Adina Institute of Pharmaceutical science

Sāgar, India

Adina Institute of Pharmaceutical science

Sāgar, India
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Jain A.K.,Adina Institute of Pharmaceutical science | Jain S.K.,Adina Institute of Pharmaceutical science
Journal of Drug Targeting | Year: 2013

The objective of the present investigation was to prepare and evaluate nanolipobeads which permit the targeting of drugs to H. Pylori and potentially used for the treatment of gastric ulcer. For this polyvinyl alcohol nanoparticles were prepared by freeze thaw cyclizing method and surface acylation was done by treating with (1M) palmitoyl chloride in hexane followed by addition of 0.1 N NaOH to induce acylation by adjusting pH below 6.5. Finally, nanolipobeads synthesis was carried out by combining equal parts of suspension of acylated poly vinyl alcohol nanoparticles (PVA-NPs) and AMOX encapsulated PE liposomes suspension. The uniformity of supported PE lipid layer on acylated PVA-NPs was examined using fluorescence and confocal laser scanning electron microscopy. The optimized nanolipobeads formulation demonstrated 773.3±4.3nm average age size and 84.7±2.9% of AMOX and 67.5±2.8% of RBC release up to 72h, respectively. Furthermore, binding specificity and targeting propensity toward H. pylori (SKP-56) was confirmed by agglutination and in situ adherence assay. Reduction of the absolute alcohol induced ulcerogenic index from 3.01±0.25 to 0.31±0.09 and 100% H. pylori clearance rate was observed. These results suggested that nanolipobeads are potential vector for development of dual drug delivery for effective treatment of H. pylori associated peptic ulcer. © 2013 Informa UK Ltd.


Bhadoriya S.S.,Adina Institute of Pharmaceutical science | Mishra V.,Dr Hari Singh Gour University | Raut S.,Adina Institute of Pharmaceutical science | Ganeshpurkar A.,Shri Ram Institute of Technology | Jain S.K.,Adina Institute of Pharmaceutical science
Scientia Pharmaceutica | Year: 2012

The present study aimed to investigate the anti-inflammatory and anti- nociceptive potential of a hydroethanolic extract of Tamarindus indica L. leaves (HTI) along with its possible mode of action. The anti-inflammatory activity of HTI was estimated by carrageenan-induced hind paw oedema in male Wistar albino rats. Furthermore, HTI was assessed to determine its effects on membrane stabilization. The antinociceptive action was determined by acetic acid-induced writhing, tail-flick, and the hot plate model. Oral administration of HTI at the dose of 500, 750, and 1000 mg/kg body weight produced significant (P< 0.01) anti-inflammatory as well as antinociceptive actions in a dose- dependent manner. Among all tested doses, 1000 mg/kg, p. o. reduced carrageenan-induced rat paw oedema at 1, 2, 3, and 4 h. Moreover, the 1000 mg/kg dose exhibited maximum percentage inhibition of acetic acid-induced writhing (48.9%), whereas standard drug diclofenac (25 mg/kg, p. o.) showed maximum inhibition (50.9%) of writhing. In the hot plate model, HTI (1000 mg/kg, orally) increased mean basal reaction time after 120 min (7.12±0.05 sec). In the tail flick model, HTI increased the maximum percentage of latency (36.06%), whereas the standard drug pethidine (4 mg/kg, intraperitoneally) showed maximum percentage of latency (43.85%) after 60 min. The findings of the present study supported anti-inflammatory and antinociceptive claims of T. indica as were mentioned in Indian traditional and folklore practices. © Bhadoriya et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.


Shukla A.,Panjab University | Mishra V.,Adina Institute of Pharmaceutical science | Kesharwani P.,Wayne State University
Drug Discovery Today | Year: 2016

Oral administration remains the most favored means of drug administration as far as patient compliance is concerned. For the majority of vaccines and biologics, the oral route is not a good choice because of diminished uptake of the administered dose. Vesicular carriers like liposomes and niosomes are among the potential candidates for vaccine delivery by the oral route but their instability in the gastrointestinal environment is a problem. Bilosomes represent a key advance in oral vaccine delivery because they are more resistant to disruption by gastric acid as well as enzymes. Here, we focus on different aspects of bilosomes including composition, developmental techniques, stability, transitional modifications and scale-up - emphasizing their biomedical potential in oral immunization against various diseases. © 2016 Elsevier Ltd. All rights reserved.


