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Torres V.M.,Pontifical Catholic University of Goias | Saddi V.A.,Pontifical Catholic University of Goias | Saddi V.A.,ACCG
Jornal de Pediatria | Year: 2015

Objectives This review aimed to organize and consolidate the latest knowledge about mutations and genetic polymorphisms related to hereditary thrombophilia and their potential association with pediatric stroke and cerebral palsy (CP). Sources Scientific articles published from 1993 to 2013, written in Portuguese, English, French, and Spanish, were selected and reviewed. The publications were searched in electronic databases, and also in the collections of local libraries. The terms "hereditary thrombophilia", "polymorphisms", "mutation", "pediatric strokes", and "cerebral palsy" were used for the research. Summary of the findings The search in databases and in the bibliographic references retrieved 75 articles for inclusion in this review. Studies that investigated hereditary thrombophilias and their associations to CP and arterial and venous pediatric stroke presented contradictory results. The meta-analysis and case-control studies that showed positive results for this association described only slightly increased relative risks and sometimes had questionable conclusions. The association of two or more hereditary thrombophilias, or the association between thrombophilia and other specific clinical risk factors, suggest a higher risk of CP and pediatric stroke than isolated hereditary thrombophilia. Conclusions Larger, multicenter studies should be developed in order to elucidate the role of mutations leading to hereditary thrombophilia and the development of CP and pediatric stroke. The complex and multifactorial etiology of CP and stroke makes this an arduous and difficult task; however, the benefits generated by these studies are immeasurable. © 2014 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved. Source


Reis A.A.S.,Pontifical Catholic University of Goias | de Paula L.B.,University of Sao Paulo | de Paula A.A.P.,ACCG | Saddi V.A.,Pontifical Catholic University of Goias | da Cruz A.D.,Replicon
Ciencia e Saude Coletiva | Year: 2010

The general objective of this article is to review the current literature regarding the epidemiology, biological behavior and risk factors for penile cancer development, such as HPV infection. Phimosis and chronic irritation related to poor hygiene are commonly associated with penile cancer, whereas neonatal circumcision reduces the relative risk for the disease. There is strong evidence that HPV types 16 and 18 are associated with penile carcinoma in as many as 50% of cases. Patients with penile lesions should undergo physical examination, which is often sufficient to diagnose and to define tumor stagging, as well as contributes to decision-making regarding therapeutical approaches and case management. Source


Sandes A.F.,Grupo Fleury | de Castro I.N.,ACCG | Miura T.E.,Grupo Fleury | Maekawa Y.H.,Grupo Fleury | And 3 more authors.
Journal of Hematopathology | Year: 2011

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a clinically aggressive hematologic malignancy derived from clonal proliferation of plasmacytoid dendritic cells. The disease has two patterns of presentation: cutaneous and leukemic. Herein we describe the case of a 9-year-old boy who presented with an unusual morphologic variant of leukemic BPDCN, showing bone marrow infiltration by medium to large cells with eccentric nuclei, regular round to oval shape, finely dispersed chromatin, one or more distinct nucleoli, and abundant basophilic cytoplasm, forming a pattern that resembled plasmablasts. Multiparameter flow cytometric immunophenotyping confirmed the diagnosis of BPDCN by identifying the expression of CD4++, CD56++, HLA-DR+++, and CD123+++ in abnormal cells, without significant expression of myeloid or lymphoid lineage-specific markers. Awareness of this plasmablastic variant of BPCDN can be helpful for directing the flow cytometry panel and the subsequent investigation of patients presenting with bone marrow infiltration by cells with plasmablastic features. © 2011 Springer-Verlag. Source


This study assessed the reliability of cancer as the underlying cause of death using probabilistic linkage between the Mortality Information System and Population-Based Cancer Registry (PBCR) in Goiânia, Goiás State, Brazil, from 2000 to 2005. RecLink III was used for probabilistic linkage, and reliability was assessed by Cohen's kappa and prevalence-adjusted and biasadjusted kappa (PABAK). In the probabilistic linkage, 2,874 individuals were identified for the reliability analysis. Cohen's kappa ranged from 0.336 to 0.846 and PABAK from 0.810 to 0.990 for 14 neoplasm groups defined in the study. For reliability of the 35 leading cancers, 12(34.3%) presented kappa values under 0.600 and PABAK over 0.981. Among the neoplasms common to both sexes, crude agreement ranged from 0.672 to 0.790 and adjusted agreement from 0.894 to 0.961. Sixty-seven percent of cases classified by the Mortality Information System as "cancer of ill-defined sites" were reclassified according to the PBCR. This study was useful for the classification of cancer mortality estimates in areas covered by the PBCR. Source


Freitas Jr. R.,Federal University of Goais | Gonzaga C.M.R.,Federal University of Goais | Freitas N.M.A.,ACCG | Martins E.,ACCG | Dardes R.C.M.,University of Sao Paulo
Clinics | Year: 2012

Objective: To describe the temporal trends in female breast cancer mortality rates in Brazil in its macro-regions and states between 1980 and 2009. Methods: This was an ecological time-series study using data on breast cancer deaths registered in the Mortality Data System (SIM/WHO) and census data on the resident population collected by the Brazilian Institute of Geography and Statistics (IBGE/WHO). Joinpoint regression analyses were used to identify the significant changes in trends and to estimate the annual percentage change (APC) in mortality rates. Results: Female breast cancer mortality rates in Brazil tended to stabilize from 1994 onward (APC = 0.4%). Considering the Brazilian macro-regions, the annual mortality rates decreased in the Southeast, stabilized in the South and increased in the Northeast, North, and Midwest. Only the states of Sao Paulo (APC = -1.9%), Rio Grande do Sul (APC = -0.8%) and Rio de Janeiro (APC = -0.6%) presented a significant decline in mortality rates. The greatest increases were found in Maranhao (APC=12%), Paraiba (APC=11.9%), and Piaui (APC=10.9%). Conclusion: Although there has been a trend toward stabilization in female breast cancer mortality rates in Brazil, when the mortality rate of each macro-region and state is analyzed individually, considerable inequalities are found, with rate decline or stabilization in states with higher socioeconomic levels and a substantial increase in those with lower socioeconomic levels. © 2012 CLINICS. Source

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