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Host'Alkova A.,ADINACO Research Group | Opletal L.,ADINACO Research Group | Novakova L.,Charles University | Hrabinova M.,University of Hradec Kralove | Cahlikova L.,ADINACO Research Group
Natural Product Communications | Year: 2015

A known alkaloid (+)-chenabinol (1) and two new secobisbenzylisoquinoline alkaloids were isolated by standard chromatographic methods from the root bark of Berberis vulgaris L. The structures of the new alkaloids, named berkristine (2) and verfilline (3), were established by spectroscopic (including 2D NMR), and HRMS (ESI) methods. The alkaloids were tested for their inhibition activity of human cholinesterases and prolyl oligopeptidase. Compound 1 inhibited human butyrylcholinesterase with an IC50 value of 44.8 ± 5.4 μM.


Hostalkova A.,ADINACO Research Group | Novak Z.,Charles University | Pour M.,Charles University | Jirosova A.,Czech Institute of Organic Chemistry And Biochemistry | And 3 more authors.
Natural Product Communications | Year: 2013

A new isoquinoline-isoquinolone alkaloid was isolated from the root bark of Berberis vulgaris and named berbanine. The structure was established by spectroscopic methods (including 2D NMR, HR-EI-MS).

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