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İstanbul, Turkey

Yilmaz G.,Maslak Acbadem Hospital | Harman F.,Beykoz State Hospital | Mut S.,Near East University | Berkman M.Z.,Maslak Acibadem Hospital
Journal of Neurological Sciences | Year: 2015

Background and Aim: The pathological course of spinal cord contusion injuries includes primary and secondary mechanisms of injury. Secondary injury may respond to pharmacologic interventions. The aim of this study was to investigate the effect of clopidogrel on the recovery of neurological functions in a rat model of spinal cord injury (SCI). Material and Methods: The study was performed at Haydarpasa Numune Training Hospital, Istanbul, Turkey. Twenty-one rats were randomly assigned to the following study groups: the control group (n=7), undergoing laminectomy procedure; trauma group (n=7), undergoing spinal cord injury after laminectomy; and trauma plus clopidogrel group, undergoing spinal cord injury after laminectomy and later administration of clopidogrel. Clopidogrel was administered at a dosage of 5mg/kg and functional outcome was evaluated by using inclined plane test and Drummond and Moore motor function score on days 1, 7, 14, 21 after SCI. Spinal cord samples for histopathologic evaluations were obtained after clinical examinations. Results: Inclined plane test and the motor function scores of trauma and trauma plus clopidogrel groups were significantly lower than the control group on days 1, 7, 14, and 21. Inclined plane test of trauma plus clopidogrel group was significantly better than the trauma group on days 14 and 21. In trauma plus clopidogrel group, the motor function scores on day 21 was significantly higher than the trauma group.Conclusion: Our results demonstrated that clopidogrel has a positive impact on neurological functions after injury to the rat spinal cord. © 2015, Ege University Press. All rights reserved.

Cifcili S.Y.,Marmara University | Akgun T.Y.,Maslak Acibadem Hospital | Akman M.,Marmara University | Unalan P.C.,Marmara University | And 2 more authors.
Nobel Medicus | Year: 2011

Objective: This study aims to explore the breast-feeding profiles and the factors that affect breast-feeding and weaning attitudes among mothers of 0-12 month old babies in a baby-friendly primary care unit. Material and Method: The study was conducted in a Mother and Child Health Centre in İstanbul in May- October 2006. All 364 mothers who were registered in the health centre were enrolled. A total of 358 mothers were included in the study. Results: The frequencies of breastfeeding initiation and of breastfeeding within the first hour were 98.9%and 62.3%respectively. Among the babies older than 6 months (n=200), 52.5%were weaned before 6 months. Pacifier use (OR: 3.01, 95%CI: 1.35-6.69), being preterm (OR: 3.36, 95%CI: 1.04-10.79), having a job (OR: 2.83, 95%CI: 1.14- 7.04) or smoking (OR: 2.27, 95%CI: 1.01-5.14) were found to be risk factors for early weaning. Conclusion: Although the frequency of initiating breastfeeding is very high, the continuation duration is below the World Health Organization (WHO)'s recommendations. Physicians and other health workers should strongly recommend against smoking during prenatal and postnatal visits. Physicians should not support pacifiers, until we have sufficient data to support its benefits. In order to increase the duration of breast feeding, health professionals should focus on preterm babies, smoking or working mothers.

Incir S.,Koc University | Bolayirli I.M.,Cerrahpasa Medical Faculty | Inan O.,Experimental Animal Research Center | Aydn M.S.,Bezmialem Foundation University | And 4 more authors.
Life Sciences | Year: 2016

