Adam Mickiewicz University
Poznan, Poland

Adam Mickiewicz University in Poznań is one of the major Polish universities, located in the city of Poznań in western Poland. It opened on May 7, 1919, and since 1955 has carried the name of the Polish poet Adam Mickiewicz. Wikipedia.

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The subject matter of the invention is novel 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula (1) where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula (1). In a third aspect, the subject matter of the invention is an application of 2,3-anhydro-2-deoxy-5-fluorouridine derivatives of general formula (1) in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.

Agency: European Commission | Branch: H2020 | Program: CSA | Phase: SC5-10a-2014 | Award Amount: 3.13M | Year: 2015

Mapping and assessment of ecosystems and their services (ES) are core to the EU Biodiversity (BD) Strategy. They are essential if we are to make informed decisions. Action 5 sets the requirement for an EU-wide knowledge base designed to be: a primary data source for developing Europes green infrastructure; resource to identify areas for ecosystem restoration; and, a baseline against which the goal of no net loss of BD and ES can be evaluated. In response to these requirements, ESMERALDA aims to deliver a flexible methodology to provide the building blocks for pan-European and regional assessments. The work will ensure the timely delivery to EU member states in relation to Action 5 of the BD Strategy, supporting the needs of assessments in relation to the requirements for planning, agriculture, climate, water and nature policy. This methodology will build on existing ES projects and databases (e.g. MAES, OpenNESS, OPERAs, national studies), the Millennium Assessment (MA) and TEEB. ESMERALDA will identify relevant stakeholders and take stock of their requirements at EU, national and regional levels. The objective of ESMERALDA is to share experience through an active process of dialogue and knowledge co-creation that will enable participants to achieve the Action 5 aims. The mapping approach proposed will integrate biophysical, social and economic assessment techniques. Flexibility will be achieved by the creation of a tiered methodology that will encompass both simple (Tier 1) and more complex (Tier 3) approaches. The work will exploit expert- and land cover-based methods, existing ES indicator data and more complex ES models. As a result the outcomes will be applicable in different contexts. The strength of the ESMERALDA consortium lies in its ability to make solutions for mapping and assessment problems available to stakeholders from the start of the project, because our expertise allows us to build on existing research projects and data sharing systems.

Agency: European Commission | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2016 | Award Amount: 2.53M | Year: 2016

Structurally weak rural regions are faced with major social and economic problems. In comparison to urban or intermediate regions, predominantly rural regions are economically less productive and they provide a less extensive scope of desired goods and services. As a consequence, the regions experience a loss of inhabitants, especially of young and highly skilled people. Thus, downward spirals are set in motion that further reduce economic opportunities and prevent rural regions from overcoming their structural deficits. The proposed RURACTION research and training network focuses on socially innovative solutions to these rural problems developed by social entrepreneurs. Social entrepreneurs are understood as practitioners who create and implement social innovations by entrepreneurial means. The question arises under which conditions they operate, how they organise solutions, how they network and empower residents, which impacts they actually have on rural development, and how they can be supported in their problem-solving activities. The European Commission identifies the subject of social innovation in rural regions as a research gap. RURACTION intends to fill this gap. The research and training network brings together highly acknowledged academics and very experienced practitioners from social enterprises to contribute their expertise in this field (e.g. with spring schools, autumn skills seminars and cross-sectoral secondments). It strives to achieve excellent research results and aims at qualifying early stage researcher as equally scientifically and practically skilled experts for social entrepreneurship and social innovations in rural regions be it in order to conduct further research in this complex scientific field, to professionally support and promote initiatives of existing social entrepreneurial organisations, and/or to professionally start their own initiatives and social enterprises.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: LCE-16-2014 | Award Amount: 3.00M | Year: 2015

