Istanbul, Turkey
Istanbul, Turkey

Acıbadem University is a private, non-profit institution, founded in 2007 and located in Istanbul, Turkey. The University is supported by the financial resources of the Kerem Aydınlar Foundation, set up by Mehmet Ali Aydınlar, a leading Turkish businessman, the largest shareholder and the CEO of the Acıbadem Healthcare Group, which is Turkey's leading healthcare institution and founded in 1992. Wikipedia.

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Pamir M.N.,Acibadem University
Acta neurochirurgica. Supplement | Year: 2011

Intraoperative imaging technologies have improved surgical results in glioma and pituitary adenoma surgeries. With improvements and refinements 3T intraoperative MRI systems offer a potential of further improving these results. Hereby we describe the equipment and technique of a cost-effective shared-resource 3-T ultra-high field intraoperative magnetic resonance imaging system and report our continuing experience on surgical tumor resection. A description of the facility design and equipment are given along with examples from our experience on low-grade gliomas and transsphenoidal surgeries. Our facility based on the twin room concept and uses a 3-T Siemens Trio (Siemens, Erlangen, Germany) scanner. The unit consists of adjacent but independent MRI and operative suites, which are connected by a wide door for ioMRI procedure but are used as conventional MRI and operative units. Rigid head fixation during neurosurgery is achieved with a custom designed 5 pin head-rest which also combines a 4+4 channel head coil. Operation is performed using regular non-MRI compatible equipment and the patient is transferred to the MRI during the procedure using a custom designed floating table. Advanced sequences such as diffusion weighted and diffusion tensor imaging, MR angiography, MR venography, MR spectroscopy can be performed with no changes in the setup and result in image quality comparable to outpatient scans. The intraoperative 3-T ultra high field MRI unit with the twin room concept permits both diagnostic outpatient imaging and image guided surgery in the same setting and is a cost effective solution to afford a highly capable ioMRI system.

Ozcan U.A.,Acibadem University
Journal of Clinical Ultrasound | Year: 2010

We report a case of rapidly involuting congenital hemangioma of the flank, which was diagnosed in the 2nd trimester of gestation and showed complete involution before term. In our case sonography revealed a highly vascular soft tissue mass with smooth contours, which was isointense with the placenta on T2-weighted MR images. The fetus was born with scar tissue at the site of the lesion. To our knowledge this is the 1st reported case of rapidly involuting congenital hemangioma showing complete involution before term. © 2009 Wiley Periodicals, Inc.

Wollmann G.,Yale University | Ozduman K.,Acibadem University | Van Den Pol A.N.,Acibadem University
Cancer Journal | Year: 2012

Twenty years of oncolytic virus development have created a field that is driven by the potential promise of lasting impact on our cancer treatment repertoire. With the field constantly expanding-more than 20 viruses have been recognized as potential oncolytic viruses-new virus candidates continue to emerge even as established viruses reach clinical trials. They all share the defining commonalities of selective replication in tumors, subsequent tumor cell lysis, and dispersion within the tumor. Members from diverse virus classes with distinctly different biologies and host species have been identified. Of these viruses, 15 have been tested on human glioblastoma multiforme. So far, 20 clinical trials have been conducted or initiated using attenuated strains of 7 different oncolytic viruses against glioblastoma multiforme. In this review, we present an overview of viruses that have been developed or considered for glioblastoma multiforme treatment. We outline the principles of tumor targeting and selective viral replication, which include mechanisms of tumor-selective binding, and molecular elements usurping cellular biosynthetic machinery in transformed cells. Results from clinical trials have clearly established the proof of concept and have confirmed the general safety of oncolytic virus application in the brain. The moderate clinical efficacy has not yet matched the promising preclinical lab results; next-generation oncolytic viruses that are either "armed" with therapeutic genes or embedded in a multimodality treatment regimen should enhance the clinical results. © 2012 by Lippincott Williams & Wilkins.

Simons C.,University of Queensland | Simons C.,Garvan Institute of Medical Research | Simons C.,Acibadem University | Simons C.,University of Liège | And 4 more authors.
Nature genetics | Year: 2015

Temple-Baraitser syndrome (TBS) is a multisystem developmental disorder characterized by intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great toe. Here we report damaging de novo mutations in KCNH1 (encoding a protein called ether à go-go, EAG1 or KV10.1), a voltage-gated potassium channel that is predominantly expressed in the central nervous system (CNS), in six individuals with TBS. Characterization of the mutant channels in both Xenopus laevis oocytes and human HEK293T cells showed a decreased threshold of activation and delayed deactivation, demonstrating that TBS-associated KCNH1 mutations lead to deleterious gain of function. Consistent with this result, we find that two mothers of children with TBS, who have epilepsy but are otherwise healthy, are low-level (10% and 27%) mosaic carriers of pathogenic KCNH1 mutations. Consistent with recent reports, this finding demonstrates that the etiology of many unresolved CNS disorders, including epilepsies, might be explained by pathogenic mosaic mutations.

