Machilipatnam, India

Acharya Nagarjuna University

www.nagarjunauniversity.ac.in
Machilipatnam, India

Acharya Nagarjuna University is a university in the region of Namburu, Guntur, Andhra Pradesh, India. It is one of the major universities in the country covering many colleges and institutes of districts in the region. It is located in Nagarjuna Nagar, Namburu on the Northern part of Guntur City, a major centre for learning in the state of Andhra Pradesh.The university is an outgrowth of a post-graduate centre of Andhra University, which was established in 1967 at Nallapadu area of Guntur and then relocated to Nambur/Kaza area on the east of the city. The centre gained affiliating university status in 1976 and opened with ten post-graduate courses. The university is named after Acharya Nagarjuna, the pro-founder of the Madhyamaka path of Mahayana Buddhism. Wikipedia.

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Sujana K.,Acharya Nagarjuna University
International Journal of PharmTech Research | Year: 2016

Salbutamol and Theophylline used for the treatment of respiratory diseases. A Simple, specific, accurate and precise Ultra-Violet spectroscopy method has been developed and validated for simultaneous determination of Salbutamol and Theophylline in bulk drugs and marketed formulation (tablets). The developed method involves solving of simultaneous equations using 0.1N NaOH as solvent where an absorbance maximum for Salbutamol and Theophylline was found to be at 242nm and 268nm respectively. Both the drugs obeyed Beer's law in the concentration range of 5- 25 µg/ ml & 3–19 µg/ ml. The developed method was validated as per ICH guidelines. The method showed good correlation coefficients (r2) 0.999, indicated good linearity of calibration curve for both the drugs. The recovery of Salbutamol and Theophylline was found to be 100.16% and 98.72% respectively. The developed method was found to be sensitive showing LOD 0.3 µg/ml for Salbutamol and 0.25 µg/ml for Theophylline and LOQ 0.9 µg/ml for Salbutamol and 0.75 µg/ml for Theophylline. The %RSD values for Robustness and Ruggedness was found to be within the acceptable limits indicating the method was robust. The methods were found to be better than previously reported methods because of lack of any extraction procedure, use of cheap solvent, no interferences during method development and time consuming and can be successfully applied for estimation of Salbutamol and Theophylline in Pharmaceutical dosage forms without any interference in Quality control. © 2016, Sphinx Knowledge House. All rights reserved.


Lopez D.,Institute for Scientific Research and Technology Services INDICASAT | Lopez D.,Acharya Nagarjuna University | Martinez-Luis S.,Institute for Scientific Research and Technology Services INDICASAT
Marine Drugs | Year: 2014

P-glycoprotein (P-gp) is a protein belonging to the ATP-binding cassette (ABC) transporters superfamily that has clinical relevance due to its role in drug metabolism and multi-drug resistance (MDR) in several human pathogens and diseases. P-gp is a major cause of drug resistance in cancer, parasitic diseases, epilepsy and other disorders. This review article aims to summarize the research findings on the marine natural products with P-glycoprotein inhibitor properties. Natural compounds that modulate P-gp offer great possibilities for semi-synthetic modification to create new drugs and are valuable research tools to understand the function of complex ABC transporters. © 2014 by the authors; licensee MDPI.


Lakey-Beitia J.,HIGH-TECH | Lakey-Beitia J.,Acharya Nagarjuna University | Berrocal R.,Acharya Nagarjuna University | Berrocal R.,HIGH-TECH | And 2 more authors.
Molecular Neurobiology | Year: 2015

Alzheimer’s disease (AD) is a complex and multifactorial neurodegenerative condition. The complex pathology of this disease includes oxidative stress, metal deposition, formation of aggregates of amyloid and tau, enhanced immune responses, and disturbances in cholinesterase. Drugs targeted toward reduction of amyloidal load have been discovered, but there is no effective pharmacological treatment for combating the disease so far. Natural products have become an important avenue for drug discovery research. Polyphenols are natural products that have been shown to be effective in the modulation of the type of neurodegenerative changes seen in AD, suggesting a possible therapeutic role. The present review focuses on the chemistry of polyphenols and their role in modulating amyloid precursor protein (APP) processing. We also provide new hypotheses on how these therapeutic molecules may modulate APP processing, prevent Aβ aggregation, and favor disruption of preformed fibrils. Finally, the role of polyphenols in modulating Alzheimer’s pathology is discussed. © 2014, Springer Science+Business Media New York.


Kala S.C.,Acharya Nagarjuna University
International Journal of Current Pharmaceutical Review and Research | Year: 2016

A large number of medicinal plants are explored from the natural flora for production of commercial drugs. Approximately 20% of the plants found in the world have been submitted to pharmacological or biological tests. Canthium parviflorum is an important medicinal plant used in indigenous system of medicine in India and abroad. To isolate and characterize biologically active molecules, many medicinal plants were screened. Though the medicinal importance of this plant is known, but the potential source of this plant for biologically active molecules is not known. So, the present review on Canthium parviflorum is opens a gateway to find out useful and novel drugs. © 2016 The Authors.


