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Patne A.B.,ACPM Medical College and Hospital | Hisalkar P.J.,ACPM Medical College and Hospital | Gaikwad S.B.,Goverment Medical College
Biomedicine (India) | Year: 2013

Background: β-thalassemia major is an inherited disease resulting from reduction or total lack of beta globin chains. Patients with this disease need repeated blood transfusion for survival, this may cause oxidative stress. The prevalence of β-thalassemia major is high in tribal and non-tribal population in area around Dhule, Nandurbar and Jalgaon districts in Maharashtra. So the present study was initiated to evaluate oxidative stress in β-thalassemia major patients. Methods: Blood samples were collected from 100 subjects (50 β-thalassemia major patients and 50 healthy controls). Serum levels of iron, total iron binding capacity (TIBC), ferritin, and MDA and TAS activity were determined using conventional methods. Results: Serum Iron, Ferritin and MDA were significantly increased while TIBC and TAS were significantly decreased in β-thalassemia major patients as compared to healthy individuals. Conclusions: The findings of this study confirmed that oxidative stress in patients with β-thalassemia major is mainly caused by tissue injury due to over production of free radical by secondary iron overload, alteration in serum trace elements (Iron) and antioxidant levels. The iron burden on the body can be estimated by means of serum ferritin, iron and TIBC levels. The combination of effective iron-chelatory agents with natural or synthetic antioxidants can be extremely helpful in clinical practice to reduce the extent of oxidative damage and related complications in β-thalassemia major still need further evaluation.

Hisalkar P.J.,ACPM Medical College and Hospital | Patne A.B.,ACPM Medical College and Hospital | Fawade M.M.,Dr. Babasaheb Ambedkar Marathwada University | Karnik A.C.,ACPM Medical College and Hospital
Biology and Medicine | Year: 2012

Antioxidants are agents that protect, prevent, or reduce the extent of oxidative damage to biomolecules. These agents may be enzymatic, non-enzymatic, or metal chelators. The enzymatic antioxidants include catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx). SOD, a copper, zinc and manganese-containing enzyme, reacts with superoxide radical to form hydrogen peroxide, which is then converted to water by GPx (a glutathione-dependent selenoprotein), or catalase, a heme enzyme. Decreased activity of these antioxidant enzymes may increase the susceptibility of diabetic patients to oxidative injury. An appropriate support of antioxidant supplies may help in preventing clinical complications of diabetes. In view of this, supplementary trace elements such as selenium, copper, zinc, and manganese, essential components of the enzymes, may be useful in preventing the development of diabetic complications. There are number of factors that affect an individual's oxidative status that include gender, age, body composition, smoking status, diet, physical activity level, and the strength of defense mechanism. Hence, this study was carried out to see the relationship of these factors with antioxidant enzymes in clinically diagnosed type 2 diabetes patients.

Tondare S.B.,ACPM Medical College and Hospital | Patil-Rawandale A.V.,ACPM Medical College and Hospital | Chitale A.M.,ACPM Medical College and Hospital | Patni L.,ACPM Medical College and Hospital | Tondare M.B.,Krishna Institute of Medical science
Journal of Krishna Institute of Medical Sciences University | Year: 2013

Background: Urolithiasis, usually affecting people in the prime of life, causes significant morbidity and loss of productivity. Ureteric stones account for 2/3rd of all urinary calculi brought to attention of doctors. The damaging effects of the calculi may result in obstruction with dilatation of the urinary tract, leading to stasis and severe infection. Aims and Objectives: To evaluate patients with urinary stones with regards to the incidence, age, sex, clinical presentation, site, size, side, management and their complications. Material and Methods: It was a prospective study carried out by Department of Surgery at Annasaheb Chudaman Patil Memorial Medical College, and Hospital Dhule for a period of two years. Patients were selected after they were diagnosed as having ureteric calculi. The patients were treated by conservative or surgical methods, and the outcome was monitored. Statistical analysis of the data was done for obtaining results. Result: The majority of the patients were males with peak age group in the second and third decade. Pain in abdomen or loin tenderness was the most common presenting symptom. Most of the patients were treated by conservative medical management. Endourological procedures were the most commonly performed surgical intervention. Conclusion: Most of the patients with ureteric calculi present with pain in abdomen and majority can be treated by medical management. With the availability of better facilities the requirement for open surgery is decreasing and endourological procedures are becoming the means of surgical intervention. Complications are minimal with surgical expertise for endourological procedures. © Journal of Krishna Institute of Medical Sciences University.

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