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Dharsana J.N.,Academy of Pharmaceutical science
International Journal of Pharma and Bio Sciences | Year: 2015

To evaluate the preliminary phytochemical and anti-inflammatory activities of various extracts of Morinda umbellata. Morinda umbellata (Family-Rubiaceae) commonly known as Ney-Valli in Malayalam, found in Southern Western Ghats. The present study aimed at preliminary evaluation of phytochemical and anti- inflammatory study of ethanol and aqueous extracts of Morinda umbellata by in vitro HRBC membrane stabilizing activity. Ethanol and aqueous extracts of Morinda umbellata were found to have significant anti-inflammatory activity. The ethanol and aqueous extract of Morinda umbellata showed potent anti-inflammatory activity when comparing with the standard drug Indomethacin, perhaps due to the presence of secondary metabolites like alkaloids, steroids, flavonoids, phenols and saponins. Source

Jose S.,Mahatma Gandhi University | Fangueiro J.F.,Fernando Pessoa University | Smitha J.,Mahatma Gandhi University | Cinu T.A.,Mahatma Gandhi University | And 4 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2012

Insulin-loaded chitosan microspheres were engineered by emulsion cross-linking method using glutaraldehyde as cross-linker. Taguchi orthogonal method was applied to optimize the production time and reduce the number of experiments required to obtain an optimized formulation. Three variables were evaluated, i.e. chitosan and glutaraldehyde concentrations, and cross-linking time at three levels. The dependent variables were the mean particle size and the encapsulation efficiency. The optimal formulation was obtained with chitosan 3% (w/v), glutaraldehyde 3.5% (v/v), and cross-linking time of 5. h, characterized by microspheres with a mean particle size of 29.5 μm, and insulin encapsulation efficiency of 71.6 ± 1.3%. In vivo studies were carried out using male Wistar albino rats, revealing a significant reduction in blood glucose level after administration of the optimized formulation, in comparison to a subcutaneous insulin injection. Chitosan microspheres were superior in terms of sustaining protein release over conventional insulin therapy. © 2011 Elsevier B.V. Source

Shirwaikar A.,Gulf Medical University | Devi S.,Pariyaram Medical College | Rajagopal P.L.,Academy of Pharmaceutical science | Kiron S.S.,Academy of Pharmaceutical science | Sreejith K.R.,Academy of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2014

Objective: To develop and validate a simple, precise and sensitive extractive spectrophotometric method for the assay of Donepezil HCl in pure and pharmaceutical preparations. Method: It is based on the formation of ion-pair complex between the drug and Bromo cresol purple in phthalate buffer solution. The formed complex was extracted with chloroform and measured at 410 nm. Results: Beer's law was obeyed in the range 2-14 μg/ ml with correlation coefficient (n = 6) ≥ 0.9999.The molar absorptivity, Sandell sensitivity, detection and quantification limits were also calculated. The composition of the ion pairs was found 1:1 by Job's method. Conclusion: This developed method was validated for accuracy and precision and has been applied successfully for the analysis of Donepezil in pure and in its dosage forms. Source

Dharsana J.N.,Academy of Pharmaceutical science | Vijayan S.K.,Academy of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

Objective: The primary objective of this study was to determine the anti-diabetic activity of Anaphyllum wightii in alloxan induced diabetic rats. Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis, resulting in severe diabetic complications. Herbal preparations of tubers of Anaphyllum wightii had been considered as effective, economical and safe treatments for curing various diseases in Indian traditional system of medicine including diabetes. Therefore, the present study to investigate the anti-diabetic activity of ethanolic extract of Anaphyllum wightii in alloxan induced diabetes in albino wistar rats. Alloxan was administered as a single dose (120mg/kg, b.wt) to induce diabetes. Administration of ethanolic extracts from tubers of Anaphyllum wightii (100, 150&200mg/kg body weight/day) for 10 days, to alloxan-induced diabetic rats. The fasting blood sugar levels and serum biochemical analysis in alloxan-induced diabetic rats were investigated. The results suggest that the administration of Anaphyllum wightii have an anti-diabetic effect in alloxan induced diabetic rats and their effect was equivalent to that of reference drug Glibenclamide. Source

Arunshirwaikar A.,Gulf Medical University | Premkumar N.,Pariyaram Medical College | Sarala A.,Pariyaram Medical College | Bhaskaran K.,Pariyaram Medical College | Rajagopal P.L.,Academy of Pharmaceutical science
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Objective: The primary objective of this study was to determine drug utilization and evaluation of adjuvant therapy in mild to severe asthma patient and whether adjuvant therapy like montelukast, an oral leukotriene receptor antagonist and theophyline, provides additional clinical benefit with prescribed asthma therapy. Study design: The present study was an open labeled study conducted for a period of two years with mild to severe asthma patients in a tertiary care hospital and Private clinics in North Malabar region of Kerala. A total of 64 patients with mild to severe asthma were included in this study. Results: In these 64 patients, 12.5% received adjuvant therapy; in these 9.5% received montelukast.LTa added baseline PFT (1.59± 0.66) and 90th day follow-up PFT (2.66±0.67) showed improvement (1.07unit) and QoL improvement (27.46unit). LTa included asthma therapy had showed -0.62 units clinical improvement in pulmonary function test and -7.49 units quality of life, when compared to other adjuvant therapy like theophyline. Conclusion: all treatments were well tolerated, adjuvant therapy in bronchial asthma patients was found to be minimal in this area, including montelukast add on asthma therapy, patients showed additional improvement in quality of life comparing with theophyline. Source

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