Acibadem Adana Hospital

Adana, Turkey

Acibadem Adana Hospital

Adana, Turkey
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Ugurluer G.,Acibadem Adana Hospital | Akbas T.,Acibadem University | Arpaci T.,Acibadem University | Ozcan N.,Acibadem University | Serin M.,Acibadem Adana Hospital
Journal of Medical Imaging and Radiation Oncology | Year: 2014

Introduction The purpose of this study was to assess the incidence, distribution and MRI characteristics of pelvic bone complications after radiation therapy. Methods The medical charts of 345 patients who received pelvic radiation therapy were retrospectively reviewed. A total of 122 patients, 99 women and 23 men, with a mean age of 57 (range 32-87 years) were included in this study. The MR images were retrospectively reviewed by two radiologists. Results Fatty replacement of bone marrow was seen in all patients. Pelvic bone complications and focal red marrow changes were identified in a total of 38 patients (31.1%). Pelvic insufficiency fracture was diagnosed in 17 patients (13.9%, with a total of 64 lesions) and radiation osteitis was diagnosed in 5 patients (4.1%, with a total of 13 lesions). Avascular necrosis of the femoral head was detected in one patient (0.8%). Focal red bone marrow changes were seen in 15 patients (12.3%). The median time from the end of radiotherapy to the diagnosis of pelvic bone complications or changes was 25 months (range 2-45 months). The 1-, 2-, and 3-year cumulative incidences were 22%, 41% and 49%, respectively. The distribution of insufficiency fractures was as follows: sacral ala, sacral body, ilium, acetabulum, pubis and lumbar spinal vertebra. The distribution of radiation osteitis was as follows: sacral ala, ilium and pubis. Conclusion Radiation-induced pelvic bone complications are not uncommon, and knowledge of characteristic imaging patterns is essential in order to rule out bone metastases and to avoid inaccurate or excessive treatment. © 2014 The Royal Australian and New Zealand College of Radiologists.


Mutlu H.,Kayseri Research and Training Hospital | Buyukcelik A.,Acibadem University | Aksahin A.,Kayseri Research and Training Hospital | Kibar M.,Acibadem Adana Hospital | And 8 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Some epidemiological studies reported that sunlight exposure and highvitamin D levels may decrease the morbidity and mortality related to cancer. We aimed to evaluate whether sunlight exposure has an impact on survival in patients with non small cell lung cancer. Materials and Methods: A total of 546 patients with NSCLC from two different regions (Kayseri and Adana) differing according to sunlight exposure were analysed retrospectively. Results: The median overall survival (OS) rates were 11. 6 (CI: 9.50-13.6) and 15.6 months (CI: 12.4-18.8) for Kayseri and Adana, respectively, in all patients (p=0.880). Conclusions: There were no differences between groups in terms of OS. While there is strong evidence regarding inverse relationship between cancer incidence and sunlight exposure, it is still controversial whether sunlight exposure is a good prognostic factor for survival in patients with lung cancer.


Mutlu H.,Acibadem Kayseri Hospital | Buyukcelik A.,Acibadem University | Kaya E.,Acibadem Kayseri Hospital | Kibar M.,Acibadem Adana Hospital | And 3 more authors.
Oncology Letters | Year: 2013

Currently, positron emission tomography with computerized tomography (PET-CT) is the most sensitive technique for detecting extracranial metastases in non-small cell lung cancer (NSCLC). It has been reported that there is a correlation between the maximal standardized uptake value (SUVmax) of primary tumors and prognosis in patients with NSCLC. The effect of sunlight exposure on PET-CT SUVmax value is not known. Therefore, we aimed to evaluate the effect of sunlight exposure on PET-CT SUVmax value in patients with NSCLC. A total of 290 patients with NSCLC from two different regions of Turkey (Kayseri, n=168 and Adana, n=122) that have different climate and sunlight exposure intensity, were included in the study. Age, gender, histology of cancer, cancer stage, smoking status, comorbidity and SUVmax of the primary tumor area at the time of staging were evaluated as prognostic factors. In the multivariate analysis, we detected that the region was the only independent factor affecting SUVmax (P=0.019). We identified that warmer climate and more sunlight exposure significantly increases the SUVmax value of the primary tumor area in patients with NSCLC. Further studies are warranted to clarify the issue. © 2013 Spandidos Publications Ltd. All rights reserved.


