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Osaki T.,Kanagawa Academy Of Science And Technology | Osaki T.,University of Tokyo | Osaki T.,Academy of Science and Technology | Kamiya K.,Kanagawa Academy Of Science And Technology | And 3 more authors.
Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) | Year: 2014

This paper describes a batch release technique for monodisperse liposomes immobilized on a substrate (Fig. 1). A single short-time pulsed voltage to the substrate induced detachment of the arrayed liposomes previously developed. Simultaneous release was observed shortly after the electrical stimulation. The release technique produced monodisperse and solvent-free liposomes freely suspended on the substrate, and allowed manipulation of the liposomes. The technique extends the application of our liposome array platform regarding collection/selection of the liposomes interested. © 2014 IEEE. Source


Gu J.F.,Ecole Polytechnique de Montreal | Grmela M.,Ecole Polytechnique de Montreal | Bousmina M.,Academy of Science and Technology
Journal of Non-Newtonian Fluid Mechanics | Year: 2010

Doi-Ohta rheological model of immiscible blends is extended by replacing the fluid interface with an elastic membrane. A symmetric tensor characterizing the in-membrane deformations joins the surface area and the orientation tensor (used in the Doi-Ohta theory) to provide morphological state variables. The governing equations of the model are solved numerically and the morphological and rheological predictions are presented. As an illustration, we regard the model as a first step in mesoscopic rheological modeling of suspensions of red blood cells. The material properties of the membrane enclosing the red blood cells, that are inferred from rheology, are indeed found to be close to the ones seen in direct experimental measurements. A more realistic model of human blood has to include additional morphological state variables describing larger structures (in particular whole red blood cells). © 2009 Elsevier B.V. All rights reserved. Source


Chen Y.,Jiangnan University | Wang Y.,Academy of Science and Technology | Liu L.,Jiangnan University | Wu X.,Jiangnan University | And 4 more authors.
Nanoscale | Year: 2015

A novel gold immunochromatographic assay (GICA) based on anti-β-lactam receptors was innovatively developed that successfully allowed rapid and simultaneous detection of fifteen β-lactams in milk samples in 5-10 minutes. By replacing the antibodies used in traditional GICA with anti-β-lactam receptors, the difficulty in producing broad specific antibodies against β-lactams was overcome. Conjugates of ampicillin with BSA and goat anti-mouse immunoglobulin (IgG) were immobilized onto the test and control lines on the nitrocellulose membrane, respectively. Since goat anti-mouse IgG does not combine with receptors, negative serum from mice labelled with gold nanoparticles (GNP) was mixed with GNP-labelled receptors. Results were obtained within 20 min using a paper-based sensor. The utility of the assay was confirmed by the analysis of milk samples. The limits of detection (LOD) for amoxicillin, ampicillin, penicillin G, penicillin V, cloxacillin, dicloxacillin, nafcillin, oxacillin, cefaclor, ceftezole, cefotaxime, ceftiofur, cefoperazone, cefathiamidine, and cefepime were 0.25, 0.5, 0.5, 0.5, 1, 5, 5, 10, 25, 10, 100, 10, 5, 5, and 2 ng mL-1, respectively, which satisfies the maximum residue limits (MRL) set by the European Union (EU). In conclusion, our newly developed GICA-based anti-β-lactam receptor assay provides a rapid and effective method for one-site detection of multiple β-lactams in milk samples. © The Royal Society of Chemistry. Source


Dong H.,Chongqing University | Dong H.,Academy of Science and Technology | Pan F.,Chongqing University | Pan F.,Academy of Science and Technology | And 4 more authors.
Materials and Design | Year: 2015

Mg-3Li and Mg-3Li-2Zn alloys were prepared by metal model casting method and extruded at 573. K with the extrusion ratio of 79, and samples of both cast alloys were also conducted to compression with ratios of 5% and 10%. Microstructures and mechanical properties were evaluated. The results showed that both the Zn element and the extruding were beneficial to microstructures and mechanical properties of Mg-3Li alloy. Zn addition has also affected the solidification style of the as-cast hexagonal Mg-Li alloy and resulted in the alteration of the texture. There was a descent of the gradient of the linear sections in each compressive strain-stress curve of the as-cast alloys at the strain of about 10%. This was attributed to the presentation of {10-11} compression twins, which presented after {10-12} tension twins. © 2014 Elsevier Ltd. Source

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