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Das R.H.,CSIR - Central Electrochemical Research Institute | Ahirwar R.,CSIR - Central Electrochemical Research Institute | Ahirwar R.,Academy of Scientific and Innovative Research Anusandhan Bhawan | Kumar S.,CSIR - Central Electrochemical Research Institute | And 2 more authors.
Nucleosides, Nucleotides and Nucleic Acids | Year: 2016

Herein we report microwave-induced enhancement of the reactions catalyzed by Escherichia coli DNA polymerase I and avian myeloblastosis virus-reverse transcriptase. The reactions induced by microwaves result in a highly selective synthesis of nucleic acids in 10–50 seconds. In contrast, same reactions failed to give desired reaction products when carried out in the same time periods, but without microwave irradiation. Each of the reactions was carried out for different duration of microwave exposure time to find the optimum reaction time. The products produced by the respective enzyme upon microwave irradiation of the reaction mixtures were identical to that produced by the conventional procedures. As the microwave-assisted reactions are rapid, microwave could be a useful alternative to the conventional and time consuming procedures of enzymatic synthesis of nucleic acids. © 2016 Taylor & Francis Group, LLC.


Ghosh P.,Indian Central Mechanical Engineering Research Institute | Saha S.K.,Indian Central Mechanical Engineering Research Institute | Saha S.K.,Academy of Scientific and Innovative Research Anusandhan Bhawan | Roychowdhury A.,Indian Central Mechanical Engineering Research Institute | And 3 more authors.
European Journal of Inorganic Chemistry | Year: 2015

Two luminescent MOFs, Zn-NDC and Cd-NDC (NDC = 2,6-naphthalenedicarboxylate), which are capable of sensing 2,4,6-trinitrophenol (TNP) and similar explosives and mutagens, are reported. Of these two MOFs, Zn-NDC shows better response in sensing nitroaromatics like TNP and 4-nitrobenzoic acid (4-NBA). Compared to Zn-NDC, Cd-NDC is more selective in the detection of explosive and pollutant nitroaromatics (epNACs). Cd-NDC is a selective TNP sensor over several other tested epNACs: 2,6-dinitrotoluene (2,6-DNT), nitrobenzene (NB), 4-NBA, 1,3-dinitrobenzene (1,3-DNB), 3,4-dinitrotoluene (3,4-DNT), and 2,4,6-trinitrotoluene (TNT). For both d10-NDC MOFs, TNP sensitivity is supported by fluorescence quenching. The experiments have been carried out with deionized water as well as various other environmental water specimens collected from several parts of West Bengal, India. Spectroscopic results are further supported by theoretical DFT calculations. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Venkateswarlu V.,Indian Institute of Integrative Medicine | Venkateswarlu V.,Academy of Scientific and Innovative Research Anusandhan Bhawan | Aravinda Kumar K.A.,Indian Institute of Integrative Medicine | Gupta S.,Indian Institute of Integrative Medicine | And 7 more authors.
Organic and Biomolecular Chemistry | Year: 2015

A novel and efficient I2/DMSO mediated metal-free strategy is presented for the direct C-C bond cleavage of aryl-/heteroaryl- or aliphatic α-ketoaldehydes by C2-decarbonylation and C1-carbonyl oxidation to give the corresponding carboxylic acids followed by esterification in one pot, offering excellent yields in both the steps. Here, DMSO acts as the oxygen source/oxidant and this reaction works very well under both conventional heating and microwave irradiation. This is a very simple and convenient protocol. This journal is © The Royal Society of Chemistry.


Sharan C.,CSIR - National Chemical Laboratory | Sharan C.,Academy of Scientific and Innovative Research Anusandhan Bhawan | Khandelwal P.,CSIR - National Chemical Laboratory | Khandelwal P.,Academy of Scientific and Innovative Research Anusandhan Bhawan | And 2 more authors.
RSC Advances | Year: 2015

Since the last decade, eco-friendly routes for the synthesis of nanostructured materials of various types and functionalities have been a topic of enormous interest in the field of nanotechnology. The primary work in this field started with the 'bottom-up' microbial synthesis of nanoparticles, however, the bioleaching potential of microbes was initially overlooked in this research. The bioleaching process is useful especially where the synthesis of particles with size < 10 nm is challenging. In the present work, the mechanistic insight of biomilling for a gradual transformation of anisotropic α-FeO(OH) rod-shaped particles into isotropic nanoparticles below 10 nm size has been explored using detailed UV-vis spectroscopy, transmission electron microscopy, atomic force microscopy, X-ray diffraction, and X-ray photoelectron spectroscopic studies which suggest that the aquo group present at the α-FeO(OH) surface may provide the site for interaction with carboxyl ions of protein molecules which results in the formation of a stable coordination compound with Fe3+ ions. This will create a new Fe3+ ion on the surface of the lattice which leads to the repetition of the process of protein complexation with Fe3+ ions and dissociation of the complex from the lattice that causes the fragmentation of bigger nanoparticles into protein functionalized smaller nanoparticles. © The Royal Society of Chemistry 2015.

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