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Herman A.,Academy of Cosmetics and Health Care | Herman A.P.,Polish Academy of Sciences
Journal of Pharmacy and Pharmacology | Year: 2015

Objectives In this paper, we focused on essential oils and their constituents as skin penetration enhancers for transdermal drug delivery, mechanism of their action as well as their possible toxicity. Key findings Essential oils and their volatile constituents can penetrate through the skin as well as enhance penetration of different drug from topical formulation into the lower skin layers using different mechanisms of action based on (1) disintegration of the highly ordered intercellular lipid structure between corneocytes in stratum corneum, (2) interaction with intercellular domain of protein, which induces their conformational modification, (3) increase the partitioning of a drug. After application to the skin, essential oils and their components are rapidly metabolized, not accumulated in the organism and fast excreted what strongly suggest that they can be successfully use as safe penetration enhancers. Summary Essential oils and their constituents may be preferred over the traditionally used synthetics materials as safe and suitable permeation enhancers to promote the percutaneous absorption of hydrophilic and lipophilic drugs from topical formulation into the lower skin layers. © 2014 Royal Pharmaceutical Society. Source

Herman A.,Academy of Cosmetics and Health Care | Mlynarczyk A.,Medical University of Warsaw
Israel Journal of Plant Sciences | Year: 2015

The aim of this study was to compare the antimicrobial activity of essential oils and extracts of Salvia officinalis, Thymus vulgaris, Mentha piperita, Juniperus communis and Rosmarinus officinalis with antibiotics against physiological and pathological strains of microorganisms isolated from the oral cavity. The antibacterial and antifungal activities of essential oils, extracts and antibiotics were evaluated using the disc diffusion method. Essential oils exhibited higher inhibitory activity against physiological microflora and all tested pathogenic microorganism strains than those observed for antibiotics and plant extracts. Essential oils and ethanolic extracts of Thymus vulgaris were the most potent growth inhibitor of all microorganisms isolated from the oral cavity. Depending on the bacterial strain tested, Thymus vulgaris oil had 3-8 times higher inhibitory activity compared with all tested antibiotics and exhibited the same strength of antifungal activity as amfotericin and miconazol against Candida albicans. Essential oils and extracts may be useful in the prevention and treatment of oral diseases caused by oral microorganisms. © 2014 Taylor and Francis. Source

Kurpiewska J.,Central Institute for Labour Protection National Research Institute CIOP PIB | Liwkowicz J.,Central Institute for Labour Protection National Research Institute CIOP PIB | Benczek K.,Central Institute for Labour Protection National Research Institute CIOP PIB | Padlewska K.,Academy of Cosmetics and Health Care
International Journal of Occupational Safety and Ergonomics | Year: 2011

Occupational skin disorders, in particular inflammations, dryness and erythema, in 80% of cases affect the skin of hands. The most frequent diagnosis, in over 90% of cases of occupational skin diseases, points to an irritant or allergic contact dermatitis. Our aim was to study the prevalence of self-reported skin symptoms on hands and forearms in different populations. The study was conducted on 581 healthcare workers, 61 hair stylists, 149 beauticians, 90 food services workers, 90 cleaners, 181 metal factory workers and 69 textile workers. Healthcare workers had greatest exposure. Eighty-six percent of dentists, 67% of midwives, 51% of nurses and 41% of physicians reported skin disorders. Problems with latex gloves were declared by 30% of healthcare workers. Thirty-four percent of food services workers, 24% of textile workers, 30% of metal factory workers, 21% of hair stylists and beauticians, and 64% of cleaners reported skin manifestations during the time of employment, which they thought could be work-related. Source

Herman A.,Academy of Cosmetics and Health Care | Herman A.P.,Polish Academy of Sciences
Journal of Nanoscience and Nanotechnology | Year: 2014

Bacterial strains that are resistant to current antibiotics have become serious public health problems that increase the need to develop new bactericidal materials. Therefore, nanoparticles have gained importance in the field of chemotherapy. This review is focused on the unique properties of nanoparticles and their mechanism of action as antibacterial agents. The activities of nanoparticles on drug-resistant bacteria and risks of using them as antibacterial agents also have been documented. Copyright © 2014 American Scientific Publishers All rights reserved. Source

Herman A.P.,Polish Academy of Sciences | Krawczynska A.,Polish Academy of Sciences | Bochenek J.,Polish Academy of Sciences | Dobek E.,Polish Academy of Sciences | And 2 more authors.
Clinical and Developmental Immunology | Year: 2013

Acting at the level of the brain, interleukin- (IL-)1β is considered to be one of the most potent downregulators of reproduction processes during immune/inflammatory challenge. IL-1β suppresses gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus resulting in the inhibition of the luteinizing hormone (LH) release from the anterior pituitary (AP). However, the presence of IL-1β receptors in the AP suggests the possible direct action of this cytokine on LH secretion. The study was designed to determine the effect of IL-1β on the LH secretion from the AP explants collected from saline and LPS-treated ewes in the follicular phase. It was found that IL-1β suppressed (P≤0.01) GnRH-stimulated LH release and LHβ gene expression in AP explants in both groups. However, IL-1β action was more potent in the explants collected from LPS-treated animals. Pituitaries from LPS-treated animals were characterized by increased (P≤0.01) IL-1 type I receptor and decreased (P≤0.01) GnRH receptor gene expression level compared to the saline-treated group. IL-1β also affected the GnRH-R gene expression in explants collected from LPS-treated animals. Our results show that direct action of IL-1β on the pituitary gonadotropes could be one of the reasons of the reproductive processes disorders accompanying an inflammatory state. © 2013 Andrzej Przemysław Herman et al. Source

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