Suneetha Dr. K.,Acharya Nagarjuna University
International Journal of Pharmacy and Pharmaceutical Sciences | Year: 2012

Freshwater fish Labeo rohita was exposed to two pesticides i.e., endosulfan an organchlorine and fenvalerate a synthetic pyrethroid. The LC50 values determined for endosulfan and fenvalerate at 24 hrs were 0.6876, 0.4749 μgL-1 respectively. The 1/10th of 24 hrs, LC50 value of both the pesticides was selected as sublethal concentrations. The fish were exposed to lethal and sublethal concentrations for 24 hrs and 15 days and the changes in the carbohydrate metabolism such as total glycogen and the activities of enzymes Lactate Dehydrogenase (LDH), Succinate Dehydrogenase (SDH) and Malate Dehydrogenase (MDH) of vital organs such as brain, gill, kidney, liver and muscle were studied.


Gnaneswara Reddy M.,Acharya Nagarjuna University
Journal of Engineering Physics and Thermophysics | Year: 2015

The unsteady two-dimensional flow of a non-Newtonian fluid over a stretching surface with the effects of thermal radiation and variable thermal conductivity is investigated. The Casson fluid model is used to characterize the non- Newtonian fluid behavior. First, using a similarity transformation, the governing time-dependent partial differential equations are transformed into coupled nonlinear ordinary differential equations with variable coefficients. Then the transformed equations are solved numerically under appropriate boundary conditions by the shooting method. An exact solution corresponding to the momentum equation for a steady case is found. The obtained numerical results are analyzed as to the effect of the pertinent parameters on the flow and heat transfer characteristics. ©2015 Springer Science+Business Media New York.


Machireddy G.R.,Acharya Nagarjuna University
Ain Shams Engineering Journal | Year: 2013

The numerical solution of transient natural convection flow of radiation effects on MHD heat and mass transfer past a moving vertical cylinder with chemical reaction is presented. The governing boundary layer equations for the above flow problem of first-order homogeneous chemical reaction are setup and non-dimensionalized. An implicit finite difference method is used to solve the unsteady, non-linear, and coupled governing equations. Numerical results are presented for various parameters. The unsteady velocity, temperature, concentration profiles, local and average skin-friction, Nusselt number, and Sherwood number are shown graphically and are discussed for both generative and destructive reaction. © 2013 Ain Shams University. Production and hosting by Elsevier B.V. All rights reserved.


Rajyasree C.,Acharya Nagarjuna University | Rao D.K.,Acharya Nagarjuna University
Journal of Non-Crystalline Solids | Year: 2011

Transparent glasses of the composition 10RO.20Bi2O 3.(70 - x) B2O3.xCuO [R = Ca, Ba] with x = 0, 0.4, 0.8 (wt.%) were prepared via melt-quenching technique and characterized using X-ray powder diffraction. Spectroscopic measurements, viz., optical absorption, EPR, FTIR and photoluminescence (PL) were studied at room temperature. Analysis of the present investigations indicates that the concentration of luminescence centers of bismuth ions (Bi2+ ions in visible region) decreased by the integration of BaO and also by increasing dopent concentration. It is also observed that addition of CuO decreases stability of the glass network in calcium series and strengthens in barium series. © 2010 Elsevier B.V. All rights reserved.


This article concerns with a steady two-dimensional flow of an electrically conducting incompressible dissipating fluid over an inclined semi-infinite surface with heat and mass transfer. The flow is permeated by a uniform transverse magnetic field. A scaling group of transformations is applied to the governing equations. The system remains invariant due to some relations among the parameters of the transformations. After finding three absolute invariants, a third-order ordinary differential equation corresponding to the momentum equation, and two secondorder ordinary differential equations corresponding to energy and diffusion equations are derived. The coupled ordinary differential equations along with the boundary conditions are solved numerically. Comparisons with previously published work are performed and the results are found to be in very good agreement. Many results are obtained and a representative set is displayed graphically to illustrate the influence of the various parameters on the dimensionless velocity, temperature and concentration profiles. It is found that the velocity increases with an increase in the thermal and solutal Grashof numbers. The velocity and concentration of the fluid decreases with an increase in the Schmidt number. The results, thus, obtained are presented graphically and discussed.


An analytical study for the problem of mixed convection with thermal radiation and first-order chemical reaction on magnetohydrodynamics boundary layer flow of viscous, electrically conducting fluid past a vertical permeable surface embedded in a porous medium has been presented. Slip boundary condition is applied at the porous interface. The heat equation includes the terms involving the viscous dissipation, radiative heat flux, Ohmic dissipation, the internal absorption and absorption of radiation, whereas the mass transfer equation includes the effects of chemically reactive species of first order. The dimensionless governing equations for this investigation are formulated and the non-linear coupled differential equations are solved analytically using the perturbation technique. Comparisons with previously published work on special cases of the problem are performed and results are found to be in excellent agreement. The results obtained show that the velocity, temperature and concentration fields are appreciably influenced by the presence of magnetic field, thermal radiation, chemical reaction and Ohmic dissipation. It is observed that the effect of magnetic field, heat source and thermal radiation is to decrease the velocity, temperature profiles in the boundary layer. The effect of increasing the values of rarefaction parameter is to increase the velocity in the momentum boundary layer. Further, it is found that increasing the value of the chemical reaction decreases the concentration of species in the boundary layer. Also, the effects of the various parameters on the skin-friction coefficient, local Nusselt number and local Sherwood number at the surface are discussed. © Società Italiana di Fisica/Springer-Verlag 2014.

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