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Stockholm, Sweden
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— ReportsnReports.com adds Chlamydia Infections Market- Pipeline Review, H1 2017 a new research reports in its store. The pipeline guide provides a snapshot of the global therapeutic landscape of Chlamydia Infections (Infectious Disease). The pipeline guide reviews pipeline therapeutics for Chlamydia Infections (Infectious Disease) by companies and universities/research institutes based on information derived from company and industry-specific sources. Browse the 21 Tables and 11 Figures, 11 Company Profiles, Spread across 66 Pages Report Available at http://www.reportsnreports.com/contacts/discount.aspx?name=983982 . Chlamydia Infections market companies are Abera Bioscience AB, Evofem Inc, Lead Discovery Center GmbH, Merck & Co Inc, NanoBio Corp, Prokarium Ltd, QureTech Bio AB, SATT IDF Innov SAS, Selecta Biosciences Inc, SIGA Technologies Inc, Vault Pharma Inc. The report provides comprehensive information on the therapeutics under development for Chlamydia Infections (Infectious Disease), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. The Chlamydia Infections (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Chlamydia Infections and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase I, Preclinical and Discovery stages are 1, 1, 9 and 2 respectively. Similarly, the Universities portfolio in Phase I and Preclinical stages comprises 1 and 4 molecules, respectively. Place Order to This Report at http://www.reportsnreports.com/purchase.aspx?name=983982 . Chlamydia Infections Drug Profiles: Ab-03, acALY-18, Amphora Small Molecules to Block Virulence for Chlamydia Infections - Drug Profile: solithromycin, ST-669, VPI-201 Chlamydia Infections (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. Scope The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages. The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities. The pipeline guide reviews key companies involved in Chlamydia Infections (Infectious Disease) therapeutics and enlists all their major and minor projects. The pipeline guide evaluates Chlamydia Infections (Infectious Disease) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type. The pipeline guide encapsulates all the dormant and discontinued pipeline projects. The pipeline guide reviews latest news related to pipeline therapeutics for Chlamydia Infections (Infectious Disease) Reasons to buy Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies. Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage. Find and recognize significant and varied types of therapeutics under development for Chlamydia Infections (Infectious Disease). Classify potential new clients or partners in the target demographic. Develop tactical initiatives by understanding the focus areas of leading companies. Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics. Formulate corrective measures for pipeline projects by understanding Chlamydia Infections Market (Infectious Disease) pipeline depth and focus of Indication therapeutics. Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope. Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline. About Us: ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 95 leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. For more information, please visit http://www.reportsnreports.com/reports/983982-chlamydia-infections-pipeline-review-h1-2017.html


