Aber Instruments Ltd.

Aberystwyth, United Kingdom

Aber Instruments Ltd.

Aberystwyth, United Kingdom
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Kedia G.,University of South Wales | Passanha P.,University of South Wales | Dinsdale R.M.,University of South Wales | Guwy A.J.,University of South Wales | And 2 more authors.
Bioresource Technology | Year: 2013

In this study, dielectric spectroscopy was utilised to evaluate and define the optimum harvesting time for polyhydroxyalkanoates (PHA) production. It is essential to harvest PHA at the optimum time during fermentation for maximum yield, otherwise cells start degrading. Two carbon sources (acetic and butyric acids) were used in laboratory based experiments and a number of samples were measured ex situ for PHA production. The real-time measured capacitance in addition of identifying the cells growth phase, it correlated very well with ex situ measured PHA produced within the cells. The probe has proven to be a useful tool to assess process kinetics, to monitor real-time cell growth, PHA produced and defining the optimum harvesting time. © 2013 Elsevier Ltd.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.0-1 | Award Amount: 6.79M | Year: 2013

The REACH-project is a direct result of the FP7 StemExpand project, which aimed at the expansion and engraftment of hematopoietic and mesenchymal stem cells (MSC) for clinical use. The results of these research activities show that a novel, closed and controlled bioreactor can be developed to grow clinically relevant numbers (>400 million) of MSCs. XPand Biotechnology BV(NL) [bioreactor development, technology valorization], Aber Instruments ltd (UK)[biomass sensor] and PreSens Precision Sensing GmbH (GE) [DO, pH sensor] are three SMEs that have teamed up to develop this novel bioreactor system to a pre-commercial scale. The overall aim of the REACH project is to further develop and engineer the bioreactor (incl. valorization, testing and technical and biological validation) to a closed-system sensor-controlled bioreactor with sampling possibilities that allows for GMP-grade MSC production outside a cleanroom. The system will contain a disposable bioreactor bag with unique miniaturized disposable sensors. The DO and pH sensors use optical chemical methods capable of high frequency sampling, this ensures an enhanced stability of the expansion process. Using an expandable bioreactor the volume can be increased during cell culture, without the need for passaging of the cells. Because of this feature the system can be truly closed, without the limitations of a fixed culture substrate area. Leiden University Medical Center (NL) will validate the system and the products in a clinical setting by comparing bioreactor-expanded MSCs with GMP grade MSCs produced by established protocols in the LUMC. Successful development of this bioreactor system will be beneficial for the participating SMEs as well as the medical sector which will be able to develop cell therapies in a faster, cheaper and more efficient way. Collectively, the partners in REACH will develop an exploitation and business plan for the successful valorization of the research done in the FP7 StemExpand project.


Patent
Aber Instruments Ltd | Date: 2013-11-23

A connector to enable connection between a device that is typically poorly supported meaning that when the connector is brought into contact with the device there can be little force applied to the device in order that it does not move. A device may be a flexible disposable bioreactor wherein a probe is secured within the bioreactor and a connection enables a reading to be taken from the electrodes of the probe. The connector includes a device connection arrangement, a collar rotatable between a first configuration enabling releasable engagement with a device and a second configuration wherein the device is restrained by the collar. A shoulder is provided in the device connection arrangement to limit insertion of at least a portion of the device into the recess wherein the shoulder aligns at least a portion of the device with a channel provided in the radially inwardly surface of the collar.


Patent
Aber Instruments Ltd | Date: 2011-07-07

A method of dealing with the electrode polarization error when analyzing a dielectric test medium is achieved by firstly applying an excitation current to the test medium at a test frequency, by means of a first electric couple (23, 24) comprising excitation electrodes (23, 24). Next the voltage across the excitation electrode couple (23, 24) is measured and the voltage across a second couple of electrodes (25, 26) is also measured. The measured voltages across the first and second electrode couples are compared in order to derive a polarization correction factor which is used to provide a corrective value for the capacitance, or conductivity measurement. The method is suitable for use in industrial on-line applications.