The accelerated development of shale gas is accompanied by growing public concern regarding the safety of shale gas extraction and its impact on human health and the environment. For the US, shale gas exploitation proved very successful in changing the energy landscape in terms of security of domestic supply and increased contribution of gas in the energy mix. For Europe, shale gas exploitation could increase our resources and production of natural gas; a critical fuel for the transition to a low carbon energy system. However, there are a number of important gaps in our present understanding of shale gas exploration and exploitation, and a strong need for independent, science-based knowledge of its potential impacts in a European context. The M4ShaleGas program focuses on reviewing and improving existing best practices and innovative technologies for measuring, monitoring, mitigating and managing the environmental impact of shale gas exploration and exploitation in Europe. The technical and social research activities will yield integrated scientific recommendations for 1) how to minimize environmental risks to the subsurface, surface and atmosphere, 2) propose risk reduction and mitigation measures and 3) how to address the public attitude towards shale gas development. The 18 research institutes from 10 European Union Member States that collaborate in the M4ShaleGas consortium cover different geopolitical regions in Europe, including Member States that are at the forefront regarding shale gas exploration and exploitation in Europe as well as Member States where shale gas exploitation is not yet being actively pursued. The project governance ensures proper integration of all research activities. Knowledge and experience on best practices is imbedded by direct collaboration with US and Canadian research partners and input from representatives from the industry. During the project, results will be public and actively disseminated to all stakeholders.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: FETPROACT-2-2014 | Award Amount: 3.64M | Year: 2015

This projects objective is to develop and to investigate closely linked symbiotic relationships between robots and natural plants and to explore the potentials of a plant-robot society able to produce architectural artifacts and living spaces. We will create a society of robot-plant bio-hybrids functioning as an embodied, self-organizing, and distributed cognitive system. The system grows and develops over long periods of time in interactions with humans resulting in the creation of meaningful architectural structures. The robotic assemblies (artificial plants) support and control the biological plants through appropriate scaffolding, watering, and stimuli that exploit the plants different tropisms. The natural plant, in turn, supports and controls the robotic plant by guiding it through growth and support the weight of the robot in later growth phases. The artificial plants are built from small heterogeneous sensing and actuation modules connected using lightweight construction elements. Each robotic plant connects wirelessly to the Internet. In contrast to top-down control, we explore a developmental plasticity of bio-hybrid systems, where robots and plans grow together from sprout to adult stage and form a closely co-dependent and self-organized system. The robot-plant organisms live in a human-inhabited environment and through interaction with humans grow into architectural structures (e.g., walls, roofs, benches) providing functionality such as shade, air quality control, and stress relief. Humans, plants, and robots form an internet-connected social garden where desired structures and behavior patterns emerge based on both local interactions and global interaction with parts of the garden growing at other locations. Hence, the social garden is a cultural system that shows long-term learning and adaptation where all past actions and interactions between the natural and artificial plants are represented in the embodiment of the garden.

Agency: European Commission | Branch: H2020 | Program: IA | Phase: WATER-1b-2015 | Award Amount: 10.74M | Year: 2016

The AquaNES project will catalyse innovations in water and wastewater treatment processes and management through improved combinations of natural and engineered components. Among the demonstrated solutions are natural treatment processes such as bank filtration (BF), managed aquifer recharge (MAR) and constructed wetlands (CW) plus engineered pre- and post-treatment options. The project focuses on 13 demonstration sites in Europe, India and Israel covering a repre-sentative range of regional, climatic, and hydrogeological conditions in which different combined natural-engineered treatment systems (cNES) will be demonstrated through active collaboration of knowledge and technology providers, water utilities and end-users. Our specific objectives are to demonstrate the benefits of post-treatment options such as membranes, activated carbon and ozonation after bank filtration for the production of safe drinking water to validate the treatment and storage capacity of soil-aquifer systems in combination with oxidative pre-treatments to demonstrate the combination of constructed wetlands with different technical post- or pre-treatment options (ozone or bioreactor systems) as a wastewater treatment option to evidence reductions in operating costs and energy consumption to test a robust risk assessment framework for cNES to deliver design guidance for cNES informed by industrial or near-industrial scale expe-riences to identify and profile new market opportunities in Europe and overseas for cNES The AquaNES project will demonstrate combined natural-engineered treatment systems as sus-tainable adaptations to issues such as water scarcity, excess water in cities and micro-pollutants in the water cycle. It will thus have impact across the EIP Waters thematic priorities and cross-cutting issues, particularly on Water reuse & recycling, Water and wastewater treatment, Water-energy nexus, Ecosystem services, Water governance, and DSS & monitoring.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: COMPET-05-2015 | Award Amount: 1.54M | Year: 2016

