer in the stratosphere practically prevents the UV photons from reaching the earth's surface of concern for human skin damage, therefore, only UV-B and UV-A radiation are relevant. In the present study an attempt has been made to formulate a cream containing alcoholic extract of pomegranate peel extract. The quantity control parameters of Punica granatum were performed as per WHO guidelines. The cream was formulated using pomegranate peel extract in two concentrations (10% and 25%). The UV analysis of different concentrations of prepared creams are done along with standard cream which has TiO 2 as the active ingredient. The extraction of peel was carried out by continuous hot percolation using Soxhlet apparatus and the phytochemical screening revealed the presence of flavanoids, tannins, anthocyanins and polyphenolic compounds. The evaluation of antibacterial activity is done by cup and plate technique using ethanolic extract of pomegranate peel against Staphylococcus aureus, Pseudomonas aeruginosa. The results showed that the ethanolic extract of pomegranate peel has very good sensitivity against both gram positive and gram negative organism.


Jayaswal S.R.,Aditya Bangalore Institute for Pharmacy Education and Research | Felix Joe V.,Aditya Bangalore Institute for Pharmacy Education and Research | Viswanath B.A.,Aditya Bangalore Institute for Pharmacy Education and Research
International Journal of Pharmacy and Technology | Year: 2014

Treatment of diabetes mellitus (DM) with conventional dosage forms is not effective as the drugs do not reach the site of action in appropriate concentration and it also requires frequent dosing. Thus an effective and safe therapy of diabetes mellitus disorder using specific drug delivery system is a challenging task to the pharmaceutical technologists. Most commonly used method of modulating the drug release is to include it in a matrix system. The objective of the present study was to develop hydrophilic polymer (HPMC) and hydrophobic polymer (Ethyl cellulose) based Glibenclamide matrix sustained release tablet which can release the drug up to time of 14 hrs in predetermined rate. The formulation of Glibenclamide matrix tablet was prepared by the polymer combination in order to get required theoretical release profile. The influence of hydrophilic and hydrophobic polymer and granulation technique on Glibenclamide was studied. The formulated tablet were also characterized by physical and chemical parameters like drug content, hardness, friability, swelling index etc. all the formulations had shown the results within prescribed limits. The in vitro drug release study indicates that formulation GBF7 containing EC, HPMC K100M in 1:2 ratios shows good release pattern for 14 hours compared to other formulations. The in–vitro release data was well fit to Peppas and Hixon crowel release kinetics. The short term stability study proven no change in the formulation upon ageing and it indicates good stability. © 2014, International Journal Of Pharmacy and Technology. All rights reserved.


Arul Revathi M.,Aditya Bangalore Institute for Pharmacy Education and Research | Felix Joe V.,Aditya Bangalore Institute for Pharmacy Education and Research | Swetha T.E.,Aditya Bangalore Institute for Pharmacy Education and Research
Research Journal of Pharmacy and Technology | Year: 2014

The objective of the study is to develop phenylephrine orally disintegrating tablet using different super disintegrants which would disintegrate tablet rapidly in oral cavity.12 batches of phenylephrine orally disintegrating tablet was prepared by direct compression method using cross povidone, cross carmellose sodium, low substituted hydroxypropyl cellulose and sodium starch glycolate as disintegrants in different concentrations. The developed oral disintegrating tablets were evaluated for different physical chemical evaluations like drug content, hardness, friability, weight variation, wetting time, invitro dispersion time, In vitro disintegration time etc. All formulations had shown the results within the prescribed limits. The In vitro drug release study indicated faster and maximum drug release from formulations F-12. © RJPT All right reserved.

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