Patent
Aber Instruments Ltd | Date: 2014-04-30

This invention relates to an improved probe designed in particular but not exclusively for measuring the concentration of live biomass. The probe has an insulating body portion arranged to carry a first and second electrode where the probe has a longitudinal axis and the first and second electrodes extend in this longitudinal axis. The body portion has a cross-sectional area perpendicular to the longitudinal axis defined by a major axis and minor axis, wherein the length of the body portion in the major axis is greater than the length of the body portion in the minor axis. The first and second electrodes are positioned on either side of the major axis. This reduces the effect of impedance between the electrode and the liquid through increasing the effective distance between the electrodes.


Patent
Aber Instruments Ltd | Date: 2014-06-04

The present invention relates to a connector 1 to enable connection between a device 2 that is typically poorly supported meaning that when the connector is brought into contact with the device there can be little force applied to the device in order that it does not move. Such a device may be a flexible disposable bioreactor wherein a probe is secured within a wall of the bioreactor and a connection is required to enable a reading to be taken from the electrodes of the probe. The connector 1 includes a collar 16 arranged to rotate between a first configuration enabling releasable engagement with the device and a second configuration wherein the device is restrained by the collar. A shoulder 46 is provided in the collar to limit insertion of at least a portion 10 of the device into a recess 22 wherein the shoulder aligns at least the portion of the device with a channel 30 provided in the radially inwardly surface of the collar.


Patent
Aber Instruments Ltd | Date: 2013-10-23

An improved probe designed in particular but not exclusively for measuring the concentration of live biomass. The probe has an insulating body portion arranged to carry a first and second electrode where the probe has a longitudinal axis and the first and second electrodes extend in this longitudinal axis. The body portion has a cross-sectional area perpendicular to the longitudinal axis defined by a major axis and minor axis, wherein the length of the body portion in the major axis is greater than the length of the body portion in the minor axis. The first and second electrodes are positioned on either side of the major axis. This reduces the effect of impedance between the electrode and the liquid through increasing the effective distance between the electrodes.


Patent
Aber Instruments Ltd | Date: 2011-10-26

A bioreactor arrangement has an enclosure (2) and an impedance monitor probe. The enclosure (2) is for containing a biological medium and includes one or more elongate port extensions (3) projecting outwardly from the enclosure and communicating from the exterior to the interior of the enclosure. The impedance monitor probe (11) is secured in one or more of the elongate ports (3) in order to have an electrode arrangement positioned (21a,21b) for monitoring of the biological medium. The impedance monitoring probe (11) comprises an elongate housing (13) having an outer surface extending along and contiguous with the elongate inner surface of the port extension. Housing extends from the electrode end (14) of the probe (11) to the remote end (16) of the probe. The remote end (16) of the probe is provided with an opening (29) of a bore (17) which extends at least part way internally along the length of the elongate housing (13) to an electrical connector (19) connected to the electrode arrangement.


Patent
Aber Instruments Ltd | Date: 2012-01-11

A method of dealing with the electrode polarization error when analyzing a dielectric test medium is achieved by firstly applying an excitation current to the test medium at a test frequency, by means of a first electric couple (23, 24) comprising excitation electrodes (23, 24). Next the voltage across the excitation electrode couple (23, 24) is measured and the voltage across a second couple of electrodes (25, 26) is also measured. The measured voltages across the first and second electrode couples are compared in order to derive a polarization correction factor which is used to provide a corrective value for the capacitance, or conductivity measurement. The method is suitable for use in industrial on-line applications.


Trademark
Aber Instruments Ltd | Date: 2013-03-01

Yeast pitching apparatus, namely, electronic yeast monitor, piping, flow meter, frame, control electronics, cables, transmitters, probes and electrodes sold as a unit; yeast measurement apparatus, namely, electronic yeast monitor, piping, flow meter, frame, control electronics, cables, transmitters, probes and electrodes sold as a unit; electronic control systems for the aforesaid goods; parts and fittings for the aforesaid goods.

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