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Poznan, Poland

Adam Mickiewicz University in Poznań is one of the major Polish universities, located in the city of Poznań in western Poland. It opened on May 7, 1919, and since 1955 has carried the name of the Polish poet Adam Mickiewicz. Wikipedia.


New vinyl-alkynylsubstituted germanium compounds having the general formula 1 are the subject of the invention. The invention also relates to a new method of obtaining vinyl-alkynylsubstituted germanium compounds having the general formula 1. A denotes: diethylgermyl R denotes: triethylsilyl, 1-(trimethylsiloxy)-1-cyclohexyl The invention also provides a solution to the problem of the method of obtaining vinyl-alkynylsubstituted germanium compounds having the general formula 1, involving the germylative coupling reaction between a suitable substituted terminal alkyne and a suitable divinylsubstituted germanium compound in the presence of a ruthenium(II) complex as catalyst.


New (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1 and A new method of obtaining (E)-styryl-alkynylsubstituted silicon compounds having the generalized formula 1. A denotes: phenylmethylsilyl, 1,4-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane, 1,1,3,3-tetramethyldisilazane, 1,1,3,3-tetramethyldisiloxane, R denotes: tri(isopropyl)silyl, 1-pentyl, 2-(trimethylsiloxy)-2-butyl, 1-(trimethylsiloxy)-1-cyclohexyl, triethylgermyl, R denotes: H or Cl and when A denotes phenylmethylsilyl then R denotes also methyl or a methoxy group. A method of obtaining (E)-styrylalkynylsubstituted silicon compounds having the generalized formula 1 where A, R and R denote the same as stated above by way of a silylative coupling reaction between a suitable substituted styrene and a suitable vinyl-alkynylsubstituted silicon compound in the presence of a ruthenium(II) complex as catalyst.


New (triorganosilyl)alkynes and their derivatives having general formula R


The subject matter of the invention is novel 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1 -difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.


Patent
Adam Mickiewicz University | Date: 2010-08-16

The subject of the invention is the method of synthesis of fluoracarbofunctional cage silsesquioxanes of the general formula in which R or HCF

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