Mishra V.,Adina Institute of Pharmaceutical science | Kesharwani P.,Wayne State University
Drug Discovery Today | Year: 2016

Despite low prevalence, brain tumors are one of the most lethal forms of cancer. Unfortunately the blood-brain barrier (BBB), a highly regulated, well coordinated and efficient barrier, checks the permeation of most of the drugs across it. Hence, crossing this barrier is one of the most significant challenges in the development of efficient central nervous system therapeutics. Surface-engineered dendrimers improve biocompatibility, drug-release kinetics and aptitude to target the BBB and/or tumors and facilitate transportation of anticancer bioactives across the BBB. This review sheds light on different aspects of brain tumors and dendrimers based on different approaches for treatment including recent research, opportunities and challenges encountered in development of novel and efficient dendrimer-based therapeutics for the treatment of brain tumors. © 2016 Published by Elsevier Ltd.All rights reserved.


Thakur A.,Indian Institute of Technology Bombay | Thakur A.,Adina Institute of Pharmaceutical science | Mishra V.,Adina Institute of Pharmaceutical science | Jain S.K.,Adina Institute of Pharmaceutical science
Scientia Pharmaceutica | Year: 2011

Pathological changes in an organ or tissue may be reflected in proteomic patterns in serum. The early detection of cancer is crucial for successful treatment. Some cancers affect the concentration of certain molecules in the blood, which allows early diagnosis by analyzing the blood mass spectrum. It is possible that exclusive serum proteomic patterns could be used to differentiate cancer samples from non-cancer ones. Several techniques have been developed for the analysis of mass-spectrum curve, and use them for the detection of prostate, ovarian, breast, bladder, pancreatic, kidney, liver, and colon cancers. In present study, we applied data mining to the diagnosis of ovarian cancer and identified the most informative points of the mass-spectrum curve, then used student t-test and neural networks to determine the differences between the curves of cancer patients and healthy people. Two serum SELDI MS data sets were used in this research to identify serum proteomic patterns that distinguish the serum of ovarian cancer cases from non-cancer controls. Statistical testing and genetic algorithm-based methods are used for feature selection respectively. The results showed that (1) data mining techniques can be successfully applied to ovarian cancer detection with a reasonably high performance; (2) the discriminatory features (proteomic patterns) can be very different from one selection method to another. © Thakur et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria.


Singh Bahia M.,Punjabi University | Kumar Katare Y.,Radharaman Institute of Pharmaceutical science | Silakari O.,Punjabi University | Vyas B.,Punjabi University | Silakari P.,Adina institute of Pharmaceutical science
Medicinal Research Reviews | Year: 2014

Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid (AA) into PGH2 that is further metabolized by terminal prostaglandin (PG) synthases into biologically active PGs, for example, prostaglandin E2 (PGE2), prostacyclin I2 (PGI2), thromboxane A2 (TXA2), prostaglandin D2 (PGD2), and prostaglandin F2 alpha (PGF2α). Among them, PGE2 is a widely distributed PG in the human body, and an important mediator of inflammatory processes. The successful modulation of this PG provides a beneficial strategy for the potential anti-inflammatory therapy. For instance, nonsteroidal anti-inflammatory agents (NSAIDs), both classical nonselective (cNSAIDs) and the selective COX-2 inhibitors (coxibs) attenuate the generation of PGH2 from AA that in turn reduces the synthesis of PGE2 and modifies the inflammatory conditions. However, the long-term use of these agents causes severe side effects due to the nonselective inhibition of other PGs, such as PGI2 and TXA2, etc. Microsomal prostaglandin E2 synthase-1 (mPGES-1), a downstream PG synthase, specifically catalyzes the biosynthesis of COX-2-derived PGE2 from PGH2, and describes itself as a valuable therapeutic target for the treatment of acute and chronic inflammatory disease conditions. Therefore, the small molecule inhibitors of mPGES-1 would serve as a beneficial anti-inflammatory therapy, with reduced side effects that are usually associated with the nonselective inhibition of PG biosynthesis. © 2014 Wiley Periodicals, Inc.


