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Kraft M.,University of Greifswald | Kraft K.,University of Greifswald | Gartner S.,University of Greifswald | Mayerle J.,University of Greifswald | And 16 more authors.
Nutrition Journal | Year: 2012

Background: Cachexia, a >10% loss of body-weight, is one factor determining the poor prognosis of pancreatic cancer. Deficiency of L-Carnitine has been proposed to cause cancer cachexia. Findings: We screened 152 and enrolled 72 patients suffering from advanced pancreatic cancer in a prospective, multi-centre, placebo-controlled, randomized and double-blinded trial to receive oral L-Carnitine (4 g) or placebo for 12 weeks. At entry patients reported a mean weight loss of 12 ± 2,5 (SEM) kg. During treatment body-massindex increased by 3,4 ± 1,4% under L-Carnitine and decreased (?1,5 ± 1,4%) in controls (p<0,05). Moreover, nutritional status (body cell mass, body fat) and quality-of-life parameters improved under L-Carnitine. There was a trend towards an increased overall survival in the L-Carnitine group (median 519 ± 50 d versus 399 ± 43 d, not significant) and towards a reduced hospital-stay (36 ± 4d versus 41 ± 9d,n.s.). Conclusion: While these data are preliminary and need confirmation they indicate that patients with pancreatic cancer may have a clinically relevant benefit from the inexpensive and well tolerated oral supplementation of L-Carnitine. © 2012 Kraft et al.

Grober U.,Academy of Micronutrient Medicine | Kisters K.,University of Munster
Dermato-Endocrinology | Year: 2012

In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins. © 2012 Landes Bioscience.

Kisters K.,Medizinische Klinik I | Kisters K.,Academy of Micronutrient Medicine | Grober U.,Medizinische Klinik I | Grober U.,Academy of Micronutrient Medicine
Plant and Soil | Year: 2013

Introduction: Magnesium is an essential electrolyte in living organisms, which has to be supplied daily in a sufficient amount. Methods: The clinical importance of a magnesium overload or a magnesium intoxication is seldom. However, a magnesium deficiency is of special importance in humans, despite of a normal magnesium supplementation. The primary effect of a magnesium deficiency results in a reduction of energy production. This reduced energy production can result in a disturbed membrane function, calcium magnesium antagonism and cell dysfunction. Results: Thereby consequences may result in an organ dysfunction and an altered answer to external and internal stress. The reduced energy status is responsible for the recovery of unhealthy individuals - e.g. cardiac arrhythmias, primary hypertension, pre-eclampsia, cramps, allergic reactions-upon repletion of Mg status. Conclusions: The importance of an oral or intravenously supplementation of magnesium has often been described in a variety of diseases. In addition of special interest is the use of magnesium in critically ill patients in intensive care medicine. © 2013 Springer Science+Business Media Dordrecht.

Grober U.,Academy of Micronutrient Medicine | Kisters K.,Academy of Micronutrient Medicine | Schmidt J.,Academy of Micronutrient Medicine
Nutrients | Year: 2013

Vitamin B12 is a cofactor of methionine synthase in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAMe), which is involved in different epigenomic regulatory mechanisms and especially in brain development. A Vitamin B12 deficiency expresses itself by a wide variety of neurological manifestations such as paraesthesias, skin numbness, coordination disorders and reduced nerve conduction velocity. In elderly people, a latent Vitamin B12 deficiency can be associated with a progressive brain atrophy. Moderately elevated concentrations of homocysteine (>10 μmol/L) have been associated with an increased risk of dementia, notably Alzheimer's disease, in many cross-sectional and prospective studies. Raised plasma concentrations of homocysteine is also associated with both regional and whole brain atrophy, not only in Alzheimer's disease but also in healthy elderly people. Clinician awareness should be raised to accurately diagnose and treat early Vitamin B12 deficiency to prevent irreversible structural brain damage. © 2013 by the authors; licensee MDPI, Basel, Switzerland.

Grober U.,Academy of Micronutrient Medicine | Schmidt J.,Academy of Micronutrient Medicine | Kisters K.,Academy of Micronutrient Medicine
Nutrients | Year: 2015

Magnesium is the fourth most abundant mineral in the body. It has been recognized as a cofactor for more than 300 enzymatic reactions, where it is crucial for adenosine triphosphate (ATP) metabolism. Magnesium is required for DNA and RNA synthesis, reproduction, and protein synthesis. Moreover, magnesium is essential for the regulation of muscular contraction, blood pressure, insulin metabolism, cardiac excitability, vasomotor tone, nerve transmission and neuromuscular conduction. Imbalances in magnesium status-primarily hypomagnesemia as it is seen more common than hypermagnesemia-might result in unwanted neuromuscular, cardiac or nervous disorders. Based on magnesium’s many functions within the human body, it plays an important role in prevention and treatment of many diseases. Low levels of magnesium have been associated with a number of chronic diseases, such as Alzheimer’s disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease (e.g., stroke), migraine headaches, and attention deficit hyperactivity disorder (ADHD). © 2015 by the authors; licensee MDPI, Basel, Switzerland.

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