Aderans Research Institute Inc.

Marietta, GA, United States

Aderans Research Institute Inc.

Marietta, GA, United States

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Ohyama M.,Keio University | Zheng Y.,Aderans Research Institute Inc. | Paus R.,University of Lübeck | Paus R.,University of Manchester | Stenn K.S.,Aderans Research Institute Inc.
Experimental Dermatology | Year: 2010

Hair follicle morphogenesis and regeneration occur by an extensive and collaborative crosstalk between epithelial and mesenchymal skin components. A series of pioneering studies, which revealed an indispensable role of follicular dermal papilla and dermal sheath cells in this crosstalk, has led workers in the field to study in detail the anatomical distribution, functional properties, and molecular signature of the trichogenic dermal cells. The purpose of this paper was to provide a practical summary of the development and recent advances in the study of trichogenic dermal cells. Following a short review of the relevant literature, the methods for isolating and culturing these cells are summarized. Next, the bioassays, both in vivo and in vitro, that enable the evaluation of trichogenic properties of tested dermal cells are described in detail. A list of trichogenic molecular markers identified by those assays is also provided. Finally, this methods review is completed by defining some of the major questions needing resolution. © 2009 John Wiley & Sons A/S.


Zheng Y.,Aderans Research Institute Inc. | Nace A.,Aderans Research Institute Inc. | Chen W.,Aderans Research Institute Inc. | Watkins K.,Aderans Research Institute Inc. | And 5 more authors.
Developmental Dynamics | Year: 2010

The hair follicle is considered to be a model system for studying organogenesis. In our initial study using mouse cells (Zheng et al., 2005) we found that new hair follicle formation always starts from an epithelial platform: the epidermal cells aggregate, the aggregates encyst, and from the periphery of the cysts, centrifugally, hair buds, pegs, and follicles form. In this report, we extend our initial study to four distantly related mammals: opossum, rat, dog and human. We find that in these four species, plus mouse, the most trichogenic cells are found in the earliest stages of hair follicle development and that the cellular mechanismof new hair follicle formation starting from dissociated cells is largely the same. These studies suggest that there is essentially one way by which dissociated mammalian skin cells form a new hair follicle in vivo and that this mechanism has been highly conserved. © 2010Wiley-Liss, Inc.


Marshall B.T.,Aderans Research Institute Inc. | Ingraham C.A.,Aderans Research Institute Inc. | Wu X.,Aderans Research Institute Inc. | Washenik K.,Aderans Research Institute Inc. | Washenik K.,New York University
Facial Plastic Surgery Clinics of North America | Year: 2013

This article reviews the history of hair follicle regeneration from follicular fragments and dissociated cells. The challenges of trichogenic in vitro culture and subsequent delivery into the patient are discussed, as well as cosmetic acceptance, recent achievements on regeneration of human hair follicles, and new potential cell sources for hair regeneration. © 2013.


Patent
Aderans Research Institute Inc. | Date: 2010-07-28

A housing body for a fluid delivery device comprises:an exterior and an interior and a syringe cartridge aperture;a pinion housing attached to the interior of the housing body, the pinion housing having a pinion receiving aperture;a pinion which is received by the pinion receiving aperture, and attached to the pinion housing such that it can rotate within the pinion receiving aperture, the pinion comprising a front section having gear ridges, a syringe cartridge receiving aperture, and a rear section;and a trigger portion having a tab section which is adapted to engage with the gear ridges of the pinion when depressed.


Patent
Aderans Research Institute Inc. | Date: 2012-11-07

The application concerns a micrometer assisted fluid delivery device (5) comprising: a holder portion (132) comprising a main body (136) having a front face (138), a back face (140), a top (142), a bottom (144), two side walls (146), an interior channel (172), a syringe body channel (158), a syringe plunger channel (164) and a micrometer receiving aperture (176) which passes through the front face (138) of the main body (136) to the interior channel (172) of the main body (136); and_a micrometer (10) having a main body (12), an adjustment thimble (16) and a spindle (18), wherein the main body (12) of the micrometer (10) is received by the micrometer receiving aperture (176) of the holder portion (132), wherein the main body (136) of the holder portion (132) preferably further comprises a micrometer securing threaded aperture (180) which receives a screw which can be tightened to secure the main body (12) of the micrometer (10) to the main body (136) of the holder portion (132),wherein the front face (138) of the main body (136) of the holder portion (132) preferably has a threaded channel that receives a screw which can be tightened to secure a finger tab (26) of a syringe (20) to the main body (136) of the holder portion (132).


Patent
Aderans Research Institute Inc. | Date: 2013-10-21

Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.


Trademark
Aderans Research Institute Inc. | Date: 2013-09-17

Medical devices, namely, injection devices for the delivery of solutions, suspensions, fluids, and substances to a patient, for use in dermatologic procedures relating to hair growth or hair restoration.


Trademark
Aderans Research Institute Inc. | Date: 2012-04-24

Medical devices, namely, injection devices for the delivery of cells, solutions, suspensions, fluids, and substances to a patient.


Trademark
Aderans Research Institute Inc. | Date: 2010-12-28

Cells for medical or clinical use, namely, hair follicle cells to be used for hair transplants; Biological hair tissue intended for a subsequent hair transplant.


Patent
Aderans Research Institute Inc. | Date: 2013-10-21

Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound. Examples demonstrate formation of hair follicles in situ.

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