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Stefanski T.,Academic Center for Dentistry | Postek-Stefanska L.,University of Silesia
Australian Dental Journal | Year: 2014

Frequent consumption of acidic beverages is related to excessive tooth wear, namely dental erosion. Preventive measures may involve reduction or elimination of acidic drink consumption. However, the success of this approach is difficult to achieve as it is highly dependent on patient compliance. Therefore, a practical way of minimizing the erosive potential of popular acidic drinks may be their chemical modification. The aim of this article was to review the different methods of modification and their shortcomings. The available literature demonstrates that the erosive potential of most acidic beverages could be reduced. To date, the effectiveness of soluble calcium salts supplementation is the best established. However, modification can reduce the sensorial quality of the drink and shorten its shelf-life. There is also a need to evaluate the lowest effective and safe dose of the additive. © 2014 Australian Dental Association.


van den Broek L.J.,VU University Amsterdam | van den Broek L.J.,Research Institute MOVE | Limandjaja G.C.,VU University Amsterdam | Limandjaja G.C.,Research Institute MOVE | And 5 more authors.
Experimental Dermatology | Year: 2014

Most cutaneous wounds heal with scar formation. Ideally, an inconspicuous normotrophic scar is formed, but an abnormal scar (hypertrophic scar or keloid) can also develop. A major challenge to scientists and physicians is to prevent adverse scar formation after severe trauma (e.g. burn injury) and understand why some individuals will form adverse scars even after relatively minor injury. Currently, many different models exist to study scar formation, ranging from simple monolayer cell culture to 3D tissue-engineered models even to humanized mouse models. Currently, these high-/medium-throughput test models avoid the main questions referring to why an adverse scar forms instead of a normotrophic scar and what causes a hypertrophic scar to form rather than a keloid scar and also, how is the genetic predisposition of the individual and the immune system involved. This information is essential if we are to identify new drug targets and develop optimal strategies in the future to prevent adverse scar formation. This viewpoint review summarizes the progress on in vitro and animal scar models, stresses the limitations in the current models and identifies the future challenges if scar-free healing is to be achieved in the future. © 2014 The Authors. Experimental Dermatology. Published by John Wiley & Sons Ltd.


Mattheos N.,University of Hong Kong | Wismeijer D.,Academic Center for Dentistry | Shapira L.,Hebrew University of Jerusalem
European Journal of Dental Education | Year: 2014

Introduction: In recent years, opportunities for postgraduate university education in implant dentistry have increased significantly, with an increase in both the number but also the complexity of available postgraduate programmes. However, there appears to be a lack of standards directing the learning outcomes of such programmes. Methods: A scientific literature search was conducted for publications reporting on university programmes within implant dentistry, including description of programmes and evaluation of learning outcomes. A separate Internet search was conducted to collect information on existing university programmes as presented on university websites. Results: Implant dentistry has reached a critical mass of an independent, multidisciplinary and vibrant domain of science, which combines knowledge and discovery from many clinical and basic sciences. Many university programmes conclude with a master's or equivalent degree, but there appears to be a great diversity with regard to duration and learning objectives, as well as targeted skills and competences. The importance of implant dentistry has also increased within established specialist training programmes. There was little indication, however, that the comprehensive aspects of implant dentistry are present in all specialist training programmes where implants are being covered. Conclusions: Although universities should maintain the options of designing academic programmes as they best see fit, it is imperative for them to introduce some form of transparent and comparable criteria, which will allow the profession and the public to relate the degree and academic credentials to the actual skills and competences of the degree holder. With regard to established specialist training programmes, the interdisciplinary and comprehensive nature of implant dentistry needs to be emphasised, covering both surgical and restorative aspects. Finally, implant dentistry is not, at present, a dental specialty. The profession has not reached a consensus as to whether the introduction of a new recognised specialist field is either necessary or desired. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


van Amerongen B.M.,VU University Amsterdam | van Amerongen B.M.,Academic Center for Dentistry | Feron F.,Aix - Marseille University
International Journal of Molecular Sciences | Year: 2012