Mutlu H.,Acibadem Kayseri Hospital | Buyukcelik A.,Acibadem University | Erden A.,Kayseri Training and Research Hospital | Aslan T.,Kayseri Training and Research Hospital | And 6 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: Of patients with non small cell lung cancer (NSCLC), around one third are locally advanced at the time of diagnosis. Because only a proprotion of stage III patients can be cured by surgery, in order to improve the outcomes , sequential or concurrent chemoradiation, or concurrent chemoradiation with induction or consolidation is offered to the patients with locally advanced NSCLC. Today, PET combined with computerized tomography (PET-CT) is accepted as the most sensitive technique for detecting mediastinal lymph node and extracranial metastases from NSCLC. We aimed to compare PET-CT and conventional staging procedures for decisions regarding curative treatment of locally advanced NSCLC. Materials and Methods: A total of 168 consecutive patients were included from Acibadem Kayseri Hospital, Acibadem Adana Hospital and Kayseri Research and Training Hospital in this study. Results: While the median PFS was 13.0±1.9 months in the PET-CT group, it was only 6.0±0.9 in the others (p<0.001). The median OS values were 20.5±15.6 and 11.5±1.5 months, respectively (p<0.001). Discussion: As a result, we found that staging with PET CT has better results in terms of survival staging. This superiority leads to survival advantage in patients with locally advanced NSCLC.


PubMed | Cukurova University, Mersin University, Acibadem Adana Hospital and Acibadem University
Type: Journal Article | Journal: Molecular and clinical oncology | Year: 2016

Following joint hemorrhages, intramuscular hemorrhages are the second most prevalent bleeding pattern in hemophiliac patients. Hematomas of the iliopsoas muscle are a well-known complication of hemophilia; however, obturator muscle hematomas are rare. We herein report a case of spontaneous bleeding of the bilateral external obturator muscles, which occured three times within a period of 9 months in a hemophilia patient with factor VIII inhibitors. To the best of our knowledge, this is the first published case of an obturator externus muscle hematoma in hemophilia. In addition to hip hemarthrosis, iliopsoas hematomas and acute appendicitis, obturator muscle hematoma should be considered as one of the diagnostic alternatives for pelvic pain in hemophilia patients. Magnetic resonance imaging enables rapid diagnosis of obturator muscle hematoma.


Alma E.,Ceyhan State Hospital | Eken A.,Acibadem Adana Hospital | Ercil H.,Adana Numune Education and Research Hospital | Yelsel K.,Viransehir State Hospital | Daglioglu N.,Cukurova University
Urology journal | Year: 2014

To evaluate the effects of orally administered dehydrated garlic powder on cytokine excretion in the urinary tract. A total of 60 healthy volunteers, randomized into 3 groups, were given a single oral dose of 1 g or 3 g of dehydrated garlic powder or placebo. Urine samples were obtained 6.0 and 24.0 h after garlic intake and assayed for interleukin-8 (IL-8), interleukin- 12 (IL-12), tumor necrosis factor-alpha (TNF-α), diallyl disulfide (DADS) and diallyl sulfide (DAS). Significant increases in IL-12 levels over baseline were noted in urine samples obtained after oral intake of 1 g and 3 g of garlic powder (P < .001). In the 1 g and 3 g garlic powder treatment groups, time-dependent variations in IL-12 levels over the study period were significantly different from the placebo group (P < .001). In both garlic treatment groups, urinary levels of IL-8 and TNF-α were not significantly different from baseline and placebo levels (P > .017). DADS and DAS were not detected in the urine samples at any time after garlic powder intake. Oral intake of doses of garlic traditionally used for daily supplementation increases urinary levels of IL-12, which is a potent stimulator of T helper cell 1 (Th-1) immune responses. This observation encourages further studies investigating the immunostimulatory role of garlic in the urinary tract.


Sakalli H.,Adana Numune Training and Research Hospital | Calikusu Z.,Acibadem Adana Hospital | Sariakcali B.,Adana Numune Training and Research Hospital | Polat A.,Adana Numune Training and Research Hospital | Canataroglu A.,Adana Numune Training and Research Hospital
Nobel Medicus | Year: 2013

Objective: Cisplatin is a widely used chemotherapeutic agent. The most important side effect due of cisplatin is nephrotoxicity. N-acetyl-beta-D-glucosaminidase (NAG), is a lysosomal enzyme that has low urine levels in healthy individuals. The urine NAG excretion increases in renal disorders. The increases of serum NAG levels in cases like diabetes mellitus, proteinuria due to the renal involvement of systemic lupus erythematosus, some nephrotoxic medications like cisplatin, are demonstrated in several studies. In this study, we aimed to evaluate the acute nephrotoxicity due to cisplatin. Material and Method: Thirty patients were included in the study. The urine NAG levels are measured 24 hours before and 24 hours after the administration of 75 mg/m2 cisplatin in the 24 hours urine sample. The serum urea, creatinine levels are also measured before and after the medication. Results: The median age of the study group was 54 (26-75). The median administrated cisplatin dosage was 130.13±8.01 mg. The urine NAG excretion was 6.98±4.49 U/L before the treatment and 10.09±5.50 U/L after the treatment (p=0.001). The blood urea level was 28.33±9.48 mg/dl before the treatment and 30.03±7.19 mg/dl after the treatment (p=0.107). The blood creatinine level was 0.75±0.27 mg/dl before the treatment and 0.78±0.29 mg/dl after the treatment (p=0.229). After therapy, there was no significant correlation between the total dosage of cisplatin and NAG level (r=-0.048, p=0.80) and creatinine level (r=-0.218, p=0.23), and also after therapy, there was no significant correlation between NAG and creatinine levels (r=0.301, p=0.10). Conclusion: For the evaluation of acute nephrotoxicity of cisplatin we suggest, to use the measurement of 24 hours urine NAG excretion, as a non invasive test.


