Adiparasakthi Dental College
Adiparasakthi Dental College
Sivasankari T.,Thai Moogambigai Dental College |
Ramakrishnan T.,Adiparasakthi Dental College |
Aruna B.,Madha Dental College
Journal of Pharmaceutical Sciences and Research | Year: 2017
Background: Rheumatoid Arthritis and Chronic Periodontitis are two chronic inflammatory disorders which share a similar pathophysiology. Previously many studies have proposed a relationship between both the diseases. Therefore, the aim of the study was to explore the co-relation between grading of Rheumatoid arthritis and severity of chronic periodontitis in south Indian population. Material And Methods: Sixty consecutive patients attending a rheumatology clinic were examined for their levels of periodontitis and rheumatoid arthritis. Patients without rheumatoid arthritis was selected on age and gender matched served as controls. Probing pocket depth, clinical attachment loss and plaque score were measured for Periodontitis. Measures of rheumatoid arthritis include DAS scores. Severity of rheumatoid disease activity score was correlated with the severity of Periodontitis and it was analyzed with the control group. Results: No difference in the plaque score between the rheumatoid arthritis and the control group was observed. More pocket depth and more number of missing teeth were found in the rheumatoid arthritis group. No significant difference was seen in the severity of rheumatoid arthritis disease group with the severity of chronic Periodontitis. But when only the severe chronic Periodontitis group was compared with the rheumatoid activity disease group there was a significant difference noted. Conclusion: The result of the study shows a positive co-relation between the rheumatoid arthritis and chronic Periodontitis. The severity of rheumatoid arthritis disease group increases with the severity of chronic Periodontitis. © 2017, Pharmainfo Publications. All rights reserved.
Devi M.,Adiparasakthi Dental College |
Saraswathi T.R.,Ragas Dental College |
Ranganathan K.,Ragas Dental College |
Vijayalakshmi D.,Adiparasakthi Dental College |
And 2 more authors.
Journal of Pharmacy and Bioallied Sciences | Year: 2014
Aim: The aim of this study is to identify and evaluate Langerhans cell (LC) in lichen planus (LP), lichenoid mucositis (LM) and normal mucosa (NM) using CD1a monoclonal antibody immunohistochemically. Materials and Methods: A total of 15 cases of oral lichen planus and 15 cases of LM were selected based on clinical examination and confirmed by histopathological analysis. The biopsies from the 10 patients were taken from normal buccal mucosa as control. Paraffin blocks of tissue were made, which are used for routine hematoxylin and eosin staining and immunohistochemical staining using biotin streptavidin methods (CD1a monoclonal antibody). Analysis of CD1a expression was performed by evaluating the labeling index (LI) for each slide. Results: The mean CD1a LI for LP was significantly higher than that of LM and NM in the basal and supra basal layer. The mean CD1a positive cells in the connective tissues for LP were higher than that of LM and NM. Conclusion: This study clearly demonstrates a statistically significant increase in number of LC in LP than in LM, indicating the possible different immunopathogenic mechanisms.