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Adana, Turkey

Sakalli H.,Adana Numune Training and Research Hospital | Calikusu Z.,Acibadem Adana Hospital | Sariakcali B.,Adana Numune Training and Research Hospital | Polat A.,Adana Numune Training and Research Hospital | Canataroglu A.,Adana Numune Training and Research Hospital
Nobel Medicus | Year: 2013

Objective: Cisplatin is a widely used chemotherapeutic agent. The most important side effect due of cisplatin is nephrotoxicity. N-acetyl-beta-D-glucosaminidase (NAG), is a lysosomal enzyme that has low urine levels in healthy individuals. The urine NAG excretion increases in renal disorders. The increases of serum NAG levels in cases like diabetes mellitus, proteinuria due to the renal involvement of systemic lupus erythematosus, some nephrotoxic medications like cisplatin, are demonstrated in several studies. In this study, we aimed to evaluate the acute nephrotoxicity due to cisplatin. Material and Method: Thirty patients were included in the study. The urine NAG levels are measured 24 hours before and 24 hours after the administration of 75 mg/m2 cisplatin in the 24 hours urine sample. The serum urea, creatinine levels are also measured before and after the medication. Results: The median age of the study group was 54 (26-75). The median administrated cisplatin dosage was 130.13±8.01 mg. The urine NAG excretion was 6.98±4.49 U/L before the treatment and 10.09±5.50 U/L after the treatment (p=0.001). The blood urea level was 28.33±9.48 mg/dl before the treatment and 30.03±7.19 mg/dl after the treatment (p=0.107). The blood creatinine level was 0.75±0.27 mg/dl before the treatment and 0.78±0.29 mg/dl after the treatment (p=0.229). After therapy, there was no significant correlation between the total dosage of cisplatin and NAG level (r=-0.048, p=0.80) and creatinine level (r=-0.218, p=0.23), and also after therapy, there was no significant correlation between NAG and creatinine levels (r=0.301, p=0.10). Conclusion: For the evaluation of acute nephrotoxicity of cisplatin we suggest, to use the measurement of 24 hours urine NAG excretion, as a non invasive test.

This article is about the trainee - tutor relationship between two eminent figures of Turkish medical history, namely Hamdi Suat Aknar (1873-1936) and Hulusi Behçet (1889-1948). Hamdi Suat Aknar was the pioneer of modern pathology in Turkey. Alongside his scientific achievements, he took educational activities seriously and exerted a great effort to train his students as proficient clinicians and physicians with good command of histology and histopathology. Hulusi Behçet met Hamdi Suat Aknar when he was a medical student and did not lose his contact with him ever since, even after becoming an internationally well-known scientist. Hulusi Behçet mentioned his tutor with gratitude at every opportunity and wrote a necrology full of sincerity after his death.

Kilicdag H.,Acibadem Adana Hospital | Daglioglu Y.K.,Cukurova University | Sencar L.,Cukurova University | Erdogan S.,Cukurova University | And 4 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects of β-estradiol on intestinal injury in rats. Methods: Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia-re-oxygenation was not performed. In group 2 (saline), the rats were injected with saline after hypoxia-re-oxygenation, and the process was repeated for 5 d. In group 3 (β-estradiol treatment), the rats were subjected to hypoxia-re-oxygenation and then given β-estradiol intraperitoneally once a day for 5 d. After these procedures, the terminal ileum was removed for analysis. Results: Statistically significant differences in histological grades were found between groups 1 and 2 (p = 0.000), groups 1 and 3 (p = 0.028), and groups 2 and 3 (p = 0.021). There were also differences in TNF-α and IL-6 levels between groups 2 and 3 (p = 0.000 and p = 0.038, respectively) and between groups 1 and 2 (p = 0.000 and p = 0.000); there was no difference between groups 1 and 3 (p = 0.574 and p = 0.195, respectively). Electron microscopy examination revealed a decrease in lipid droplets at the apical cytoplasm of the columnar cells in group 2; in group 3, the absorption of the lipids as lipid droplets was similar to that of group 1. Conclusion: In this study, β-estradiol was found to decrease the intensity of intestinal injury significantly by inhibiting TNF-α and IL-6. © 2015 Taylor & Francis.

Alma E.,Ceyhan State Hospital | Eken A.,Acibadem Adana Hospital | Ercil H.,Adana Numune Education and Research Hospital | Yelsel K.,Viransehir State Hospital | Daglioglu N.,Cukurova University
Urology journal | Year: 2014

To evaluate the effects of orally administered dehydrated garlic powder on cytokine excretion in the urinary tract. A total of 60 healthy volunteers, randomized into 3 groups, were given a single oral dose of 1 g or 3 g of dehydrated garlic powder or placebo. Urine samples were obtained 6.0 and 24.0 h after garlic intake and assayed for interleukin-8 (IL-8), interleukin- 12 (IL-12), tumor necrosis factor-alpha (TNF-α), diallyl disulfide (DADS) and diallyl sulfide (DAS). Significant increases in IL-12 levels over baseline were noted in urine samples obtained after oral intake of 1 g and 3 g of garlic powder (P < .001). In the 1 g and 3 g garlic powder treatment groups, time-dependent variations in IL-12 levels over the study period were significantly different from the placebo group (P < .001). In both garlic treatment groups, urinary levels of IL-8 and TNF-α were not significantly different from baseline and placebo levels (P > .017). DADS and DAS were not detected in the urine samples at any time after garlic powder intake. Oral intake of doses of garlic traditionally used for daily supplementation increases urinary levels of IL-12, which is a potent stimulator of T helper cell 1 (Th-1) immune responses. This observation encourages further studies investigating the immunostimulatory role of garlic in the urinary tract.

Arpaci T.,Acibadem Adana Hospital
European review for medical and pharmacological sciences | Year: 2012

To define the radiological imaging features and clinical findings of the patients with skeletal muscle metastasis. 4454 computed tomography (CT), 1802 magnetic resonance imaging (MRI) and 2569 positron emission tomography/computed tomography (PET/CT) imaging studies of the oncology patients performed between March 2009 and July 2012 in the Radiology and Nuclear Medicine Departments of our hospital were retrospectively reviewed. Fifty-two patients had 91 different metastatic skeletal muscle masses. Twenty-one patients (40%) were diagnosed with lung carcinoma as being the most common primary source. Forty-seven patients (90%) had metastatic disease somewhere else at the time of detection of skeletal muscle metastasis. Thirty-three patients (63%) had lymph node metastasis which was the most common site. Muscles mostly affected by metastatic disease were gluteals (15%), psoas (8.7%), erector spinae (8.7%), rectus abdominis (7.6%), latissimus dorsi (6.5%). The mean size of the lesions was 30 mm (range, 10-120 mm). The most common appearance on contrast-enhanced CT was a rim-enhancing intramuscular mass with central hypoattenuation. On MRI, skeletal muscle metastases mostly revealed isointense signal on T1-weighted images, heterogeneous high signal with peritumoral edema on T2-weighted images and extensive enhancement with central necrosis on gadolinium-DTPA (diethylene triamine pentaacetic acid) enhanced images. Skeletal muscle metastasis may be an incidental finding on CT. The most common CT appearance is a rim-enhancing intramuscular mass with central hypoattenuation. On MRI, extensive tumoral enhancement, central necrosis and peritumoral edema are highly acceptable features of skeletal muscle metastasis.

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