Cosar C.B.,Acibadem University | Sener A.B.,Acibadem Maslak Hospital
European Journal of Ophthalmology | Year: 2014

Purpose: To investigate refractive and visual outcomes and complications of the Supracor procedure to treat presbyopia. Methods: A total of 123 eyes from 68 presbyopic patients with hyperopia were enrolled in this prospective, nonrandomized, clinical trial. The Supracor procedure was performed using the Technolas excimer laser 217P (Technolas Perfect Vision GmbH). Follow-up eye examinations were performed at postoperative day 1, month 1, and month 6. Results: All 123 surgeries were uneventful. At 6 months postoperatively, uncorrected distance visual acuity was 20/20 or better in 27 (22.0%) eyes and 20/25 or better in 45 (36.6%) eyes. At 6 months postoperatively, 35 (28.5%) eyes lost 1 line and 13 (10.6%) eyes lost 2 lines of corrected distance visual acuity (CDVA). At 6 months postoperatively, uncorrected near visual acuity was 20/20 or better in 95 (77.2%) eyes and 20/25 or better in 110 (89.4%) eyes. At 6 months postoperatively, 6 (4.9%) eyes lost 1 line of corrected near visual acuity. Conclusions: The Supracor presbyopia procedure showed good near visual acuity outcomes over 6 months follow-up but loss of CDVA occurred in 39.1% of eyes. © 2013 Wichtig Editore.

Sipahi I.,Acibadem University | Sipahi I.,Case Western Reserve University | Akay M.H.,Acibadem University | Dagdelen S.,Acibadem University | And 2 more authors.
JAMA Internal Medicine | Year: 2014

IMPORTANCE Recent trials of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) for multivessel disease were not designed to detect a difference in mortality and therefore were underpowered for this outcome. Consequently, the comparative effects of these 2 revascularization methods on long-term mortality are still unclear. In the absence of solid evidence for mortality difference, PCI is oftentimes preferred over CABG in these patients, given its less invasive nature. OBJECTIVES To determine the comparative effects of CABG vs PCI on long-term mortality and morbidity by performing ameta-analysis of all randomized clinical trials of the current era that compared the 2 treatment techniques in patients with multivessel disease. DATA SOURCES A systematic literature search was conducted for all randomized clinical trials directly comparing CABG with PCI. STUDY SELECTION To reflect current practice, we included randomized trials with 1 or more arterial grafts used in at least 90%, and 1 or more stents used in at least 70% of the cases that reported outcomes in patients with multivessel disease. DATA EXTRACTION Numbers of events at the longest possible follow-up and sample sizes were extracted. DATA SYNTHESIS A total of 6 randomized trials enrolling a total of 6055 patients were included, with a weighted average follow-up of 4.1 years. There was a significant reduction in total mortality with CABG compared with PCI (I2 = 0%; risk ratio [RR], 0.73 [95%CI, 0.62-0.86]) (P < .001). There were also significant reductions in myocardial infarction (I2 = 8.02%; RR, 0.58 [95%CI, 0.48-0.72]) (P < .001) and repeat revascularization (I2 = 75.6%; RR, 0.29 [95%CI, 0.21-0.41]) (P < .001) with CABG. There was a trend toward excess strokes with CABG (I2 = 24.9%; RR, 1.36 [95%CI, 0.99-1.86]), but this was not statistically significant (P = .06). For reduction in total mortality, there was no heterogeneity between trials that were limited to and not limited to patients with diabetes or whether stents were drug eluting or not. Owing to lack of individual patient-level data, additional subgroup analyses could not be performed. CONCLUSIONS AND RELEVANCE In patients with multivessel coronary disease, compared with PCI, CABG leads to an unequivocal reduction in long-term mortality and myocardial infarctions and to reductions in repeat revascularizations, regardless of whether patients are diabetic or not. These findings have implications for management of such patients. Copyright © 2014 American Medical Association. All rights reserved.

Tanyeri H.M.,Acibadem University
European Archives of Oto-Rhino-Laryngology | Year: 2011

The objective of the study was to evaluate the efficacy and safety of temperature-controlled radiofrequency (RF) tonsil ablation in the treatment of halitosis caused by chronic tonsillitis with caseum. The study method was retrospective. The medical records of 58 patients undergoing temperature-controlled RF tonsil ablation due to chronic tonsillitis with caseum between November 1, 2005 and November 30, 2008 were reviewed. Forty-nine (84.4%) of 58 patients reported complete disappearance of bad breath after the first treatment; five patients (8.6%) reported as having insufficient improvement and four (6.9%) patients had no change. Two patients from "insufficient group" and all four patients from "no change" group agreed to a repeat treatment. After the second session, four (6.9%) patients reported complete disappearance of halitosis with the disappearance of caseum formation. But two patients still suffered from halitosis. One of these patients underwent tonsillectomy, other patient is under our follow-up. Overall, complete elimination of halitosis was accomplished with one session in 49 (84.4%) patients, two sessions in four (6.9%) patients, making a total of 53 (91.3%) patients. Postoperative morbidities included one transient mild bleeding, one secondary bleeding and one mild edema. Temperature-controlled RF tonsil ablation is an effective method for treating halitosis which derived from chronic tonsillitis with caseum. This well-tolerated technique avoids the post-procedure morbidities and discomfort of more invasive surgical modalities currently used. © 2010 Springer-Verlag.

