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Aba, Nigeria

Abia State Polytechnic is located in the heart of Abia State, Aba, Nigeria. It is composed of different schools, such as the School of Science & Engineering and the School of Business Administration.The color is Yellow and Dard Red.The Rector is Onukaogu Abalogun A. Wikipedia.


Eleazu C.O.,National Root Crops Research Institute | Eleazu K.C.,Abia State Specialist and Diagnostic Center | Ironkwe A.,National Root Crops Research Institute | Iroaganachi M.A.,Abia State Polytechnic
Diabetes and Metabolism Journal | Year: 2014

Background: The effect of livingstone potato (Plectranthus esculenthus N.E.Br) on diabetes and its complications in Streptozotocin induced diabetic rats was investigated. The duration of the experiment was 4 weeks. Methods: The blood glucose level of the rats was measured with a glucometer, the protein and glucose and specific gravity in the urine samples of the rats were measured using urine assay strips and urinometer respectively. The liver and kidney function parameters in the serum of the rats were determined using Biosystem Kits. Results: The diabetic rats given livingstonepotato incorporated feeds, had 129.7% decrease in their hyperglycemia with corresponding amelioration of their elevated urinary protein, sugars, specific gravity, renal growth, liver growth as well as 15.64% decrease in body weights compared with the nondiabetic rats that had 5.54% decrease in blood glucose and 20.39% increase in body weight unlike the diabetic control rats that had 18.34% decrease in blood glucose and 52.68% decrease in body weight. There were significant differences (P<0.05) in the relative liver, pancreas, and kidney weights of the diabetic rats given livingstone potato feeds compared with the diabetic control while there were no significant differences (P>0.05) in the relative heart weights of all the rats in the three different groups. In terms of liver and kidney function parameters, values obtained for the diabetic rats given livingstone potato incorporated feeds were not significantly different from that of the nondiabetic rats except for total bilurubin, aspartate transaminase, and creatinine (P>0.05) while they were significantly different from the values obtained for the diabetic control rats (P<0.05). In addition, the serum amylase of the diabetic control rats were significantly higher (P<0.05) than that of the nondiabetic and diabetic rats treated with livingstone potato incorporated feeds. Conclusion: Results show the antidiabetic actions of livingstone potato and its ability to ameliorate glomerular complication and liver hypertrophy in diabetics. © 2014 Korean Diabetes Association. Source


Ojiako O.A.,Federal University of Technology Owerri | Chikezie P.C.,Imo State University | Ogbuji A.C.,Abia State Polytechnic
Journal of Traditional and Complementary Medicine | Year: 2016

The current study sought to investigate the capacities of single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Asystasia gangetica, Emilia coccinea, and Hibiscus rosasinensis to reverse hyperglycemia and dyslipidemia in alloxan-induced diabetic male rats. Phytochemical composition of the herbal extracts, fasting plasma glucose concentration (FPGC), and serum lipid profile (SLP) of the rats were measured by standard methods. The relative abundance of phytochemicals in the four experimental leaf extracts was in the following order: flavonoids > alkaloids > saponins > tannins. Hyperglycemic rats (HyGR) treated with single and combinatorial herbal formulations showed evidence of reduced FPGC compared with the untreated HyGR and were normoglycemic (FPGC < 110.0 mg/dL). Similarly, HyGR treated with single and combinatorial herbal formulations showed evidence of readjustments in their SLPs. Generally, HyGR treated with triple herbal formulations (THfs) exhibited the highest atherogenic index compared with HyGR treated with single herbal formulations (SHfs), double herbal formulations (DHfs), and quadruple herbal formulation (QHf). The display of synergy or antagonism by the composite herbal extracts in ameliorating hyperglycemia and dyslipidemia depended on the type and number of individual herbal extract used in constituting the experimental herbal formulations. Furthermore, the capacities of the herbal formulations (SHfs, DHfs, THfs, and QHf) to exert glycemic control and reverse dyslipidemia did not follow predictable patterns in the animal models. Copyright © 2014 Center for Food and Biomolecules, National Taiwan University. Source


Ojiako O.A.,Federal University of Technology Owerri | Chikezie P.C.,Imo State University | Ogbuji A.C.,Abia State Polytechnic
Journal of Traditional and Complementary Medicine | Year: 2016

