Adekunle Ajasin University
Ondo, Nigeria

The Ondo State University, now Adekunle Ajasin University was established as a state-owned university in December 1999 by the governor of Ondo State in Western Nigeria, Chief Adebayo Adefarati.It is named after Michael Adekunle Ajasin, the former Ondo State governor and educator who signed the law establishing the Ondo State University in 1982.It is located in Akungba Akoko, a small town near Ikare-Akoko. Wikipedia.

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Akogun O.B.,Heritage Foundation | Badaki J.A.,Adekunle Ajasin University
Acta Tropica | Year: 2011

Procedures for health facility-based management of lymphoedema and adenolymphangitis (ADL) have proved very effective in some countries. Unfortunately, in resource-poor communities of Africa where health facilities are few, overburdened and inaccessible, an alternative approach is required. Community-based care (CC), patient care (PC) and health facility care (HC) approaches were compared. In the CC arm, communities were required to select one of their members for care-giving to its affected members, while in the PC, participants were allocated to groups under a leader with responsibility for care giving to group members. In HC, care was given by the nearest health facility. Caregivers from the three arms were trained and supplies were kept at the local government health office. At the sixth month of intervention, 325 lymphoedema and adenolymphangitis patients had been recruited into the study as participants. Within 12 months, compliance with hygiene practices increased from 29.4% to 62.6% and ADL episodes declined from 43.1% to 4.4% in the community designs arm and the cost on the health system was minimal. However, in the patient and health care arms, compliance and accessibility to supplies was severely affected by poor coordination, delay in resource collection leading to very minimal effect on lesions, odour, ADL frequency and duration. Participants abandoned the health facilities after the second visit. Community care approach was more culturally acceptable and effective for the management lymphoedema and ADL than other approaches. © 2010 Elsevier B.V.

Ofomaja A.E.,University of Benin | Unuabonah E.I.,Redeemer's University | Oladoja N.A.,Adekunle Ajasin University
Bioresource Technology | Year: 2010

Mansonia wood sawdust is applied as a biosorbent for the removal of copper and lead ions from single and binary aqueous solution. The effect of solution pH, electrolyte, metal ion competition and temperature were examined to obtain insight of its application for industrial waste water treatment. The Langmuir isotherm provided a better fit to experimental data for lead ion sorption with a higher monolayer capacity, while copper ion sorption was best described by the Freundlich and BET isotherms. The combined effect of adsorbing one metal ion in the presence of the other metal ion reduced the adsorption capacity of either metal ion. In a binary solution, removal of lead ions in the presence of copper ions followed the Langmuir isotherm model while the removal of copper ions in presence of lead ions followed both the Langmuir and BET isotherm models. © 2009 Elsevier Ltd. All rights reserved.

Ashogbon A.O.,Adekunle Ajasin University | Akintayo E.T.,Ekiti State University, Ado Ekiti
Starch/Staerke | Year: 2014

Starch is, after cellulose, the most abundant organic compound in nature. Modification of starch is carried out to enhance the positive attributes and to eliminate the shortcomings of the native starches. Various methods have been developed to produce a range of modified starches with a variety of characteristics and applications. Physically modified starches are simple and inexpensive because they can be produced without chemicals or even biological agents. In contrast, chemical modification is possible due to ubiquitous hydroxyl groups in starches that have been exploited for over a century, principally in the preparation of starch esters and ethers, but also in more subtle alterations, e.g., in order to tune the structure of starches for specific applications. All these techniques tend to alter the highly flexible starch polymer with changed physicochemical properties and modified structural attributes of high technological value for the food and non-food industries. Modification of starch is an ever evolving industry with numerous possibilities to generate novel starches which includes new functional and value added properties as demanded by the industry. This review aims to summarize the latest developments and recent knowledge regarding physically and chemically modified starches. This paper covers physical modification methods (pre-gelatinization, hydrothermal, and non-thermal processes), some chemical modifications and a combination of both. Received: April 30, 2013 Revised: July 10, 2013 Accepted: July 17, 2013. © 2013 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.

