Adesh Institute of Dental science and Research
Adesh Institute of Dental science and Research
Kaur A.,Adesh Institute of Dental science and Research |
Natt A.S.,Dasmesh Institute of Research and Dental science |
Mehra S.K.,Rayat Bahra Dental College and Hospital |
Maheshwari K.,Adesh Institute of Dental science and Research |
And 2 more authors.
Journal of Contemporary Dental Practice | Year: 2016
Introduction: The position of the condyle in the glenoid fossa plays an important role in the stability of occlusion after orthodontic treatment. Cone beam computed tomography (CBCT) provides an optimal imaging of the osseous components of the temporomandibular joint (TMJ) and give a full size truly threedimensional (3D) description in real anatomical size. The present study aimed to visualize and compare the position of condyle in the glenoid fossa for different occlusions by using CBCT. Materials and methods: Cone beam computed tomographic images of 45 subjects, aged 18 to 42 years, were evaluated. Subjects were equally divided into three groups according to the A point, nasion, B point (ANB) angle. Results: In the sagittal plane, condyle is positioned nonconcentrically; positioned anteriosuperiorly in class I and III occlusions and lies posteriosuperiorly in class II occlusion. In the frontal plane, condyle is positioned centrally (mediolaterally) in all the three types of occlusions. In the axial plane, the parameters showed significant difference between the different occlusions. No statistical significant distinction could be made in the position of the condyle when comparing the right and left joints. Conclusion: The position of condyle in glenoid fossa influences sagittal, transverse, and vertical relationships of the jaws which eventually contribute to development of various malocclusions. Nonconcentricity is the feature of the condyle in the sagittal plane in different malocclusions. Clinical significance: An important consideration in orthodontic treatment is the recognition of the importance that the dentition should be in harmony with the related musculoskeletal structures. Therefore, the condylar position is an important concern in maintaining or restoring temporomandibular harmony with the dentition and the position of the condyle in the glenoid fossa plays an important role in the stability of occlusion after orthodontic treatment.
Arora S.,JCD Dental College |
Gill G.S.,JCD Dental College |
Saluja P.,JCD Dental College |
Setia V.,Adesh Institute of Dental science and Research
Journal of Clinical and Diagnostic Research | Year: 2015
The present case describes the successful management of a rare case of communicating internal-external resorption in which both internal and external resorption seem to develop independent of each other. The case report highlights the importance of correct diagnosis and need of revision of classification system of resorptive defects. © 2015, Journal of Clinical and Diagnostic Research. All right reserved.
PubMed | Genesis Research Institute, Adesh Institute of Dental science and Research and Laxmi Bai Dental College and Hospital
Type: | Journal: Autoimmunity reviews | Year: 2016
Autoimmune reactions reflect an imbalance between effector and regulatory immune responses, typically develop through stages of initiation and propagation, and often show phases of resolution (indicated by clinical remissions) and exacerbations (indicated by symptomatic flares). The fundamental underlying mechanism of autoimmunity is defective elimination and/or control of self-reactive lymphocytes. Periodontal diseases are characterized by inflammatory conditions that directly affect teeth-supporting structures, which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidence of involvement of immunopathology has been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T-cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses.
Kaur S.,Adesh Institute of Dental science and Research |
Singh G.,Adesh Institute of Medical science and Research |
Kaur K.,Institute of Dental Studies and Technologies
Journal of Cancer Research and Therapeutics | Year: 2014
The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. Rare CSCs have been isolated from a number of human tumors, including hematopoietic, brain, colon, and breast cancer. With the growing evidence that CSCs exist in a wide array of tumors, it is becoming increasingly important to understand the molecular mechanisms that regulate self-renewal and differentiation because corruption of genes involved in these pathways likely participates in tumor growth. Understanding the biology of CSCs will contribute to the identification of molecular targets important for future therapies.
PubMed | Rama Dental College, Dasmesh Institute of Research and Dental science, Melaka Manipal Medical College, Surendera Dental College and Research Institute and Adesh Institute of Dental science and Research
Type: Journal Article | Journal: Journal of Indian Society of Periodontology | Year: 2015
Gingival enlargement comprises any clinical condition in which an increase in the size of the gingiva is observed. It is a side effect associated with some distinct classes of drugs, such as anticonvulsants, immunosuppressant, and calcium channel blockers. Among calcium channel blockers, nifedipine causes gingival enlargement in about 10% of patients, whereas the incidence of amlodipine, a third-generation calcium channel blocker, induced gingival enlargement is very limited. Because the calcium antagonists, albeit to a variable degree, act as inhibitors of P-glycoprotein (P-gp), the gene product of multidrug resistance 1 (MDR1), and inflammation may modify P-gp expression. We hereby, report a case of amlodipine-induced gingival enlargement with MDR1 3435C/T polymorphism, associated with inflammatory changes due to plaque accumulation, in a 50-year-old hypertensive male patient. The genotype obtained for the polymorphism was a heteromutant genotype, thus supporting the contention that the MDR1 polymorphism may alter the inflammatory response to the drug.
