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Changchun, China

Liu Y.,Academy of Military Medicine | Hu R.-L.,Academy of Military Medicine
Chinese Journal of Biologicals | Year: 2011

Non-human primates (NHPs) were necessary to medical study in humans in several fields such as tissue structure, immunity, physiology and metabolism. However, NHPs carry various viruses of zoonoses, which threaten the health even life of humans. This paper reviews the pathogenic character of herpes virus in NHPs as well as its biosafety to humans. Source


Nguyen X.P.,Institute of Materials Science IMS VAST | Mai T.T.T.,Institute of Materials Science IMS VAST | Ha P.T.,Institute of Materials Science IMS VAST | Pham H.N.,Institute of Materials Science IMS VAST | And 7 more authors.
IFMBE Proceedings | Year: 2015

The main task of nanomedicine is to fabricate, normally by chemical engineering, nanoscale systems that can play various functions of both diagnosis and treatment. This report aims to present some researches, carried out by the Laboratory of Biomedical Nanomaterials (IMS/VAST in Hanoi), on fabrication and characterization of nanovectors for the disease of cancer. The first part deals with magnetite (Fe3O4) nanoparticles (MNPs) based nanoconjugates, functionalized by coating with several polymers as well as loaded with a drug of curcumin. The used MNPs were obtained by coprecipitation, exhibited spherical shape of diameter of 15-20 nm, saturation magnetization of Ms ~ 65-70 emu/g. The coating polymers were acrylic acid (PAA), chitosan (CS) and Alginate (Alg) which were confirmed using the infrared (FTIR) spectra. Magnetic Inductive Heating (MIH) measurements demonstrated that the fabricated MNPs-based conjugates exhibited quite high heating performance, perspective for hyperthermia application. The application of Fe3O4@PAA for in-vivo hyperthermia treatment of cancer incubated on mice will be shown. As for imaging application, the Fe3O4@CS@Cur was used to demonstrate a dual possibilities, fluorescence and magnetic resonance, of monitoring cell penetration by macrophage. In the second part, we show a recent study on targeted delivery systems of paclitaxel/doxorubicin/curcumin-loaded copolymer/polymer nanoparticles, which were prepared by a modified solvent extraction/evaporation technique and decorated by folic acid. The obtained spherical nanoparticles were negatively charged with a zeta potential of about − 30 mV with the size around 50 nm and a narrow size distribution. The targeting effect of anticancer-drugs nanoparticles with folate decoration was investigated in vitro by the uptake in cancer cell lines and in nude mouse. The results indicate that the targeted paclitaxel/doxorubicin/curcumin-loaded copolymer/polymer nanoparticles are successful anticancer-targeted drug delivery system for effective cancer chemotherapy. © Springer International Publishing Switzerland 2015. Source


Zhu Y.-F.,National University of Defense Technology | Mei S.,National University of Defense Technology | Zheng T.,Academy of Military Medicine | Zu Z.-H.,Academy of Military Medicine
Xitong Fangzhen Xuebao / Journal of System Simulation | Year: 2011

Infectious diseases and bioterroristic attacks are of great concerns for national security. Analyses of emergencies and decision making of public health policies are important to holding back epidemics. With analyzing relevant simulation systems developed in the USA, it could be concluded that the agent-based method stands for the future direction of infectious diseases modelling and simulation. Based on agent theory and technology, an overall framework, architecture and logic structure of simulation system for infectious diseases analysis were designed. Then important models such as an air flowing model, a virus spreading model, an individual model, an infection effect model and a city geographical information model, etc., were discussed. Finally, a prototype of heavy infectious diseases simulation system was constructed. The research achievement could guide the construction of simulation system prototypes for severe infectious diseases, and the consideration of various models and techniques. Source

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