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Hien N.D.,Center for Research and Production of Vaccine and Biologicals PolyVac | Luan L.T.,Center for Research and Production of Vaccine and Biologicals PolyVac | Huong N.T.,Center for Research and Production of Vaccine and Biologicals PolyVac | Thu N.N.A.,Center for Research and Production of Vaccine and Biologicals PolyVac | And 9 more authors.
Eastern Journal of Medicine | Year: 2011

The goal of measles elimination has been set for 2012 in the WHO Western Pacific Region. To achieve this goal, an enhanced immunization strategy is required, and measles vaccines have been provided through the Expanded Programme on Immunization (EPI) in Vietnam. A large quantity of vaccines should be supplied for a two-dose immunization schedule with a supplementary catch-up campaign. The live measles vaccine AIK-C strain was produced in Vietnam through technical transfer from the Kitasato Institute, Japan. PolyVac I was produced from bulk materials imported from Japan and PolyVac II from the AIK-C seed. Two clinical trials were conducted using three vaccines: PolyVac I, and II, and the EPI vaccine (Rouvax) for the control. A total of 160 subjects were examined for the immunogenicity of PolyVac I and 57 for that of the EPI vaccine. All subjects became seroconverted in PolyVac I groups for three different Lots, but 54 (94.7%; 88.9-100%) of 57 recipients of the EPI vaccine became sero-positive. For PolyVac II, 118 initially sero-negatives became sero-converted. Whereas, 107 (95.5%; 91.7-99.3%) of 112 initially sero-negatives in the EPI group showed sero-conversion. The mean titers of post-immunization sera of sero-converted subjects receiving PolyVac I and II were lower than that for the EPI vaccine. No significant difference was observed in the incidence of adverse clinical events. Essentially the same results were obtained using PolyVac I and II, showing higher sero-conversion rates than the EPI vaccine, and PolyVac measles AIK-C will be favorable in Vietnam and Southeast Asian countries.

PubMed | University of Greifswald, Military Academy of Medicine, Charité - Medical University of Berlin, Psychotherapy and Psychosomatic Ev. and Center for Public Mental Health
Type: Journal Article | Journal: The International journal of social psychiatry | Year: 2016

To examine, for the first time in Vietnam, whether urbanity of respondents among other socio-demographic factors affects the public perception of stigma attached to persons with mental illness in Hanoi.A general population-based survey was carried out in 2013 in the greater Hanoi area. The perception of stigma attached to people with mental illness was elicited using Links perceived discrimination and devaluation scale (PDDS) carried out in Vietnamese language. The survey sample (n=806) was stratified for gender, urban/rural location, age, household size and marital status, in accordance with the 2013 Vietnamese census.Comparing the total score of the PDDS and its single items, we found less perceived stigma and discrimination among the rural population of Hanoi and in respondents who reported religious attainment to either Buddhism or Christianity. Logistic regression analyses found no significant influences of gender, age, household size or marital status regarding the perceived stigma toward persons with mental illness.Less negative perception of stigma attached to persons with mental illness that was observed among the rural population in the Hanoi area may be interpreted in the light of possibly more demanding living conditions in modern urban Vietnam with less opportunities for mentally ill patients and points toward a dynamic interaction with rapidly changing living conditions in Asian megacities.

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