Desai V.D.,Jaipur Dental College |
Narang P.,Adesh Institute of Dental science and Research
Indian Journal of Public Health Research and Development | Year: 2015
Objective: The objective of this study was to evaluate the diagnostic reliability and efficacy of invivo staining with toluidine blue, in the detection of oral epithelial dysplasia in patients with oral leukoplakia. Materials and method: The study comprised of 50 clinically suspicious cases of oral leukoplakia. All lesions were submitted to staining with an aqueous solution of 1% toluidine blue followed by biopsy and histologic analysis. Results: The sensitivity and specificity for the detection of dysplastic lesions by this test were 69.77% and 85.71%, respectively. The positive and negative predictive values calculated were 96.77% and 31.58%. Conclusion: Toluidine Blue staining was found to be highly reliable in the detection of severe and moderate dysplasias but its use is questionable in the detection of mild dysplasias, owing to high false negative results. It is a simple, inexpensive and sensitive chair side test; a valuable adjunct to diagnostic process but not a substitute for either clinical judgment or biopsy. It has high feasibility, especially in low socioeconomic areas. © 2015, Indian Journal of Public Health Research and Development. All rights reserved.
Gupta H.K.,Adesh Institute of Dental science and Research |
Garg A.,Adesh Institute of Dental science and Research |
Bedi N.K.,Adesh Institute of Dental science and Research
Journal of Clinical and Diagnostic Research | Year: 2011
Peri-implantitis is a site specific infectious disease that causes an inflammatory process in soft tissues, and bone loss around an osseointegrated implant in function. Implant failure has classically been attributed to bacterial infections, occlusal overload, surgical trauma, faulty or incorrect prosthetic design and/or improper surgical placement. The management of implant infection should be focused both on the infection control of the lesion, the detoxification of the implant surface and regeneration procedures. The treatment option can be surgical or non- surgical. It was observed that the non surgical treatment of peri-implantitis was unpredictable, while the use of chemical agents such as chlorhexidine had only limited clinical effects. Adjunctive local or systemic antibiotics were shown to reduce bleeding on probing and probing depths and some beneficial effects of laser therapy on peri-implantitis have been shown. Regenerative therapies can also be applied in conjunction with the anti-infective procedures. The purpose of this paper is to review the literature with regards to peri-implantitis as a risk factor in implant failure and also to identify the protocols which may assist in its diagnosis and management.
PubMed | Subharti Dental College Meerut, D Av Dental College Yamuna Nagar and Adesh Institute of Dental science and Research
Type: Journal Article | Journal: International journal of clinical pediatric dentistry | Year: 2014
Of this in vivo study was to evaluate various space maintainers in terms of survival rate, gingival health and presence of caries.A total of 60 extraction sites in the age group of 4 to 9 years were divided into four groups and different space maintainers were placed in them viz (conventional band and loop, prefabricated band with custom made loop, Ribbond, Super splint).Prefabricated bands with custom made loop showed maximum success rates (84.6%), while super splint (33.33%) was found to be least successful. In terms of gingival health, prefabricated band with custom made loop reported minimum cases with poor gingival health (27.2%), while maximum cases with poor gingival health (50%) were reported with Super splint. None of the space maintainers developed caries at the end of 9 months. How to cite this article: Setia v, Pandit IK, Srivastava N, Gugnani N, Gupta M. Banded vs Bonded Space Maintainers: Finding Better Way Out. Int J Clin Pediatr Dent 2014;7(2):97-104.
PubMed | Adesh Institute of Dental science and Research
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2013
Early orthodontic interventions are often initiated in the developing dentition to promote favourable developmental changes. Interceptive orthodontic can eliminate or reduce the severity of a developing malocclusion, the complexity of orthodontic treatment, overall treatment time and cost. The safest way to prevent future malocclusions from tooth loss is to place a space maintainer that is effective and durable. An appropriate use of space maintainer is advocated to hold the space until the eruption of permanent teeth. This case report describes the various changing trends in use of space maintainers: conventional band and loop, prefabricated band with custom made loop and glass fibre reinforced composite resins as space maintainers.
PubMed | Carier Postgraduate Institute of Dental science and Hospital, Adesh Institute of Dental science and Research, Daswani Dental College & Hospital, KD Dental College Mathura and Maharaja Ganga Singh Dental College and Research Center
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2015
The role of mast cells as the key effector of allergic inflammation, anaphylactic inflammatory reactions and in the pathogenesis of chronic inflammation, is well-known. The present study is adopted to compare mast cells and inflammatory cells within periapical granuloma and cysts and localize the mast cells and quantify their number in the periapical cysts so as to propose a role of mast cells in the pathogenesis of this lesion.Biopsy specimens of 30 periapical lesions were stained with hematoxylin-eosin, and immunohistochemical Mast Cell Tryptase from Bio SB (IHC detection system kit) antibody. The tryptase positive mast cells and mononuclear inflammatory cells were counted in 10 consecutive high power fields (100X) using the binocular microscope from Motic attached to a computer with Motic Advanced Images 3.2 software.Comparative microscopic analysis indicated that periapical cyst shows more percentage of mast cells and less percentage of inflammatory cell than periapical granuloma (comparison of mean and standard deviation of total number of mast cells and inflammatory cells, mast cells 3.151.39 in the granuloma group and 4.431.91in the cyst group, inflammatory cells, 67.111.2 in the granuloma group and 52.660.8 in the cyst group). Numerous degranulated mast cells were observed in the fibrous wall than the inflammatory infiltrate of the periapical cysts. The mean and standard deviation of degranulated mast cells between the inflammatory and fibrous zone within the cyst group, being 0.951.10 and1.681.34 respectively. The values varied significantly between the two zones.The number of inflammatory cells in the cyst group is less than periapical granuloma and total number of mast cells in the cyst group is more as compared to periapical granuloma. The degranulated cells were quantified and they were higher in the fibrous area of the cysts than the inflammatory zone. This study could support the fact that the various mediators released on degranulation play a role in the connective tissue remodeling, chronicity and expansion of the periapical lesion.