Lockhart S.R.,Centers for Disease Control and Prevention |
Iqbal N.,Centers for Disease Control and Prevention |
Bolden C.B.,Centers for Disease Control and Prevention |
Thakur R.,Adesh Institute of Medical science and Research |
Harris J.R.,Centers for Disease Control and Prevention
Diagnostic Microbiology and Infectious Disease | Year: 2012
Cryptococcus gattii causes infection in tropical and subtropical regions worldwide but has garnered increased attention since its 1999 emergence in North America. C. gattii can be divided into 4 molecular types that may represent cryptic species. Recent evidence has shown that azole antifungal MIC values differ among these molecular types. We tested a large collection of C. gattii isolates for susceptibility to 4 azole drugs. We found that isolates of molecular type VGII have the highest geometric mean (GM) fluconazole MIC values (8.6 μg/mL), while isolates of molecular type VGI have the lowest (1.7 μg/mL). For fluconazole, itraconazole, and voriconazole GM MIC values, VGI < VGIII < VGIV < VGII. The GM MIC values for posaconazole were similarly represented across molecular types, with the exception that VGII < VGIII and VGIV. We used the MIC values to establish preliminary epidemiologic cutoff values for each azole and molecular type of C. gattii. © 2012.
Kaur M.,Adesh Institute of Medical science and Research |
Dharampal S.S.,Adesh Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2014
Introduction: Allergic bronchopulmonary aspergillosis (ABPA) is a progressive disease which can lead to recurrent exacerbations, bronchiectatic changes and end-stage fibrosis. Early diagnosis and treatment prevents its progression and alleviate its clinical manifestations. High resolution CT of the chest has emerged as a promising investigation for its diagnosis. Aims and Objectives: To review the high resolution computed tomography chest manifestations in allergic bronchopulmonary aspergillosis patients. Materials and Methods: This study included 110 patients with ABPA who had undergone HRCT of the chest in the routine diagnostic workup for ABPA. The scans were assessed for changes in bronchi, parenchyma and pleura and findings consistent with ABPA were evaluated. Results: HRCT chest was normal in 24 patients. 86 patients demonstrated central bronchiectasis with predilection for upper and middle lobes. Centrilobular nodules with or without linear opacities (tree in bud pattern), mucoceles and high-attenuation mucus were seen in 86%, 59% and 36% patients respectively. Conclusion: Central bonchiectasis combined with centrilobular nodules and mucus impaction (especially high attenuation mucus) strongly favour the diagnosis of ABPA.
Kaur S.,Adesh Institute of Dental science and Research |
Singh G.,Adesh Institute of Medical science and Research |
Kaur K.,Institute of Dental Studies and Technologies
Journal of Cancer Research and Therapeutics | Year: 2014
The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. Rare CSCs have been isolated from a number of human tumors, including hematopoietic, brain, colon, and breast cancer. With the growing evidence that CSCs exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. Understanding the biology of CSCs will contribute to the identification of molecular targets important for future therapies.
Ahi R.S.,Adesh Institute of Medical science and Research |
Garg V.,Adesh Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2011
Aim: The present study was conducted to assess the level of potassium in the vitreous fluid, to calculate the post mortem interval from it and to study the effects of environmental factors like temperature and humidity on it. Material and Methods: 176 cases were included in the study. The vitreous fluid was taken from the left eye just before the commencement of autopsy and was assessed for potassium level. The potassium level was determined by flame photometry method. The post mortem interval (PMI) was then calculated by applying the Sturner equation. Result: Level of potassium in vitreous was found to be increased significantly with increase in PMI. It was found that the vitreous humour potassium concentration was increasing in a linear fashion with increasing time since death (TSD) and this increase in the level was independent of the factors like environmental temperature and humidity. Conclusion: Potassium level in the vitreous fluid increases significantly with increase in PMI and the environmental factors like temperature and humidity has no significant effect on the potassium levels in vitreous fluid.
Mahajan R.,Adesh Institute of Medical science and Research |
Gupta K.,Adesh Institute of Medical science and Research
Indian Journal of Pharmacology | Year: 2010
New drug development is a time-consuming and expensive process. Recently, there has been stagnation in the development of novel compounds. Moreover, the attrition rate in clinical research is also on the rise. Fearing more stagnation, the Food and Drug Administration released the critical path initiative in 2004 and critical path opportunity list in 2006 thus highlighting the need of advancing innovative trial designs. One of the innovations suggested was the adaptive designed clinical trials, a method promoting introduction of pre-specified modifications in the design or statistical procedures of an on-going trial depending on the data generated from the concerned trial thus making a trial more flexible. The adaptive design trials are proposed to boost clinical research by cutting on the cost and time factor. Although the concept of adaptive designed clinical trials is round-the-corner for the last 40 years, there is still lack of uniformity and understanding on this issue. This review highlights important adaptive designed methodologies besides covering the regulatory positions on this issue.
