ADINACO Research Group

Czech Republic

ADINACO Research Group

Czech Republic
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Opletal L.,ADINACO Research Group | Chocholousova-Havlikova L.,Charles University | Siatka T.,ADINACO Research Group | Cahlikova L.,ADINACO Research Group | And 8 more authors.
Natural Product Communications | Year: 2017

Extracts of Hibiscus sabdariffa calyces have been shown to have various medicinal properties, some of which have been reported to be due to anthocyanins present in the calyces. To study whether these claims are valid, it is necessary to produce an extract with a high anthocyanin content and to have available a method to identify and quantify the individual compounds in the product. A method of extraction and purification has been developed based on a polyamide column chromatographic purification step. Using this method, anthocyanin concentrates were produced containing from 57 to 64% of delphinidin-3-sambubioside plus cyanidin-3-sambubioside. A rapid, efficient and validated HPLC analytical method was developed and used for the analysis of the anthocyanin concentrate.


Host'Alkova A.,ADINACO Research Group | Opletal L.,ADINACO Research Group | Novakova L.,Charles University | Hrabinova M.,University of Hradec Kralove | Cahlikova L.,ADINACO Research Group
Natural Product Communications | Year: 2015

A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 ± 5.4 μM.


Hostalkova A.,ADINACO Research Group | Novak Z.,Charles University | Pour M.,Charles University | Jirosova A.,Czech Institute of Organic Chemistry And Biochemistry | And 3 more authors.
Natural Product Communications | Year: 2013

A new isoquinoline-isoquinolone alkaloid was isolated from the root bark of Berberis vulgaris and named berbanine. The structure was established by spectroscopic methods (including 2D NMR, HR-EI-MS).

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