Academy of Scientific & Innovative Research

Delhi, India

Academy of Scientific & Innovative Research

Delhi, India
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Thakur V.,CSIR - Central Electrochemical Research Institute | Thakur V.,Academy of Scientific & Innovative Research | Sharma D.,CSIR - Central Electrochemical Research Institute | Das P.,CSIR - Central Electrochemical Research Institute | Das P.,Academy of Scientific & Innovative Research
Molecular Diversity | Year: 2016

Abstract: Ethyl 3-(2,4-dioxocyclohexyl)propanoate has been explored as a precursor for the synthesis of N-substituted 4,4a,5,6-tetrahydroquinoline-2,7(1H,3H)-diones following conventional protecvtion, selective amidation, and deprotective-cyclization approaches. Moreover, a facile process for the selective dehydrogenative aromatization of these diones was developed to afford the corresponding N-substituted 3,4-dihydro-7-hydroxyquinolin-2(1H)-ones and N-substituted 7-hydroxyquinolin-2(1H)-ones under mild conditions. Graphical Abstract: [Figure not available: see fulltext.] © 2015, Springer International Publishing Switzerland.


Ratha S.,Indian Institute of Technology Bhubaneswar | Samantara A.K.,CSIR - Institute of Minerals And Materials Technology | Samantara A.K.,Academy of Scientific & Innovative Research | Rout C.S.,Indian Institute of Technology Bhubaneswar | And 2 more authors.
Journal of Solid State Electrochemistry | Year: 2016

The non-precious metal catalysts and their hybrids have drawn a substantial attention towards the energy conversion and storage application. In this report, we have demonstrated the electrocatalytic activity of a hybrid comprising of ZnCo2O4 (ZCO) spheres and reduced graphene oxide (RGO) in an alkaline medium consisting of 0.1 M KOH solution which showed an onset potential of −0.02 V vs. Ag/AgCl and reduction peak at −0.22 V vs. Ag/AgCl, depicting its impressive catalytic activity towards oxygen reduction reaction (ORR) and thus having the potential to be used as a high-performance cathode catalyst in a typical fuel cell. © 2015, Springer-Verlag Berlin Heidelberg.


Geesala R.,Indian Institute of Chemical Technology | Geesala R.,Academy of Scientific & Innovative Research | Gangasani J.K.,Indian Institute of Chemical Technology | Gangasani J.K.,National Institute of Pharmaceutical Education and Research | And 7 more authors.
European Journal of Medicinal Chemistry | Year: 2016

A series of twenty-five 2-azitidinone (β-lactam) derivatives were synthesized and evaluated for anti-cancer properties against breast cancer, MCF-7 and MDA-MB-231. These β-lactam derivatives depicted significant cytotoxicity in cancer cell lines but not in normal human mammary epithelial cells, MEpiC. Interestingly, derivatives of 2-bromo ethyl acrylonitrile (19w) exhibited - potent anti-proliferative activity with IC50, 5.79 ± 0.01 μM in MCF-7 and 6.86 ± 0.009 μM in MDA-MB-231. In addition, an increased expression of pro-apoptotic genes (p53, Bax, Bid) as well as decreased mRNA expression of cyclins D1, E and Cdk 2, 6 along with cell cycle arrest at G1 phase was observed. 19w treatment has shown higher percentage of Annexin-positive cells indicating induction of apoptosis. Further, docking studies confirmed an interaction between 19w and ATP-binding catalytic site of AKT1. Mechanistically, 19w depicted dose-dependent decrease in phosphorylation of AKT and GSK-3β and significant decrease in AKT kinase activity. In conclusion, β-lactam derivative 19w is a potential anti-breast cancer therapeutic candidate targeting cell survival pathway (AKT/GSK3β). © 2016 Elsevier Masson SAS


Chandra V.,Academy of Scientific Innovative Research | Tiwari U.,Council of Scientific and Industrial Research Central Scientific Instruments Organization | Das B.,Council of Scientific and Industrial Research Central Scientific Instruments Organization
IEEE Sensors Journal | Year: 2016

