ABITEC Corporation

Columbus, OH, United States

ABITEC Corporation

Columbus, OH, United States

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Prajapati H.N.,St. John's University | Dalrymple D.M.,ABITEC Corporation | Serajuddin A.T.M.,St. John's University
Pharmaceutical Research | Year: 2012

Purpose: To compare physiochemical properties of mono-, di- and triglycerides of medium chain fatty acids for development of oral pharmaceutical dosage forms of poorly water-soluble drugs using phase diagrams, drug solubility, and drug dispersion experiments. Methods: Phase diagrams were prepared using a monoglyceride (glycerol monocaprylocaprate: CapmulMCM® EP), a diglyceride (glycerol dicaprylate) and two triglycerides (glycerol tricaprylate: Captex 8000®; caprylic/capric triglycerides: Captex 355 EP/NF®) in combination with a common surfactant (PEG-35 castor oil: Cremophor EL®) and water. Psuedoternary phase diagrams using mixtures of monoglyceride with either diglyceride or triglyceride were constructed to determine any potential advantage of using lipid mixtures. Result: The monoglyceride gave microemulsion (clear or translucent liquid) and emulsion phases, whereas di- and triglycerides exhibited an additional gel phase. Among individual mono-, di- and triglycerides, the oil-in-water microemulsion region was the largest for the diglyceride. Gel phase region within diglyceride and triglyceride phase diagrams could be practically eliminated and microemulsion regions expanded by mixing monoglyceride with di- or tri-glycerides (1:1). Addition of a model drug, danazol, had no effect on particle sizes of microemulsions formed. Dispersion of drug in aqueous media from mixtures of mono- and diglyceride or mono- and triglyceride was superior to individual lipids. Conclusion: Systematic study on comparison of mono-, diand triglyceride of medium chain fatty acids will help formulators select components for optimal lipid-based formulation. © The Author(s) 2011.


Gumaste S.G.,St. John's University | Dalrymple D.M.,ABITEC Corporation | Serajuddin A.T.M.,St. John's University
Pharmaceutical Research | Year: 2013

Purpose: To develop tablet formulations by adsorbing liquid self-emulsifying drug delivery systems (SEDDS) onto Neusilin®US2, a porous silicate. Methods: Nine SEDDS were prepared by combining a medium chain monoglyceride, Capmul MCM EP, a medium chain triglyceride, Captex 355 EP/NF, or their mixtures with a surfactant Cremophor EL, and a model drug, probucol, was then dissolved. The solutions were directly adsorbed onto Neusilin®US2 at 1:1 w/w ratio. Content uniformity, bulk and tap density, compressibility index, Hausner ratio and angle of repose of the powders formed were determined. The powders were then compressed into tablets. The dispersion of SEDDS from tablets was studied in 250 mL of 0.01NHCl (USP dissolution apparatus; 50 RPM; 37 C) and compared with that of liquid SEDDS. Results: After adsorption of liquid SEDDS onto Neusilin®US2, all powders demonstrated acceptable flow properties and content uniformity for development into tablet. Tablets with good tensile strength (>1 MPa) at the compression pressure of 45 to 135 MPa were obtained. Complete drug release from tablets was observed if the SEDDS did not form gels in contact with water; the gel formation clogged pores of the silicate and trapped the liquid inside pores. Conclusion: Liquid SEDDS were successfully developed into tablets by adsorbing them onto Neusilin®US2. Complete drug release from tablets could be obtained. © 2013 The Author(s).


Gumaste S.G.,St. John's University | Pawlak S.A.,St. John's University | Dalrymple D.M.,ABITEC Corporation | Nider C.J.,ABITEC Corporation | And 2 more authors.
Pharmaceutical Research | Year: 2013