News Article | November 21, 2016
Site: www.prnewswire.co.uk

ReportsnReports.com adds "Tuberculosis - Pipeline Review, H2 2016" to its store providing comprehensive information on the therapeutics under development for Tuberculosis (Respiratory), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Complete report on H2 2016 pipeline review of Tuberculosis with 108 market data tables and 17 figures, spread across 393 pages is available at http://www.reportsnreports.com/reports/755901-tuberculosis-pipeline-review-h2-2016.html. Tuberculosis, commonly known as TB, is a bacterial infection that can spread through the lymph nodes and bloodstream to any organ in body. It is most often found in the lungs. The symptoms of tuberculosis range from no symptoms (latent tuberculosis) to symptoms of active disease. Symptoms include overall sensation of feeling unwell; cough, possibly with bloody mucus, fatigue, shortness of breath, weight loss and pain in the chest. Companies discussed in this Tuberculosis Pipeline Review, H2 2016 report include Abera Bioscience AB, Akthelia Pharmaceuticals Limited, Alvogen Korea Co., Ltd., Anacor Pharmaceuticals, Inc., Archivel Farma S.L., AstraZeneca Plc, Beech Tree Labs, Inc., BioDiem Ltd, BioLingus AG, Biomar Microbial Technologies, Bioversys AG, Celgene Corporation, Cellceutix Corporation, Chongqing Zhifei Biological Products Co., Ltd., Crestone, Inc., Dafra Pharma International Ltd., Daiichi Sankyo Company, Limited, Demuris Limited, Eisai Co., Ltd., Eli Lilly and Company, Ensol Biosciences Inc., EpiVax, Inc., FIT Biotech Oy, GangaGen Inc., GlaxoSmithKline Plc, Globeimmune, Inc., Hager Biosciences, LLC, Hsiri Therapeutics LLC, Imaxio SA, Immunitor, Inc., ImmunoBiology Limited, Inovio Pharmaceuticals, Inc., Johnson & Johnson, Lakewood-Amedex Inc, Lipotek Pty Ltd., Matinas BioPharma Holdings, Inc., Microbion Corporation, Microbiotix, Inc., NEARMEDIC PLUS, Ltd, Novartis AG, NovoBiotic Pharmaceuticals, LLC, Otsuka Holdings Co., Ltd., QureTech Bio AB, Recce Pty Ltd, Rodos BioTarget GmbH, Sanofi, Sanofi Pasteur SA, Sarepta Therapeutics, Inc., Sequella, Inc., Shionogi & Co., Ltd., Sphaera Pharma Pvt. Ltd., Spring Bank Pharmaceuticals, Inc., Takeda Pharmaceutical Company Limited, TetraLogic Pharmaceuticals, TGV-Laboratories, Theravectys SA, Tomegavax, Inc., Transgene SA, TVAX Biomedical, Inc., Univalue Valorizacion, S.L., Vaccibody AS, Vakzine Projekt Management GmbH, Vaxil Bio Therapeutics Ltd. and Vichem Chemie Research Ltd. The Tuberculosis (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Tuberculosis and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 1, 5, 7, 8, 61, 37 and 3 respectively. Similarly, the Universities portfolio in Phase III, Phase II, Phase I, Preclinical and Discovery stages comprises 2, 4, 5, 35 and 37 molecules, respectively. Tuberculosis (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis. The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. Scope of this report: The report provides a snapshot of the global therapeutic landscape of Tuberculosis and reviews pipeline therapeutics for Tuberculosis by companies and universities/research institutes based on information derived from company and industry-specific sources and key players involved Tuberculosis therapeutics and enlists all their major and minor projects. The research covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages. The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities and assesses Tuberculosis therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report summarizes all the dormant and discontinued pipeline projects with latest news related to pipeline therapeutics for Tuberculosis. ReportsnReports.com is your single source for all market research needs. Our database includes 500,000+ market research reports from over 100+ leading global publishers & in-depth market research studies of over 5000 micro markets. With comprehensive information about the publishers and the industries for which they publish market research reports, we help you in your purchase decision by mapping your information needs with our huge collection of reports. Connect With Us on: Facebook: https://www.facebook.com/ReportsnReports/ LinkedIn: https://www.linkedin.com/company/reportsnreports Twitter: https://twitter.com/marketsreports G+ / Google Plus: https://plus.google.com/111656568937629536321/posts RSS/Feeds: http://www.reportsnreports.com/feed/l-latestreports.xml


Jong W.S.P.,Abera Bioscience AB | Jong W.S.P.,VU University Amsterdam | Vikstrom D.,Xbrane Biopharma AB | Houben D.,Abera Bioscience AB | And 4 more authors.
Microbial Cell Factories | Year: 2017

Background: Heterologous protein production in Escherichia coli often suffers from bottlenecks such as proteolytic degradation, complex purification procedures and toxicity towards the expression host. Production of proteins in an insoluble form in inclusion bodies (IBs) can alleviate these problems. Unfortunately, the propensity of heterologous proteins to form IBs is variable and difficult to predict. Hence, fusing the target protein to an aggregation prone polypeptide or IB-tag is a useful strategy to produce difficult-to-express proteins in an insoluble form. Results: When screening for signal sequences that mediate optimal targeting of heterologous proteins to the periplasmic space of E. coli, we observed that fusion to the 39 amino acid signal sequence of E. coli TorA (ssTorA) did not promote targeting but rather directed high-level expression of the human proteins hEGF, Pla2 and IL-3 in IBs. Further analysis revealed that ssTorA even mediated IB formation of the highly soluble endogenous E. coli proteins TrxA and MBP. The ssTorA also induced aggregation when fused to the C-terminus of target proteins and appeared functional as IB-tag in E. coli K-12 as well as B strains. An additive effect on IB-formation was observed upon fusion of multiple ssTorA sequences in tandem, provoking almost complete aggregation of TrxA and MBP. The ssTorA-moiety was successfully used to produce the intrinsically unstable hEGF and the toxic fusion partner SymE, demonstrating its applicability as an IB-tag for difficult-to-express and toxic proteins. Conclusions: We present proof-of-concept for the use of ssTorA as a small, versatile tag for robust E. coli-based expression of heterologous proteins in IBs. © 2017 The Author(s).


