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Raskob G.E.,The University of Oklahoma Health Sciences Center | Angchaisuksiri P.,Mahidol University | Blanco A.N.,Academia Nacional de Medicina | Gallus A.,Flinders Medical Center | And 8 more authors.
Journal of Thrombosis and Haemostasis | Year: 2014

Thrombosis is a common pathology underlying ischemic heart disease, ischemic stroke, and venous thromboembolism (VTE). The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study 2010 documented that ischemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden caused by VTE in low-income, middle-income and high-income countries. Studies from western Europe, North America, Australia and southern Latin America (Argentina) yielded consistent results, with annual incidence rates ranging from 0.75 to 2.69 per 1000 individuals in the population. The incidence increased to between 2 and 7 per 1000 among those aged ≥ 70 years. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low, because of population aging. VTE associated with hospitalization was the leading cause of disability-adjusted life-years (DALYs) lost in low-income and middle-income countries, and the second most common cause in high-income countries, being responsible for more DALYs lost than nosocomial pneumonia, catheter-related bloodstream infections, and adverse drug events. VTE causes a major burden of disease across low-income, middle-income and high-income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems, and to evaluate whether improved utilization of preventive measures will reduce the burden. © 2014 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.


News Article | February 15, 2017
Site: www.businesswire.com

IRVINE, Califórnia--(BUSINESS WIRE)--O Dr. Javier Dávila Torres -- junto com 11 oficiais do México -- anunciou, durante a Cúpula Mundial sobre Segurança do Paciente, Ciência e Tecnologia da Patient Safety Movement Foundation (PSMF) que 25 hospitais assinaram um compromisso de implementar processos para erradicar mortes evitáveis de pacientes. Além disso, a Academia de Cirurgia, a Federação de Anestesiologistas e a Faculdade de Profissionais de Qualidade da Saúde da região oeste, Guadalajara e Jalisco (México) se juntaram à Fundação como "parceiros comprometidos" que compartilham a missão da PSMF. "O nosso Patient Safety Movement começou nos Estados Unidos, mas sua visão de proteger a vida dos pacientes sempre foi global. Estamos muito entusiasmados por ver compromissos com a segurança dos pacientes representando 33 hospitais e 3 organizações de cuidados de saúde no México, protegendo nossos vizinhos contra mortes evitáveis", disse Joe Kiani, Fundador da Patient Safety Movement Foundation. "A segurança do paciente nos hospitais é uma preocupação global, e esperamos que todos os países participem". "Agradecemos a todos os médicos, enfermeiros e equipes multidisciplinares que avançaram e fizeram um compromisso com o Patient Safety Movement", disse o Dr. Javier Davila, presidente do Conselho regional da Patient Safety Movement no México e antigo diretor médico do Instituto da Previdência Social no México. "Este é apenas o começo para o México, e precisamos que todos os hospitais participem, se quisermos erradicar os erros médicos e as mortes evitáveis". "Estamos muito felizes por trabalhar de perto com a Patient Safety Movement. A meta do nosso instituto é promover a formação abrangente sobre segurança do paciente e erradicar infeções graves associadas ao cuidado de saúde", disse o Dr. David Kershenobich, diretor geral do Instituto Nacional de Ciências Médicas e Nutrição, e ex-presidente da Academia Nacional de Medicina do México. "Estamos satisfeitos por ver a saúde mental como um dos desafios abordados na cúpula deste ano", disse a Dr. María Elena Medina-Mora, diretora geral do Instituto Nacional de Saúde Mental. "As pessoas que sofrem com condições de saúde mental vivem grande parte da vida sem acesso a tratamentos adequados. Nossa missão é tentar oferecer a elas qualidade de vida e tratamentos seguros. Estamos empolgados por trabalhar com a Patient Safety Movement". "A Academia Mexicana de Cirurgia, em conjunto com o setor de Saúde Pública do Governo Federal do México, oferecerá formação médica contínua em diferentes especializações cirúrgicas a organizações acadêmicas e universidades", disse o Dr. Jesús Tapia, presidente da Academia Mexicana de Cirurgia. "Esperamos que todos os nossos membros se comprometam em fazer com que a erradicação de mortes evitáveis de pacientes até 2020 seja sua meta de segurança". Mais de 200 mil pessoas morrem todos os anos em hospitais dos EUA, e três milhões em todo o mundo, de formas que poderiam ser evitadas. A Patient Safety Movement Foundation foi estabelecida a partir do apoio da Masimo Foundation for Ethics, Innovation, and Competition in Healthcare com o objetivo de reduzir a zero a quantidade de mortes evitáveis até 2020 (0x2020). Aprimorar a segurança do paciente exigirá um esforço de colaboração de todas as partes interessadas, o que inclui pacientes, prestadores de cuidados de saúde, empresas de tecnologia médica, governos, empregadores e pagadores privados. A Patient Safety Movement Foundation trabalha com todas as partes interessadas para abordar os problemas com soluções acionáveis para segurança do paciente. A Fundação também realiza a Cúpula Mundial sobre Segurança do Paciente, Ciência e Tecnologia. A cúpula reúne algumas das melhores mentes do mundo para a realização de debates instigantes e novas ideias que desafiem o status quo. Ao apresentar soluções específicas e de alto impacto para atender aos desafios de segurança de pacientes, chamadas Soluções Acionáveis para a Segurança do Paciente, incentivando empresas de tecnologia médica a compartilhar os dados sobre a compra de seus produtos e pedir que os hospitais se comprometam em implementar soluções acionáveis para a segurança de pacientes, a Fundação está trabalhando para alcançar a meta de erradicar as mortes evitáveis até 2020. Acesse o site http://patientsafetymovement.org. O texto no idioma original deste anúncio é a versão oficial autorizada. As traduções são fornecidas apenas como uma facilidade e devem se referir ao texto no idioma original, que é a única versão do texto que tem efeito legal.


