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Goswami D.V.,P.A. College | Modi A.,Adina Institute of Pharmaceutical science | Tiwari R.,P.A. College
International Journal of Pharma and Bio Sciences | Year: 2010

Bark of Tectona grandis Linn. commonly known as "Sagwan" belongs to the Verbenaceae family and, traditionally used in diabetes, bronchitis, constipation and in various skin ailments. Present work is related to standardization of Tectona grandis by using pharmacognostic (macroscopy, microscopy and physical constants) and phytochemical investigation on stem bark of Tectona grandis. All the parameters were studied according to the WHO and pharmacopoeial guidelines to standardize the Tectona grandis. Source


Modi A.,Adina Institute of Pharmaceutical science | Kumar V.,Nirma University
Asian Pacific Journal of Tropical Disease | Year: 2014

Luffa echinata Roxb. (Cucurbitaceae) is a spreading climbing herb of tremendous medicinal importance, distributed throughout Pakistan, India, Bangladesh and Northern Tropical Africa. Traditionally various parts of the plant are being used for the treatment of different ailments such as jaundice, intestinal colic, enlargement of liver and spleen, leprosy, diabetes, bronchitis, nephritis, rheumatism, cirrhosis, dropsy, anthelmintic, stomach ache, snake bite, dog bite, fever, diarrohea and hemorrhoid disorder. The plant also possesses antioxidant, analgesic, anti-inflammatory, antidepressant, anxiolytic, antiepileptic, hepatoprotective, antibacterial, antifungal, antiulcer and anticancer activity. Research has been carried out using different techniques to support most of these claims. This review is an attempt to compile an up-to-date data on its ethanomedicinal, phytochemical and pharmacological perspective. © 2014 Asian Pacific Tropical Medicine Press. Source


Singh Bahia M.,Punjabi University | Kumar Katare Y.,Radharaman Institute of Pharmaceutical science | Silakari O.,Punjabi University | Vyas B.,Punjabi University | Silakari P.,Adina Institute of Pharmaceutical science
Medicinal Research Reviews | Year: 2014

Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid (AA) into PGH2 that is further metabolized by terminal prostaglandin (PG) synthases into biologically active PGs, for example, prostaglandin E2 (PGE2), prostacyclin I2 (PGI2), thromboxane A2 (TXA2), prostaglandin D2 (PGD2), and prostaglandin F2 alpha (PGF2α). Among them, PGE2 is a widely distributed PG in the human body, and an important mediator of inflammatory processes. The successful modulation of this PG provides a beneficial strategy for the potential anti-inflammatory therapy. For instance, nonsteroidal anti-inflammatory agents (NSAIDs), both classical nonselective (cNSAIDs) and the selective COX-2 inhibitors (coxibs) attenuate the generation of PGH2 from AA that in turn reduces the synthesis of PGE2 and modifies the inflammatory conditions. However, the long-term use of these agents causes severe side effects due to the nonselective inhibition of other PGs, such as PGI2 and TXA2, etc. Microsomal prostaglandin E2 synthase-1 (mPGES-1), a downstream PG synthase, specifically catalyzes the biosynthesis of COX-2-derived PGE2 from PGH2, and describes itself as a valuable therapeutic target for the treatment of acute and chronic inflammatory disease conditions. Therefore, the small molecule inhibitors of mPGES-1 would serve as a beneficial anti-inflammatory therapy, with reduced side effects that are usually associated with the nonselective inhibition of PG biosynthesis. © 2014 Wiley Periodicals, Inc. Source


Modi A.,Adina Institute of Pharmaceutical science | Jain S.,Adina Institute of Pharmaceutical science | Kumar V.,Nirma University
Asian Pacific Journal of Tropical Disease | Year: 2014

Zizyphus xylopyrus (Retz.) Willd (Rhamnaceae) is an ever-green shrub of tremendous medicinal importance, distributed throughout the North-Western India, Pakistan, and China. Various parts of plant are used in Ayurvedic and other folk medicine for the treatment of different ailments such as obesity, diabetes, snake bite, fever, diarrhoea, insomnia and digestive disorders. The plant also possesses antisteroidogenic, anticonvulsent, antinociceptive, antiinflammatory, antidepressant, antidiarroheal and wound healing activity. Research has been carried out using different techniques to support most of these claims. This review is an attempt to compile an up-to-date on its folkloric or traditional uses, phytochemical as well as pharmacological properties of Zizyphus xylopyrus. © 2014 Asian Pacific Tropical Medicine Press. Source


Gulbake A.,Dr Hari Singh Gour University | Jain A.,Adina Institute of Pharmaceutical science | Jain S.K.,Dr Hari Singh Gour University
Nanoscience and Nanotechnology - Asia | Year: 2012

Aqueous dispersions of lipid nanoparticles are being investigated as drug delivery system for different therapeutic purpose. In the present investigation, aqueous dispersion of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared by ethanol injection method and then incorporated into the freshly prepared water removable cream base. Lipid nanoparticles were characterized for particle size, PDI, zeta potential and surface morphology. The optimized lipid nanoparticles bearing oxybenzone were incorporated into cream base and were evaluated for in vitro and in vivo parameters. Cream base formulations containing SLN and NLC with 5% oxybenzone equivalent showed slow drug permeation compared to cream base containing 5% oxybenzone solution. The cream base formulations containing oxybenzone loaded lipid nanoparticles had shown better sun protecting factor (SPF 21 for NLC & 24 for SLN) as compared to cream base formulation. The confocal laser scanning microscopy (CLSM) study shows higher retention of SLN in the subcutaneous skin as compare to NLC and plain cream base. Hence studies revealed the SLN exhibited good skin retention and sun protection effect as compared to NLC and plain cream based formulation. © 2012 Bentham Science Publishers. Source

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