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Halifax, Canada

Hasan M.S.,Dalhousie University | Kehoe S.,Dalhousie University | Boyd D.,Dalhousie University | Boyd D.,ABK Biomedical
Journal of Biomaterials Applications | Year: 2014

Embolization of vascular tumors is an important tool in minimally invasive surgical intervention. Radiopaque, non-degradable, and non-deformable spherical zinc-silicate glass particles were produced in a range of 45-500-μm. Three size ranges (45-150, 150-300, and 300-500-μm) were used in the current study. The glass microspheres were eluted in polar (saline solution) and non-polar (dimethyl sulfoxide) medium, and ion release profiles were recorded using inductively coupled plasma atomic emission spectroscopy. Approximately 80% of Gaussian distribution was achieved by simple sieving. The ions released from the microspheres were dependent upon surface area to volume ratio as well as the nature of elution media. Greater ions were released from smaller particles (45-150-μm) having largest surface area in polar medium. For the genotoxicity bacterial mutation Ames assay, the concentrations of all the ions were well below their therapeutic concentration reported in the literature. No mutagenic effect was observed in the bacterial mutation Ames test. Hence, it can be concluded that the glass microspheres produced herein are non-mutagenic further supporting the materials potential as a suitable embolic agent. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

ABK Biomedical | Entity website

ABK Biomedical | Entity website

Occlu90Y OccluDEBABK Biomedicals radiopaque embolic bead platform includes drug eluting beads that continue the theme of inherent radiopacity set by OccluSystem. OccluDEB is engineered to deliver chemotherapy while occluding the vessels feeding a tumor, with a prime clinical application of liver cancer ...

ABK Biomedical | Entity website

ABK Biomedical Inc. Innovative Embolic Therapies ...

ABK Biomedical | Entity website

Dr. Aaron Berez, MD ...

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