Aims This experimental study was designed to investigate the effects of 10 weeks genistein administration on oxidative stress and inflammation in serum and liver of rats fed with fructose. Main methods 6–8 weeks old, 40 male Sprague-Dawley rats were included. Group 1 (control) was fed with standard chow food and 100 μl/kg/day/rat dimethyl sulfoxide (DMSO) administered subcutaneously; group 2 (genistein) with standard chow food and 0.25 mg/kg/day/rat genistein; group 3 (fructose) with standard chow food and drinking water 20% fructose, group 4 (fructose + genistein) with standard chow food, drinking water with 20% fructose and 0.25 mg/kg/day/rat genistein. TNF-α, IL-6, visfatin as inflammatory markers and 8-isoprostane as a oxidative stress marker were measured by ELISA, glucose, triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol by enzymatic colorimetric method, AST and ALT by kinetic UV method. Key findings Significantly high 8-isoprostane levels in serum (p < 0.001) and liver (p < 0.05) in group 3 compared to control group indicate that presence of oxidative stress. Significantly high TNF-α and IL-6 levels in serum (p < 0.05) and liver (p < 0.01) and visfatin levels in serum (p < 0.001) of group 3 indicate inflammation accompanying insulin resistance and oxidative stress. Genistein administration to fructose group causes a significant decrease in HOMA-IR (p < 0.001) and LDLC (p < 0.05) level. Significantly lower serum 8-isoprostane (p < 0.01) level indicates the antioxidant effect of genistein and significantly lower liver TNF-α (p < 0.01), serum, liver IL-6(p < 0.01) and serum visfatin (p < 0.01) levels reflect the antiinflammatory effects of genistein. Significance Genistein administration to rats fed with fructose causes an ameliorating effect on HOMA-IR values and lipid status markers in addition to its antioxidant and antiinflammatory effects. © 2016 Elsevier Inc.

Atug F.,Istanbul Science University | Kural A.R.,Maslak Acibadem Hospital | Tufek I.,Acibadem University | Srivastav S.,Tulane University | Akpinar H.,Istanbul Science University
Journal of Endourology | Year: 2012

Background and Purpose: Urinary incontinence is a significant cause of morbidity after robot-assisted radical prostatectomy (RARP). Several techniques have been developed to improve continence rates. In this study, we compared the continence rates of patients who underwent RARP with total reconstruction and without reconstruction. Patients and Methods: Between March 2005 and September 2009, 245 patients underwent RARP at our institution. The initial 120 patients (control group) underwent standard RARP without reconstruction and the last 125 patients (reconstruction group) underwent a total reconstruction technique, which included an anterior and posterior reconstruction. Patients were followed for 1, 4, 12, 24, 36, and 52 weeks after the operation. Continence was defined with strict criteria-no usage of pads and no leakage of urine. Results: In the reconstruction group, the continence rates at, 1, 4, 12, 24, 36, and 52 weeks postoperatively were 71%, 72%, 80%, 84%, 86%, and 91%, respectively; in the control group, the continence rates were 23%, 49%, 76%, 80%, 85%, and 88%, respectively. Conclusion: The overall continence rates were similar in both groups at 52 weeks of follow-up. Patients in the total reconstruction group, however, had higher early continence rates compared with patients in the control group. The total reconstruction procedure is an efficient way to achieve an early return to continence. © Copyright 2012, Mary Ann Liebert, Inc.

Gucyetmez B.,International Hospital | Salihoglu E.,Acibadem University | Ayyildiz A.,Maslak Acibadem Hospital | Saltik L.,Istanbul University | Telci L.,Istanbul University
Ulusal Travma ve Acil Cerrahi Dergisi | Year: 2013

Posttraumatic pulmonary arteriovenous fistula is a rare complication of penetrating injury. Cases may remain asymptomatic for years prior to diagnosis. We present a case of pulmonary arteriovenous fistula related to a penetrating injury of the thorax 6 years previously that was occluded with a septal occluder device. Consistent use of CT or conventional catheter pulmonary angiography following penetrating injury to the thorax is essential to the early diagnosis of pulmonary arteriovenous fistula during the asymptomatic stage. Modern occlude devices facilitate the transcath-eter approach as a viable alternative to surgery for the closure large, high pressure defects. © 2013 TJTES.

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