Adesh Institute of Medical Science and Research

Bathinda, India

Adesh Institute of Medical Science and Research

Bathinda, India
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Gupta K.,Adesh Institute of Medical science and Research
International Journal of Pharmacology | Year: 2010

Metabolic Syndrome (MS) is a collection of risk factors including insulin resistance, central obesity, hypertension and dyslipidemia and itself is a risk factor for coronaiy arteiy disease. In recent times, its prevalence is on a rise in obese children too. Many working criteria for diagnosing MS are doing-the-round; given by World Health Organization, Adult Treatment Panel 3 and American Association of Clinical Endocrinologists. Risk factors involved in the pathogenesis of MS are many-fold; accordingly pharmacotherapy of MS is also multifacet. This review article is an account of pathogenesis, diagnosis and available treatment options in MS with a brief account of future prospect. © 2010 Asian Network for Scientific Information.


Mahajan R.,Adesh Institute of Medical science and Research | Gupta K.,Adesh Institute of Medical science and Research
Internet Journal of Pharmacology | Year: 2010

Hyperglycemia, obesity, insulin resistance, dyslipidemia and hypertension are interrelated cardiometabolic risk factors for the development of type-2 diabetes and metabolic syndrome. Prevalence of type-2 diabetes is growing at an alarming rate. Treatment target for type-2 diabetes is to keep daily glucose profile as close as possible to that of a non-diabetic person. Sulfonylureas, thiazolidinediones, meglitinides, biguanides and acarbose inhibitors are already being used in controlling glucose levels in type-2 diabetes. This review discusses the new drugs with novel mechanism of actions; which are in pipeline and were marketed recently or will be in market in near future. © Internet Scientific Publications, LLC., 1996 to 2010.


Mahajan R.,Adesh Institute of Medical science and Research | Gupta K.,Adesh Institute of Medical science and Research
Journal of Young Pharmacists | Year: 2010

Monitoring of adverse drug reactions of a drug is a continuous process and runs through-out the life of a drug. Many rare adverse effects of a drug are documented after years of use; when a single case (signal generation) is reported leading subsequently to reporting of more cases. Deficiency of Vitamin B12 (vit B 12 ) is a known sequel of prolonged metformin therapy. It was recommended to have annual measurement of serum vit B 12 levels in patients on long term metformin therapy way back in 1970 itself. After more than 50 years of use of metformin, we have come to know that metformin induced vit B12 deficiency can cause neuropathy; forcing to change the recommendation from annual screening of vit B 12 levels to annual supplementation of vit B12.


Kaur M.,Adesh Institute of Medical science and Research | Dharampal S.S.,Adesh Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2014

Introduction: Allergic bronchopulmonary aspergillosis (ABPA) is a progressive disease which can lead to recurrent exacerbations, bronchiectatic changes and end-stage fibrosis. Early diagnosis and treatment prevents its progression and alleviate its clinical manifestations. High resolution CT of the chest has emerged as a promising investigation for its diagnosis. Aims and Objectives: To review the high resolution computed tomography chest manifestations in allergic bronchopulmonary aspergillosis patients. Materials and Methods: This study included 110 patients with ABPA who had undergone HRCT of the chest in the routine diagnostic workup for ABPA. The scans were assessed for changes in bronchi, parenchyma and pleura and findings consistent with ABPA were evaluated. Results: HRCT chest was normal in 24 patients. 86 patients demonstrated central bronchiectasis with predilection for upper and middle lobes. Centrilobular nodules with or without linear opacities (tree in bud pattern), mucoceles and high-attenuation mucus were seen in 86%, 59% and 36% patients respectively. Conclusion: Central bonchiectasis combined with centrilobular nodules and mucus impaction (especially high attenuation mucus) strongly favour the diagnosis of ABPA.


Kaur S.,Adesh Institute of Dental science and Research | Singh G.,Adesh Institute of Medical science and Research | Kaur K.,Institute of Dental Studies and Technologies
Journal of Cancer Research and Therapeutics | Year: 2014

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. Rare CSCs have been isolated from a number of human tumors, including hematopoietic, brain, colon, and breast cancer. With the growing evidence that CSCs exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. Understanding the biology of CSCs will contribute to the identification of molecular targets important for future therapies.


