The Academy of science and Arts of Bosnia and Herzegovina

Sarajevo, Bosnia and Herzegovina

The Academy of science and Arts of Bosnia and Herzegovina

Sarajevo, Bosnia and Herzegovina
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Zerem E.,University of Tuzla | Zerem E.,The Academy of science and Arts of Bosnia and Herzegovina | Selmanovic K.,University of Sarajevo | Kunosic S.,University of Tuzla | And 4 more authors.
European Geriatric Medicine | Year: 2017

Background/Aim: Percutaneous cholecystostomy (PC) has been effectively used for the treatment of acute cholecystitis (AC) for patients unfit for early cholecystectomy. This study investigates the recurrence rate after successful PC and factors associated with recurrence. Patients and methods: This was a retrospective descriptive review of the medical records of 71 patients that underwent PC for AC at a single institution between 2000 and 2016. Primary outcome was relief of cholecystitis and need for later cholecystectomy after successful PC. Secondary outcomes were hospital stay, catheter dwell-time, catheter problems and complications following the procedure. We used multivariable logistic regression analysis sequentially to identify factors associated with each outcome. Results: PC was initially successful and symptoms disappeared within 96. hours in all patients. In total, 67 of 71 (94.4%) patients had recovered by PC only and were discharged. During follow-ups, 7 patients succumbed to their underlying diseases (unrelated to AC) and they were not included into analyses since they did not survive one year after successful intervention. The one-year recurrence rate was 23.3% (14/60). Perforation of the gallbladder, presence of bile duct stones, C-reactive protein, hospital stay and catheter dwell-time positively correlated (P <. 0.05) with one-year recurrence. Hospital stay and catheter dwell-time were 16.8. ±. 6.3 and 19.1. ±. 9.8 days, respectively. Conclusion: Patients with AC were promptly relieved from their symptoms following PC. The one-year recurrence rate was relatively low after successful PC. Predictors for recurrence included the severity of initial AC and subsequently provided treatments. © 2017 Elsevier Masson SAS and European Union Geriatric Medicine Society.


PubMed | University of Tuzla, Cantonal Hospital Dr Safet Mujic, The Academy of science and Arts of Bosnia and Herzegovina, Medical Center Plava Poliklinika and University of Mostar
Type: Journal Article | Journal: Journal of thrombosis and haemostasis : JTH | Year: 2016

Essentials D-dimer could provide important information about abdominal aortic aneurysm (AAA) progression. The greatest diameter of the infrarenal aorta and the value of plasma D-dimer were determined. AAA progression is correlated with increasing plasma D-dimer levels. The increasing value of plasma D-dimer could be a predictor of aneurysm progression.Background The natural course of abdominal aortic aneurysm (AAA) is mostly asymptomatic and unpredictable. D-dimer could provide potentially important information about subsequent AAA progression. Objectives The aims of this study were to establish the relationship between the progression of an abdominal aortic aneurysm (AAA) and plasma D-dimer concentration over a 12-month period and determine the value of plasma D-dimer in patients with sub-aneurysmal aortic dilatation. Patients/Methods This was a prospective observational study that involved 33 patients with an AAA, 30 patients with sub-aneurysmal aortic dilatation and 30 control subjects. The greatest diameter of the infrarenal aorta, which was assessed by ultrasound, and the value of plasma D-dimer were determined for all subjects at baseline assessment, as well as after 12 months for those with an AAA. Results A positive correlation was found between the diameter of an AAA and plasma D-dimer concentration at the baseline and the control measurement stages. There was a strong positive correlation between AAA progression and increasing plasma D-dimer concentration over a 12-month period. Among patients with sub-aneurysmal aortic dilatation (n = 30), the value of plasma D-dimer was higher compared with matched controls (n = 30). Conclusions There is a strongly positive correlation between AAA progression and increasing plasma D-dimer concentration. The value of plasma D-dimer is higher in patients with sub-aneurysmal aortic dilatation than in control subjects.

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