Oladoja N.A.,Adekunle Ajasin University | Ahmad A.L.,Universiti Sains Malaysia
Separation and Purification Technology | Year: 2013

The synergies of binary metal oxides, habitual in natural system, in sequestrating metal ions were the premise on the synthesis of binary alkali earth and transition metal oxides (ATM) for possible environmental remediation. Gastropod shell (GS) was used as a precursor for alkali earth metal generation in the perspective of wastes recycling and cost minimization in material synthesis. ATM of different combination ratios of Ca: Fe, were synthesized and characterized (XRD, SEM, EDAX, TGA and PZC) and the potential for Cr(VI) attenuation in aqua system was appraised. The Langmuir sorption capacities (mg/g) of the ATM (112.36-117.65) were higher than that of the respective metal ion constituents (101.01-105.26). Kinetic modeling showed that the pseudo second order gave the best description of the process. pH had nominal effect on the extent of Cr(VI) sorption while the magnitude of Cr(VI) sorbed reduced with increase in molar concentrations of anions and ionic strength. The spent ATM stability, determined via the toxicity characteristic leaching procedure (TCLP), was higher in acidic medium than the alkaline medium. SEM and EDAX elucidation, confirmed the presence of Cr(VI) on the sorbent while the formation of complexes of Cr ions with metal-O functional groups was confirmed via FTIR analysis. © 2013 Elsevier B.V. All rights reserved.

Ige O.E.,Adekunle Ajasin University
Research Journal of Botany | Year: 2011

Results of a palynological analysis of sediments from Bassan-1 well, Niger delta, Nigeria are presented. These form the basis for reconstructing of the vegetation and climate history for the tertiary period covered by the studied sediments. In all the strata, pollen and spores are well represented and diversified. Five pollen zones (PZ 1-V) were recognized in the sequences penetrated by the well. Only one period of markedly dry, seasonal climate is indicated. This period corresponds to pollen zone I. It is suggested that during this period, savanna vegetation extended over most of the delta and the climate was dry and cool. This dry period was followed by wet phases corresponding to pollen zones II, III, IV and V. During these wet periods, mangrove swamp forest flourished and occupied most of the delta region with patches of freshwater swamp and lowland rain forest. © 2011 Academic Journals Inc.

Elekofehinti O.O.,Adekunle Ajasin University
Pathophysiology | Year: 2015

Diabetes mellitus (DM) represents a global health problem. It is the most common of the endocrine disorders and is characterized by chronic hyperglycemia due to relative or absolute lack of insulin secretion or insulin actions. According to the World Health Organization projections, the diabetes population is likely to increase to 300 million or more by the year 2025. Current synthetic agents and insulin used effectively for the treatment of diabetes are scarce especially in rural areas, expensive and have prominent adverse effects. Complementary and alternative approaches to diabetes management such as isolation of phytochemicals with anti-hyperglycemic activities from medicinal plants is therefore imperative. Saponins are phytochemical with structural diversity and biological activities. This paper reviews saponins and various plants from which they were isolated as well as properties that make them ideal for antidiabetic remedy. © 2015 Elsevier B.V.

Shodehinde S.A.,Adekunle Ajasin University | Oboh G.,Federal University of Technology Akurre
Asian Pacific Journal of Tropical Biomedicine | Year: 2013

Objective: To evaluate and compare antioxidant activities of the aqueous extracts of unripe plantain (Musa paradisiaca), assess their inhibitory action on sodium nitroprusside induced lipid peroxidation in rat pancreas in vitro and to characterize the main phenolic constituents of the plantain products using gas chromatography analysis. Methods: Aqueous extracts of plantain products (raw, elastic pastry, roasted and boiled) flour of 0.1 g/mL (each) were used to determine their total phenol, total flavonoid, 1,1 diphenyl-2 picrylhydrazyl (DPPH) and hydroxyl (OH) radical scavenging ability. The inhibitory effect of the extracts on sodium nitroprusside induced lipid peroxidation was also determined. Results: The results revealed that all the aqueous extracts showed antioxidant activity. The boiled flour had highest DPPH and OH radical scavenging ability while raw flour had the highest Fe2+ chelating ability, sodium nitroprusside inhibitory effect and vitamin C content. The antioxidant results showed that elastic pastry had the highest total phenol and total flavonoid content. Characterization of the unripe plantain products for polyphenol contents using gas chromatography showed varied quantity of apigenin, myricetin, luteolin, capsaicin, isorhaemnetin, caffeic acid, kampferol, quercetin, p-hydroxybenzoic acid, shogaol, glycitein and gingerol per product on the spectra. Conclusions: Considering the antioxidant activities and ability to inhibit lipid peroxidation of unripe plantain, this could justify their traditional use in the management/prevention of diseases related to stress. © 2013 Asian Pacific Tropical Biomedical Magazine.