Purpose: To compare six commonly available silicates for their suitability to develop tablets by adsorbing components of liquid lipid-based drug delivery systems. Methods: The tabletability of Aerosil® 200, Sipernat® 22, Sylysia® 350, Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were studied by compressing each silicate into tablets in the presence of 20% microcrystalline cellulose and measuring the tensile strength of tablets produced. Three components of lipid based formulations, namely, Capmul® MCM EP (glycerol monocaprylocaprate), Captex® 355 EP/NF (caprylic/capric triglycerides) and Cremophor® EL (PEG-35 castor oil), were adsorbed individually onto the silicates at 1:1 w/w, and the mixtures were then compressed into tablets. The SEM photomicrographs of neat silicates and their 1:1 w/w mixtures (also 1:2 and 1:3 for Neusilin® US2 and Neusilin® UFL2) with one of the liquids (Cremophor® EL) were recorded. Results: Neat Aerosil® 200, Sipernat® 22 and Sylysia® 350 were non-tabletable to the minimum acceptable tensile strength of 1 MPa, and they were also non-tabletable in presence of liquid. While Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were tabletable without the addition of liquids, only Neusilin® US2 retained acceptable tabletability with 1:1 liquid. The SEM images of silicate-liquid mixtures indicated that, except for Neusilin® US2, much of the adsorbed liquid distributed primarily at the surface of particles rather than inside pores, which hindered their compaction into tablets. Conclusion: Among the six silicates studied, Neusilin® US2 was the only silicate able to produce tablets with acceptable tensile strength in presence of a lipid component at 1:1 w/w ratio due to the fact that the liquid was mostly adsorbed into the pores of the silicate rather than at the surface. © 2013 The Author(s).


Patel N.,St. John's University | Dalrymple D.M.,ABITEC Corporation | Serajuddin A.T.M.,St. John's University
Journal of Excipients and Food Chemicals | Year: 2012

Solid self-emulsifying drug delivery systems (SEDDS) for medium chain triglycerides (Captex® 355, ABITEC) were developed using stearoyl polyoxyl glycerides (Acconon® C-50, ABITEC and Gelucire® 50/13, Gattefosse) as both solidifying and emulsifying agents. Different mixtures of the lipid and each solidifying agent were heated to 65°C until homogenously mixed clear liquids were formed. Probucol was dissolved as the model drug. The molten mass was then filled into hard gelatin capsules, which upon cooling to room temperature converted to a solid mass inside capsules. The triglyceride could be incorporated into the system to a concentration as high as 80% w/w, still maintaining the solid or semisolid consistency of the system. Powder XRD, DSC, microscopy (cross-polarization and confocal fluorescence techniques), dispersion test and particle size analysis of the solid systems with, and without, drug were conducted to characterize different formulations. The solidifying agents maintained their crystallinity in solid systems, while the lipids were interspersed in between crystalline regions. The drug remained solubilized in the lipid phase. The formulations dispersed almost completely in 2 hours with particle size of the dispersed lipid in the range of 250 to 500 nm when the lipid content in the formulation was up to 50% w/w. Thus, a novel method of developing solid formulations of liquid triglycerides by incorporating lipids in stearoyl polyoxyl glycerides has been developed. © IPEC-Americas Inc.


Trademark
Abitec Corporation | Date: 2012-08-28

Chemicals for use in the manufacture of goods in the nature of amphoterics, quaternary ammonium cationics, and blends thereof, which can act as cations or anions depending on the pH, or as both cation and anion, for use in a wide variety of goods including household, industrial, and institutional applications, personal care, and oilfield exploration.


Trademark
Abitec Corporation | Date: 2012-06-26

Powdered high melting point vegetable oil fat for use as an emulsifier in the manufacture of foods, specifically used in confections and coatings as preventive of liquefaction of other fats at high temperature and intended to produce dry texture in materials in which it is used.


Trademark
Abitec Corporation | Date: 2012-06-26

Chemicals for use in the manufacture of goods, in the nature of fatty alkanolamides used as emollients, surfactants and builders in shampoo, hard surface cleaners, and assorted personal care, household, industrial and institutional items.


Trademark
Abitec Corporation | Date: 2012-06-26

Chemicals for use in the manufacture of goods in the nature of ethoxylated fatty amines and amine derivatives used as emulsifiers and surfactants in household, industrial and institutional applications for products such as lotions, shampoos, oil field, metalworking, and asphalt enhancers.


Trademark
Abitec Corporation | Date: 2012-06-26

Chemicals for use in the manufacture of goods in the nature of ethoxylated and nonionic compounds used as detergents, surfactants, emulsifiers, and wetting agents in household, industrial, institutional and personal care applications such as fabric treatment, personal care preparations, pulp and paper, and oil recovery.


Trademark
Abitec Corporation | Date: 2012-06-26

Chemicals for use in the manufacture of goods, in the nature of fatty quaternary ammonium compounds used for anti-static and softening of textiles, fibers, hard surfaces, personal care applications, and in household, industrial, institutional, personal care and paper industries.

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