Grant
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: HEALTH.2011.1.4-4 | Award Amount: 40.88M | Year: 2011

Vaccines so far have been developed mostly by following an empiric approach. To prevent and possibly cure unresolved and emerging infectious diseases we need to fully exploit the potential of the human immune system. Progress in science and technology makes it possible to achieve what was previously deemed impossible. The scope of this project is to produce knowledge necessary to develop novel and powerful immunization technologies for the next generation of human vaccines. This goal requires a multidisciplinary approach in which diverse but complementary scientific disciplines and technologies converge. Therefore some of the most competitive European research groups from public institutions and biotechs have agreed to join forces in ADITEC, together with top US groups on systems biology and adjuvants to support this enterprise. A systems biology approach will be used to study licensed and experimental vaccines in patient characterization studies and in clinical trials, to investigate the effect of adjuvants, vectors, formulations, delivery devices, routes of immunization, homologous and heterologous primeboost schedules, as well as the impact of host factors such as age, gender, genetics and pathologies. Animal models will be used to complement human studies, and to select novel immunization technologies to be advanced to the clinic. To address these issues in a coordinated manner, ADITEC is organised on a matrix structure in which research themes and experimental approaches feed into each other. Training curricula will be created to impact on the formation of the next generation of EU researchers in the field. ADITEC scientists and institutions are part of the Sclavo Vaccines Association (SVA), which is dedicated to vaccines and vaccine research. SVA, acting as the coordinating institution, guarantees the long-term commitment and sustainability of this initiative, beyond the duration of ADITEC itself.


Drobnak I.,University of Notre Dame | Drobnak I.,Acies Bio d.o.o. | Braselmann E.,University of Notre Dame | Braselmann E.,University of Colorado at Boulder | And 8 more authors.
Molecular Microbiology | Year: 2015

Autotransporter (AT) proteins provide a diverse array of important virulence functions to Gram-negative bacterial pathogens, and have also been adapted for protein surface display applications. The 'autotransporter' moniker refers to early models that depicted these proteins facilitating their own translocation across the bacterial outer membrane. Although translocation is less autonomous than originally proposed, AT protein segments upstream of the C-terminal transmembrane β-barrel have nevertheless consistently been found to contribute to efficient translocation and/or folding of the N-terminal virulence region (the 'passenger'). However, defining the precise secretion functions of these AT regions has been complicated by the use of multiple overlapping and ambiguous terms to define AT sequence, structural, and functional features, including 'autochaperone', 'linker' and 'junction'. Moreover, the precise definitions and boundaries of these features vary among ATs and even among research groups, leading to an overall murky picture of the contributions of specific features to translocation. Here we propose a unified, unambiguous nomenclature for AT structural, functional and conserved sequence features, based on explicit criteria. Applied to 16 well-studied AT proteins, this nomenclature reveals new commonalities for translocation but also highlights that the autochaperone function is less closely associated with a conserved sequence element than previously believed. © 2014 John Wiley & Sons Ltd.


