Li M.,CAS Shenyang Institute of Automation |
Li M.,University of Chinese Academy of Sciences |
Liu L.,CAS Shenyang Institute of Automation |
Xi N.,CAS Shenyang Institute of Automation |
And 7 more authors.
2010 IEEE Nanotechnology Materials and Devices Conference, NMDC2010 | Year: 2010
Illuminating the underlying mechanism of drug action at single-cell and single-molecule levels is of great significance for the personalized treatment of diseases. In this paper, with the use of the atomic force microscopy (AFM), the mechanical property of the lymphoma cells was quantitatively measured and the CD20-Rituximab binding force was measured on the surface of the lymphoma cells by linking the Rituximab molecules onto the AFM tip. The results lay the foundation for the further study of the molecular mechanism of Rituximab anti-cancer effect. © 2010 IEEE.