AcharyaNagarjuna University

Guntūr, India

AcharyaNagarjuna University

Guntūr, India

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Karthick V.,AcharyaNagarjuna University | Kumar P.V.,UCSI University | Ali M.A.,Universiti Sains Malaysia
Letters in Drug Design and Discovery | Year: 2013

A series of 2-(substituted benzylidene)-7-(4-fluorophenyl)-5-(furan-2-yl)- 2H-thiazolo[3,2-a]pyrimidin-3(7H)- one derivatives were newly synthesized by the reaction of 7-(4-fluoro phenyl)-5-(furan-2-yl)-2H-thiazolo[3,2- a]pyrimidin-3(7H)-one (3) with appropriate substituted benzaldehyde in the presence of anhydrous sodium acetate and glacial acetic acid. Their structures were confirmed by IR, 1H NMR, mass and elemental analyses. These novel thiazolopyrimidine derivatives were screened for their antiepileptic activity by using MES: Maximal Electroshock Seizure test and ScPTZ: Subcutaneous pentylenetetrazole seizures tests. The neurotoxicity was determined by rotorod test. Among these compounds 4f revealed protection in MES at a dose of 30 mg kg-1 and 100 mg kg-1 0.5 h and 4 h after i.p. administration respectively. This molecule provided also protection in the scPTZ at a dose of 300 mg kg-1 in both time intervals. © 2013 Bentham Science Publishers.


Punugoti R.A.,Acharyanagarjuna University | Jupally V.R.,Acharyanagarjuna University
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: to develop and validate a new very rapid, sensitive, reverse phase Ultra Performance Liquid Chromatography (RP-UPLC) technique for the estimation of Olanzapine in dosage form, as there is no official monograph & no analytical method by UPLC. Methodology: Chromatographic separation was achieved on a Waters Acquity HSS T-3 C18 column (100 × 2.1 mm, 1.8μm) using an isocratic method with mobile phase composed of Potassium di-hydrogen phosphate: methanol in the ratio 60:40 v/v. The flow rate was 0.8 ml/min, temperature of the column was maintained at ambient and detection was made at 228 nm. The run time was as short as 6 min. The developed method was validated according to the International Conference on Harmonization (ICH) guidelines with respect to linearity, accuracy, precision, specificity and robustness. Results: The developed method was linear for Olanzapine from 10 - 50 μg/ml and the linear regression obtained was > 0.999. Precision, evaluated by intra- and inter-day assays had relative standard deviation (R.S.D) values within 1.5 %. Recovery data were in the range 98.2% to 100.9% with R.S.D. values < 1.5 %. Conclusion: The method is precise, accurate, linear, robust and fast. The short retention time of 2.433 min allows the analysis of a large number of samples in a short period of time and, therefore, should be cost-effective for routine analysis in the pharmaceutical industry.


Sastry S.S.,AcharyaNagarjuna University | Mallika K.,AcharyaNagarjuna University | Rao B.G.S.,AcharyaNagarjuna University | Tiong H.S.,University Tunku Abdul Rahman | Lakshminarayana S.,Koneru Lakshmaiah College of Engineering
Liquid Crystals | Year: 2012

Polarizing optical microscope with a hot stage and high-resolution camera was used to record the textures of 4-Cyano-4′-pentylbiphenyl (5CB) and p-ethoxybenzylidene-p-n-butylaniline (EBBA) liquid crystals. The homogeneity histogram method was used to analyse the textures of liquid crystals by considering local and global image information. An efficient peak detection algorithm was employed to identify the most significant peaks of the homogeneity histogram. This method is useful to identify uniform regions and detect defects in liquid crystal textures. © 2012 Copyright Taylor and Francis Group, LLC.


Vijayakumari B.,AcharyaNagarjuna University | Vengaiah P.C.,A.P.S. University | Kiranmayi P.,AcharyaNagarjuna University
International Journal of Pharma and Bio Sciences | Year: 2015

This study report the phytochemicals present in ethanolic extract of palmyra fruit pulp (PFP). Phytochemical screening of fruit pulp extract revealed the presence of saponins, flavonoids, phenolic compounds and glycosides. The extract was analyzed by Gas Chromatography-Mass Spectrometry (GC-MS) and 10 different compounds were identified. Well diffusion method was employed to determine the effect of antibacterial potential against Gram positive bacteria i.e., Staphylococcus aureus, Gram negative bacteria i.e., Escherichia coli.


Vijayakumari B.,AcharyaNagarjuna University | Vengaiah P.C.,A.P.S. University | Kiranmayi P.,AcharyaNagarjuna University
International Journal of Pharma and Bio Sciences | Year: 2015

To identify the presence of various amino acids in ethanolic extract of palmyra fruit pulp, HPTLC finger printing analysis was carried out. The analysis was carried out by using CAMAG LINOMAT5 instrument which revealed the presence of five amino acids especially alanine, valine, methionine, leucine and phenylalanine with Rf values 0.16, 0.21, 0.27, 0.35, 0.37. The concentration of phenylalanine was maximum (36.56 mg/100mg) and methionine was present in minimum concentration (1.49 mg/100 gm).


Chamundeswaramma K.V.,Sri Krishnadevaraya University | Das P.,Acharyanagarjuna University | Rathnamma V.V.,Acharyanagarjuna University | Philip G.H.,Sri Krishnadevaraya University
Ecology, Environment and Conservation | Year: 2010

Present investigation work Activity levels of Aspartate Transaminase (AAT) and Alanine Transaminase (ALAT) in freshwater fish Labeo rohita exposed to Deltamethrin. Aspartate and Alanine transaminases (AAT and ALAT) are widely distributed in the cells of all animals and serve to link the carbohydrate and protein metabolism, by interconverting dynamic substances. These two enzyme activity levels were estimated in lethal 1, 4 days and sublethal 1, 4 and 8 days concentrations in different tissues. In lethal concentrations activity was more than that of sublethal concentrations. Whereas in the sublethal concentration the increase of these parameters in the tissues of fish was more at day 4 and less at day 8 which was in the order 1 < 4 > 8 day. The activity levels were in order to gills > muscles > liver. Copyright@EM International.


Kereena C.H.,AcharyaNagarjuna University | Vishnuvardhan Z.,Acharyanagarjuna University | Raju D.S.,Government General Hospital | Neeraja M.,AcharyaNagarjuna University | Harsha Vardhan Y.,AcharyaNagarjuna University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Anemia is a common occurrence in patients with cancer. Aim of the study is to know the impact of anemia in cancer patients and the role of nutrition in the management of anemia in cancer patients. For this study 200 patients were selected. Nutritive values were calculated from various food groups, before, during and after diet counseling. In the present study 98% of the patients observed fall in low socioeconomic group (less than Rs5000/month), and 89% of them are illiterates. This indicates that economic status & illiteracy are major contributing factors to anemic condition in cancer patients. The patients are grouped under three categories based on the hemoglobin (HB) levels viz., that requires balanced iron rich food diet alone (HB above 10g/dl), Iron supplementation (HB 8g/dl to 10g/dl), Blood transfusion (below 8g/dl). Before diet counseling their hemoglobin levels were low compared to after diet counseling. Intake of suggested diet counseling regarding iron rich balanced diet improvement was observed substantially after diet counseling and iron supplementation period. After diet counseling their hemoglobin levels, mean nutrient intake of the cases were improved and the number that requires blood transfusion decreased. Guidelines for anemia management regarding diet modification, and consideration of further outcomes such as survival and cognitive function, may help to ensure that the cancer patient receives the best possible course of supportive care.

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