Tiras B.,Acibadem University | Cenksoy P.O.,Yeditepe University
Seminars in Reproductive Medicine | Year: 2014

Many patient and embryo factors influence the outcome of assisted reproductive technology (ART) treatment. The predictors for a successful ART cycle include female age, ovarian reserve, embryo quality, endometrial receptivity, and embryo transfer (ET) technique. ET, the final step of ART, has recently been noted as a crucial step affecting ART success. Variables affecting pregnancy rates following ET include ultrasound guidance, ease of ET transfer, catheter type, transfer and catheter-loading technique, blood or mucus effects, retained embryos, trial transfer, the physician's experience, and catheter tip placement. Despite the lack of consensus regarding the optimal ET technique, it is generally recommended that during ET, the disruption of the endometrium and the induction of uterine contractions should be avoided. The exposure of embryos to the ambient conditions should be minimized, and the embryo(s) should be placed at an optimal position within the fundal region of the uterine cavity. © 2014 by Thieme Medical Publishers, Inc.

Ozkiris A.,Acibadem University
Documenta Ophthalmologica | Year: 2010

We aimed at investigating the efficacy of intravitreal bevacizumab injection by evaluation of pattern electroretinogram (PERG) in diabetic patients with clinically significant macular edema (CSME). Thirty-five eyes of 35 patients with diabetes were treated with 2.5 mg of intravitreal bevacizumab injection as the primary therapy for CSME. The main outcome measures included best-corrected visual acuity, fundus fluorescein angiography, and P50 amplitudes of pattern electroretinogram (PERG) before and after intravitreal injection. Mean visual acuity improved significantly from a mean LogMAR value of 1.1 ± 0.2 at baseline to a maximum of 0.7 ± 0.3 after a mean follow-up time of 6.4 months. The mean baseline P50 and N 95 amplitudes of PERG before intravitreal injection were 1.4 ± 0.7 and 2.4 ± 0.8 μV, respectively. After the treatment, the mean P50 amplitude of PERG was 2.4 ± 0.9 μV at 1-month, 2.3 ± 0.8 μV at 3-month, and 2.2 ± 0.8 μV at the last visit, and the mean N95 amplitude of PERG was 3.4 ± 1.05 μV at 1-month, 3.3 ± 0.9 μV at 3-month, and 3.2 ± 0.9 μV at the last visit, and the mean P50 and N95 amplitudes were significantly higher when compared with baseline values (for each, P < .001). Mild anterior chamber inflammation in four eyes was controlled with topical corticosteroids. Eyes with diabetic macular edema treated with intravitreal bevacizumab showed improvement in visual acuity that was accompanied by improvement in PERG amplitudes. Further randomized trials are needed to investigate the role of PERG measurements in the evaluation of the efficacy of intravitreal bevacizumab injection. © 2010 Springer-Verlag.

Yavuz B.G.,Acibadem University
The journal of headache and pain | Year: 2013

The aim of this study is to investigate the associations between migraine related disability and somatosensory amplification, depression, anxiety, and stress. Fifty-five migraine patients who applied to the outpatient unit of the Neurology Department of Acibadem University School of Medicine, Maslak Hospital in Istanbul, Turkey, and twenty-eight subjects without migraine were recruited for the study. The participants were asked to complete a sociodemographic form, Migraine Disability Assessment Scale (MIDAS), Depression Anxiety Stress Scale, Somatosensory Amplification Scale (SSAS). Somatosensory amplification scores were significantly higher in the migraineurs than in the control group (29.85+/-6.63 vs 26.07+/-7.1; p=0.027). Somatosensory amplification scores and depression scores were significantly higher in migraineurs with moderate and severe disability than in patients with minimal and mild disability (31.7+/-6.4 vs 27.71+/-5.49; p=0.01, 11.27+/-8.7 vs 7.38+/-8.11; p=0.04, respectively). A significant positive correlation was found between the frequency of migraine attacks for at least three consecutive months (MIDAS A scores) and the SSAS scores (r=0.363, p=0.007) in migraineurs. The MIDAS total scores were also significantly correlated with the DASS depression subcale scores (r=0.267, p=0.04), and the DASS stress subscale scores (r=0.268, p=0.05). Psychological factors, and vulnerability to bodily sensations may incease the burden of migraine. We point out that the timely assessing of somatic amplification and the evaluation of mental status would help improve the quality of life of in migraineurs.

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