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Zhang L.,Shenyang Pharmaceutical University | Liu M.-S.,Academy of South Medicine and Li Medicine of Hainan Province | Huang J.,Shenyang Pharmaceutical University | Li G.-Y.,Shihezi University | And 5 more authors.
Journal of Asian Natural Products Research | Year: 2014

A new 3,4-seco-labdane diterpenoid, 3,4-seco-12R,13S-dihydroxy-4(18),8(17), 14(15)-labdatrien-3-oic acid (1), was isolated from the leaves of Callicarpa nudiflora. The structure of 1 was elucidated by 1D NMR, 2D NMR and HRESIMS data, and confirmed by single-crystal X-ray diffraction analysis. 3,4-seco-12R,13S-Dihydroxy-4(18),8(17),14(15)-labdatrien-3-oic acid (1) exerted inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by lipopolysaccharide. © 2013 Taylor & Francis.


Dong L.,Hainan Medical University | Li Y.-M.,Shenyang Pharmaceutical University | Wang J.-H.,Shenyang Pharmaceutical University | Liu M.-S.,Academy of South Medicine and Li Medicine of Hainan Province
Chinese Traditional and Herbal Drugs | Year: 2014

Objective: To study the chemical constituents of Li medicine Lihua Bidou Yan prescription. Methods: Chemical constituents were isolated by using various column chromatography. The structures were elucidated on the basis of physicochemical constants and spectral analysis. The anti-inflammatory activities of compound 1 were evaluated using LPS-induced RAW 264.7 cells. Results: Two compounds were obtained from Lihua bidou yan Prescription and identified as rhyncoside A-4-methly ether (1) and rhyncoside C (2), respectively. The NO production in LPS-induced RAW264.7 cells was slightly inhibited by compound 1 at a concentration of 50 μmol/L. Conclusion: Compound 1 is a new phenolic glycoside; Compound 2 is obtained from the prescription for the first time. Rhyncoside A-4-methyl ether has anti-inflammatory activity. ©, 2014, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.


Dong L.,Hainan Medical College | Zhang X.-P.,Hainan Medical College | Liu M.-S.,Academy of South Medicine and Li Medicine of Hainan Province | Li Y.-M.,Shenyang Pharmaceutical University | And 2 more authors.
Journal of Asian Natural Products Research | Year: 2013

Two new ent-3,4-seco-labdane diterpenoids, methylcallicarpate (1) and callicarpic acid (2), were isolated from the leaves of Callicarpa nudiflora Hook et Arn. Their structures and relative configurations were established by analysis of spectroscopic data. Their absolute configurations were assigned by the application of the CD technique for the first time among the ent-3,4-seco-labdane-type diterpenes. © 2013 Copyright Taylor and Francis Group, LLC.


Zhang L.,Shenyang Pharmaceutical University | Huang J.,Shenyang Pharmaceutical University | Liu M.,Academy of South Medicine and Li Medicine of Hainan Province | Zhang C.,Shenyang Pharmaceutical University | And 5 more authors.
Heterocycles | Year: 2013

Two new ent-3,4-seco-labdane diterpenoids, ent-3,4-seco-16-hydroxy-12,15- epoxy-4(18),8(17),12,14-labdatetraen-3-oic acid (1) and ent-3,4-seco-12R,15- epoxy-4(18),8(17),13-labdatrien-3-oic acid (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by extensive spectroscopic analysis and the biosynthetic pathways leading to these compounds were proposed. The two compounds both exerted potent inhibitory activity against the production of nitric oxide (NO) in RAW264.7 stimulated by lipopolysaccharide (LPS). © 2013 The Japan Institute of Heterocyclic Chemistry.


Dong L.,Hainan Medical University | Zhang L.,Shenyang Pharmaceutical University | Zhang X.,Hainan Medical University | Liu M.,Academy of South Medicine and Li Medicine of Hainan Province | And 2 more authors.
Phytochemistry Letters | Year: 2014

Two new 3,4-seco-labdane diterpenoids, callicarpaolide (1) and callicarpic acid A (2) were isolated from the leaves of Callicarpa nudiflora. Their structures were elucidated by 1D and 2D NMR spectroscopy and high resolution mass spectrometry. The absolute configuration of 1 was assigned by the application of the CD technique. Compounds 1 and 2 showed potent inhibitory activity against the production of nitric oxide (NO) in LPS-activated macrophage cell line, RAW 264.7 cells. © 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

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