Ahi R.S.,Adesh Institute of Medical science and Research | Garg V.,Adesh Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2011

Aim: The present study was conducted to assess the level of potassium in the vitreous fluid, to calculate the post mortem interval from it and to study the effects of environmental factors like temperature and humidity on it. Material and Methods: 176 cases were included in the study. The vitreous fluid was taken from the left eye just before the commencement of autopsy and was assessed for potassium level. The potassium level was determined by flame photometry method. The post mortem interval (PMI) was then calculated by applying the Sturner equation. Result: Level of potassium in vitreous was found to be increased significantly with increase in PMI. It was found that the vitreous humour potassium concentration was increasing in a linear fashion with increasing time since death (TSD) and this increase in the level was independent of the factors like environmental temperature and humidity. Conclusion: Potassium level in the vitreous fluid increases significantly with increase in PMI and the environmental factors like temperature and humidity has no significant effect on the potassium levels in vitreous fluid.


Mahajan R.,Adesh Institute of Medical science and Research | Gupta K.,Adesh Institute of Medical science and Research
Indian Journal of Pharmacology | Year: 2010

New drug development is a time-consuming and expensive process. Recently, there has been stagnation in the development of novel compounds. Moreover, the attrition rate in clinical research is also on the rise. Fearing more stagnation, the Food and Drug Administration released the critical path initiative in 2004 and critical path opportunity list in 2006 thus highlighting the need of advancing innovative trial designs. One of the innovations suggested was the adaptive designed clinical trials, a method promoting introduction of pre-specified modifications in the design or statistical procedures of an on-going trial depending on the data generated from the concerned trial thus making a trial more flexible. The adaptive design trials are proposed to boost clinical research by cutting on the cost and time factor. Although the concept of adaptive designed clinical trials is round-the-corner for the last 40 years, there is still lack of uniformity and understanding on this issue. This review highlights important adaptive designed methodologies besides covering the regulatory positions on this issue.


Gupta A.,Adesh Institute of Medical Science and Research
Journal of medicine and life | Year: 2012

Hydatid disease is a parasitic disease that is endemic in many parts of the world, especially in South America, the Middle East, Africa, Australia, and the Mediterranean region, including Turkey. This article presents an unusual case of subcutaneous hydatid cyst in the right medial side of the thigh. According to our world literature search, few cases are reported. This site of localization is very rarely diagnosed on ultrasonography.


Sidhu T.K.,Adesh Institute of Medical science and Research
Indian Journal of Community Health | Year: 2012

Background:What is the morbidity pattern of the adolescent patients coming to seek treatment in Psychiatry Deptt.? Objectives: To evaluate the pattern of mental disorders in adolescents. Methods:The study was a hospital based cross-sectional study conducted in the Deptt. of Psychiatry, Rajindra Hospital,Patiala. 500 adolescents aged 10-19 were interviewed. Results: More of the morbid patients were from nuclear familes, 6.4% were married among whom, 2.4% were either divorced or separated.13.2% patients had positive history of any family member having psychiatric problem. Only 21.2% had contacted a psychiatrist at first instance while 50.8% had been to traditional healers. The most common diagnosis was Mood (affective) disorders followed by neurotic, stress-related and somatoform disorders. Next was mental retardation followed by schizophrenia and delusional disorders. The most common diagnosis among males was neurotic, stress related and among females was mood disorders. The difference of distribution of diagnosis among urban and rural, nuclear and joint families was statistically significant. Conclusion: Patients reporting to the hospital with psychiatric disorders were urban males. Most of the patients were eldest in birth order and belonged to nuclear families. Most of the patients had been to traditional healers. The most common diagnosis was mood disorders followed by neurotic stress related illness.


Gupta R.,Adesh Institute of Medical Science and Research
Journal of medicine and life | Year: 2012

Primary breast tuberculosis manifested as abscess is a rare entity. We are reporting a case of primary breast tuberculosis, which presented as breast abscess. Abscess was drained and tissue sent for histopathology. To our surprise, diagnosis came as breast tuberculosis. Aspiration cytology was not done, as it is not a routine test for abscess cases. Patient was put on anti- tubercular drugs. In the follow-up of 6 months, she was asymptomatic and advised to continue medicine.

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