Mounting evidence correlate vitamin D3 (cholecalciferol) supplementation or higher serum levels of vitamin D (25(OH)D) with a lower risk of developing multiple sclerosis (MS), reduced relapse rate, slower progression or fewer new brain lesions. We present here the case of a woman who was diagnosed with MS in 1990. From 1980 to 2000, her ability to walk decreased from ~20 to 1 km per day. Since January 2001, a vitamin D3 supplement was ingested daily. The starting dose was 20 mcg (800 IU)/day and escalated to 100 mcg (4000 IU)/day in September 2004 and then to 150 mcg (6000 IU)/day in December 2005. Vitamin D3 intake reduced muscular pain and improved ambulation from 1 (February 2000) to 14 km/day (February 2008). Vitamin D intake over 10 years caused no adverse effects: no hypercalcaemia, nephrolithiasis or hypercalciuria were observed. Bowel problems in MS may need to be addressed as they can cause malabsorption including calcium, which may increase serum PTH and 1,25(OH)2D levels, as well as bone loss. We suggest that periodic assessment of vitamin D3, calcium and magnesium intake, bowel problems and the measurement of serum 25(OH)D, PTH, Ca levels, UCa/Cr and bone health become part of the integral management of persons with MS. © 2012 by the authors; licensee MDPI, Basel, Switzerland.


Turksma A.W.,VU University Amsterdam | Braakhuis B.J.,VU University Amsterdam | Bloemena E.,VU University Amsterdam | Bloemena E.,Academic Center for Dentistry | And 3 more authors.
Immunotherapy | Year: 2013

Head and neck squamous cell carcinoma is the sixth most common cancer in the western world. Over the last few decades little improvement has been made to increase the relatively low 5-year survival rate. This calls for novel and improved therapies. Here, we describe opportunities in immunotherapy for head and neck cancer patients and hurdles yet to be overcome. Viruses are involved in a subset of head and neck squamous cell carcinoma cases. The incidence of HPV-related head and neck cancer is increasing and is a distinctly different disease from other head and neck carcinomas. Virus-induced tumors express viral antigens that are good targets for immunotherapeutic treatment options. The type of immunotherapeutic treatment, either active or passive, should be selected depending on the HPV status of the tumor and the immune status of the patient. © 2013 Future Medicine Ltd.


van der Meulen M.J.,Academic Center for Dentistry
Journal of orofacial pain | Year: 2010

To examine temporomandibular disorder (TMD) patients' illness beliefs and self-efficacy in relation to bruxism, and to examine whether these beliefs are related to the severity of patients' self-perceived bruxing behavior. A total of 504 TMD patients (75% women; mean age ± SD: 40.7 ± 14.6 years), referred to the TMD Clinic of the Academic Centre for Dentistry Amsterdam, completed a battery of questionnaires, of which one inquired about the frequency of oral parafunctional behaviors, including bruxism (clenching and grinding). Patients' illness beliefs were assessed with a question about the perceived causal relationship between bruxism and TMD pain; patients' self-efficacy was assessed with questions about the general possibility of reducing oral parafunctional behaviors and patients' own appraisal of their capability to accomplish this. Sleep bruxism or awake bruxism was attributed by 66.7% and 53.8% of the patients, respectively, as a cause of TMD pain; 89.9% believed that oral parafunctions could be reduced, and 92.5% believed themselves capable of doing so. The higher a patient's bruxism frequency, the more bruxism was believed to be the cause of TMD pain (Spearman's rho 0.77 and 0.71, P < .001) and the more pessimistic the self-efficacy beliefs were about the reducibility of oral parafunctions (Kruskal-Wallis ?2 = 19.91, df = 2, P < .001; and Kruskal-Wallis ?2 = 7.15, df = 2, P = .028). Most TMD patients believe in the harmfulness of bruxism and the possibility of reducing this behavior. Bruxism frequency is associated with illness beliefs and self-efficacy.


Nikolopoulou M.,Academic Center for Dentistry
Journal of orofacial pain | Year: 2013

