Columbia, MD, United States
Columbia, MD, United States

ACell, Incorporated is a Columbia, Maryland-based biotechnology company. They work in regenerative medicine, in which they own several valuable extracellular matrix patents. They develop, manufacture and market products for medical and veterinary applications. The company is founded by Alan R. Spievack, a former associate professor at Harvard Medical School and currently run by Jim Defrancesco.Their use of porcine cellular structure, called MatriStem, as a scaffold for human tissue regeneration was named the "medical breakthrough of the year" by Esquire. The use of pig bladder ground up into "magical pixie dust" to regrow Spievak's brother's finger received considerable mainstream coverage. Ken Muneoka of Tulane University, who works with ACell's scientific advisors on US-government funded investigations into regenerative medicine, said that the news should be viewed with caution because it was not a controlled study. Wikipedia.


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The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction, The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.


A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.


The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.


Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.


Patent
ACell | Date: 2015-02-04

A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.


A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.


Patent
ACell | Date: 2015-12-15

A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.


The present invention is directed to methods of manufacturing bioactive gels from ECM material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ECM material can be created by digesting particularized ECM material in an alkaline environment and neutralizing to provide bioactive gels.


Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.


The invention disclosed herein is directed to a porous wound healing foam composition that is made from an extracellular matrix of a mammal, method of making, and method of using.

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