Kilicdag H.,Acibadem Adana Hospital | Daglioglu Y.K.,Cukurova University | Sencar L.,Cukurova University | Erdogan S.,Cukurova University | And 4 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2016

Objective: Necrotizing enterocolitis has been investigated and debated extensively in recent years; however, there is still no effective treatment. The aim of this study was thus to examine the effects of β-estradiol on intestinal injury in rats. Methods: Twenty-four newborn female rat pups were divided into three groups. In group 1 (sham), hypoxia-re-oxygenation was not performed. In group 2 (saline), the rats were injected with saline after hypoxia-re-oxygenation, and the process was repeated for 5 d. In group 3 (β-estradiol treatment), the rats were subjected to hypoxia-re-oxygenation and then given β-estradiol intraperitoneally once a day for 5 d. After these procedures, the terminal ileum was removed for analysis. Results: Statistically significant differences in histological grades were found between groups 1 and 2 (p = 0.000), groups 1 and 3 (p = 0.028), and groups 2 and 3 (p = 0.021). There were also differences in TNF-α and IL-6 levels between groups 2 and 3 (p = 0.000 and p = 0.038, respectively) and between groups 1 and 2 (p = 0.000 and p = 0.000); there was no difference between groups 1 and 3 (p = 0.574 and p = 0.195, respectively). Electron microscopy examination revealed a decrease in lipid droplets at the apical cytoplasm of the columnar cells in group 2; in group 3, the absorption of the lipids as lipid droplets was similar to that of group 1. Conclusion: In this study, β-estradiol was found to decrease the intensity of intestinal injury significantly by inhibiting TNF-α and IL-6. © 2015 Taylor & Francis.


This article is about the trainee - tutor relationship between two eminent figures of Turkish medical history, namely Hamdi Suat Aknar (1873-1936) and Hulusi Behçet (1889-1948). Hamdi Suat Aknar was the pioneer of modern pathology in Turkey. Alongside his scientific achievements, he took educational activities seriously and exerted a great effort to train his students as proficient clinicians and physicians with good command of histology and histopathology. Hulusi Behçet met Hamdi Suat Aknar when he was a medical student and did not lose his contact with him ever since, even after becoming an internationally well-known scientist. Hulusi Behçet mentioned his tutor with gratitude at every opportunity and wrote a necrology full of sincerity after his death.


Arpaci T.,Acibadem Adana Hospital
European review for medical and pharmacological sciences | Year: 2012

To define the radiological imaging features and clinical findings of the patients with skeletal muscle metastasis. 4454 computed tomography (CT), 1802 magnetic resonance imaging (MRI) and 2569 positron emission tomography/computed tomography (PET/CT) imaging studies of the oncology patients performed between March 2009 and July 2012 in the Radiology and Nuclear Medicine Departments of our hospital were retrospectively reviewed. Fifty-two patients had 91 different metastatic skeletal muscle masses. Twenty-one patients (40%) were diagnosed with lung carcinoma as being the most common primary source. Forty-seven patients (90%) had metastatic disease somewhere else at the time of detection of skeletal muscle metastasis. Thirty-three patients (63%) had lymph node metastasis which was the most common site. Muscles mostly affected by metastatic disease were gluteals (15%), psoas (8.7%), erector spinae (8.7%), rectus abdominis (7.6%), latissimus dorsi (6.5%). The mean size of the lesions was 30 mm (range, 10-120 mm). The most common appearance on contrast-enhanced CT was a rim-enhancing intramuscular mass with central hypoattenuation. On MRI, skeletal muscle metastases mostly revealed isointense signal on T1-weighted images, heterogeneous high signal with peritumoral edema on T2-weighted images and extensive enhancement with central necrosis on gadolinium-DTPA (diethylene triamine pentaacetic acid) enhanced images. Skeletal muscle metastasis may be an incidental finding on CT. The most common CT appearance is a rim-enhancing intramuscular mass with central hypoattenuation. On MRI, extensive tumoral enhancement, central necrosis and peritumoral edema are highly acceptable features of skeletal muscle metastasis.

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