To assess the influence of occlusal stabilization splints on sleep-related respiratory variables in obstructive sleep apnea (OSA) patients. Ten OSA patients (47.3 ± 11.7 years of age) received a stabilization splint in the maxilla. All patients underwent three polysomnographic recordings with their splint in situ, and three recordings without their splint in situ, using a randomized crossover design. Repeated-measures ANOVAs did not yield statistically significant differences in the Apnea-Hypopnea Index (AHI) or in the Epworth Sleepiness Scale (ESS), neither between the three nights without the stabilization splint (AHI: F = 2.757, P = .090; ESS: F = 0.153, P = .860) nor between the nights with the splint in situ (AHI: F = 0.815, P = .458; ESS: F = 0.231, P = .796). However, independent ANOVAs revealed that the mean AHI of the three nights with the stabilization splint in situ (17.4 ± 7.0 events/hour) was significantly higher than that of the nights without the splint in situ (15.9 ± 6.4 events/hour) (F = 7.203, P = .025). The mean increase in AHI with the splint in situ was 1.4 ± 1.7 (95% confidence interval = -1.9-4.7). No difference in ESS was found when both conditions were compared (F = 1.000, P = .343). The use of an occlusal stabilization splint is associated with a risk of aggravation of OSA; however, the effect size was small, which reduces the clinical relevance of the study.


Kalaykova S.I.,Academic Center for Dentistry
Journal of orofacial pain | Year: 2011

To test the hypothesis that oral parafunctions and symptomatic temporomandibulair joint (TMJ) hypermobility are risk factors in adolescents for both anterior disc displacement with reduction (ADDR) and intermittent locking. Participants were two hundred sixty 12- to 16-year-old adolescents (52.3% female) visiting a university clinic for regular dental care. ADDR and symptomatic TMJ hypermobility were diagnosed using a structured clinical examination. During the anamnesis, reports of intermittent locking and of several parafunctions were noted, eg, nocturnal tooth grinding, diurnal jaw clenching, gum chewing, nail biting, lip and/or cheek biting, and biting on objects. The adolescents' dentitions were examined for opposing matching tooth-wear facets as signs of tooth grinding. Risk factors for ADDR and intermittent locking were first assessed using univariate logistic regression and then entered into a stepwise backward multiple model. While in the multiple model, ADDR was weakly associated only with increasing age (P = .02, explained variance 8.1%), intermittent locking was weakly correlated to diurnal jaw clenching (P = .05, explained variance 27.3%). In adolescence, diurnal clenching may be a risk factor for intermittent locking while age may be a risk factor for ADDR. Symptomatic TMJ hypermobility seems to be unrelated to either ADDR or to intermittent locking.


Kalaykova S.,Academic Center for Dentistry
Journal of orofacial pain | Year: 2010

To test if the disappearance of clicking associated with anterior disc displacement with reduction (ADDR) is related to a gradual loss of reducing capacity of the disc in the temporomandibular joint. Twenty-five ADDR subjects without and 30 ADDR subjects with intermittent locking participated in this 2-year follow-up study. Clinical examinations and mandibular movement recordings were performed at baseline and after 1 and 2 years. If mandibular movement recordings no longer showed signs of an ADDR, magnetic resonance imaging (MRI) of the disc was carried out. Mandibular movement recordings showed the moment of disc reduction (MDR) to be stable over the observation period in the subjects without intermittent locking (P = .95). In the subjects with intermittent locking, MDR had shifted to a later mouth opening (P = .000). In seven of these subjects, clicking had totally disappeared, usually without symptoms of permanent locking. On the MRI scans of these subjects, the disc displacement was still present, but with no, or only a partial, reduction. Intermittent locking may be indicative of the development of a disc displacement without reduction. This loss is only rarely accompanied by symptoms of permanent locking.


Van Diermen D.E.,Academic Center for Dentistry | Van Der Waal I.,Academic Center for Dentistry | Hoogvliets M.W.,Academic Center for Dentistry | Ong F.N.,Academic Center for Dentistry | Hoogstraten J.,Academic Center for Dentistry
International Journal of Oral and Maxillofacial Surgery | Year: 2013

The aim was to evaluate the management strategies of Dutch oral and maxillofacial surgeons when performing invasive dental or oral surgery in patients using oral antithrombotic medication (OAM). In November 2009 a survey was mailed to all 213 members of the Dutch Society for Oral and Maxillofacial Surgery. A response rate of 57% was achieved with 79 surveys returned through mail and 38 surveys answered through the Internet. The results show that many different treatment strategies are advocated by Dutch oral and maxillofacial surgeons, regarding preferred international normalised ratio (INR) value and continuation or discontinuation of OAM prior to invasive dental or oral surgery. The risk of bleeding during or after an invasive dental procedure was overestimated. A need for a practice guideline on this topic was expressed by 73% of respondents.

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