Reactive oxygen and nitrogen species (RONS) are involved in deleterious/beneficial biological processes. The present study sought to investigate the capacity of single and combinatorial herbal formulations of Acanthus montanus, Emilia coccinea, Hibiscus rosasinensis, and Asystasia gangetica to act as superoxide radicals (SOR), hydrogen peroxide (HP), nitric oxide radical (NOR), hydroxyl radical (HR), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical antagonists using in vitro models. The herbal extracts were single herbal formulations (SHfs), double herbal formulations (DHfs), triple herbal formulations (THfs), and a quadruple herbal formulation (QHf). The phytochemical composition and radical scavenging capacity index (SCI) of the herbal formulations were measured using standard methods. The flavonoids were the most abundant phytochemicals present in the herbal extracts. The SCI50 defined the concentration (μg/mL) of herbal formulation required to scavenge 50% of the investigated radicals. The SHfs, DHfs, THfs, and QHf SCI50 against the radicals followed the order HR > SOR > DPPH radical > HP > NOR. Although the various herbal formulations exhibited ambivalent antioxidant activities in terms of their radical scavenging capabilities, a broad survey of the results of the present study showed that combinatorial herbal formulations (DHfs, THfs, and QHf) appeared to exhibit lower radical scavenging capacities than those of the SHfs in vitro. Copyright © 2014 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. All rights reserved. Source


Ojiako O.A.,University of Nigeria | Chikezie P.C.,Imo State University | Ogbuji A.C.,Abia State Polytechnic
International Journal of Green Pharmacy | Year: 2015

Background and Aim: The present study investigated the capacity of single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Asystasia gangetica, Emilia coccinea, and Hibiscus rosasinensis to reverse renal and hepatic injuries in alloxan-induced hyperglycemic rats. Settings and Design: A total of 102 male Wistar rats were allotted into 17 groups of six rats each. The animals were deprived of food and water for additional 16 h before the commencement of treatment. The animal groups were designated on the basis of treatments received at regular intervals of 2 days for 30 days. Materials and Methods: Histological images of renal and hepatic tissue sections were captured using charge-couple device camera under a light microscope. Blood biochemical indices were measured using spectrophotometric methods. Statistical Analysis: The data were analyzed by one-way ANOVA followed by Dunnett test, with the level of significance set at P < 0.05. Results: Histopathological studies of the untreated hyperglycemic rats showed evidence of hypertrophy and disarrangements of the hepatic parenchyma. The architecture of hepatic parenchyma showed evidence of varying levels of necrosis and restoration of cellular integrity following herbal treatment. Similarly, histopathological studies of the renal tissues showed evidence of cells swellings and fibrotic changes of the glomeruli. However, herbal treatments restored cellular integrity and reversed glomeruli atrophy and turf disarrangement. In addition, blood biochemical indices showed evidence of restoration of cellular integrity. Conclusion: Both histological and biochemical indices revealed varying capacities of single and combinatorial herbal formulations to reverse renal and hepatic tissues injuries in hyperglycemic rats. © 2015 International Journal of Green Pharmacy. Source


Eleazu C.O.,National Root Crops Research Institute | Iroaganachi M.,Abia State Polytechnic | Okafor P.N.,Michael Okpara University of Agriculture | Ijeh I.I.,Michael Okpara University of Agriculture | Eleazu K.C.,Michael Okpara University of Agriculture
International Journal of Biomedical Science | Year: 2013

The ameliorating potentials of ginger incorporated feed (10%) on the relative organ weights of Streptozotocin (ST Z) induced diabetic rats was investigated. The experiment lasted for three weeks. Results show that administration of 10% ginger feed to the diabetic rats of group 3, resulted in a 29.81% decrease in their resulting hyperglycemia with a corresponding amelioration of elevated urinary protein, sugars, specific gravity as well as renal growth. In addition, administration of the ginger incorporated feeds to the diabetic rats of group 3, resulted in 9.88% increase in body weight with a corresponding 60.24% increase in growth compared with the non-diabetic rats administered standard rat pellets that had 6.21% increase in weight with a corresponding 60.14% increase in growth unlike the diabetic control rats that recorded 28.62% decrease in body weight with a corresponding 239.9% decrease in growth rates. Analysis of the chemical composition of the flour of the ginger incorporated feed indicated that it contained low quantities of moisture but significant quantities of crude fibre, proteins, lipids, carbohydrates, ash, alkaloids, flavonoids, saponins, tannins, calcium, magnesium, potassium, iron, zinc, phosphorous in addition to considerable amount of energy. There was no significant difference (P>0.05) in the liver and relative liver weights of the diabetic control rats and the diabetic -ginger treated rats. In addition, there were no significant differences in the kidney weights of the non-diabetic, diabetic control and diabetic treated rats (P>0.05) and there was also no significant difference in the relative kidney weight of the non-diabetic rats and the diabetic rats treated with ginger feeds (P>0.05). Results show that the use of ginger in the dietary management of diabetes mellitus could be a breakthrough in the search for novel plants that could prevent the development of diabetic glomerular hypertrophy. © 2013 C. O. Eleazu et al. Source

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