Yaqub S.,Edwards Comprehensive Cancer Center | Ballester G.,Edwards Comprehensive Cancer Center | Ballester O.,Academia Nacional de Medicina
Cancer Investigation | Year: 2013

The past decade has seen significant progress in the development of new and effective therapies for multiple myeloma. Stem cell transplantation and the introduction of novel agents, such as thalidomide, lenalidomide, and bortezomib, have significantly improved outcomes of myeloma patients. In the current review, we analyzed the available data provided by published randomized clinical trials for the frontline therapy of myeloma patients. We attempted to assess the relative contribution and impact of these new therapies in the setting of both, transplant eligible and transplant ineligible patients. © 2013 Informa Healthcare USA, Inc.


Ruggiero R.A.,Academia Nacional de Medicina | Bruzzo J.,Academia Nacional de Medicina | Chiarella P.,Academia Nacional de Medicina | Bustuoabad O.D.,Academia Nacional de Medicina | And 2 more authors.
Cancer Research | Year: 2012

Concomitant tumor resistance (CR) is a phenomenon in which a tumor-bearing host is resistant to the growth of secondary tumor implants and metastasis. Although previous studies indicated that T-cell-dependent processes mediate CR in hosts bearing immunogenic small tumors, manifestations of CR induced by immunogenic and nonimmunogenic large tumors have been associated with an elusive serum factor. In a recently published study, we identified this factor as meta-tyrosine and ortho-tyrosine, 2 isomers of tyrosine that would not be present in normal proteins. In 3 different murine models of cancer that generate CR, both meta- and orthotyrosine inhibited tumor growth. Additionally, we showed that both isoforms of tyrosine blocked metastasis in a fourth model that does not generate CR but is sensitive to CR induced by other tumors. Mechanistic studies showed that the antitumor effects of the tyrosine isomers were mediated in part by early inhibition of the MAP/ERK pathway and inactivation of STAT3, potentially driving tumor cells into a state of dormancy in G 0-phase. Other mechanisms, putatively involving the activation of an intra-S-phase checkpoint, would also inhibit tumor proliferation by accumulating cells in S-phase. By revealing a molecular basis for the classical phenomenon of CR, our findings may stimulate new generalized approaches to limit the development of metastases that arise after resection of primary tumors or after other stressors that may promote the escape of metastases from dormancy, an issue that is of pivotal importance to oncologists and their patients. ©2012 AACR.