News Article | December 2, 2016
Site: www.PR.com

Report provides broad information on the therapeutics under development for tuberculosis globally. This covers the descriptive pharmacological action of the therapeutics with its complete research & development history. Albany, NY, December 02, 2016 --( This covers the descriptive pharmacological action of the therapeutics with its complete research & development history as well as latest news and press release featured from company/university sites and industry-specific third party sources. Request for Free Sample Report: http://www.marketresearchhub.com/enquiry.php?type=S&repid=873477 Firstly, the report begins with the overview of Tuberculosis along with its therapeutic developments. Tuberculosis, commonly known as TB is an infectious disease that usually affects the lungs. It is a bacterial infection which spreads through the lymph nodes and bloodstream to any organ in the body. It is the second greatest killer due to a single infectious agent worldwide. In 2012, about 1.3 million people died from the disease and 8.6 million were infected. Symptoms of TB include: sensation of feeling unwell cough (possibly with bloody mucus) fatigue Night sweats shortness of breath weight loss chest pain The research studies that, an active tuberculosis, particularly if it's a drug-resistant strain will require several drugs at once. The most common medications used to treat tuberculosis include, Rifampin (Rifadin, Rimactane), Isoniazid, Ethambutol and Pyrazinamide. In this review, an update on the recent developments in the tuberculosis drug-development pipeline is offered (including new antimicrobials and host-directed drugs), as they are applied to new regimens to reduce and improve outcomes of tuberculosis treatment. Some new or repurposed antimicrobial drugs are in advanced trial stages for MDR (Multi drug resistant) tuberculosis, and two new antimicrobial drug candidates are in early-stage trials. Several trials to decrease the duration of therapy in MDR and drug-susceptible tuberculosis are ongoing. Further, the report also covers the details of companies involved in the therapeutics development. Some of them are mentioned below: Abera Bioscience AB Akthelia Pharmaceuticals Limited Alvogen Korea Co. Ltd. Hsiri Therapeutics LLC Anacor Pharmaceuticals GlaxoSmithKline Plc TGV-Laboratories Sarepta Therapeutics, Inc and others. Browse Full Info with TOC: http://www.marketresearchhub.com/report/tuberculosis-pipeline-review-h2-2016-report.html Additionally, an overview of several key players’ in therapeutic development along with their dormant and discontinued projects are also mentioned in the report. This will prove helpful for the buyers in identifying and tracking emerging players which boosts decision making capabilities and helps to create effective counter strategies to gain competitive advantage. About Us Market Research Hub (MRH) is a next-generation reseller of research reports and analysis. MRH’s expansive collection of market research reports has been carefully curated to help key personnel and decision makers across industry verticals to clearly visualize their operating environment and take strategic steps. MRH functions as an integrated platform for the following products and services: Objective and sound market forecasts, qualitative and quantitative analysis, incisive insight into defining industry trends, and market share estimates. Our reputation lies in delivering value and world-class capabilities to our clients. Contact Us 90 State Street Albany, NY 12207, United States Toll Free : 866-997-4948 (US-Canada) Tel : +1-518-621-2074 Email : press@marketresearchhub.com Website : http://www.marketresearchhub.com Albany, NY, December 02, 2016 --( PR.com )-- A recent pipeline review analysis report has been launched by Global Market Direct’s pharmaceutical and healthcare disease pipeline guide. This report has been announced to the massive database of Market Research Hub (MRH). This research study of 393 pages is titled as “Tuberculosis- Pipeline Review, H2 2016” and offers broad information on the therapeutics under development for tuberculosis globally.This covers the descriptive pharmacological action of the therapeutics with its complete research & development history as well as latest news and press release featured from company/university sites and industry-specific third party sources.Request for Free Sample Report: http://www.marketresearchhub.com/enquiry.php?type=S&repid=873477Firstly, the report begins with the overview of Tuberculosis along with its therapeutic developments. Tuberculosis, commonly known as TB is an infectious disease that usually affects the lungs. It is a bacterial infection which spreads through the lymph nodes and bloodstream to any organ in the body. It is the second greatest killer due to a single infectious agent worldwide. In 2012, about 1.3 million people died from the disease and 8.6 million were infected. Symptoms of TB include:sensation of feeling unwellcough (possibly with bloody mucus)fatigueNight sweatsshortness of breathweight losschest painThe research studies that, an active tuberculosis, particularly if it's a drug-resistant strain will require several drugs at once. The most common medications used to treat tuberculosis include, Rifampin (Rifadin, Rimactane), Isoniazid, Ethambutol and Pyrazinamide. In this review, an update on the recent developments in the tuberculosis drug-development pipeline is offered (including new antimicrobials and host-directed drugs), as they are applied to new regimens to reduce and improve outcomes of tuberculosis treatment. Some new or repurposed antimicrobial drugs are in advanced trial stages for MDR (Multi drug resistant) tuberculosis, and two new antimicrobial drug candidates are in early-stage trials. Several trials to decrease the duration of therapy in MDR and drug-susceptible tuberculosis are ongoing.Further, the report also covers the details of companies involved in the therapeutics development. Some of them are mentioned below:Abera Bioscience ABAkthelia Pharmaceuticals LimitedAlvogen Korea Co. Ltd.Hsiri Therapeutics LLCAnacor PharmaceuticalsGlaxoSmithKline PlcTGV-LaboratoriesSarepta Therapeutics, Inc and others.Browse Full Info with TOC: http://www.marketresearchhub.com/report/tuberculosis-pipeline-review-h2-2016-report.htmlAdditionally, an overview of several key players’ in therapeutic development along with their dormant and discontinued projects are also mentioned in the report. This will prove helpful for the buyers in identifying and tracking emerging players which boosts decision making capabilities and helps to create effective counter strategies to gain competitive advantage.About UsMarket Research Hub (MRH) is a next-generation reseller of research reports and analysis. MRH’s expansive collection of market research reports has been carefully curated to help key personnel and decision makers across industry verticals to clearly visualize their operating environment and take strategic steps.MRH functions as an integrated platform for the following products and services: Objective and sound market forecasts, qualitative and quantitative analysis, incisive insight into defining industry trends, and market share estimates. Our reputation lies in delivering value and world-class capabilities to our clients.Contact Us90 State StreetAlbany, NY 12207,United StatesToll Free : 866-997-4948 (US-Canada)Tel : +1-518-621-2074Email : press@marketresearchhub.comWebsite : http://www.marketresearchhub.com Click here to view the list of recent Press Releases from Market Research Hub