Gupta A.,Adesh Institute of Medical Science and Research
Journal of medicine and life | Year: 2012
Hydatid disease is a parasitic disease that is endemic in many parts of the world, especially in South America, the Middle East, Africa, Australia, and the Mediterranean region, including Turkey. This article presents an unusual case of subcutaneous hydatid cyst in the right medial side of the thigh. According to our world literature search, few cases are reported. This site of localization is very rarely diagnosed on ultrasonography.
Sidhu T.K.,Adesh Institute of Medical science and Research
Indian Journal of Community Health | Year: 2012
Background:What is the morbidity pattern of the adolescent patients coming to seek treatment in Psychiatry Deptt.? Objectives: To evaluate the pattern of mental disorders in adolescents. Methods:The study was a hospital based cross-sectional study conducted in the Deptt. of Psychiatry, Rajindra Hospital,Patiala. 500 adolescents aged 10-19 were interviewed. Results: More of the morbid patients were from nuclear familes, 6.4% were married among whom, 2.4% were either divorced or separated.13.2% patients had positive history of any family member having psychiatric problem. Only 21.2% had contacted a psychiatrist at first instance while 50.8% had been to traditional healers. The most common diagnosis was Mood (affective) disorders followed by neurotic, stress-related and somatoform disorders. Next was mental retardation followed by schizophrenia and delusional disorders. The most common diagnosis among males was neurotic, stress related and among females was mood disorders. The difference of distribution of diagnosis among urban and rural, nuclear and joint families was statistically significant. Conclusion: Patients reporting to the hospital with psychiatric disorders were urban males. Most of the patients were eldest in birth order and belonged to nuclear families. Most of the patients had been to traditional healers. The most common diagnosis was mood disorders followed by neurotic stress related illness.
Singla S.,Veer Chander Singh Garhwal Government Medical College andHospital |
Singla S.,Adesh Institute of Medical science and Research |
Kumar A.,Indira Gandhi Medical College |
Singla M.,Adesh Institute of Medical science and Research
Indian Journal of Surgery | Year: 2012
Diabetes mellitus may lead to amputation in 3 % of population. Risk for amputation is 15 folds in diabetics compared with nondiabetics. The aim of the study is to compare the outcome of dressing a diabetic foot ulcer with epidermal growth factor with that of conventional dressing with normal saline. The patients with diabetic foot were divided into study and control groups of 20 each. In the study group, epidermal growth factor (EGF) gel was used as dressing; in control group, dressing was done with normal saline. Treatment was given for 8 weeks or until ulcer healed, whichever occurred first. Evaluation of healing response was recorded on 1, 3, 5, and 8 weeks. After the first week of dressing 90 % of the study group and 30 % of the control group patients showed decrease in wound soakage, size, and increase in proliferation of healthy granulation tissue. After the eighth week of dressing in the study group, 80 % of the patients showed complete response to EGF application. Whereas in control group only 35 % of the patients showed complete response. Duration of hospital stay in the study group was lower as compared with the control group. EGF dressing causes early healing up to first 5 weeks as compared with conventional dressing. The results in healing were not significantly different in two study groups after 8-week duration. Hospital stay was lower in the study group as compared with the control group. © 2012 Association of Surgeons of India.
Gupta R.,Adesh Institute of Medical Science and Research
Journal of medicine and life | Year: 2012
Primary breast tuberculosis manifested as abscess is a rare entity. We are reporting a case of primary breast tuberculosis, which presented as breast abscess. Abscess was drained and tissue sent for histopathology. To our surprise, diagnosis came as breast tuberculosis. Aspiration cytology was not done, as it is not a routine test for abscess cases. Patient was put on anti- tubercular drugs. In the follow-up of 6 months, she was asymptomatic and advised to continue medicine.
Soni S.,Adesh Institute of Medical science and Research |
Wadhwa A.,Adesh Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2010
Introduction - The knowledge of the commonest pattern of the arterial supply of the abdomen and the deviants thereof is mandatory in various diagnostic, interventional and surgical procedures. Methods - Multiple variations in the origin of the lateral branches of the abdominal aorta were observed during the routine dissection of the abdominal cavity in an adult male cadaver in the Department of Anatomy, Govt. Medical College, Amritsar. Results - The variations encountered during the dissection were- 1) Double renal arteries were seen on the left side. 2) Double testicular arteries were seen on the left side, with the superior testicular artery arising from the inferior renal artery and the inferior testicular artery arising directly from the abdominal aorta. 3) Triple renal arteries were seen on the right side. 4) The right inferior phrenic artery was found to originate from the celiac trunk and the left inferior phrenic artery was found to arise directly from the abdominal aorta. Conclusions - Accessory renal arteries may constitute a danger in nephrotomy and in the partial resection of the kidney. The presence of triple renal arteries is infrequent, with a reported incidence of 1-2%. A gonadal artery originating from an inferior renal artery may be injured during the percutaneous treatment of the syndrome of pelvi-ureteral junction and so it may become a major contraindication. Also, this anatomical variation enhances the importance of arteriography or the Doppler ultrasound examination of the renal hilum.