Caruso V.,Academia Nacional de Medicina | Di Castelnuovo A.,Catholic University | Meschengieser S.,Academia Nacional de Medicina | Lazzari M.A.,Academia Nacional de Medicina | And 4 more authors.
Blood | Year: 2010

Thrombotic complications in hematologic malignancies have important clinical implications. In this meta-analysis we sought to obtain accurate estimates of the thrombotic risk in lymphoma patients. Articles were searched in electronic databases and references. Eighteen articles were identified (29 cohorts, 18 018 patients and 1149 events). Pooled incidence rates (IRs) were calculated by the use of a method based on the exact maximum likelihood binomial distribution. The global IR of thrombosis was 6.4% (95% confidence interval [CI] 6.0%-6.8%). The global IRs of venous or arterial events were 5.3% (95% CI, 5.0%-5.7%) and 1.1% (95% CI, 0.9%-1.2%), respectively. The IR of thrombosis observed in subjects with non-Hodgkin lymphoma (NHL) was 6.5% (95% CI, 6.1%-6.9%), significantly greater than that observed for patients with Hodgkin lymphoma (4.7%; 95% CI, 3.9%-5.6%). Within NHL, patients with high-grade disease had a greater risk of events (IR 8.3%; 95% CI, 7.0%-9.9%) than low-grade disease (IR 6.3%; 95% CI, 4.5%-8.9%). This meta-analysis shows that the IR of thrombosis in lymphoma patients is quite high, especially in those with NHL at an advanced stage of the disease. These results may help better defining lymphoma populations at high thrombotic risk, to whom prophylactic approaches could be preferentially applied. © 2010 by The American Society of Hematology.


Carrillo-Esper R.,Academia Nacional de Medicina
Medicina Interna de Mexico | Year: 2010

The measurement of intra-abdominal pressure is a new monitoring technique in critical ill patients. The intra-abdominal pressure can be related with intra-abdominal hypertension and abdominal compartmental syndrome the last has been associated with increased in morbidity and mortality. In the last few years, there has been progress in the understanding of the pathophysiology of abdominal compartmental syndrome leads to early diagnosis and appropriate and in the implementation of different treatment alternatives ranging from non-invasive approach to decompressive laparotomy. The aim of this paper is to describe the scientific evidence base to the current concepts related to the abdominal compartmental syndrome and intra-abdominal hypertension and its impact on clinical practice.


Muci-Mendoza R.,Academia Nacional de Medicina
Gaceta Medica de Caracas | Year: 2013

We present the clinical case of a patient who, after being hit in the face by a falling coconut, with consequent trauma to his face, fractured his orbital floor with muscle entrapment and undiagnosed diplopia which was mistaken for a brain aneurysm. We make considerations about such accidents on sandy beaches where coconut trees abound, compare its frequency with shark attacks and discuss how a medical article can be misrepresented by its author and become news in order to obtain the nomination for the Ig Nobel Prize for medicine based on r̈esearch that cannot or should not be duplicated; achievements that first make you laugh and then make you think and try to celebrate the unusual, imaginative and spur interest in science, medicine and technology. Copyright © Indice Mexicano de Revistas Biomédicas Latinoamericanas 1998 - 2013.


Karam E.,Academia Nacional de Medicina
Gaceta Medica de Caracas | Year: 2013

We present the case of a 30-year-old previously healthy patient, who developed after numerous trips on a roller coaster a spontaneous hematoma subdural and a contralateral hygroma. Extreme speed and G-force deployment, the succession of moments of acceleration and deceleration, sudden cephalic movements with snarling side of the brain and the number of times that he repeated the trip, they constituted a significant risk of rupture of veins bridge, being possible that repeated falls from a towed buoy have produced the latest trauma and final trigger. Copyright © Indice Mexicano de Revistas Biomédicas Latinoamericanas 1998 - 2013.