Akanbi O.M.,Adekunle Ajasin University
African journal of reproductive health | Year: 2010

This work studied the effect of malaria infection and antimalarial drugs on oxidative stress in 259 pregnant and nonpregnant women at Ade-Oyo hospital, Ibadan, Nigeria. Oxidative stress was determined by measuring serum lipid peroxidation, ascorbic acid, and reduced glutathione (GSH) levels using spectrophotometer. The results showed that mean lipid peroxidation was significantly higher (p < 0.05) in malaria positive than malaria negative women, while GSH and ascorbic acid levels were significantly (p < 0.05) reduced. The parasite density was significantly reduced in patients who had taken antimalarial drugs relative to those without. While mean ascorbic acid and GSH levels were significantly reduced in those who had taken drugs as compared with those without drugs, the lipid peroxidation level was significantly higher in them. The increase in lipid peroxidation and decrease in GSH and ascorbic acid levels in women who were malaria positive and in those who had taken drugs is indicative of oxidative stress.

The study tested whether attitude towards littering mediates the relationship between personality attributes (altruism and locus of control) and responsible environmental behavior (REB) among some residents of Ibadan metropolis, Nigeria. Using multistage sampling technique, measures of each construct were administered to 1360 participants. Results reveal significant independent and joint influence of personality attributes on attitude towards littering and responsible environmental behavior, respectively. Attitude towards littering also mediates the relationship between personality characteristics and REB. These findings imply that individuals who possess certain desirable personality characteristics and who have unfavorable attitude towards littering have more tendencies to engage in pro-environmental behavior. Therefore, stakeholders who have waste management as their priority should incorporate this information when guidelines for public education and litter prevention programs are being developed. It is suggested that psychologists should be involved in designing of litter prevention strategies. This will ensure the inclusion of behavioral issues in such strategies. An integrated approach to litter prevention that combines empowerment, cognitive, social, and technical solutions is recommended as the most effective tool of tackling the litter problem among residents of Ibadan metropolis. © 2011 Elsevier Ltd.

Omotuyi I.O.,Nagasaki University | Omotuyi I.O.,Adekunle Ajasin University
Journal of Biomolecular Structure and Dynamics | Year: 2015

Ebola virus (EboV) is currently ravaging West Africa with estimated case fatality rate of 52%. Currently, no drug treatment is available and immunoglobulin therapy is still at the rudimentary stage. For anti-EboV drug development, druggable viral and host protein targets, including human Furin are under intense investigation. Here, molecular dynamics simulation was performed on Apo-Furin, meta-guanidinomethyl-Phac-RVR-Amba-bound, and two EboV glycoprotein (GP) 494-TGGRRTRREA-503/Furin complexes (Accurate and one amino acid shift alignment). The results of the simulation established ligand-induced desolvation of Furin active site and structural compactness. Accurately aligned EboV-GP peptide exhibited a tighter binding mode with Furin and showed 1.5- and 3.0-fold MMPBSA binding free energy estimate compared with the displaced peptide and inhibitor, respectively. The difference in free energy was traced to the difference in contribution of threonine residues of the peptides. Furthermore, Furin subsites I conferred substrate specificity and ligand binding accuracy. Accurately aligned peptide trapped active site His194 side chain into gauche (-) (+60o) χ1-dihedral compared with gauche+ (-60o) in other biosystems while Asp153 is trapped in gauche+ (-60o) in ligand bound not Apo state. Ramachandran plot showed that the scissile Arg8 of the accurately aligned peptide showed β conformation distribution as apposed to 310R, βL, and 310L. Finally, the active site proximal Na+ binding is dependent on substrate peptide occupancy of the active site but detaches in the absence of a ligand. In conclusion, Furin might represent candidate drug target for Ebola virus disease treatment via therapeutic target of the active site and Na+ binding pocket. © 2014 Taylor & Francis.

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