We propose a benchmark study that will address critical points in reconstructing physical and thermal properties of near-Earth, main-belt, and trans-Neptunian objects. The combination of the visual and thermal data from the ground and from astrophysics missions (like Herschel, Spitzer and Akari) is key to improving the scientific understanding of these objects. The development of new tools will be crucial for the interpretation of much larger data sets from WISE, Gaia, JWST, or NEOShield-2, but also for the operations and scientific exploitation of the Hayabusa-2 mission. Our approach is to combine different methods and techniques to get full information on selected bodies: lightcurve inversion, stellar occultations, thermo-physical modeling, radiometric methods, radar ranging and adaptive optics imaging. The applications to objects with ground-truth information from interplanetary missions Hayabusa, NEAR-Shoemaker, Rosetta, and DAWN allows us to advance the techniques beyond the current state-of-the-art and to assess the limitations of each method. The SBNAF project will derive size, spin and shape, thermal inertia, surface roughness, and in some cases even internal structure and composition, out to the most distant objects in the Solar System. Another important aim is to build accurate thermo-physical asteroid models to establish new primary and secondary celestial calibrators for ALMA, SOFIA, APEX, and IRAM, as well as to provide a link to the high-quality calibration standards of Herschel and Planck. The target list comprises recent interplanetary mission targets, two samples of main-belt objects, representatives of the Trojan and Centaur populations, and all known dwarf planets (and candidates) beyond Neptune. Our team combines world-leading expertise in different scientific areas in a new European partnership with a high synergy potential in the field of small body and dwarf planet characterization, related to astrophysics, Earth, and planetary science.

Agency: European Commission | Branch: H2020 | Program: RIA | Phase: ICT-09-2014 | Award Amount: 4.00M | Year: 2015

The rapid growth of web data creates demand for software engineering methods which can build and maintain applications that extract, process and publish web data. However, converting Big Data sources into high-quality, structured knowledge for use in business processes is usually considered data engineering. ALIGNED will develop models, methods and tools for engineering information systems based on co-evolving software and web data. Tools for model-driven software evolution based on Linked Data sources, runtime data quality analytics, human data curation and process integration will aid more efficient governance, increased agility and higher productivity. The opportunities for web data have recently led to intense research and innovation, but most efforts are siloed in the software or data spaces. Past integration of data and software engineering used formal ontologies rather than Linked Data. ALIGNED will provide lightweight methods for European data and software engineering industries to exploit the new opportunities in web data. Information companies like Wolters Kluwer need better ways to extract web data and build applications on top of it. Public bodies like the UK National Health Service (NHS) need evolving systems for data collection and re-use. Web data publishers like DBpedia need new methods to improve data quality. Scientific publications, industry workshops, training programs, open source tools and engaging the OMG, W3C and ISO standards bodies will transfer ALIGNED outputs. ALIGNED combines world class researchers in model driven software engineering (Oxford are transforming NHS systems), Linked Data quality (Leipzig and Trinity College have published foundational papers) and web systems (Leipzig are co-creators of DBpedia) with innovative enterprises (Wolters Kluwer have Linked Data in production systems, Semantic Web Company lead the world in enterprise Linked Data) and pioneering expert-curated data publishers (Oxford Anthropology and Posnan).

Adam Mickiewicz University | Date: 2016-07-06

The invention relates to new cage monovinylgermasilsesquioxanes of the general formula 1,^(1) are the same and represent a C_(1) to C_(6) alkyl group or a cyclopentyl or cyclohexyl group or a phenyl group. The invention also relates to the method of synthesis of cage monovinylgermasilsesquioxanes of the general formula 1.

The invention relates to new functionalized unsaturated derivatives of (dimethylvinylgermoxy)heptasubstituted silsesquioxanes of the general formula 1, R are the same and represent linear and branched C_(2) to C_(8) alkyl groups, or cyclopentyl and cyclohexyl groups, or phenyl groups R represents an unsubstituted aryl group containing between 1 and 2 rings or an aryl group substituted in any position in the ring. The invention also relates to the method of synthesis of functionalized unsaturated derivatives of (dimethylvinylgermoxy)heptasubstituted silsesquioxanes.

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