Fiber Mach-Zehnder interferometers (F-MZI) are widely used for fiber Bragg grating (FBG) sensor interrogation purpose due to their advantages in terms of wide bandwidth, high resolution, and tunable sensitivity. They are appropriate for dynamic strain measurement applications in the areas of vibration analysis, hydrophones, and acoustic emission studies. The interferometer converts the Bragg wavelength shift of an FBG sensor into a corresponding phase shift which is finally recorded as intensity variations at the output. Power fluctuations of the light source as well as disturbances in the light guiding path and/or dependence of light source intensity on wavelength introduce fictitious output intensity variations resulting into significant measurement errors. We propose and experimentally demonstrate a dual-channel F-MZI approach that eliminates the light intensity disturbance noise. Furthermore, the proposed method also improves the demodulated signal quality by a factor of ∼3 dB. © 2016 IEEE.


Ratha S.,Indian Institute of Technology Bhubaneswar | Samantara A.K.,CSIR - Institute of Minerals And Materials Technology | Samantara A.K.,Academy of Scientific & Innovative Research | Rout C.S.,Indian Institute of Technology Bhubaneswar | And 2 more authors.
Journal of Solid State Electrochemistry | Year: 2015

The non-precious metal catalysts and their hybrids have drawn a substantial attention towards the energy conversion and storage application. In this report, we have demonstrated the electrocatalytic activity of a hybrid comprising of ZnCo2O4 (ZCO) spheres and reduced graphene oxide (RGO) in an alkaline medium consisting of 0.1 M KOH solution which showed an onset potential of −0.02 V vs. Ag/AgCl and reduction peak at −0.22 V vs. Ag/AgCl, depicting its impressive catalytic activity towards oxygen reduction reaction (ORR) and thus having the potential to be used as a high-performance cathode catalyst in a typical fuel cell. © 2015 Springer-Verlag Berlin Heidelberg


Pal R.K.,Academy of Scientific & Innovative Research | Pal R.K.,CSIR - Central Electrochemical Research Institute | Garg H.,CSIR - Central Electrochemical Research Institute | Sarepaka R.V.,CSIR - Central Electrochemical Research Institute | Karar V.,CSIR - Central Electrochemical Research Institute
Materials and Manufacturing Processes | Year: 2016

It has been a challenge to finish optical glass surfaces due to their hard and brittle nature. Moreover, tight tolerances of surface figure and finish make polishing a more critical operation. This work reports the results of an experimental study performed for full aperture polishing of BK7 optical glass. Flat samples of borosilicate (BK7) glass are polished using an optical pitch polisher and cerium oxide (CeO2) slurry. Taguchi's L9 orthogonal array is used for the design of experiments. Abrasive concentration, pressure and overarm speed are considered as variable process parameters. Polishing is performed for duration of 120 minutes for each combination of parameters. Material removal is measured using the precision weighing balance. Surface roughness was measured using a Form Talysurf PGI 120 profiler. Abrasive slurry concentration is observed to be one of the most significant parameters in the optical polishing process. It affects both the material removal rate (MRR) and the surface roughness. Pressure applied at the workpiece–polisher interface affects the MRR, but the variation of pressure is not found to affect the surface roughness significantly. Relative motion at the workpiece–polisher interface is also observed to be significant in defining the final polishing outputs. © Taylor & Francis Group, LLC.


PubMed | Academy of Scientific & Innovative Research
Type: Journal Article | Journal: Nanoscale | Year: 2015

Graphene quantum dots (GQDs) are a promising category of materials with remarkable size dependent properties like tunable bandgap and photoluminescence along with the possibility of effective chemical functionalization. Doping of GQDs with heteroatoms is an interesting way of regulating their properties. Herein, we report a facile and scalable one-step synthesis of luminescent GQDs, substitutionally co-doped with N, F and S, of 2 nm average size by a microwave treatment of multi-walled carbon nanotubes in a customized ionic liquid medium. The use of an ionic liquid coupled with the use of a microwave technique enables not only an ultrafast process for the synthesis of co-doped GQDs, but also provides excellent photoluminescence quantum yield (70%), perhaps due to the interaction of defect clusters and dopants.

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