Daleke-Schermerhorn M.H.,VU University Amsterdam | Daleke-Schermerhorn M.H.,Abera Bioscience AB | Felix T.,Institute Pasteur Paris | Felix T.,French Institute of Health and Medical Research | And 25 more authors.
Applied and Environmental Microbiology | Year: 2014

Outer membrane vesicles (OMVs) are spherical nanoparticles that naturally shed from Gram-negative bacteria. They are rich in immunostimulatory proteins and lipopolysaccharide but do not replicate, which increases their safety profile and renders them attractive vaccine vectors. By packaging foreign polypeptides in OMVs, specific immune responses can be raised toward heterologous antigens in the context of an intrinsic adjuvant. Antigens exposed at the vesicle surface have been suggested to elicit protection superior to that from antigens concealed inside OMVs, but hitherto robust methods for targeting heterologous proteins to the OMV surface have been lacking. We have exploited our previously developed hemoglobin protease (Hbp) autotransporter platform for display of heterologous polypeptides at the OMV surface. One, two, or three of the Mycobacterium tuberculosis antigens ESAT6, Ag85B, and Rv2660c were targeted to the surface of Escherichia coli OMVs upon fusion to Hbp. Furthermore, a hypervesiculating ΔtolR ΔtolA derivative of attenuated Salmonella enterica serovar Typhimurium SL3261 was generated, enabling efficient release and purification of OMVs decorated with multiple heterologous antigens, exemplified by the M. tuberculosis antigens and epitopes from Chlamydia trachomatis major outer membrane protein (MOMP). Also, we showed that delivery of Salmonella OMVs displaying Ag85B to antigen-presenting cells in vitro results in processing and presentation of an epitope that is functionally recognized by Ag85B-specific T cell hybridomas. In conclusion, the Hbp platform mediates efficient display of (multiple) heterologous antigens, individually or combined within one molecule, at the surface of OMVs. Detection of antigen- specific immune responses upon vesicle-mediated delivery demonstrated the potential of our system for vaccine development. © 2014, American Society for Microbiology.

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