Mehta N.,Punjabi University | Kaur M.,Punjabi University | Singh M.,Punjabi University | Chand S.,Punjabi University | And 4 more authors.
Bioorganic and Medicinal Chemistry | Year: 2014

Purinergic receptors, also known as purinoceptors, are ligand gated membrane ion channels involved in many cellular functions. Among all identified purinergic receptors, P2X7 subform is unique since it induces the caspase activity, cytokine secretion, and apoptosis. The distribution of P2X7 receptors, and the need of high concentration of ATP required to activate this receptor exhibited its ability to function as 'danger' sensor associated with tissue inflammation and damage. Further, the modulation of other signalling pathways associated with P2X7 has also been proposed to play an important role in the control of macrophage functions and inflammatory responses, especially towards lipopolysaccharides. Experimentally, researchers have also observed the decreased severity of inflammatory responses in P2X 7 receptor expressing gene (P2RX7) knockout (KO) phenotypes. Therefore, newly developed potent antagonists of P2X 7 receptor would serve as novel therapeutic agents to combat various inflammatory conditions. In this review article, we tried to explore various aspects of P2X7 receptors including therapeutic potential, and recent discoveries and developments of P2X7 receptor antagonists. © 2013 Published by Elsevier Ltd. All rights reserved.


Mishra D.,ADINA Institute of Pharmaceutical science | Jain N.,ADINA Institute of Pharmaceutical science | Rajoriya V.,ADINA Institute of Pharmaceutical science | Jain A.K.,ADINA Institute of Pharmaceutical science
Journal of Pharmacy and Pharmacology | Year: 2014

Objective The present study was focused to prepare controlled release glycyrrhizin (GL) conjugated low molecular weight chitosan nanoparticles (CS-NPs) for liver targeting. The hydrophilic antiretroviral drug lamivudine was chosen as a model drug and encapsulated within glycyrrhizin conjugated low molecular weight chitosan nanoparticles (GL-CS-NPs) for liver specificity. Methods First, the low molecular weight chitosan (CS) was synthesized through depolymerization method. The low molecular weight chitosan nanoparticles were prepared by inotropic gelation method. Then glycyrrhizin was conjugated with previously prepared low molecular weight chitosan nanoparticles (CS-NPs) and conjugation was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Key findings The prepared GL-CS-NPs were characterized using dynamic light scattering, transmission electron microscopy and FT-IR. The encapsulation efficiency and in-vitro drug release behaviour of drug-loaded GL-CS-NPs were studied using ultra violet spectroscopy and high performance liquid chromatographic methods. Release of lamivudine from the nanoparticles exhibited a biphasic pattern, initial burst release and consequently sustained release. In-vivo biodistribution study suggested the target ability of GL-CS-NPs is better and haematological study shows decline of the tissue damage in comparison with plain drug solution. Conclusion The experimental results show that the glycyrrhizin conjugated LMWC nanoparticles may be used as a potential drug delivery system with hepatocyte-targeting characteristics. © 2014 Royal Pharmaceutical Society.


Modi A.,ADINA Institute of Pharmaceutical science | Kumar V.,Nirma University
Asian Pacific Journal of Tropical Disease | Year: 2014

Luffa echinata Roxb. (Cucurbitaceae) is a spreading climbing herb of tremendous medicinal importance, distributed throughout Pakistan, India, Bangladesh and Northern Tropical Africa. Traditionally various parts of the plant are being used for the treatment of different ailments such as jaundice, intestinal colic, enlargement of liver and spleen, leprosy, diabetes, bronchitis, nephritis, rheumatism, cirrhosis, dropsy, anthelmintic, stomach ache, snake bite, dog bite, fever, diarrohea and hemorrhoid disorder. The plant also possesses antioxidant, analgesic, anti-inflammatory, antidepressant, anxiolytic, antiepileptic, hepatoprotective, antibacterial, antifungal, antiulcer and anticancer activity. Research has been carried out using different techniques to support most of these claims. This review is an attempt to compile an up-to-date data on its ethanomedicinal, phytochemical and pharmacological perspective. © 2014 Asian Pacific Tropical Medicine Press.


Modi A.,Adina Institute of Pharmaceutical science | Jain S.,Adina Institute of Pharmaceutical science | Kumar V.,Nirma University
Asian Pacific Journal of Tropical Disease | Year: 2014

Zizyphus xylopyrus (Retz.) Willd (Rhamnaceae) is an ever-green shrub of tremendous medicinal importance, distributed throughout the North-Western India, Pakistan, and China. Various parts of plant are used in Ayurvedic and other folk medicine for the treatment of different ailments such as obesity, diabetes, snake bite, fever, diarrhoea, insomnia and digestive disorders. The plant also possesses antisteroidogenic, anticonvulsent, antinociceptive, antiinflammatory, antidepressant, antidiarroheal and wound healing activity. Research has been carried out using different techniques to support most of these claims. This review is an attempt to compile an up-to-date on its folkloric or traditional uses, phytochemical as well as pharmacological properties of Zizyphus xylopyrus. © 2014 Asian Pacific Tropical Medicine Press.

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