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Desai V.D.,Jaipur Dental College | Narang P.,Adesh Institute of Dental science and Research
Indian Journal of Public Health Research and Development | Year: 2015

Objective: The objective of this study was to evaluate the diagnostic reliability and efficacy of invivo staining with toluidine blue, in the detection of oral epithelial dysplasia in patients with oral leukoplakia. Materials and method: The study comprised of 50 clinically suspicious cases of oral leukoplakia. All lesions were submitted to staining with an aqueous solution of 1% toluidine blue followed by biopsy and histologic analysis. Results: The sensitivity and specificity for the detection of dysplastic lesions by this test were 69.77% and 85.71%, respectively. The positive and negative predictive values calculated were 96.77% and 31.58%. Conclusion: Toluidine Blue staining was found to be highly reliable in the detection of severe and moderate dysplasias but its use is questionable in the detection of mild dysplasias, owing to high false negative results. It is a simple, inexpensive and sensitive chair side test; a valuable adjunct to diagnostic process but not a substitute for either clinical judgment or biopsy. It has high feasibility, especially in low socioeconomic areas. © 2015, Indian Journal of Public Health Research and Development. All rights reserved. Source


Kaur S.,Adesh Institute of Dental science and Research | Singh G.,Adesh Institute of Medical Science and Research | Kaur K.,Institute of Dental Studies and Technologies
Journal of Cancer Research and Therapeutics | Year: 2014

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. Rare CSCs have been isolated from a number of human tumors, including hematopoietic, brain, colon, and breast cancer. With the growing evidence that CSCs exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. Understanding the biology of CSCs will contribute to the identification of molecular targets important for future therapies. Source


Arora S.,JCD Dental College | Gill G.S.,JCD Dental College | Saluja P.,JCD Dental College | Setia V.,Adesh Institute of Dental science and Research
Journal of Clinical and Diagnostic Research | Year: 2015

The present case describes the successful management of a rare case of communicating internal-external resorption in which both internal and external resorption seem to develop independent of each other. The case report highlights the importance of correct diagnosis and need of revision of classification system of resorptive defects. © 2015, Journal of Clinical and Diagnostic Research. All right reserved. Source


Setia V.,Adesh Institute of Dental science and Research | Pandit I.K.,DAV Dental College | Srivastava N.,Subharti Dental College | Gugnani N.,DAV Dental College | Sekhon H.K.,Adesh Institute of Dental science and Research
Journal of Clinical and Diagnostic Research | Year: 2013

Early orthodontic interventions are often initiated in the developing dentition to promote favourable developmental changes. Interceptive orthodontic can eliminate or reduce the severity of a developing malocclusion, the complexity of orthodontic treatment, overall treatment time and cost. The safest way to prevent future malocclusions from tooth loss is to place a space maintainer that is effective and durable. An appropriate use of space maintainer is advocated to hold the space until the eruption of permanent teeth. This case report describes the various changing trends in use of space maintainers: conventional band and loop, prefabricated band with custom made loop and glass fibre reinforced composite resins as space maintainers. Source


Shiromany A.,Kd Dental College | Sood R.,Maharaja Ganga Singh Dental College and Research Center | Akifuddin S.,Daswani Dental College and Hospital | Sidhu G.K.,Maharaja Ganga Singh Dental College and Research Center | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Objective: The role of mast cells as the key effector of allergic inflammation, anaphylactic inflammatory reactions and in the pathogenesis of chronic inflammation, is well-known. The present study is adopted to compare mast cells and inflammatory cells within periapical granuloma and cysts and localize the mast cells and quantify their number in the periapical cysts so as to propose a role of mast cells in the pathogenesis of this lesion.Materials and Methods: Biopsy specimens of 30 periapical lesions were stained with hematoxylin–eosin, and immunohistochemical Mast Cell Tryptase from Bio SB (IHC detection system kit) antibody. The tryptase positive mast cells and mononuclear inflammatory cells were counted in 10 consecutive high power fields (100X) using the binocular microscope from Motic attached to a computer with Motic Advanced Images 3.2 software.Results: Comparative microscopic analysis indicated that periapical cyst shows more percentage of mast cells and less percentage of inflammatory cell than periapical granuloma (comparison of mean and standard deviation of total number of mast cells and inflammatory cells, mast cells 3.15±1.39 in the granuloma group and 4.43±1.91in the cyst group, inflammatory cells, 67.11±1.2 in the granuloma group and 52.66±0.8 in the cyst group). Numerous degranulated mast cells were observed in the fibrous wall than the inflammatory infiltrate of the periapical cysts. The mean and standard deviation of degranulated mast cells between the inflammatory and fibrous zone within the cyst group, being 0.95±1.10 and1.68±1.34 respectively. The values varied significantly between the two zones.Conclusion: The number of inflammatory cells in the cyst group is less than periapical granuloma and total number of mast cells in the cyst group is more as compared to periapical granuloma. The degranulated cells were quantified and they were higher in the fibrous area of the cysts than the inflammatory zone. This study could support the fact that the various mediators released on degranulation play a role in the connective tissue remodeling, chronicity and expansion of the periapical lesion. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source

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