The aim of this study was in the first part to determine the prevalence of negative dysphotopsia pseudophakic based on a type of intraocular lens, multifocal specifically, in a sample of 90 patients whom underwent a cataract surgery at the Centro Medico Docente La Trinidad de Caracas between the years 2004-2006 . We also evaluated the degree of satisfaction and tolerability of the negative dysphotopsia phenomenon in 70 of the 90 patients. In a second part, we evaluated 54 patients with negative dysphotopsia with different types of intraocular lenses that attend to the neuroophthalmology consultation at the Centro Medico Docente La Trinidad y la Unidad Oftalmologica de Caracas from 2006 to 2013. Prismatic lenses were used as a therapeutic alternative for negative dysphotopsia. The following variables were analyzed in both groups of patients with negative dysphotopsia: postoperative visual acuity, age, sex and laterality of the symptom. In addition, to the first group the questionnaire of the National Eye Institute Visual Functioning -25 (VFQ-25) 2000 version was applied to measure the degree of satisfaction and tolerability of this phenomenon. In the second group the prevalence of intraocular lens type was assessed. Prism lenses were employed to treat the visual phenomenon. In the first part the patients were 33 (36.7 %) male and 57 (63.3 %) female, aged between 30 and 70 years old. The prevalence of negative pseudophakic dysphotopsia was in 25.9 %; bilateral in 50 (55.6 %) and unilateral in 40 (44.4 %). Predominant visual acuity was 20/20 (0.00 logMAR) in 50 % of patients. Based in the questionnaire performed, 45 (64.3 %) patients get used to the visual phenomenom, 14 (20 %) were not and 11 (15.7 %) it disappeared. Patients showed high degree of satisfaction with the obtained visual acuity and in 54 (77 %) there was a tolerability to the phenomenon. In part two, 9 patients (17 %) were male and 45 (83 %) female, aged between 30 and 82 years old. The prevalence was higher in multifocal lenses: 30 (56 %) in relation to the monofocal 24 (44 %). No difference was found regarding the laterality (50 %). Predominant visual acuity was 20/20 in 65 % of patients. The prism slowed down dysphotopsia for far vision with 2DP value and near vision with 4 DP value. From the analysis and based on scientific evidence it was concluded that negative dysphotopsia is an undesirable visual phenomenon that arises as a result of the new intraocular lens design, that refracts the incident light in the straight edge to over 30 degree of the nasal retina causing temporarily increasing stimulation. Entoptic phenomenon explains the degree of independence of visual acuity, visual field and / or ophthalmic pathology. The prism is a therapeutic alternative in the treatment of the visual phenomenon despite the patient's large capacity of neuroadaptation.


Arce M.,Academia Nacional de Medicina
Revista Peruana de Medicina Experimental y Salud Publica | Year: 2015

This article describes and discusses issues related to the process of childhood growth and development, with emphasis on the early years, a period in which this process reaches critical speed on major structures and functions of the human economy. We reaffirm that this can contribute to the social availability of a generation of increasingly better adults, which in turn will be able to contribute to building a better world and within it a society that enjoys greater prosperity. In the first chapter, we discuss the general considerations on the favorable evolution of human society based on quality of future adults, meaning the accomplishments that today’s children will gain. A second chapter mentions the basics of growth and development in the different fields and the various phenomena that occur in it. In the third we refer to lost opportunities and negative factors that can affect delaying the process and thereby result in not obtaining the expected accomplishments. In the fourth, conclusions and recommendations are presented confirming the initial conception that good early child care serves to build a better society and some recommendations are formulated to make it a good practice. © 2015, Instituto Nacional de Salud. All rights reserved.

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